CLUSTAL 2.1 multiple sequence alignment ENST00000300107.2 GCGCGCAAGCTCCCCGGGCCCAGTAGGCTGGGGGTGGGGGTAGAAGGAGAAGGAGGGGAA ENST00000419615.1 ------------------------------------------------------------ ENST00000300107.2 GGGAGGGGGGGGTTGGGTGTCTACTCTGGTGAATAGACGGCTGTGGGGCAGAGAAGCGTG ENST00000419615.1 ------------------------------------------------------------ ENST00000300107.2 AAGGCCTGGCTGCCGGGCAGGTGAACTCTCCACGGGGTCTAGGGCCCGCGAAAGGGTTCG ENST00000419615.1 ------------------------------------------------------------ ENST00000300107.2 GAACCGAGTCAGCGCGCCTTGCGGGCAGGATTCACGCCGCTGTGACCCGGAGGTCCTCAG ENST00000419615.1 ------------------------------------------------------------ ENST00000300107.2 GGGGCGAAGCCCCGGCCTAGGCCTCGCGGAGATGCCCAGCTGCGGTGCTTGTACTTGCGG ENST00000419615.1 -------------------------------ATACGCAGCTGCAGTGTTTGTACTTTTA- ** * ******* *** ******** ENST00000300107.2 CGCGGCGGCCGTCCGGCTCATCACCTCCTCACTCGCCTCCGCGCAGAGAGGTATTTCTGG ENST00000419615.1 TACAGTGA------AACTCATTACCACCTTGCTTACTTCCTAGTAGAGAGATGTGTCTTG * * * ***** *** *** ** * *** * ****** * * *** * ENST00000300107.2 TGGTCGCATTCATATGTCAGTTTTAGGAAGGCTTGGGACATTTGAAACTCAGATTCTGCA ENST00000419615.1 TAGTTACACTGAAACACCTG----------GCTGGGCACAT---------AGGT-----G * ** ** * * * * * *** ** **** ** * ENST00000300107.2 AAGAGCTCCTCTTAGATCCTTTACAGAAACACCAGCATACTTTGCCTCAAAAGATGGGAT ENST00000419615.1 AAG-----CTGTTGAGTCTGTAA------------------TTGTC-------------- *** ** ** ** * * *** * ENST00000300107.2 AAGTAAAGATGGTTCTGGAGATGGAAATAAGAAATCAGCAAGTGAGGGAAGTAGTAAGAA ENST00000419615.1 -----AAACTGCTCCC--AGGTGCCAATTATAAT-------GTAGAAGAGGCA-CAAGAA ** ** * * ** ** *** * ** ** ** * * ***** ENST00000300107.2 ATCAGGCTCTGGGAATTCTGGGAAAGGTGGAAACCAGCTGCGCTGTCCTAAATGTGGCGA ENST00000419615.1 --------------------GATGAAGTGGA-----------------TAAGCCTGGCAG * * ***** *** **** ENST00000300107.2 CTTGTGCACACATGTAGAGACCTTTGTATCATCCACCCGTTTTGTCAAGTGTGAAAAGTG ENST00000419615.1 TTTGT-----CAAG---------------CATTCATCAGT--TGTCAAG----------- **** ** * *** ** * ** ******* ENST00000300107.2 TCATCATTTTTTTGTTGTGCTATCTGAAGCAGACTCAAAGAAAAGCATAATTAAAGAACC ENST00000419615.1 ----CATTTGTCAGTTGCAGAATGT-AGGTAGGCT---GCCAAGGCTTTATTGTAG--CC ***** * **** ** * * * ** ** ** ** * *** ** ** ENST00000300107.2 TGAATCAGCAGCAGAAGCTGTAAAATTGGCATTCCAACAGAAACCACCACCTCCCCCTAA ENST00000419615.1 TGGTTCTATTGC---AGCTTTA---------TTCTAGCA-AGGCTGCTG----------- ** ** ** **** ** *** * ** * * * ENST00000300107.2 GAAGATTTATAACTACCTCGACAAGTATGTTGTTGGCCAGTCATTTG-CTAAGAAGGTGC ENST00000419615.1 GAAAAT--------------ACAA-------------TAATCACTGGTCCAAGAAAGAAC *** ** **** * *** * * * ***** * * ENST00000300107.2 TTTCAGTTGCTGTGTACAATCATTATAAGAGAATATATAATAATATCCCAGCTAATCTGA ENST00000419615.1 TCTTA--TACTCT-----ATCTATATGA-AGAA---ACAGTAAAA-----GTCAATTC-- * * * * ** * *** *** * **** * * *** * * *** ENST00000300107.2 GACAGCAAGCAGAGGTTGAGAAGCAGACATCATTAACACCAAGAGAGTTAGAAATAAGAA ENST00000419615.1 ---------------------AGTAGAAATCAT--------------------------- ** *** ***** ENST00000300107.2 GACGGGAGGATGAGTACAGATTTACAAAATTGCTTCAGATTGCTGGAATTAGCCCACATG ENST00000419615.1 ------------------GATTT------TTGTGCCTGGT-GCT--------TTCACTTT ***** *** * * * *** *** * ENST00000300107.2 GTAATGCTTTAGGAGCATCAATGCAGCAACAGGTAAATCAACAAATACCTCAGGAAAAAC ENST00000419615.1 TTTATGC--------CA-CAATAC--CAAGAGGTTAA----------------------- * **** ** **** * *** **** ** ENST00000300107.2 GAGGAGGTGAAGTATTGGATTCTTCTCATGATGACATAAAACTTGAAAAAAGTAATATTT ENST00000419615.1 -----AATGAAGTGT------CTT----TGAT-----------TGGGAA---TACCAT-- ****** * *** **** ** ** ** ** ENST00000300107.2 TGCTGCTTGGACCAACTGGGTCAGGTAAAACTCTGCTGGCACAAACCCTAGCTAAATGCC ENST00000419615.1 --CTATCTGGGAAAA----GACAGG---------GCTG---CAA--CTT--CTGAAGACC ** *** ** * **** **** *** * * ** ** ** ENST00000300107.2 TTGATGTCCC-TTTTGCTATCTGTGACTGTACAACTTTGACTCAGGCTGGATATGTAGGC ENST00000419615.1 TTGACACTCTGTCCTGTTACC-----CTGCTTCATTTTT-CTC----------------- **** * * ** ** * *** * *** *** ENST00000300107.2 GAAGATATTGAATCTGTGATTGCAAAACTACTCCAAGATGCCAATTATAATGTGGAAAAA ENST00000419615.1 -------------CTGCGCTTATCA--CTACTT---GATGC----TATA----------- *** * ** * ***** ***** **** ENST00000300107.2 GCACAACAAGGAATTGTCTTTCTGGATGAAGTAGATAAGATTGGCAGTGTGCCAGGCATT ENST00000419615.1 ----AACAA-------------------------ATAAAA---------------ACATA ***** **** * *** ENST00000300107.2 CATCAATTACGGGATGTAGGTGGAGAAGGCGTTCAGCAAGGCTTATTAAAACTACTAGAA ENST00000419615.1 TAT---------GATATA--------------------AGGTCTATTTCTCCTACT---- ** *** ** *** **** ***** ENST00000300107.2 GGCACAATAGTCAATGTTCCAGAAAAGAATTCCCGAAAGCTCCGTGGAGAAACAGTTCAA ENST00000419615.1 ----CAACTGTAA--GTTCCATGAGGG-------CAGGGCTTTCT----------TTCTT *** ** * ****** * * * *** * *** ENST00000300107.2 GTTGATACAACAAACATCCTGTTTGTGGCATCTGGTGCTTTCAATGGTTTAGACAGAATC ENST00000419615.1 GTT--TACTAC------TCTATTCCCTGTATCTAAAAC----AGTGCTT--GGCA----C *** *** ** ** ** * **** * * ** ** * ** * ENST00000300107.2 ATCAGCAGGAGGAAAAATGAAAAGTATCTTGGATTTGGAACACCATCTAATCTGGGAAAA ENST00000419615.1 AT-AGCAAGTGC-----TAAAAAATATTCT----TTGAA-------TGAGTGTATGAA-- ** **** * * * **** *** * *** * * * * *** ENST00000300107.2 