CLUSTAL 2.1 multiple sequence alignment ENST00000254037.2 CTCCAATACCGCAGGAGGGCGGTCTTCCCCGGCTCGCCAACTCGGCTGCTCTGGGGGATT ENST00000525564.1 -----GTGAC-CAGGTGGGCA--------CAAGTTACCA--------------------C * * **** **** * * *** ENST00000254037.2 CGTGCGCGGTAAGAAGCTGCGCGGTAGCGCGGTGAGGTGAGGTTCTCAGCCACCAAAGCT ENST00000525564.1 CACACATAACAAGAGAC---------------------------CCTTGCC--------T * * **** * * *** * ENST00000254037.2 GCAGGGTCTCGTCGTTCGTTCCCTCTGGCCTGGCGGAACTTGCGTGGGAAGCTGGGAGGA ENST00000525564.1 GCAG-----CATCAT--------------------------------------GGGAGGA **** * ** * ******* ENST00000254037.2 CAGAAGGCTTAGCCGCTGGGTCCCTGAGCTGGCTGGAGCGCGGGCTGTCTAGGGGCGGCG ENST00000525564.1 TACAAA-----------AAGTCCTT--------TGAGGGACAAAATCTTTCAAAGCACCA * ** **** * ** * * * * * ** * ENST00000254037.2 ACCTCAGCTGTTGGGCTCCGGCTGCTGGGGGCTGTGCGTCCAGCCGCCCTGGAATCCGCC ENST00000525564.1 A---CAACT----------------------------------------TGAA------- * ** ** ** * ENST00000254037.2 TGTGGGTGGGCCGCTTGGCTCTCCCACTTCACCCTCTTGATAACCCAGAGCCTCCCCCTT ENST00000525564.1 ---------GCCAATAGGCTCTCCC--TTCAA------AATGACGCA------------- *** * ********* **** ** ** ** ENST00000254037.2 CCCACGTACGTAGGGGAAGGATAATCTACTTCCTTTTGAACAGCTTCGGTCCCCACTATG ENST00000525564.1 -CCACAAGCAAAACAGAAAAAAAA------------------------------------ **** * * *** * ** ENST00000254037.2 ACAGTCGCATAAACTTCAGCGAAGAGTGCGCTGGTAAAGTGGCATGGAGTTTCTCACACC ENST00000525564.1 AGAGT-------ACCTAAGTGGAGA-TGTG--AATGGATT--CATGGAATACCT------ * *** ** * ** * *** ** * * * * ****** * ** ENST00000254037.2 AATTCATTGGGTCCACCCTTCAGCTTCTGTGGAAGGGGTCTTTCTGTTACTAGGAGCTGA ENST00000525564.1 AAGGCA--GAACTCAC----------------AGATGGT-------TTACGA-------- ** ** * *** * *** **** * ENST00000254037.2 GACTTGGGGGGTTGCCAGGGATGCTGGTCTTAAAAGGTGATAATTTAGGCCGGGC-GCGG ENST00000525564.1 ----TGGGGAGATGATAGCAACGATGG-----GGAGATGATAGCAACGATCAGGCAGTAA ***** * ** ** * * *** ** ***** * * *** * ENST00000254037.2 TGGCTCACGCCTGTAATCCCAGC-ACTTTGGGAGGTCGAGGCGGGCAGATCTCCTGAGCT ENST00000525564.1 GGGAATA-------AATTGCAGTTGCTTTAA-------AGAAAGACAG-TCTTATGGGA- ** * *** *** **** ** * *** *** ** * ENST00000254037.2 CAGGAGTTCGAGACCACCCTGGGCAACATGGTGAAACCCCTTCTCTACTAAAATACAAAA ENST00000525564.1 -AGGA-----AAACAA---TGAATGACAAG--------------CAGCAAAGAGAAAGAC **** * ** * ** *** * * * ** * * * * ENST00000254037.2 AATTAGCTGGGCGTGGTGGCACGCGCCTGTAATCCCAGCTATTCGGGAGGCTGAGGCCCG ENST00000525564.1 AAT------AGTATGTTTCCAT-TGCA-GAAAACCTGGTCATACAA-----------CTG *** * ** * ** ** * ** ** * ** * * * ENST00000254037.2 