CLUSTAL 2.1 multiple sequence alignment ENST00000244020.3 GTGAGGCGCGTGTTCGGGCTCTTGCCGTCCCCGCACCCGCACCGCGGTTACTGGCTTGCG ENST00000447169.1 ------------------------------------------------------------ ENST00000244020.3 GTCCGCCGTTCGACAACCAGCCCTTGGGTCCCCGCCCGCCACGGACATGCCGCGCGTCTA ENST00000447169.1 ------------------------------------------------------------ ENST00000244020.3 CATAGGACGCCTGAGCTACAACGTCCGGGAGAAGGACATCCAGCGCTTTTTCAGTGGCTA ENST00000447169.1 ------------------------------------------------------------ ENST00000244020.3 TGGCCGCCTCCTCGAAGTAGACCTCAAAAATGGGTACGGCTTCGTGGAGTTCGAGGACTC ENST00000447169.1 ------------------------------------------------------------ ENST00000244020.3 CCGCGACGCCGACGACGCCGTTTACGAGCTGAACGGCAAGGAGCTCTGCGGCGAGCGCGT ENST00000447169.1 ------------------------------------------------------------ ENST00000244020.3 GATCGTAGAGCACGCCCGGGGCCCGCGTCGCGATCGCGACGGCTACAGCTACGGAAGCCG ENST00000447169.1 ------------------------------------------------------------ ENST00000244020.3 CAGTGGTGGAGGTGGATACAGCAGTCGGAGAACATCTGGCAGAGACAAATACGGACCACC ENST00000447169.1 ----GGTGGAAGTGGATACAGCAGTCAGAGAACATCTGGCAGAGACAAATATGGACCACC ****** *************** ************************ ******** ENST00000244020.3 TGTTCGTACAGAATACAGGCTTATTGTAGAAAATCTTTCTAGTCGGTGCAGTTGGCAAGA ENST00000447169.1 TGTTCATACAGAATACGAGCTTATTATAGAAAGTCTTTCTAGTTGTTACAGTTGGCAAGA ***** ********** ******* ****** ********** * * ************ ENST00000244020.3 TTTAAAGGATTTTATGCGACAAGCAGGTGAAGTAACCTATGCGGATGCCCACAAGGAACG ENST00000447169.1 TTTAAAGGATTTTATGCAACAAGCAGATGAAGTAACCTATGTTGATGCTCACAAGGAATG ***************** ******** ************** ***** ********* * ENST00000244020.3 AACAAATGAGGGTGTAATTGAGTTTCGCTCCTACTCTGACATGAAGCGTGCTTTGGACAA ENST00000447169.1 CACAAGTGAGGGCGT---TGAGTTTCACTCCTATTTTGACATGAAGCTTGCTTTGGACAA **** ****** ** ******** ****** * *********** ************ ENST00000244020.3 ACTGGATGGCACAGAAATAAATGGCAGAAATATTAGGCTTATTGAAGATAAGCCACGCAC ENST00000447169.1 ACTGGATGGT-------------GCAGAAATATTAGGCTTATTGAAGGTAAGCCAGGCAC ********* ************************ ******* **** ENST00000244020.3 AAGCCATAGGCGATCTTACTCTGGAAGCAGATCCAGGTCTCGATCTAGAAGACGGTCACG ENST00000447169.1 AAGCCATAGGCGATCTGATTCTGGAAGCAGATCCAGGTATAGATCTAGAAGATGGTCACG **************** * ******************* * *********** ******* ENST00000244020.3 AAGTAGGAGTCGCAGGAGCAGCCGCAGTAGATCTCGAAGTATCTCAAAAAGTCGCTCCCG ENST00000447169.1 AAGTAGGAGTCGCAGGAGCAGCCACAGTAGATCTCGAAGTATCTCAAAAAGTCACTCCTG *********************** ***************************** **** * ENST00000244020.3 