GGCAGAAGGGCTGCAGCTGCTGCAGACCTTGCTAATCGAAGTGGGGAATCGAATACTCAC ENST00000419615.1 -----------TGGAACT--TACAGTC------AGCTGAAGGAG--------ACAGTTAT ** * ** * *** * * **** * * * * * ENST00000300107.2 CAAGACATTGAAGAAAAA-GATCGGTT--ATTGCGTCATGTGGAAGCCAGAGATCTGATT ENST00000419615.1 TAAG-CAT--AAGAGTGATGACCAGTCCAATTGTGT-GTGT------CAGGCATGTG--T *** *** **** * ** * ** **** ** *** *** ** ** * ENST00000300107.2 GAGTTTGGCATGATTCCTGAGTTTGTGGGACGGTTGCCTGTGGTGGTTCCATTGCATAGC ENST00000419615.1 GAA---AACGTG----CTAAATTTG----AC--TTGCTTAT---------------TAG- ** * ** ** * **** ** **** * * *** ENST00000300107.2 CTAGATGAGAAAACACTTGTACAAATATTAACTGAGCCACGAAATGCTGTTATTCCTCAG ENST00000419615.1 -----------------------GACAGTAACTGATACTTCTAATGTTCTTGCAGCCCAT * * ******* * **** * ** * ** ENST00000300107.2 TACCAGGCCTTATTCAGCATGGATAAGTGTGAACTGAATGTTACTGAGGATGCTTTGAAA ENST00000419615.1 GACC---TCTTCTTTA------AGAAGTGTCCATTCTGTACTACT--------TTC---- *** *** ** * * ****** * * * **** ** ENST00000300107.2 GCTATAGCCAGATTGGCACTAGAACGAAAAACAGGTGCACGAGGCCTTCGGTCCATAATG ENST00000419615.1 -CCATT-----ATT--CACT------------------------CATTCATTCC------ * ** *** **** * *** *** ENST00000300107.2 GAAAAGCTGTTACTAGA-ACCAATGTTTGAAGTCCCTAATTCTGATATCGTATGTGTGGA ENST00000419615.1 --AAAGCATTTGCTATACAGCAGTATT----ATACCAGATACC-ATAT--TAGGTGCTGG ***** ** *** * * ** * ** * ** ** * **** ** *** * ENST00000300107.2 GGTTGACAAAGAAGTAGTAGAAGGAAAAAAGGAACCAGGATACATCCGGGCTCCAACAAA ENST00000419615.1 GGC--------------TAGAGAGAATATAAAAGCTA----ACATT--GATT-------- ** **** *** * * * * * **** * * ENST00000300107.2 AGAATCCTCTGAAGAGGAGTATGACTCTGGAGTTGAAGAAGAAGGATGGCCCCGCCAAGC ENST00000419615.1 -GAGTGTTT--------AGTATG-----------------------------CGCCAGGC ** * * ****** ***** ** ENST00000300107.2 AGATGCTGCAAACAGCTAAACTGTCATATTGCTGTCTTGTATATACAGCTTTTCCTTCTT ENST00000419615.1 C--------------CTGAACT-----------------------CAGC----------- ** **** **** ENST00000300107.2 TTGTTTAGGATCATAATTGTCTCTACAGTCTGATATTAAAGGCATTGGATCTATCTTGGA ENST00000419615.1 --------------------------------ACATTACATGTATTAACTCTTT------ * **** * * *** *** * ENST00000300107.2 TATCATACATGGTCAGAGAAGCCTTTAGGAGAAGAATCAGATCATGTATATAATTGTAAC ENST00000419615.1 -AACCCCTATGGC-----AGCCCTTTGAGATAAAAAC-------------------TAAT * * **** * ***** ** ** ** *** ENST00000300107.2 ATCACATTGATTTTACGGAAGATGTTATATGGACTTTAATGACACAATGTTTAGAGA-TA ENST00000419615.1 ATTATCTTCACTTTACAGATAA-GTTG---AGAC-------ACAGAAAGTTAGGTGACTC ** * ** * ***** ** * *** *** *** ** *** * ** * ENST00000300107.2 AAATGTACATTATTTTGGTTCAGTTTTTTAAAAAAAATATGCTTTAACAAAATTCTTAGG