CLUSTAL 2.1 multiple sequence alignment ENST00000292246.3 GACCGCATCTAGGCCCCGCCGCGTCCGCCACGCCCAGCGCTCGGCGGCGCCCGCCCCACT ENST00000539655.1 ------------------------------------------------------------ ENST00000292246.3 GGCCTGGCCCGCCCCCCGCACCGAGCACTCTTTCGCCCGGCCTCCGGTTCTCGCCGGCTC ENST00000539655.1 ------------------------------------------------------------ ENST00000292246.3 TCGGACCCGCCTCCGAAGACGTGGAGCGCTGCGGCGGCTGATTTGTCAAAGATGAAAGTG ENST00000539655.1 ------------------------------------------------------------ ENST00000292246.3 ACCTTATCAGCTTTGGATACTTCTGAGAGTTCTTTCACACCTTTGGTGGTCATAGAACTT ENST00000539655.1 ------------------------------------------------------------ ENST00000292246.3 GCTCAGGATGTCAAAGAAGAAACCAAAGAATGGCTGAAAAACAGAATTATAGCTAAAAAA ENST00000539655.1 ------------------------------------------------------------ ENST00000292246.3 AAAGATGGAGGTGCCCAGTTGTTGTTTAGACCATTGTTAAATAAATATGAACAAGAAACA ENST00000539655.1 ----------GTGCCCAGTTGTTGTTTAGACCATTGTTAAATAAATATGAACAAGAAACA ************************************************** ENST00000292246.3 CTAGAAAATCAGAACTTATATCTTGTTGGTGCCTCCAAGATTAGAATGTTACTAGGGGCA ENST00000539655.1 CTAGAAAATCAGAACTTATATCTTGTTCGTGCCTCCAAGATTAGAATGTTACTGGGGACA *************************** ************************* *** ** ENST00000292246.3 GAAGCAGTGGGATTGGTAAAAGAGTGCAATGATAACACCATGAGAGCCTTCACATACAGA ENST00000539655.1 GAAGCAGTGGGATTGGTAAAAGAGTGCAATGATAACACCATGAGAGCCTCCACATACAGA ************************************************* ********** ENST00000292246.3 ACCAGACAGAACTTCAAAGGTTTTGATGATAA-CAATGATGATTTCCTGACAATGGCAGA ENST00000539655.1 ACCAGGCAGAACTTCAAAGGTTTTGATGGTAAGCCCTAA--GTTCTTTGTCTCTGTTAGA ***** ********************** *** * * * ** ** * ** *** ENST00000292246.3 ATGTCAATTCATTATCAAACATGAACTTGAAAATCTTAGAGCTAAAGATGAAAAAATGAT ENST00000539655.1 AT--CCATT---TATCAAAAAGAAGTTTATGATGAATAGA-TCAGGGGTCAGCAAACTTT ** * *** ******* * * ** * **** * * * * *** * ENST00000292246.3 CCCTGGTTACCCTCAGGCAAAGTTGTATCCAGGAAAATCATTGTTGAGAAGATTGCTCA- ENST00000539655.1 TTTCAGTAAA----AGGTCAAATAGTA--------AAT-ATTTT-----AGGTTTTGCAG ** * *** ** * *** *** *** * ** ** ** ENST00000292246.3 --CGTCTGGCATCGTGATTCAGGTGTTTC-CACTGCATGACAGTGAAGCCCTGAAGAAGC ENST00000539655.1 TCCGTGTGGTCTC-TGCTGCAGTTACTCAACACTGCC--ATTGTGAAGCAAAAAAGCAGC *** *** ** ** * *** * * ****** * ******* *** *** ENST00000292246.3 TTGAGGACACCTGGTACACTCGGTTTGCTTTGAAGTATCAGCCCATAGA-CAGTATTCGT ENST00000539655.1 CATAGACCATA-AGTA-AATGAATGGGC---GAGGCTGTGTTCAATAAAACTGTATTTAT ** ** *** * * * ** ** * * *** * * ***** * ENST00000292246.3 GGCTACTTTGGGGAAACAATTGCTCTGTACTTTGGATTTTTGGAGT-ATTT--CACTTTT ENST00000539655.1 AAA-ACCATGTGGCAGG-------CTGGA-TTTGGCCTGTTGCCATCATTTGCCTCCCCT ** ** ** * *** * ***** * *** * **** * * * ENST00000292246.3 GCATTAATCCCCATGGCTGTCATTGGGTTACCTTACTACTTGTTTGTGTGGGAAGACTAT ENST00000539655.1 GGATGAA----CACAA--ATTAGAGGAACACAT-GTAACTTACTTATAT---TATTCTAT * ** ** ** * * ** ** * **** ** * * * **** ENST00000292246.3 GACAAGTACGTGATCTTTGCCTCGTTCAACCTCATCTGGT--CCAC-GGTGATTCTGGAA ENST00000539655.1 ----TCTATTTCTTCTTTTTTTTTTTTTTTTTTTTTTAGTATTTATTGATCATTCTTGGG ** * ***** * ** * * * ** * * * ***** * ENST00000292246.3 CTGT-----GGAAGCGTGGCTGTGCCAA---CATGACCTACAGGTGGGGGACACTGCTCA ENST00000539655.1 -TGTTTCTCGGAGAGGGGGATTTGGCAGGGTCATAGGACAATAGTGGAGGGAA--GGTCA *** *** * ** * ** ** *** * **** ** * * *** ENST00000292246.3 TGAAGAGAAAGTTTGAGGAGCCCCGGCCAGGATTTCATGGTGTCTTGGGTATCAATTCC- ENST00000539655.1 -GCAGATAAA-CATGTGAA-------CAAAGGTCTCTGGTTTTCCTAGGCAGAGGGCCCT * *** *** ** * * * * * * ** * * ** * ** * ** ENST00000292246.3 ATCACTGGGAAGGAGGAGCCTCTGTACCCC-AGCTACAAGAGACAGTTGCGCATTTACCT ENST00000539655.1 GCCGCCT----TCCGCAGTGTTTGTGCCCCTGGGTACTTGAGATTAGGGAGTGGTGAT-- * * * ** * *** **** * *** **** * * * * ENST00000292246.3 GGTCTCCCTGCCATTCGTG-TGCCTCT--GCCTCTATTTCTCACTGTATGTCATGATGAT ENST00000539655.1 -GACTCTTAACCAG-CATGCTGCCTTCAAGCATCTGTTTAACAAAGCACATC-------- * *** *** * ** ***** ** *** *** ** * * ** ENST00000292246.3 TTACTTCGACATGGAGGTTTGGGCCTTGGGTCTACATGAGAACAGCGGGTCTGAGTGGAC ENST00000539655.1 TTGCACCG---------------CCCTTAATCCATTT---AAC------CCTGAGTGGAC ** * ** ** * ** * * *** ********** ENST00000292246.3 -CAGTGTCCTGTTGTATGTGCCCAGCATCATCTATGCCATTGTGATTGAGATCATGAATC ENST00000539655.1 ACAGCA-CCTGTTTCA-GAG---AGCAC-------GGGGTTGGGGGCAAGGTTATAGATT *** ****** * * * **** * *** * ** * ** ** ENST00000292246.3 GTCTCTATCGATATGCTGCCGAGTTTTTAACTTCATGGGAGAATCACAGATTGGAATCTG ENST00000539655.1 AACAGCATCCCAAGGCAGAAGAATTTTT--CTTAGTAC-AGAA---CAAAATGGAGTCT- * *** * ** * ** ***** *** * **** ** * **** *** ENST00000292246.3 CCTATCAGAACCATCTAATTCTGAA-AGTTTTAGTGTTCAACTT--CCTCAATTGCTTTG ENST00000539655.1 CCTAT---GTCTACTTCTTTCCACACAGACACAG-GAACAATCCAATCTCTCTTTCTTTT ***** * * * *** * ** ** * *** *** ** **** ENST00000292246.3 CCTCACTCTTCTATATTGCCTTTGTCTTGAAAGATATGAAGCTTTTGCGCCAGAGCTTGG ENST00000539655.1 CCCCACACTTCC----CCCCTTTCTATT-------------------CGACAAAACC--G ** *** **** ***** * ** ** ** * * * ENST00000292246.3 CCACTCTCCTAATTACCTCCCAGATCCTCAACCAAATTATGGAATCTTTTCTTCCTTATT ENST00000539655.1 CCATTGTCATCATGGCCC-----GTTCTCGATGAGCTGTTGGGTACACCTC--------- *** * ** * ** ** * *** * * * *** * ** ENST00000292246.3 GGCTCCAAAGGAAGCATGGTGTGCGGGTGAAGAGGAAGGTGCAGGCTTTAAAGGCAGACA ENST00000539655.1 ----CCAGACGGGG--TGGCGGCCGGGC--AGAGG--------GGCT------------- *** * * * *** * **** ***** **** ENST00000292246.3 