TTCCAGGTCGCGGAGCAAAGGTCGATCACGTTCTCGATCAAAAGGCAGGAAATCTAGATC ENST00000447169.1 ATC-AGGTTGCGGAGCAAAGGTCGATCACGTTCTCGTTCAAAAGGCAGGAAATCTAGCTC ** **** *************************** ******************** ** ENST00000244020.3 AAAGAGCAAATCTAAGCCCAAGTCTGATCGGGGCTCCCATTCACATTCTCGAAGCAGATC ENST00000447169.1 AAGGAGCAAATCTATGCCCAAATCTGATCTGGGCTCCTGTTCTTGTTCTCAAAGCAGATC ** *********** ****** ******* ******* *** ***** ********* ENST00000244020.3 TAAGGATGAGTATGAGAAATCTCGAAGCAGGTCTCGGTCCCGATCCCCTAAAGAAAATGG ENST00000447169.1 TAAGGATGAGTATGAGAAATCTCCAAGCAGGTCTCTGTCCCGATCTTCCAAAGAAAATGG *********************** *********** ********* * *********** ENST00000244020.3 AAAGGGTGATATAAAGTCAAAATCCAGATCAAGGAGCCAGTCCCGTTCCAATTCGCCGCT ENST00000447169.1 AAAAGGTGATATGAAGTCAAAATACAGATCAAGGAGCCAGTCTCGTTCCAATTCACCCCT *** ******** ********** ****************** *********** ** ** ENST00000244020.3 ACCTGTTCCACCCTCAAAGGCCCGTTCTGTGTCCCCTCCACCAAAAAGAGCTACTTCAAG ENST00000447169.1 ACCTGCTCCACCCTCAAAGGGTCATTCTGTGTCCCCTCCGCCAAAAAGAGCTACTTCAAG ***** ************** * *************** ******************** ENST00000244020.3 ATCCCGTTCTAGATCTCGCTCAAAGTCAAGATCAAGGTCCAGGTCGAGTTCCAGAGATTA ENST00000447169.1 ATCCCGTTCTAGATCCCATTCAAAATAAAGATCAGGGTGCAGGTTGAGTTCCAGAGATTA *************** * ***** * ******* *** ***** *************** ENST00000244020.3 ACTCAGAACTCCTTGTT---TGCACATTATTATGGAACACTTTCCTACTT----AGGCAG ENST00000447169.1 ATCCAGAACTCTTCATTCATTGCGCACTATTATGGAACACTTTTCTACTTGCTTAGGCAG * ******** * ** *** ** **************** ****** ****** ENST00000244020.3 TTACTCTTCCATGTTTATACTTGGCCTCTTCTGCAAGAGGAATCTCTTGAAAACAGGGGC ENST00000447169.1 TTGTTCTTCCATGTTTATACTTGGCTTCTTTTGCAAGAGGAATCTCCTGAAAACAGGGGC ** ********************* **** *************** ************* ENST00000244020.3 ACACAGAAATTTGATTTGTGGCCAAATTGGATGAAAAAGATGAGGCTCTAAGGAAATGGT ENST00000447169.1 ACACAGAAATTTGATTTGTGGCCAAATTTGATGAAAAAGATGAGGCTCTAAGGAAATGGT **************************** ******************************* ENST00000244020.3 GGCATGAAG------ACCCTCTCCCTTCTTTGTAGAATTAAGATAACTTTGATTTTATAG ENST00000447169.1 GGCATAAAGTCAAAGACCCTCTCCCTTCTTTGTAGAATTAAGATAACTTCAATTTTATAG ***** *** ********************************** ********* ENST00000244020.3 CTTTTGAGCTAACGTAACTTTTGTAAAGATTAAGCTCATTTAGTGTTGTTTTTTTTTTTT ENST00000447169.1 CTTTTGAGCTAAAATAACTTTTGTAAAGATTAAGCTCATTTAGA---------------- ************ ***************************** ENST00000244020.3 TTTTTTTTTTTTTTTTTTTTTTTTTAGTATTTCAGCAGGATCTGCTGGCAGGGTTTTTT- ENST00000447169.1 ---------------TGTTTTTAAAAGTATTTCAGCAGGATCTGCTG-CAGGGTTTGTTG * ***** ********************** ******** ** ENST00000244020.3 ----------TGTTTTATTTGTTTGCTTATTTTTAAATTAACTGTTTTGAGCTTTGAATA ENST00000447169.1 TTGTTGTTGTTGTGTTACTTGTTTGCTTATTTTAAAATTAACCGTTTCAAGCTTTGAATA *** *** *************** ******** **** *********** ENST00000244020.3 CTTAAGGCTTTAGAGGGAGAACCCAATTTTCAATTATGTTGGCTTTTTATAAAGCTTGAG ENST00000447169.1 CTTAAGGCTTTAGAGGGACAACCCAATTTTCAATTACATTTGCTTTTTATAAAGCTTGAG ****************** ***************** ** ******************* ENST00000244020.3 TTATGTAAGATTTAAATAAAAGTTTGCTACCAAGATGATTGCCTTATTGAATAGGTCACT ENST00000447169.1 TTATGTAAGCTTTAAATAAAAGTTTGCTACCAAAAAAA----------AAAAAGA----- ********* *********************** * * ** ** ENST00000244020.3 ATTAAATTCCTTTAAATGTTGATATCTGCCATTTGTGGAAACAACGTAAATTCTACTTAA ENST00000447169.1 ---AAATAC-----------AGTATTCACAAGATGTGAAA---------------CCCAA **** * *** * * **** ** * ** ENST00000244020.3 GTGTAAACAAGGCAAGCCTCAGACCAGCAATAAATTACTCAGTTTGGATAACATTATTTT ENST00000447169.1 GTATAGGGAGGGCCAACTTC-------TCATA---TACGTGG-------------GTTCT ** ** * *** * * ** *** *** * ** * ENST00000244020.3 GTGCAGTTAATCAAATTTGCCAAAGTCTTTATCTGCCCCTTTAACAAGTTGAGTAAAAAT ENST00000447169.1 GTAGGGCTGA----------------------CTGT-------GGGACTTGAGTATATGT ** * * * *** * ******* * * ENST00000244020.3 AAAAGGTATTTTTTAGTCAATGTGTTCCATGATTTTGCTTAAATTAATACTTT-TAAGTA ENST00000447169.1 GAA--------TTTGG---GTATACCCCAGGGAC---CTTGAACAAATCCCCTGCATGTA ** *** * * * *** * *** ** *** * * * *** ENST00000244020.3 --ATGGAACTTTTTTCA-AAGGCAAATTTAAACTATTTAAGAAATAGCTCCTAATACTTG ENST00000447169.1 CCAAGGGACAATTATAATGAGGTA---TAAAGCTGT---AAAAGTG--TCCTAGTACACA * ** ** ** * * *** * * ** ** * * ** * ***** *** ENST00000244020.3 GGATCTTGTTTAGAGAATCCACTTTCTGGAAGTTCTCAGCATAATTAGTGTTGAGAGTG- ENST00000447169.1 AGAGGATGATCTT-GAATTT-CCTGCTGCAGGGCCACA-CATGGGTAATGTGCAACGTGC ** ** * **** * * *** * * * ** *** ** *** * *** ENST00000244020.3 --GTTCAGTTGTCTTTAATGTTTGTCATGTGGAAATGGAAGTAGCCTCTTTTTGTTCTGA ENST00000447169.1 ACATTCAGT--------AGGTAAATCAGATGTA--TAGAAATGGCTCGCACATGCTGCCA ****** * ** *** ** * * *** * ** ** * * ENST00000244020.3 AATTGAGTTTATTCAAAGTGTAAAAGCACATACTGCATTTTCTGCTGAAAGATCATTATG ENST00000447169.1 -------CCCACTTAAGCTGTACCAATG---ACAGC--TATCTG--GGAAGAATACCAAC * * ** **** * ** ** * **** * **** * * ENST00000244020.3 TTTAACAGGCACTTAATCTCAGTAAAGTCAGTTGCCAGTTAAGTTCCACCCAGTAGTCAG ENST00000447169.1 TCT--------TTTTTTCCCAGC----CCAGGAGCAGTCTTAGCCCTTCTTCAT-GCTAG * * ** ** *** *** ** * ** * * * * ** ENST00000244020.3 