ENST00000419615.1 AAATG-----------GGTTCACTGCCTTAAGGA-------------------TCTCAG- ***** ****** * **** * *** ** ENST00000300107.2 AATTCTTTTAAGCAATGCAGGTATTGCGATAACTGTAGATTTTACAATAATGTTACTCTA ENST00000419615.1 ---TCTAATAAGGAAAGCAG---------------------------------------- *** **** ** **** ENST00000300107.2 CAAATGGGAAAATAAATTCTTTAAAATTGAATATTGAGATACCATTCTTTAGTGTTACCT ENST00000419615.1 --AAAAGCAAAGCAA---CCTTATAAT---ATGGTGCAATA------------------- ** * *** ** * *** *** ** ** *** ENST00000300107.2 TTTTTACCCACATGTGTTTCTGAAAATATTGGAATTTTATTCATCTTAAAAATTGGACCA ENST00000419615.1 -----------ATTTGCT-------ATAATGAAGTTATAT-------ACAAAGTGAA--- ** ** * *** ** * ** *** * *** ** * ENST00000300107.2 GGTAGGCCGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGG ENST00000419615.1 -GTAGA---AGCATAGAAG-----------AAGC--AGCACT-----AAATTTGTCTGGG **** ** * * * ** * ****** * *** ENST00000300107.2 TGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGGTGAAACCCCATCTCTA ENST00000419615.1 TGAGTCA-GAG-----------AAGGCTAACCAGGA-AAAATAGTT--------TCTGAA ** *** *** *** * * ** ** ** ** ** *** * ENST00000300107.2 CTAAAAATATGAAAAATTAGCTGGGTGCCGTGGCAGGTGCCTGTAATCCCAGCTACTCGG ENST00000419615.1 CTAACACT-TGAAGGA-------GGT---GTAGCAGTT------CATC---ACTGACAGT **** * * **** * *** ** **** * *** ** * ENST00000300107.2 GAGGCTGAGGCAGGAGAATCGCTTGAACTC-GGAGGGCAGAGTTTACAGTGAGCTGAGGT ENST00000419615.1 GATGTTGGGGTGGG-------TCTGGTTTCAGGAGAGGGGAG-------------GAAAT ** * ** ** ** ** ** **** * *** ** * ENST00000300107.2 TGTGCCACTGCACTCCAGCCTGGGCGACAAAGTGAGACTCCGTCTCAGGGCGAAAACAAA ENST00000419615.1 TG---------GCTTTGGTCTG------------AGGCT-------GAGGTGTGGGCAAA ** ** * *** ** ** ** * **** ENST00000300107.2 AAATTGGACCAGGTAGTTTTCAAGTAGTTAAACATTTCATTGAAAAATACCCTGAAGAAC ENST00000419615.1 GCATTAGCTTATGTGGG--TCCATTAGCT---TATGT-------GAGTCCACAAAAGGTG *** * * ** * ** * *** * ** * * * * * *** ENST00000300107.2 TATATTTTGATAATTGGTTTAGCTGTATTCCTAGTCTTATCTGCTAATGCATGACACTAA ENST00000419615.1 TGTGTGT---------GTTTGTGTGTATGTGTG----TGTGTGTGTGTGTGTG------- * * * * **** ***** * * * ** ** ** ENST00000300107.2 CTTCCCAATTGGTTCTGTAAAAAAGGCCATTTTCTTACCAAGTTGTCTGATTTATTTACC ENST00000419615.1 ---------TGTGTGTGTACGAAATGGGGGCT------CAA------TGATTTGGTAGTG ** * **** *** * * *** ****** * ENST00000300107.2 ATCTTTTTTTTTTTTTTTTTTTTAATTGAGCGGAGTCTCACGCTGTCCCAAGCTGAAGTG ENST00000419615.1 GT-----------TTGGTTTGTCAA------GAAG---CAGGCTG---------GGAACT * ** *** * ** * ** ** **** * * ENST00000300107.2 CAGTGGTGCGATCTTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTTTCCTGC ENST00000419615.1 CAATAA-GC-ATCTT---------------------------TCCATTCATTTCTACTGT ** * ** ***** * ** ** ** * *** ENST00000300107.2 CTCAGCCTTCCAAGTAGCTGGGATTATAGGCACGCACCACCACACCTGGCTAATTTTTGT ENST00000419615.1 ----GTATCCCA--CAGCT----TCACA--CACACAT----GCAC-------ATTTCAAC * * *** **** * * * *** ** *** **** ENST00000300107.2 ATTTTTAGTAGAGACAGGGTTTCACCCTGTTGGCCAGGCTAGTCTGTAACTCCTGACCTT ENST00000419615.1 ATT------GGTGACTG--CTTCACT-TGC------------------ACACCTAAGGTA *** * *** * ***** ** ** *** * * ENST00000300107.2 GTGATCTGCTGGCCTCAGCCTCCCAAAGTGCTGGGATTGCAGGCGTAAGCCACCACACCC ENST00000419615.1 ATGAT-----GGACACA-CCTGTAGCAATGT--AGATTCTT--CCTAAGCTAA------- **** ** * ** *** * ** **** * ***** * ENST00000300107.2 GGCCTTATTTACCATCTTTAATCCATTTTAGTACTATGGGTGAGTACATGGAATTGAAGT ENST00000419615.1 ------------------TAATTAGTTTCAGGA-----GGT-AGCACATACATTTAAAAA **** *** ** * *** ** **** * ** ** ENST00000300107.2 CTGGCTTAAATCTTCAGAAAGTTATATATCTATTTTATTTTATTTTTTTGAGACAGAGTC ENST00000419615.1 TAGGTTAAAAT------AAAGTG-----------TTATTTTAATTGGT--AGGTGGA-TC ** * **** ***** ******** ** * ** ** ** ENST00000300107.2 TCGCTGTGTCACCCAGGCTGGAGTACAGTGCCACAATCTTGGCTCACTGCAACCTCTGAG ENST00000419615.1 T-GTTG----------------GCAC-------CAATGATTATTCACGGCATC----AAG * * ** * ** **** * **** *** * ** ENST00000300107.2 TCCCAGGTTCAAGCGATACTCATGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGTGC ENST00000419615.1 ACCCAGG--------------GTGCC-------CGTCAGAAGTT----CTCCAG------ ****** **** * * ** ** * ** *** ENST00000300107.2 ACCACCACACCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCGCCATGTTGCC ENST00000419615.1 -CCTCTACATCT--CTCAGTTTAT------------------------CATCATGTA--- ** * *** ** ** * *** * * ***** ENST00000300107.2 CAGGCTGGTCTCTCCTGAGCTCAGGCAATCGGCCACCTTGGCCTCTGAAAGTGCTAGAAT ENST00000419615.1 -----TAGTCT----TGAT----GGGAA-------------------GAAGTGGCAGACT * **** *** ** ** ***** *** * ENST00000300107.2 TACGGGCATGAGCCACCGCATCCAGCCAGAAAGATACATATCTAATTCTAGAAATAGCAT ENST00000419615.1 TATCG----------------------AGGAAATTCCAC-TGGAACCTTA---ATGGTAT ** * ** ** * ** * ** ** ** * ** ENST00000300107.2 GCAGTATCAGTCATAGTAACAGCCATGTGCTGACCTAAATAAAATTTCTTGATATTGTGT ENST00000419615.1 GTA--ATTAGTCAT--------------------TTAAAGGGAATGCCTGAATACT---- * * ** ****** **** *** ** *** * ENST00000300107.2 ATTTAACCTGAAGTATTGAGCTAGTTTTTTTGTTTTGTTTTTTGGTGCTGAACATTTTGG ENST00000419615.1 -------TTAAAGAATTTTGGCAGATTTCAGATATTG---------GACAAACACTCT-- * *** *** * ** *** * *** * **** * * ENST00000300107.2 TCTAATTCTTTGGCTTCTTAGAAC---ATTTTAAAAAATCTATGTTTTGCT-ATCAGCCA