CLUSTAL 2.1 multiple sequence alignment ENST00000249822.3 GCCATTTTCGCGGGCGGAGGCGGCCCGGCGGGCCCTGGGAGAGCTGGGACGGGCGGCGGC ENST00000376856.2 ------------------------------------------------------------ ENST00000249822.3 CGGGTGGCCTCGGCCACCCGCTAATTGCATCTTTTCCCGGCGTCTCGTCTGCAGAGGGAG ENST00000376856.2 ------------------------------------------------------------ ENST00000249822.3 CACTATGTCTGCGGAAGTCCCCGAGGCAGCCTCCGCGGAGGAGCAGAAGGAAATGGAAGA ENST00000376856.2 ----ATGTCTGTGGAAGTCTCCGAGGCAGCCTCTGTGGAGGAGCAGAAGGAAATGGAAGA ******* ******* ************* * ************************ ENST00000249822.3 TAAAGTGACTAGTCCAGAGAAAGCAGAAGAAGCAAAATTAAAAGCAAGATATCCTCATCT ENST00000376856.2 TACAGTGACTAGTCCAGAGAAAGTTGAAGCAGCAAAATTAAAAGCAAGATATCCTCATCT ** ******************** **** ****************************** ENST00000249822.3 GGGACAAAAGCCTGGAGGTTCAGATTTCTTAAGGAAACGGTTGCAGAAAGGGCAAAAATA ENST00000376856.2 GGGACAAATGCCTGGAGGTTCAGATTTCTTAAGGAAACGATTGCAGAAAGGGCAAAAATA ******** ****************************** ******************** ENST00000249822.3 TTTTGATTCTGGGGATTACAACATGGCTAAAGCAAAAATGAAGAACAAGCAACTTCCTAC ENST00000376856.2 TTTTGATTCTGGGGATTACAACATGGCTAAAGCAAAAATGAAGAACGAGCAACTTCCTAC ********************************************** ************* ENST00000249822.3 TGCAGCTCCGGATAAGACGGAGGTCACTGGTGACCACATTCCCACTCCGCAAGACCTTCC ENST00000376856.2 TGCAGCTCTGGATAAGATGGAGGTCACGGGTGACCACATTCCCACTCCAGAGGACCTTCC ******** ******** ********* ******************** * ******** ENST00000249822.3 TCAACGGAAGCCGTCCCTTGTTGCTAGCAAGCTGGCTGGCTGATTAAGAGGCTGAACTGC ENST00000376856.2 TCAACAGAAACCATCCATTGTTGCTAGCAAGCTGGCTGGTTGA--AAGAA-CTGAACTGC ***** *** ** *** ********************** *** **** ********* ENST00000249822.3 ATGAATCTGCTAAATCTCATTATTTCTCCTTAATATGTTACTTATCTACTTTTTATTTCC ENST00000376856.2 ATGAATCTGCTAATTCCCATTATTTCTCCTTATTATGTTACTTATCTACTTTTTATTTCC ************* ** *************** *************************** ENST00000249822.3 TTTCATTCACTAGTCATTTGAGACTGACAGCTTTGCAGGT-AGCAGTAGTGTGTGCTGCT ENST00000376856.2 TTTCATTACCCCATCATTTGAGACTGACAGCTTTGCAGGTGAGCAGTAGTGTGTGCTGCT ******* * *************************** ******************* ENST00000249822.3 ATTGTGGAATATACGTGTGTAGAGTTTTTGATTAGTTTAACAGTGCACTGGTGAAGAGGA ENST00000376856.2 ATTGTGGGATATACATGTGTAGAGTTTTTGATTAGTTTAACAGTGCACTGGTGAAGAGGA ******* ****** ********************************************* ENST00000249822.3 CATGTTAGAGCAACATAAGTAAA----CTACTTGAAAATAGTTGTATATATTACCTAACT ENST00000376856.2 CGTGTTAGAGCAACATAAGTAAGTAATCTACTTGAAAATAATTGTATATATTACCTAACT * ******************** ************* ******************* ENST00000249822.3 TCTAGTGTAGTACTGGTTCTAACAAGTAACAAGCAAGTTTTAAAATTTTAATGTTTTGGC ENST00000376856.2 CCTAGTGTAGTACTGGTTCTAACAAGTAACAAGCAAGTTTTAAAATTTTAATGTTTTGGC *********************************************************** ENST00000249822.3 TTTCATTACTTCATCTTAATTATAGCTTTGTATGTTACTCTTATTTAATATAATCTCTAT ENST00000376856.2 TTTCATTGCTTCATCTTAATTATAGCTTTGTATGTTACTCTTATTTAATATAATCTCTAT ******* **************************************************** ENST00000249822.3 TGTATTGATTTCTTCTGTATTTACCTTTTGGATTTTGTAAAACAGAAGTTTAAGACCACA ENST00000376856.2 TGTATTGATTTCTTCTGTATTT------TGGATTTTGTAAAACAGAAGTTTAAGACCACA ********************** ******************************** ENST00000249822.3 AGTTAGAAGAAAGGTCACATATTTCAAACACAACTAGATGGGGCTCTGAAAGATTTGTAT ENST00000376856.2 AGTTAGAAGAAAGGTCACATATTTCAAACACAACTAGATGGGGATCCAAAAGATTTCTAT ******************************************* ** ******** *** ENST00000249822.3 CTCTGTGCTTGAACTTGAATGGCCTTAAACCTGTTTCAGCTTTAACAGTAGAATTTTACT ENST00000376856.2 CTCTGTGCTTGAACTAGAATCGCCTTAAACCTGTTTCAGTTTTAACAGTAGAATTTTACT *************** **** ****************** ******************** ENST00000249822.3 TGGGCAATATTTGCCCATTCTGGTGTAACTTATGTGACTCTAGTGCTTAACAGCTGCCGT ENST00000376856.2 TGGGCAATATTTGCCCATTCTGGTGTAACTTATGTGACTCTAGTGCTTAACAGCTGCCAT ********************************************************** * ENST00000249822.3 TGAAGCTAATATTC------AGTTCTGTAGAGTTAGAATACCTTTTGTTGTTGAAGATGT ENST00000376856.2 TGAAGCTAATATTCTTATTCAGTTCTGTAAAGTTAAAATACCTTTTGTTGTTGAAGATGT ************** ********* ***** ************************ ENST00000249822.3 GAATGAAGTATGCATGTGCATTAACTGTTGAATTCACTTTTGTGCCATTTTTGTAAATAC ENST00000376856.2 GAATAAACTATGCATGTGCATTGACTGTTGGATTCACTTTTGTGTCATTTTTGTAAATAC **** ** ************** ******* ************* *************** ENST00000249822.3 AGTAGTTTTGCACAACCTCTCACAAATGTCTGTATTAATTTCACATACTTAAAAAGTAGA ENST00000376856.2 AATATTTTTGCACAA--------AAA-------ATTAA------------AAAAAG---- * ** ********** *** ***** ****** ENST00000249822.3 TAATGTGCCAACCAGAAGCACAAGAGTTCCTACACAAAACTCTGTAAATCATTATAGCTT ENST00000376856.2 -AATAT----------------AGGG----------AAACT--GAAAAACATCAT----- *** * ** * ***** * *** *** ** ENST00000249822.3 TTGTATAATAAGAGTAGTTTACAATCTCGGGCTTATAGAATACCAAACTGAAATCTTAGT ENST00000376856.2 ---------------------CAATCA-------ATAGAAT--CTAATTGATGTTT---- ***** ******* * ** *** * * ENST00000249822.3 TCAATCTGCCATAGACTTAAGCTTTTCATTTGTTACTAATATCCATGACATTCAGTGGCC ENST00000376856.2 ----------ATAGAA---------------------------CATGCCATTCAACAGT- ***** **** ****** * ENST00000249822.3 TTGTGCAAATACGATATGTTGCTTAGGCATATCTTTTGTCCTATGCAGAACCTTTCATTT ENST00000376856.2 -------AGCAGGGTGTG------AAACACATGAAATATTC-AC-CAAGACTGACCAT-- * * * * ** * ** ** * * * * ** ** *** ENST00000249822.3 TGATTTTTATGAAAGTTGCAATTCATGTAATTTATATAAACTTTTTAAATGTAGAAACTT ENST00000376856.2 --ATTTT-----GAGTCATAAAACA---AACCTGAACAAATTTAAAAGACATGAAA---- ***** *** ** ** ** * * *** ** * * * ** ENST00000249822.3 TTTACTTCCACACTCAGTTTTGGAGACCCTAGAATAAAAGGCTTCAATACTCTGCATTCC ENST00000376856.2 -------TCATAC-----------------AGAATAAA---------------------- ** ** ******** ENST00000249822.3 ATGCCCTCTGCCACCTGCTTTTTTTTCCCCTTTGTTCTTTGACTCAAATGGTATTGAGCT ENST00000376856.2 ----------------------------------TTCTCTGACCATAATGGAATCAAACT **** **** ***** ** * ** ENST00000249822.3 GTTTGTTGTATATGGAAGCATAGGTGTCTATATCCTTACTCTTTTATATAACACAATAAT ENST00000376856.2 A------------GAAA---------------------------TAAATAATAGAAAAAC * ** ** **** * ** ** ENST00000249822.3 GGCGTTTTCCTTCTAATTTCTCAGTTGTTAACTTCTTTCTCTTTTTTTTTTAGGATAGGG ENST00000376856.2 ------------------------------------------------------ATA--- *** ENST00000249822.3 CCTTGCTCTGTCACCTGAGCTCTAGTGCAGTAGTGCAATCACAGCTCACTGCAACCTTAC ENST00000376856.2 ---------------------------------------CACAA--------AA------ **** ** ENST00000249822.3 TCCTAGGCTCAAGTTAACTATTCTTGATCCTTTATTATTACTAATATTCTACAATTGTTT ENST00000376856.2 ---------------------------------ATTATCA--AACACTTGAAAATT---- ***** * ** * * * **** ENST00000249822.3 AAATAAAAGGAACTTTATAATGAAACGGTTCGGAATACTGGCTCAAGAACCTATGTCAAG ENST00000376856.2 AAACAACAT--ACCTCTTAAT-----AGTCCAAA------GGTCAAAGAC---------- *** ** * ** * **** ** * * * **** ** ENST00000249822.3 ATGAGCTGAATTTTGGTAAATTATTTTAGGAATTATGACAAGCTAATTGAATTAGGCTTG ENST00000376856.2 -----------------AAA--ATTTCAAAGA---------------------------- *** **** * * ENST00000249822.3 TGACAATTAGAGTAATTTACATGACAGGTAAAACTCCTATTAAAAATGTTTAGATGTTTG ENST00000376856.2 ----AAATAAAAAAGTGTATAG---AGGCAAGGC-----------ATGTTA----GCTCA ** ** * * * ** * *** ** * ***** * * ENST00000249822.3 CTTCTGTAGATGTCACTTTAGTAAAATACCAATTTAGTTTTACTTGTGGCTTATCTAGTT ENST00000376856.2 CTCCTGTA------ATTCCAGCA-----------------TCCTTGGAG---GTCGAGGC ** ***** * * ** * * **** * ** ** ENST00000249822.3 AGAACTTAGCAGACTTTACTGGGACAAGTTTACTGCTCTTGTAGGAGCTCCTCTCACAAG ENST00000376856.2 AGGA-----------------GGACTGATT--------------GAGCCC--------AG ** * **** ** **** * ** ENST00000249822.3 TAGTTGTAATGCTGTAGCATGATACTCAGGATCAGTAGCTTGAGATGCTACTATTTTTCT ENST00000376856.2 GAGTT---------------------CAAGACCAG---CCTAGGAAACAA---------- **** ** ** *** * * ** * * ENST00000249822.3 CTTCATCTTTGACTTGCAGAGAGCCTCCCGTTTTTGGATCCAGGCATCTTTTCTGAATCC ENST00000376856.2 -----------------AGTGAG----------------------ACCTTGTCTG----- ** *** * *** **** ENST00000249822.3 TGGTTCCATCAGTATACCTGCTCTCCTATGACCCCAAATCATAGTCAATGGTGCCTCAAA ENST00000376856.2 -----------------------------------------TAGACAAAAAT----CAAA *** *** * **** ENST00000249822.3 CATAGCACCTTAAGTTAAAGGCTGCCTAGTGCTCTGAGGAAAGCTTGCTGATTATCTTCC ENST00000376856.2 -----------AAATTA------GCCGGGTGTGGTGGTGTGGGCCTGTGG------TCCC ** *** *** *** ** * ** ** * * ** ENST00000249822.3 TGATCTACTCACCCCAAAAGGCAGAAAAGCAACACAGTCACTGCTGTGGTCATTTGTAAT ENST00000376856.2 AG--CTACATGT-----GAGGCGGA--GGCAGGAGGATCACT--TGAGCTCA-------- * **** **** ** *** * ***** ** * *** ENST00000249822.3 GTAAAGATCAGTTATATATATATATTTGTAATGAGAGCAAGTATATACTCATTATAGAAT ENST00000376856.2 --GGAGGTCAA------------GGCTGCAGTGAGC-CAAGGTCGTAC-CACTGCACT-C ** *** ** * **** **** *** ** * * ENST00000249822.3 CAATTTAAGAAGTTTAAAATAACCCAGAGTAGAATTTCTATATCTAGTCTTGGTTTTTTT ENST00000376856.2 CAGCCCGGGTGG------------CAGAGCAAGAC-------------CTTG-----TCT ** * * ***** * * **** * * ENST00000249822.3 CATGAATATTTGCAAGTAATTACCATTAAATTCACACATGAAAGATTAATCTGAAAGATC ENST00000376856.2 CA--AA-------AAATAA--------------ACACATAAA---------TAAAA---- ** ** ** *** ****** ** * *** ENST00000249822.3 AGAGACCATGTTATTCCTGACCACGATAGAACTGCTCCTGTGGTTTGGGACAAGTAATAA ENST00000376856.2 -------ATGTTA----AAAGTAC-ATAGAACTG------------------AGTGAAAA ****** * ** ********* *** * ** ENST00000249822.3 AACAACTGCTTGAGTTTTGTTTGTAAAATACATAATTAATATTTGACCTACCTCAAAATG ENST00000376856.2 -----------------------TGAAA-ACACAAT--ATA-----------TCAAAAT- * *** *** *** *** ******* ENST00000249822.3 TATTGAGGATCTGTGAAATGCTAAGTGCCCAAAATAAAATATTGCTGATTGTCTTTTTAT ENST00000376856.2 ----------TTCTGAGATGC----------ATGTAAAGTAATGCT-------------- * *** **** * **** ** **** ENST00000249822.3 TAAAAGTAAATTTCCTCATTAAGCCAACCTGCCTTCTGTAAGTCACAGTGCTTAAATCTC ENST00000376856.2 -AAGAGAAAATTAACACACTAAG------------------------------------- ** ** ***** * ** **** ENST00000249822.3 AGGATTTTTCATTAGGAGAGACCTGTCGTTAAGGATTTGTAGGTATAATTGCTTAGCCTC ENST00000376856.2 -------------------------------------------------TGCTTAG---- ******* ENST00000249822.3 CATTATTGGTGCTTGGGATAGAGAGGTTTTAGATTTTTGTTTTTTTTTTGTTCTGCCTCA ENST00000376856.2 ----ATTAG----------AGAAAGATCTCAGATTAATAATTTC---------------- *** * *** ** * * ***** * *** ENST00000249822.3 AAGCTCAGTTTATTGAAGACATTTGTAAGCTATTGGATCATCACTTGAATCAAGATTTTG ENST00000376856.2 -AGCT---TTTACT-----------------------------------TCAAGA----G **** **** * ****** * ENST00000249822.3 ACTAGTGAGCTTAATTGTCCATTTCTTACAATTTCAAAGTTACAGTCTCAGAAATGGTTA ENST00000376856.2 ACTAG----------------------GCAA------------------AGAA------- ***** *** **** ENST00000249822.3 ATTTTAATAACTGTCCTATCATAAATTAATGTTGGAATAAATTGAAGTTGTTGATAAATA ENST00000376856.2 ------------------------------------------------------------ ENST00000249822.3 CTTCATGAAAACTAAAGTCTGAAATAAATTACTTGTTTTATGTCCAATAGCTACTACATT ENST00000376856.2 ------GAGAA----------AAATAA--------------GCCCAA------------- ** ** ****** * **** ENST00000249822.3 TGATAGAACAGTTTTGAGGAACATTTCATTCTTGAACGCAGCATCTGACATGGTTCTCAG