TCCCCTTTGTAGTTAGTGGGATTATTTGATAATTGGTTAGATCATACTTGTAAATTTTAA ENST00000447169.1 GCACCTAT-TGATTGGAACAGTCACTTA-----TGATGAAAT-ACATTTGCCATTCCTGA * *** * * ** * * * ** ** * * ** * * *** * * * * ENST00000244020.3 TGCTTTGTGTAATTGGTTTGAAAAACAGTGAAATGGGTAAACGCAAAACTTTTGTACTTT ENST00000447169.1 T-CTAAAAACATTCTTTCTGCAAAAAAAAAAA------AAAAAAAAATCACGTGGACATG * ** * * * ** **** * ** *** *** * ** ** * ENST00000244020.3 ATT-ACGAGTAAAGTGTAATGAGTA-CTGTGGAAACCAAATTTGAATACTGCAAATTTGT ENST00000447169.1 ATTCAAAAGTA---TGTTATGGTTGTCTTTTAGAACTGTGCCTAGCCTCAAGTAATTGAT *** * **** *** *** * ** * *** * * **** * ENST00000244020.3 AGGAGTTACTAGGTTAGCAATTAGTCCATACATCCATAAGCCTGATGAGTTGAAATTGCA ENST00000447169.1 AAAACCTTCC---TTCAGAACC---TCAACCACTCCCAACCCC------------CTGCA * * * * ** ** ** ** * ** ** **** ENST00000244020.3 GTTTGAGAAGTGAATTAACCTTACATCCCTTTGTTCAGATACCTTAAAAGTTACTTTATT ENST00000447169.1 GT-------GCATACTATCTAAACATCCCATTGG-CATTTACCATAGG-----CTTCCT- ** * * ** * ******* *** ** **** ** *** * ENST00000244020.3 TAAAAGCATTTATTAATCTTAGTCTGAAATCAAAATATAGATTAATTGGCTCAGCTTTAA ENST00000447169.1 ---GAGCTTTTATTTATTTT---CTCAGGT----ATATAGG---ATTG---CAG-----A *** ****** ** ** ** * * ****** **** *** * ENST00000244020.3 TACCTTTCTAGGAGGTGTCACAATGTAGGGTACCAAGGGTTGGATTGTGATGGGGCATGG ENST00000447169.1 CCCCTCACCAGTGGGGACCACATCTCATCCTATC----TCTCTGTTATGCTG-------- *** * ** ** **** * ** * * ** ** ** ENST00000244020.3 TCGTACACTGCTCATTGTGCCACAGGTGTGACTGGAAAGCATGATATTCTAGGGTTGGTT ENST00000447169.1 TCATATAGTGCT----GTG------ATTTGTTT---ATGTAAGATGTTC-AGAACTG--- ** ** * **** *** * ** * * * * *** *** ** ** ENST00000244020.3 TGTAGATTCAAATAATCCAGAAATATACCTAATAAGATTGAGTGAAAAATTTGAGTCAAA ENST00000447169.1 TGCATG-----ATGATGTTAACATAATGCT--TGAGGCTGGGCGCAA----TGGCTCA-- ** * ** ** * *** ** * ** ** * * ** ** *** ENST00000244020.3 TATCTAGGGCATTCACAGAGTAGCTGTGAGTTCTTGGTAATGTGAAAAAGGCCTTGTTTT ENST00000447169.1 CACCT---GCAATCCCAGCACT-TTGGGAGGCTGAGGCAG-GTGGA-------TTGTTT- * ** *** ** *** ** *** ** * *** * ****** ENST00000244020.3 TCAGAAATTCCTGGGTTTCCTGTTAAAAAATCTTAAAGCCCAACCTTAGGAATATAGTGC ENST00000447169.1 ---GAGGTC---GGGGTTC----------------AAGACCAGCCTTACCAACATGGTG- ** * *** *** *** *** ***** ** ** *** ENST00000244020.3 CCCAAAAGGCGGATGCTTCTTCCATTATCTTATTTTCTTTGATACTTTATTTAATTAGAT ENST00000447169.1 ----------AAATCCCGTCTCTACTAAA-----------AATACAAAAATTAGCCAGGC ** * ** * ** **** * *** ** ENST00000244020.3 GTTTATAAAGAAATGGGT--TTATTTTTCCAGCATAAACCTCAGAATTTAAGGAAAGAAA ENST00000447169.1 