ENST00000419615.1 ----------TAGCTTCCACAAACTTAATTCCAAAAAATA-ATTTTTCACTTATGAGC-- * ***** *** *** ******* ** *** ** ** *** ENST00000300107.2 AAGTAAATGTGTTCACACTAACATATAAGTTACTAACCTTCATTATACAGCAAAGCTAAA ENST00000419615.1 -AATAGA---GTTATTACGGACATAT---------------------CAGCAA-----AA * ** * *** ** ****** ****** ** ENST00000300107.2 AAGTGGTGGGATATTTGGGGTCTTAATGAAAATTGTATCATTTAATTCCATAAATATTAA ENST00000419615.1 ATGTAGTAG--------------------------TGTCA---AGGCTCATAGATGATAG * ** ** * * *** * **** ** ** ENST00000300107.2 AATATTTGGGTACCTTTTAAGCTTTTTTTCTTTCCTTCTATAATGGTGGTACAAGTTCTA ENST00000419615.1 AA----------------------------------------ATGA----AGAGATGCTG ** *** * * * ** ENST00000300107.2 TATTCATTCAGTTTAATCTCATTTGAAATTGTTTAAATCAGAGTACATGTAAATATTTGT ENST00000419615.1 TATTGATAGAAAT--ATGTGATTCAGGACTGTGTGGATTG------------ATGATTGT **** ** * * ** * *** * *** * ** ** **** ENST00000300107.2 GGGTTTTTTTTTTTGGTTTATAGACTCGAGCTTTCCTTTTACACAGTTTTTTTTAGGGAA ENST00000419615.1 GAGCTT---------GCTTATGGA-------TATCCT-------AGGTTT---------G * * ** * **** ** * **** ** *** ENST00000300107.2 AAACTAAAGCTATTAGGAAATTCTAAATCTTGTTGATGAAGAGTTGGGCTTTCTTTGATA ENST00000419615.1 AGGTTA----TAGTAGGACA------ATCAGGTTG---AAATGTCCAGC--------AGG * ** ** ***** * *** **** ** ** ** * ENST00000300107.2 TAATTAATAAAAGGGATGTATGGTATTTATGGCTGGGTAGGACCAGAAATGCACTTTGTA ENST00000419615.1 CAGTAGGTGAAAGACAAGT-------TTAGG---GGGCAAAACCATGGATG--------- * * * **** * ** *** * *** * **** *** ENST00000300107.2 TTACAGAGTGTTAAGGCTGGTTGCTATAGTATGGAACAGAAACACCTCTCCTTGGTCTCC ENST00000419615.1 -----GAG-ATGAAGATTCATGACTTCCACATAAAA-----------------GG----- *** * *** * * ** ** ** ** ENST00000300107.2 CTAGTAATGGTTCAAGTTCTTCCCAGGAAGTCTTACATATTATAACTTTGTTCATTATCT ENST00000419615.1 ------ATGGGTGAAACTTT-----GGGAAT--------TGATGA--------------- **** * ** * * ** * * * ** * ENST00000300107.2 TTCCCTTATAGCATCATTTTCCTTTTTGTAGAGTGGAAATCAGACTAGCTGCTAAACATA ENST00000419615.1 ---------------ATTCTC-------TAGAGGTGAGCTCAA---GACCCTTAAA---- *** ** ***** ** *** * **** ENST00000300107.2 TTAAGGTTAATCCTCCAGAAATGTACTGGGGAGGCATTTTAGTCACAACAACTTACATTT ENST00000419615.1 ---GGCTTAAAACCTCAG----------------CGTTATTGTC----TACTCTTCCCTC * **** * *** * ** * *** * * * * ENST00000300107.2 GGCTTTGGAAGTTGTTAACAAAGCATAGTCGATGTTTTTAAATCAAACATAATTTGTATC ENST00000419615.1 ATTTTTA-----TGCCCACAAATC-TGGTCAATCCTTT---------------------- *** ** ***** * * *** ** *** ENST00000300107.2 TTGGAACTTACATTTTGACATTTGAATAAAACAAAAAGACTAAATGAAA ENST00000419615.1 -------------------------------------------------