ENST00000376856.2 --ATCAAGCAG----AAGGAAG-------------------------------------- ** * *** ***** ENST00000249822.3 CAAGTTGGAATAGTAAGGATTATTGGCTTGTTTCGATGAGTGGAAGCGGCATGTTTGTAG ENST00000376856.2 ------GGAATAATAAAGATTAT---------------GGCAGAA--------------- ****** *** ****** * *** ENST00000249822.3 CATACAAGTTATTCAATAATCTTGTGCTGATGACCTAAAAATATGTCTTAACTATTCATC ENST00000376856.2 ----------ATCCA------------TGA--AATTGAAAACA----------------- ** ** *** * * **** * ENST00000249822.3 AAGGAAAGCCTGGTGAAGCCTTTACTTGTTACTACTTCAACAGTTGGAATTAGTTGCTCT ENST00000376856.2 --GAAAAACATAG--------------------------------AAAATTAGT------ * *** * * * ******* ENST00000249822.3 TTTTACTTGATGAAACAAAACTATACCTCTGAATATTTATGGATACTTTTTACTAAATCA ENST00000376856.2 -----------GAAACAAAA---------------------------------------- ********* ENST00000249822.3 GGCTTGTGTTCTTAATCCAAATTAGTAAAGTTTTATGGAAGCTGAAATGTAATACAGTAG ENST00000376856.2 ---------------------------------------AGCTGG--------------- ***** ENST00000249822.3 TCTCCCCTTATCTGTAAGAGATACATTCCAAGACCCCTAGTGGATGCCTGAAACCTCAGA ENST00000376856.2 -CTCTCCTTA-----AAAAAATTCATT--GAGATC-----------------------GA *** ***** ** * ** **** *** * ** ENST00000249822.3 TAGTACTGAACCCTTTATCAACTATGTTTTTTCAGTCTGACAACCAAGGCGGCTACTAAG ENST00000376856.2 TA-----------------AACT------------TCTAGCAA----------TATTAA- ** **** *** *** ** *** ENST00000249822.3 TGACTAAGGGGCAGGTAGTATACAGTGTGGATAAGCAGGACAAAGGGGTGATTCACATCC ENST00000376856.2 -----------------------------------------AAA---------------- *** ENST00000249822.3 CAGGCAGGACAGAGCAGGAGATCATGAGATTTCATCACTCAGGATGGCTTGTGATTTATT ENST00000376856.2 ------------------------------------------------------------ ENST00000249822.3 TTATTTTATTCTTTTTTTTTTTTGAGATGGAGTCTCACTCTTGCCCAGGCTGGAGTGCAG ENST00000376856.2 ------------------------------------ACTCTAGCCTGGG----------- ***** *** ** ENST00000249822.3 TGGTGCGATCTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAGTTCTCCTGCCTC ENST00000376856.2 ----------------------------------------------AATT---------- * ** ENST00000249822.3 AGCCTCCCAAGTAGCTGGGATTACAGGCGTCCGCCACCATGCCCAGCCAATTTTTGTACT ENST00000376856.2 -----------------GGATT-------------------------------------T ***** * ENST00000249822.3 TTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGG ENST00000376856.2 TTTAGAAAA--------------------------------------------------- ***** * * ENST00000249822.3 TGATCCACTCGCCTCGGCCTCCCAAAGTGCTGGGATTATAGGCATGTGCCACCATGCCCG ENST00000376856.2 ------------------TTCCCTAAG-----GGATTCCA---ATGTGC----AT----- **** *** ***** * ****** ** ENST00000249822.3 GCCGGCTTATGATTTAAAACATGAATTGTTTATTTCTGGAATTTTCCACATAATATTTTT ENST00000376856.2 ------------------------------------------------------------ ENST00000249822.3 GGACCAAGGTTGCCTCAGGTAACAAACTACAGAAAGTGAAATTGCAGATAAAGGGGATTA ENST00000376856.2 ---CCAAAGTTG---------------------------------AGA------------ **** **** *** ENST00000249822.3 CTGCTCCTCTGCTCTAAAATTGGTGTTTGGGTGATCAGAAGCAGGTAGCCAATGGGAAGA ENST00000376856.2 -----CCT----------ACTGGTA-----------------AGGT-------------- *** * **** **** ENST00000249822.3 GCACTTCTGAGTGATAACTAAAGCAGTTTGGTGGCCTTTTCACATTCTCCAATGTTCAAA ENST00000376856.2 ---CTTCAG------------------------GCCTGTTGAC----------------- **** * **** ** ** ENST00000249822.3 CATATTTTCCACTTTCCATTTTCTCTTTCACCTCATTTTGCCTCTCTATCCCCCATCCCT ENST00000376856.2 -------------------------------------TTGCTCCT--------------- **** ** ENST00000249822.3 GCTTATTTCTTAAGCCCATTGATGGCACTCATTAAATTGTATTTAGGGCTAATGAGTCAT ENST00000376856.2 ----------------------TGGC----------------------CTGATGAG---- **** ** ***** ENST00000249822.3 TGTTCCTTAATATCGTTTTCAATATGCCACAATTTAGGACACATTTAAAATTTTCTAAAA ENST00000376856.2 -----------------------------------AGAAGAGATTT-------------- ** * * **** ENST00000249822.3 CAATATCCTAATCAATATTGACTAATTTGAGCCACATTCCCAACTCTAACTCAGCACACA ENST00000376856.2 -----------------------------------------------------GCATACA *** *** ENST00000249822.3 CTGCCAGTCTTCCCCAATATCTGTCTCCTCTCAATTCCCCACCACACCTTATAAAATTGT ENST00000376856.2 C--------------AA---------------------------------AAAACATTGT * ** * ** ***** ENST00000249822.3 AATCAAAGATATCTCACTCTGTCATTGTTAATCTAAGAATAAAAACACTGACTTTAATAC ENST00000376856.2 AT------ATATCCAACGGTTTCACCATTAA---------GAAAATACTGA--------- * ***** ** * *** **** **** ***** ENST00000249822.3 GGTTTTACTAAGTTTCAACCTTCTAATTAGGTAGGCCTCTAGGTATTCTGCAGATCACTG ENST00000376856.2 -----------------GCCT------------GGCC---AGGTG--CGGTGGCTCAC-- *** **** **** * * * **** ENST00000249822.3 CTGGTCTTGATAGCCATTAATATATGTTTGTATTATGTTATTTTTCAACTAAATCGCAGT ENST00000376856.2 -------------------------GCCTGTA---------------------------- * **** ENST00000249822.3 TGGAAAAAAACATATTTAATATTATGCCCTTGGATCTGTTACTGCATCACTAGCACTTGT ENST00000376856.2 ---------------------------------ATCT-------------CAGCACTT-- **** ******* ENST00000249822.3 GATGCAATAGAACACTTCGCCTGTACTGAAAGGGCCAAGAGTAAATGCCTTGTTTTGTTT ENST00000376856.2 -------TGGGAGGCT-------------GAGG----AGAGGGAATATCTTG-------- * * * ** *** **** *** **** ENST00000249822.3 TTTTGTTTTGTTTTGTTTTGCTTTTTGTTAAAACATGTCTATAGAGTTGGCAGTTAATGC ENST00000376856.2 ------------------------------------------AGA-TCAGGAGTT----- *** * * **** ENST00000249822.3 TGAATTTGTCAAATACCCCTTCCAAAATTATACTTGTATTTAAAAAATAAATGGATCTAC ENST00000376856.2 ----------------------CGAGACCATCC--------------------------- * * * ** * ENST00000249822.3 CTAATTTCTATTG ENST00000376856.2 -------------