GC------GGTGGTGGGTGCCTGTAATCCCAGCT---ACTCCGGAGGCTGAGGCAGGAGA * * ***** * * * ***** ** * ** * *** * ** * ENST00000244020.3 ATGATGTCTGTTGTTATAGTTCATTGTTTTGCCTACTCAGCAGAAGTGATGACTCTTAAA ENST00000447169.1 ATCAC---------------------TTGAACCTGGGAGGCAGAGGTTACAGTGAGCTGA ** * ** *** ***** ** * * ENST00000244020.3 AATTGGCTTTGACCAAAGTTCTCTTGTTTTCAGGGAAAGAACATAAAAGCTTTTTGAACT ENST00000447169.1 GATGG----TG-CCATTGCACTCCAGCCT---GGGTGACACGATAAGA-CT--------- ** * ** *** * *** * * *** * * **** * ** ENST00000244020.3 ACAGCCTTTTTAAAAGAGGGATGGGAGGATATTACAGTAAGAAATTAGGCTTTCTAAAAG ENST00000447169.1 ----CCATCTCAAAAAAGAAA--------------AAAAAAAGATAATGCTTGATGGAG- ** * * **** ** * * ** * ** * **** * * ENST00000244020.3 TATGAAACATCCTTCAACTGGGCTCTCTTGTTAATAGGACATCATATGGTAATAGACTGG ENST00000447169.1 -----AGCAT-----------------TTGGAAGTAGGA---------GTAATAAA--AG * *** *** * ***** ****** * * ENST00000244020.3 TTTGACTATATTGTTAGCTGCCACAGTAAGCAGGTCATTG-TATAGGTAAATGCCTGCAC ENST00000447169.1 ---GACTA-------AGATGGTGCAGATGGCCCAGCATTGATTTGGGTCA---------- ***** ** ** *** ** ***** * * *** * ENST00000244020.3 CCATAATTTTCTAGTAATAGCCACGACCAATTTATTAACAGTCAGGGCCTATCCTTGCCT ENST00000447169.1 CCATTATTG------AAGA---ACGAC--------------TCAGCTTCCACTCTTAC-- **** *** ** * ***** **** * * *** * ENST00000244020.3 GTAGTTCTCAGTCACTGGATGCACAAAATCACTGTGTAACATTGGCTCACTTGGTGAGCA ENST00000447169.1 ----TGCTCA-----TGGGTCAGCAGTATTGCTTTG-----------CACAGGAAAGGGA * **** *** * ** ** ** ** *** * * * ENST00000244020.3 TAGGGTTGACTGATAAAATGTTTAATTCCCTTGCTAGCTTG--TGAGAAGAATGAGTTGA ENST00000447169.1 AAATATT--CTAACAGAATGTTCAATTTTATTGTAAGTCTGACCCAGAGGAAAAGGGAGA * ** ** * * ****** **** *** ** ** *** *** * ** ENST00000244020.3 T-GACATGCTCCATACCAGTGGCTAGATGGAGTATTAAGGTGGAGCAGAAAAGAAGTGAG ENST00000447169.1 GAGACAGGCCCAGGACCTGT--CTA--TTGGTTGCT---TTGTGGCAGAAAACAAG---- **** ** * *** ** *** * * * * ** ******** *** ENST00000244020.3 AACATC-TTGATTCCCCTTTCTTTTACTTGATGGTGTTTATGAACATGCCGTAGTGCCTT ENST00000447169.1 GTCATCCTTGCATGACAGGACCTCTCCAAGACAGC---TAGGCTCATGGGGCA-TGC-TT **** *** * * * * * * ** * ** * **** * * *** ** ENST00000244020.3 TATGGCCAGTTTGAGTCCTGCCTACTTTGACTTTTACGTTCCCATTCCTGTGTTACCACC ENST00000447169.1 CATGGAT-GTCTGAG----GTGGAATGAGATTTGTA-------------AAGCTGCC-CC **** ** **** * * * ** ** ** * * ** ** ENST00000244020.3 TTCCTCCCGATTTGTTCACCTATTTTGTGCTTTAAATCTCAATAAAATACTTACTGAGGG ENST00000447169.1 TTC--------TTGGTGGCTTGCTTCAAGTTTT---CCTC-------TGCT--CTA---- *** *** * * * ** * *** *** * ** ** ENST00000244020.3 AAA ENST00000447169.1 ---