AGAATCGCTTGAGCCCTGGCGGCAGAGGTTGCAGTGAGCCAAGAT-CGCCCACTGCACTC ENST00000525564.1 CAGATTGCC-------------CAGTTGCCCTAGAAAATCAACATACGGGCACTG----- ** ** *** * ** * *** ** ** ***** ENST00000254037.2 CAGGTTGGGCTACAGAGTGAGACTCCGTCTCAACAACGACCACAACAACAACAAAAAAGG ENST00000525564.1 --GAACGTGTT-CTGGGTCTGGGTCCGTG--------GAGCGCAA-AATGATCAAG--GG * * * * * * ** * ***** ** * *** ** * ** ** ENST00000254037.2 TGGTGGCTTAATACAGCCATGCTCCCCTTAAGAACTGGTATAGTTATGAGAAATGGTTGG ENST00000525564.1 CAG-GGCT-AAAGTAGCCCTG--GCTCTT---AATTAATTTCCTTTTGCGAAATGTTTG- * **** ** **** ** * *** ** * * * ** ** ****** *** ENST00000254037.2 GCCGTTTCGTGGTTGTGTGAACATCATAGTGTACTTGCACAAACCTACACAGCTGGGCCG ENST00000525564.1 -----TTTGTGGG-----GAA----ATGAGACAGCTGTCCAGATCT-------------- ** **** *** ** * ** ** * ** ENST00000254037.2 TATGGGATAGCCTGTTACTCCTAGTCTACAGACCTGTACAGTATAACTACTAAATACTGT ENST00000525564.1 -------TGTCCTGATCATCCCAA-----AGGACTCTG---------TGCT---TATGGT * **** * *** * ** ** * * ** ** ** ENST00000254037.2 AGGCAGTTGTAAAAGGATGGTGTGTATCTAAACACAGAAAAGATACTGTAAAAATATAGT ENST00000525564.1 -GGTGGTTGCAAA----CTTTGTGGCTCT----GTGGA----ATATTTTAAGAAGG-ATT ** **** *** **** *** ** *** * *** ** * * ENST00000254037.2 GTAAAAGAAAACATGGTACAGCTGAATAGGGCACTTACGCATGGAGCTTGCAGGGCTGTC ENST00000525564.1 GTCCTGAAAGTCAGAATTCAG-----------ATTTTGGAATGG---TCACAG-----TT ** ** ** * *** * ** * **** * *** * ENST00000254037.2 GGTAGCTATTAAGTGAGTCAGTGAGTGGTATGTGAGTGTGAAGGCCTACGATATTATTTA ENST00000525564.1 GATTGCTGGTCAAAGGG--AGTGAGTGGA----GACTCTGAAGAA--ACTGGATGACTTA * * *** * * * * ********* ** * ***** ** ** * *** ENST00000254037.2 GGGTATTACTGTACACTACTGTAGACTTTATAAATGCGGTATGCTTAGTCTAAGTTTATT ENST00000525564.1 A---ATTACAG--------------------AAATCC----------------------- ***** * **** * ENST00000254037.2 AAAAATAAGGTAATAACCTTAGCTTACTGTGCTTTTTTAACTTTATAAACTTTTAAATTA ENST00000525564.1 -AAAACAAAG--ATA-CCTAAA---ATTGTTATTTTTTGA--TAATGAG----TAAGT-- **** ** * *** *** * * *** ****** * * ** * *** * ENST00000254037.2 ATTTTAACTCCTTGACCTTTTTTTTTTTTTTTTGAGACGGAGTTTATTCTCTCTGTCTCT ENST00000525564.1 ACTGTTGCTACTTA------------------------------CAACCTCATTGTT--- * * * ** *** * *** *** ENST00000254037.2 CATTTTTGAGACAGAGTTTTGCTCTTGTCACCCAGGCTGGAGTGCAGTGGCGCAATCTCA ENST00000525564.1 -ACTTTCCAAACAGGACAT-ACT----TCAC--AAATTAGAGC----TGG-GCA------ * *** * **** * ** **** * * *** *** *** ENST00000254037.2 GCTCACTGCAACGTCCACCTCTTGAGTTCAAGCGATTCTCCTGCCTCAGCTTCCCAGGTG ENST00000525564.1 ------------------CCCTTGGAGTCAAGC----------CTTTA------------ * **** ****** * * * ENST00000254037.2 GTGCGCGCCTGTAGCTGGGACTACAAGAGTGCGCCACCACGCCCAGCTAATTTTTGTATT ENST00000525564.1 --------TTGTAG----------------GTGTCA-------------------GTAT- ***** * * ** **** ENST00000254037.2 TTTAGTAGAGATGGGGTTTGACCATGTTGGCCAGGATGGTCTCG-ATATCCTGACCTTGT ENST00000525564.1 ---GATCGAGATGTAGT-------------CAAAAACAGTTTTGTGTATTCTG------- * ****** ** * * * ** * * *** *** ENST00000254037.2 GATCCACCTGGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATACCCG ENST00000525564.1 --TCCA-------TTGA------GAAGTACT-------------------TCTAT----- **** *** **** ** * ** ENST00000254037.2 GCCCACTCTTTTGTAATAA-CACTTAGCTTAAAATGCTAATGTGTTGTATAGCTATATAA ENST00000525564.1 ---CACTGTTTGGAGAAAATCACTGAA--GGAAATAATAATAT----------TAAATAG **** *** * * ** **** * **** **** * ** *** ENST00000254037.2 AAATATTTTCTTTATTCCCTTACATTATTCTATAGCTTTTTCCTGTAAAAATTTTTTTTG ENST00000525564.1 AATT-----------------------TTCTAAAG-----------GAACATATGTTTAA ** * ***** ** ** ** * *** ENST00000254037.2 TTGTTATAAACTAAGACACACACATTGTGCCTACACCGGGTCAGGAGCATCAATATCACT ENST00000525564.1 CTGATACAA-CTTAGACATA--------------ACTAAGT--GG-----CGATATAACT ** ** ** ** ***** * ** ** ** * **** *** ENST00000254037.2 CTTTTCTTCCTCCACATCTTGTCCTACTGGAAGGTTTTCAGGGGCAGTAACATGAATGGA ENST00000525564.1 --------------------------------GATT----------GTAACA-------- * ** ****** ENST00000254037.2 GCTGTCATCTCCTATAATAACTGCTTTTTTCTGGAATACTTATAATTGTCTAGTATTATG ENST00000525564.1 ---ATCATCT-----------------TTTTGAAAATGC------------AAAATTAC- ****** *** *** * * **** ENST00000254037.2 TACAGTACATCATTGTAAGCATTATGCTTGTATATGACTGGCATCCCAGGT-TTGTTTAC ENST00000525564.1 ------ACATAAATGTGA--ATCACCCCTG---------AGCA---AAGATACTGCTTT- **** * *** * ** * * ** *** ** * ** ** ENST00000254037.2 ACCAGCATTACCACAGACATGAGTAATGTGTTACACTACAAGTTATGAGGGCTACAAAGT ENST00000525564.1 ----GCATT----TGGAAATGAATTTTTCTTTGTATTAT--TTTCTT---GCTTCAAACT ***** ** **** * * ** * ** ** * *** **** * ENST00000254037.2 CAATAGGAATTTTTCAGCTCCATTATAATCATCTGAGACCAGTATCATGTGTGCAGTCGC ENST00000525564.1 ----ATCAATTTATT------ATTATAATAGTATAAGT---------TGCACAAAATCTT * ***** * ******** * * ** ** * ** ENST00000254037.2 TGTTGACCTAAATGTTATGTAGCATGTGACTAGCTGATGAATCTTTGATTATGGCTGAAT ENST00000525564.1 TGTT----TAAA----ATATATTGAGTGA---------AAATCCAT--TTAT--CTGATT **** **** ** ** **** **** * **** **** * ENST00000254037.2 GTTCTCATTCATTGCAGGAAAAAAATATCCTCCAAATCACTAGGTAGTATGTAAGTGACC ENST00000525564.1 ATTCT----------GGGAAAAAAAAA------AAA----------------AAAGAACA **** ********* * *** ** ** ENST00000254037.2 AAAACTTTTTTCCATTTTATGTTGGAGCCAAATCATTAGTGTTAGGATAAATTACTTCTT ENST00000525564.1 AAGAGTTC-------------------CCAATTC-------------TCAAATACT-CTT ** * ** **** ** * ** **** *** ENST00000254037.2 TATGTATGTGCTCTAAAATGAAAAGTTATTTCTGAATATTAAAGCATATGTATTAAGAGT ENST00000525564.1 TA--------CTC----------AGCT-TTTCCAAATGGTAA------CATTTTA----T ** *** ** * **** *** *** * *** * ENST00000254037.2 ATAAAAACAAGATACAGATTTTGGTGTGAAATATATCTTATGATTCAAGTCATAATTTAA ENST00000525564.1 ATAAACACAAT-TATTGAATCTAG---GAAAT-TAACAT-TTATTCAATTC-TATTTCAA ***** **** ** ** * * * ***** ** * * * ****** ** ** ** ** ENST00000254037.2 ATAGAATTGAAGATG-ATGTGAAATCACTGGGCTGGAAGTAGCTTATACCTTGATTAGTA ENST00000525564.1 ATTTTGCTAATTATCCATGTTCATTCATT---CT---------TTCTCTCTCTCTCTCT- ** * * ** **** * *** * ** ** * ** * * ENST00000254037.2 AGAGGAAGCCCGGGATCATCCTGTGATGGTAAACACTTTTATATGTTTTACTTATAACTT ENST00000525564.1 --------CTCTCTACCCCCCTTTCCCTCT---CTCTCCCCCCTGCTTTCTCTTT--CTT * * * * *** * * * ** ** *** * * *** ENST00000254037.2 TGCCAGGAAATTTCAACAAACTTCATATTAAAGGACATGATTTCTGTATACTTAGTAATC ENST00000525564.1 T---------CTTTA------TTTAGACC--AGGATACAATT-CTGAAT---------TC * ** * ** * * **** * *** *** ** ** ENST00000254037.2 TGCTATGCAAATTGTTGCATTGAAATGGCAGACGAAGCAAGAAGATTGGGAGAAAGTAGC ENST00000525564.1 CA-----------GTTTCATTTAGTTTTCA------------------------------ *** **** * * ** ENST00000254037.2 TGTGGGACTTGGAGATAGGAAAATAAACAGCCGGGAAAACTGCAGAATGTGGGAGGAATA ENST00000525564.1 TGT---ACTTTTAG---------------GCT-------CTTTT-AATCTGGAAAAGAT- *** **** ** ** ** *** *** * ** ENST00000254037.2 ATTGCATTCATTGTATTACTATCTGATTTATATTTTATGAAATAATTTGGTTTCTTAAGA ENST00000525564.1 ----CTTCCATCTTCCT-TTGTCT--TTCATGACTTTTATACT--TCTGATTGGCTAAGA * * *** * * * *** ** ** ** * * * * ** ** ***** ENST00000254037.2 TAGTTTTTCAATTTTAAGCACACCTTTTTTAACTGGTGTGGCAGCTTTTCTGGTAAGTGG ENST00000525564.1 ----------ATTT--GGTAAAATATTTTCAATTTGTCTGAT---TTTTCTGGTAA---- **** * * * **** ** * ** ** *********** ENST00000254037.2 TAGATTTATGTTAGAAGCATGTCTATGCAGCATATTATAGCATTAAATATGTATACAGAT ENST00000525564.1 ----TTCATGTTA--------TTAAT--------TTTTGGCA--AAATAT---------- ** ****** * ** ** * *** ****** ENST00000254037.2 ATCTAACTGAAATAAAAAGTGTTTTAATAATTAAAAGTTTAACATATGGGCATATGTGAC ENST00000525564.1 -----ACCAAGA-ATGATGTGTTCCC----TTAAATGCT---------GGGATTTTTGA- ** * * * * ***** ***** * * ** ** * *** ENST00000254037.2 ATATAGTGATATAGCATGTCTCTTTAGTTTTGTTGTTTTTGTTGTTGATGGCTAACCACC ENST00000525564.1 ------------AGGAT-CCCATTTA--TTAATTATTAGTCTTTTT--------ACCATC ** ** * **** ** ** ** * ** ** **** * ENST00000254037.2 CATGCTTGTCTTAAAAATTGATAAGGTACCACTGATGAAATTATGACCAGGTGGGCCCGA ENST00000525564.1 -AGACTT---TTAACAAATGGAGAAATAGTCTT--TGGAGTTA----CATAGGGATCAAA * *** **** ** ** * ** * ** * *** ** ** * * ENST00000254037.2 GTTAGTACCACATATAACAAGAGACCCTTGCCTGCAACATCATGGGAGGACATGAAGAAG ENST00000525564.1 ---------ACATATG---------CTTTGT------TATT---------TATAAAG--- ****** * *** ** ** *** ENST00000254037.2 GGATCCTTTGAGGGAACAAGCCAAAACCTACCAAAGCGTAAACAACTTGAAGCCAATAGG ENST00000525564.1 -----CT------GAATTAGATAA-------TAAACCTTAGA---CTTGATTCC------ ** *** ** ** *** * ** * ***** ** ENST00000254037.2 CTATCCCTCAAAAATGATGCACCCCAAGCAAAACATAAAAAGAACAAAAAGAAAAAAGAG ENST00000525564.1 TTTCTCTTCTGAATTGA----------GTTAGTCATTCAGGCAATGGCATAGCAGATAAG * * ** ** *** * * *** * ** * * * ** ENST00000254037.2 TACTTAAATGAAGATGTGAATGGATTCATGGAATACCTAAGACAGAATTCACAGATGGTT ENST00000525564.1 TA----AACCCAGATGCC------TTCTT---ATGCAGAGGCAGGGACTC--------TC ** ** ***** *** * ** * * * * * ** * ENST00000254037.2 CACAATGGGCAAATTATAGCAACAGACAGTGAGGAAGTAAGG--GAAGAAATTGCAGTTG ENST00000525564.1 CA-----GGTATTTTATTGTAA--GGAGGAGAAGA-GCAAACTCGAATACATTACACTTA ** ** * **** * ** * * ** ** * ** *** * *** ** ** ENST00000254037.2 CTTTAAAGAAAGACAGTCGACGGGAAGGAAGAAGATTAAAAAGACAAGCGGCAAAGAAAA ENST00000525564.1 CTC---AGTAA---AATCTATGGGCC--------------AATGCAAGTTACA------- ** ** ** * ** * *** ** **** ** ENST00000254037.2 ATGCAATGGTGTGTTTCCATTGTAGAAAACCTGGTCATGGAATTGCAGATTGCCCCGCCG ENST00000525564.1 ---CCATGG----TTTTCA------------TAGTC------TTGTTGGT------GCTG * **** *** ** * *** *** * * ** * ENST00000254037.2 CCCTTGAAAATCAAGACATGGGCACTGGGATATGTTACAGGTGTGGGTCCACAGAGCACG ENST00000525564.1 CT-----ATAACAGAATAC---CACAGGG------TATAAAT---------CAGAGTATG * * * ** * * *** *** ** * * ***** * * ENST00000254037.2 AAATAACCAAGTGTAAGGCTAAAGTAGACCCGGCTCTTGGCGAATTTCCTTTTGCAAAAT ENST00000525564.1 TCAT--CCAGTTTTAGGG----AACAGA--------------AATTTATT-------AAC ** *** * ** ** * *** ***** * ** ENST00000254037.2 GTTTTGTTTGTGGAGAAATGGGGCACCTGTCTAGATCTTGTCCTGATAATCCCAAAGGAC ENST00000525564.1 -TCATGGTTCTGGA-AGCTGGGAAATC---CAAGATCAAG--CTGCTGGCCTC------- * ** ** **** * **** * * * ***** * *** * * * ENST00000254037.2 TCTATGCTGATGGTGGCGGTTGCAAACTTTGTGGCTCTGTGGAACATTTAAAGAAAGATT ENST00000525564.1 ----------TGGTGAGGGCCT---ACTTT----CTATGTCATGTCATTGGAGAAGGGC- ***** ** ***** ** *** ** **** * ENST00000254037.2 GCCCTGAAAGTCAGAATTCAGAGCGAATGGTCACAGTTGGTCGCTGGGCAAAGGGAAT-G ENST00000525564.1 ------AAAA--AGAA---AGAGTGAGAGA----------------GGCAAAGGGGGCCA *** **** **** ** * ********* ENST00000254037.2 AGTGCAGACT---ATGAAGAAATTTTGGATGTACCTAAACCGCAAAAACCCAAAACAAAA ENST00000525564.1 AACTCACCTTTCCATAAGGAACT-----AGGTACCATGATAACAA--ACCCACTCCAACA * ** * ** * *** * * ***** * *** ***** *** * ENST00000254037.2 ATACCTAAAGTTGTTAATTTTTGATAACAGCTAGCACTATCATGAG-TTACTACCTCATT ENST00000525564.1 ATAGC-------ATTAATTT--------ACTTTGCCCT--TGTGGCCTTATCACCTC--- *** * ******* * * ** ** ** *** ***** ENST00000254037.2 GTTACTTTCTAAACCAGGC-CCGCTTCACGAGTTAGAGTTGAGCTCCCCTGTAGCCAGGA ENST00000525564.1 -TCATTT---------GGCGCCACCTCCCAA--CACAGTTG-----CATTG-----GGGA * * ** *** ** * ** * * * ***** * ** *** ENST00000254037.2 CTATGCTGTAGATATCAGTATGATCTGGGTGTGGCCAAAAACAATTTTCTTTATTCTGTC ENST00000525564.1 TTAAGTTTCCAAC----GCATGCTTT---TTTGG----GGACA--------CATTCAAAC ** * * * * *** * * * *** *** **** * ENST00000254037.2 TATCAAATAGTACTTCTACCACTGTTTGGAGAAAATTGAAGAAAAGAATAAGATGATTAA ENST00000525564.1 CAT-----AGC-CTTCTGCCCCGGCCCCTA--AAATTCA--------------CGTCT-- ** ** ***** ** * * * ***** * * * ENST00000254037.2 ATGAATTCTCTAAAAGAACATATTTTAAGAGACAGAACTTAGACATAACCAAGTAGTTGT ENST00000525564.1 -----TTCTTATGTACAAAATACACTAA----TTGCATTCCAATAAATTCAA--AGTCCT **** * ** *** *** * * * * * * *** *** * ENST00000254037.2 ATACCTGATTGTAACAATCATCTTTTATAAAAG--CAAAATTATGCATAAATGTAAAACA ENST00000525564.1 AT--TTTATTCCAGCA-CCATCTC----AAAAGTCCAAAGTC---CA-GAGTGTCA---- ** * *** * ** ***** ***** **** * ** * *** * ENST00000254037.2 CCCCTAAACAAAGGGAACAAATGAATTTTTGGTTATATTGTTTTCTTGGCTCAAAGTATC ENST00000525564.1 --TCTAAATCA--GATATAGGTGA-----------------------GATTCAAGGCA-C ***** * * * * *** * **** * * * ENST00000254037.2 AATTTATTATTATAATAGAAATTTATAAGTTGCTAGAAAGTCTATATTTTTAAAGTACGG ENST00000525564.1 AATTCACCCCGA----GGCAAATTCTCCTCCTCTTGTGAGCCTGTA-------------A **** * * * ** ** * ** * ** ** ** ENST00000254037.2 AATAAAAATATGTTTTCTATTAAGCAATAGAAATATTTTTGTGTATAATTTTTCTGAATA ENST00000525564.1 AATCAAAACAAGTTATC-ACTCCCAAATGACAATG-----GCG------------GGACA *** **** * *** ** * * *** *** * * * * * ENST00000254037.2 CTTGATTCTCGATTGAAATATCCATTGTTCGTTAATATCCATGTAACAATCCCATTGGAA ENST00000525564.1 ---GGT-----ATAGGAAAG-------------------------ACAATCCCATTTCAA * * ** * ** *********** ** ENST00000254037.2 ACAAGATTTTTTTTGAATCCTAGATGAGAATAAACAGGGATTTGGTTTTT-GTTTTAGTT ENST00000525564.1 AAGGGA--------GAAA--TAGGCAAGAAGAAAGGGATAACTAGTCCCAAGTAACAACA * ** *** *** **** *** * * * ** ** * ENST00000254037.2 TTGA ENST00000525564.1 TT-- **