TTGATGCTACATTATATGAACAAGTCATCCTGGAAAAAGAAATGGGAACTTATTTGGGCA ENST00000539655.1 ------CCTCACT--------------TCCCAGACG-------GGGCGCC-----GGGCA * ** * *** ** *** * ***** ENST00000292246.3 CCTTTGATGATTACTTGGAGTTATTCCTGCAGTTTGGTTATGTGAGCCTTTTCTCCTGTG ENST00000539655.1 -----------------GAGGCGCCCCCGCAACTC--CCAGACGGG-----------GCG *** ** *** * * * * * * ENST00000292246.3 TTTACCCATTAGCAGCTGCCTTTGCTGTGTTAAATAACTTCACTGAAGTAAATTCAGATG ENST00000539655.1 GCGGCTGGGCGGGGGCTGCCCCCC------------ACCTCCCTGACGGGG---CAGCTG * * ****** ** ** **** * *** ** ENST00000292246.3 CCTTAAAAATGTGCAGGGTCTTCAAACGTCCATTCTCAGAACCTTCAGCCAATATTGGTG ENST00000539655.1 CC--------AGGCGG-------AGACGC---TCCTCA----CTTC--CCAG-------A ** ** * * *** * **** **** *** ENST00000292246.3 TGTGGCAGTTGGCTTTTGAAACGATGAGTGTTATATCTGTGGTCACTAACTGTGCGCTGA ENST00000539655.1 CGGGGCGGCCGG--TCAGAGA------------------TGCTCCTCACCT---CCCAGA * *** * ** * ** * ** ** * ** * * ** ENST00000292246.3 TTGGAATGTCACCACAAGTGAATGCAGTCTTTCCAGAATCAAAAGCAGACCTCATTTTGA ENST00000539655.1 C-GGGGTGGCGGCA-GGGCAGAGACA--CTCCTCAGT-TCCCAGACGG----------GG ** ** * ** * * ** ** *** ** * * * * ENST00000292246.3 TTGTAGTAGCAGTGGAGCACGCACTCCTGGCTTTAAAGTTTATACTTGCATTTGCCATAC ENST00000539655.1 TCGCTGCA-CGGCAGAG---GCGCTCCT--------------------CACATCCCAGAC * * * * * * *** ** ***** ** * *** ** ENST00000292246.3 CTGATAAGCCACGGCATATCCAGATGAAACTAGCCAGACTGGAATTTGAGTCTTTGGAGG ENST00000539655.1 -TGGGCGGCCGGG-------CAGA-GGGGCT--CCTCAC----ATCCCAGACGATG--GG ** *** * **** * ** ** ** ** ** * ** ** ENST00000292246.3 CACTCAAGCAGCAGCAAATGAAGCTCGTGACCGAGAACCTGAAGGAGGAACCAATGGAAA ENST00000539655.1 CGGCCGGGCAGAGAC-------GCTCCTCACT----TCCTAGACGGGG------TGGCG- * * **** * **** * ** *** * * ** *** ENST00000292246.3 GCGGGAAGGAGAAGGCAACCTGAGTGCCCAGCGTGCCCAGCTGCCCTGTTGGCAGAGGCC ENST00000539655.1 GCGGGGCAGAGGCTGCAATCTCGGCACTTTGGGAGGCCAA----------GGCAGGCGGC ***** *** **** ** * * * * * *** ***** * * ENST00000292246.3 TGTGTCTGTGCCACACCTGCCACGGTGGCAGGGGGGGTACCCGGGGCAGCATCGTGGCTC ENST00000539655.1 TG---------------------GGAGGTGGAGATTGTAGC-GAGCCAAGATCACG-CCA ** ** ** * * *** * * * ** *** * * ENST00000292246.3 CTGAACCCAGACC----CAATGCTTAGCCAAACGAAGTGGCTCCCATGTGGCAAGCACCC ENST00000539655.1 CTGCACTCCAGCCTGGGCAACATTGAGC---ACTGAGTG----------AGCGAGACTCC *** ** * ** *** * *** ** **** ** ** ** ENST00000292246.3 TTCTCAGTTTCGCAGTGGCTTGGCTCGGGATCCTTGGCAGTTCCCCCAGCCCCACCCTGT ENST00000539655.1 GTCT-------GCAAT-------CCCGGCACCTCGGG----------AGGCCGAGGCTGG *** *** * * *** * * ** ** ** * *** ENST00000292246.3 CTGCTCCTTCCCAGTTCCTTCCCGGGCCCCACACGCTGCTCCAGCTGCCAACTTTGCTGC ENST00000539655.1 CAGATCACTCGCGGT-------CAGGAGCTGGAGACCAGCCCGG---CCAAC---ACTGC * * ** ** * ** * ** * * * ** * ***** **** ENST00000292246.3 AGAGCCACTGCCGCCCTTGAGCCTCTCACCATGAGTGAGC-CACCAGCTCTCCACGTTCC ENST00000539655.1 AAAACC----CCGTCT------------CCACGAAAAAATACAAAAACCAGTCAGG---- * * ** *** * *** ** * ** * * ** * ENST00000292246.3 CCTCATAGCAGTGT-CACTCCCAACCCCACCATGGCCCAGGGACCCGTGGACAGGTTGGG ENST00000539655.1 ---CGTGGTGGCGTGCACCTGCAATC----------CCAGGCAC---TGGGCAGGCTAAG * * * * ** *** *** * ***** ** *** **** * * ENST00000292246.3 GATGGGGTGTGTGCCCACTGTGCTCATCACAGGAGCCTCAGTTGAGAGTGAGCGGGGTAC ENST00000539655.1 G----------------------------CAGGAGAATCAG------GCAGGGAGGTTGC * ****** **** * * ** * * ENST00000292246.3 AGTAAGGCAGTGCTTCCCACACTGGACCTCTTTCCTGGTTCTCTTTTGCAATACATTAAC ENST00000539655.1 AGTGAG----------CCGAGATGG--------------------CGGCAGTACAGT--C *** ** ** *** *** **** * * ENST00000292246.3 AGACCCTTTATCAACATAAACAATAGTAACTGAGCTATTAAAGGCAACCTCTCTGACTCC ENST00000539655.1 CAGCCTCCGCTCGGCATCAG--AGGGAGACCGTGC----AAAGGGGA-------GA---- ** ** *** * * * ** * ** ***** * ** ENST00000292246.3 TTCTGCCTACATAGGTACCGCAATGGGCTTCCCTTTTCTGAAGCACTTGGTGAGGTCACT ENST00000539655.1 ------------GGGAGAGGGAGAGGGC-------------AGCA-----TAAAGCTTTT ** * * **** **** * * * * ENST00000292246.3 GAAGGTGGAGCGGTGAGATCAGGAGCCCAGGGTGAGGGGCTTGGCTGGA-GGCCAGGCAC ENST00000539655.1 GAAGGTCAA---------TCAGAACTTCA----------TTTGTTTTTATGGCTGAATAA ****** * **** * ** *** * * *** * ENST00000292246.3 CAA-AGCTTGTAGCTGAAGGCTGGGCCATTTTTGAGAACTGCTGCTGGTGGTGCCCACCT ENST00000539655.1 TAACAATTTGTAGCTATA-------TCACATTT---------TGTT-----TATTCATTC ** * ******** * ** *** ** * * ** ENST00000292246.3 ACAG--GGACACTAGGGCTGCTTTCACATGCAGGGTGT-ACCCATGGTGCCAAGCCAAGG ENST00000539655.1 ACTGATGGACATTTGGCTTGTTTCCATCTTTTGGCTGTTGTGAATAATGCTA--CTATA- ** * ***** * ** ** ** ** * ** *** ** *** * * * ENST00000292246.3 GCCAGCAGCCACTCCTGGTGCCCTGGCCTGGGCTTGGGCTTGCAGAGAAAAGGGCCCTCC ENST00000539655.1 ---AACATTCATATATAATAATTTA--------------TT----AGAATA---CCTTTC * ** ** * * * ** **** * ** * * ENST00000292246.3 TTGCCCAGTGGTGCTGCCCACCTCCCTAGCT---GTGTCCATGGACTGCCCTGCATTCAC ENST00000539655.1 TT----------------CAATTCTTTAGGTTATATATCTA-GGATTG----GAATTTTT ** ** ** *** * * ** * *** ** * *** ENST00000292246.3 AGG-CACA--AGAATGCCATGTAGGCCAGTGCTGCCCACGTATACAGCCCTTCCCACCAG ENST00000539655.1 AGATCATATTATAATTCTATAT---TTAA--CTTTTGAGGAATA-----------GCCAA ** ** * * *** * ** * * ** * * *** *** ENST00000292246.3 CGCTGGCCGTCCTGCTGTAGCCAAGACACTACAGACCCGTGGGCACCTCCACTCGGACAG ENST00000539655.1 -ACTG--TTTTCTACAATGGCCGCACCATTTTACATTCC----CACCAGCAATTGATGAG *** * ** * * *** ** * * * * **** ** * * ** ENST00000292246.3 --CAGCAGATGCCCTGGCCC ENST00000539655.1 GTTTCCAATTTCTCCA---- ** * * *