CLUSTAL 2.1 multiple sequence alignment ENST00000304546.1 GGCGGCGGGCGCTGGGAGACACCGGACGCCCGCTCGGCTGCGCTGCGGCTCAGGCCCCCG ENST00000373592.2 ------------------------------------------------------------ ENST00000304546.1 CTCGGGCCCGACCCGCTCGGTCACCGCCGGCTCGGGCGCGCACCTGCCGGCTGCGGCCCC ENST00000373592.2 ------------------------------------------------------------ ENST00000304546.1 AGGGCCATGCGGAGGCCCACGAGGAGGCCGGCGGCCACGCGCATCCCGTAGCCCAGGTGG ENST00000373592.2 ------------------------------------------------------------ ENST00000304546.1 CCCAGGTCTGCACCGCGGCGGCCTCGGCGCCATGGAGCCCCCGTATTCGCTGACGGCGCA ENST00000373592.2 -------------------------------ATGGAGCCCG-GTATTCGCTGACGGCGCA ********* ****************** ENST00000304546.1 CTACGATGAGTTCCAAGAGGTCAAGTACGTGAGCCGCTGCGGCGCGGGGGGCGCGCGCGG ENST00000373592.2 CTACGACGCGTTCCAGGAGGTCAAGTACCTAAGCTGCTGTGGCGCGGGGATCGTGCA-AG ****** * ****** ************ * *** **** ********* ** ** * ENST00000304546.1 GGCCTCCCTGCC-CCCGGGCTTCCCGTTGGGCGCTGCGCGCAGCGCCACCGGGGCCCGGT ENST00000373592.2 GGCCTTTCTGCCGCCCAGGCTTCTC-TCAAG------GAGCAGCGCCACCAGGACCTGG- ***** ***** *** ****** * * * * *********** ** ** ** ENST00000304546.1 CCGGGCTGCCGCGCTGGAACCG-GCGCGAGGTGTGCCTGCTGTCGGGGCTGGTGTTCGCC ENST00000373592.2 ----GCTGCCGCGCTGGAACCCTGCGTGAGGTGAGCCTGCGGTCGGGGCTGGTGTTCGCC ***************** *** ****** ****** ******************* ENST00000304546.1 GCCGGCCTCTGCGCCATTCTGGCGGCTATGCTGGCCCTCAAGTACCTGGGCCCGGTCGCG ENST00000373592.2 GCTGATCTCTGCGCCATCCTGGCGGCTATGCTGGCGCTCAAGTACCTGGGCCCGGTCGCG ** * *********** ***************** ************************ ENST00000304546.1 GCCGGCGGCGGCGCCTGTCCCGAGGGCTGCCCTGAGCGCAAGGCCTTCGCGCGCGCCGCT ENST00000373592.2 GCGGGCGGCGGCGCCTGTCCCGAGAGCTGCCCCGAGGGCAAGGCCTTAGCGCGCGCCGCC ** ********************* ******* *** ********** *********** ENST00000304546.1 CGCTTCCTGGCCGCCAACCTGGACGCCAGCATCGACCCATGCCAGGACTTCTACTCGTTC ENST00000373592.2 GGCCTCCTGGCAGCCAACCTGGACGCCAGCATGGACTCGTACCAGAACTTCTACTTTTTC ** ******* ******************** *** * * **** ********* *** ENST00000304546.1 GCCTGCGGCGGTTGGCTGCGGCGCCACGCCATCCCCGACGACAAGCTCACCTATGGCACC ENST00000373592.2 GTCTGCGGCTGCTGACTGAAGCGCCATGCCACCCCCAACGAAAAGCTCACCTATGGCACC * ******* * ** *** ****** **** **** **** ****************** ENST00000304546.1 ATCGCGGCCATCGGCGAGCAAAACGAGGAGCGCCTACGGCGCCTGCTGGCGCGGCCCGGG ENST00000373592.2 ATCGCGGCCTTCGGCGAGCAGAAAGAGGAGCGCCTGAGGCGCCTGCTGGCACGGCCCAGG ********* ********** ** *********** ************* ****** ** ENST00000304546.1 GGTGGGCCTGGCGGCGCGGCCCAGCGCAAGGTGCGCGCCTTCTTCCGCTCGTGCCTCGAC ENST00000373592.2 GATGGGCCCGGCGGCGCGGCCCAGTGCAAGGTGAGCGCCTTTTTCCGTTCGTGCCTCGAC * ****** *************** ******** ******* ***** ************ ENST00000304546.1 ATGCGCGAGATCGAGCGACTGGGCCCGCGACCCATGCTAGAGGTCATCGAGGACTGCGGG ENST00000373592.2 ATGCGCGAGATAGAGCTACTGAGTCCTCGGCCCATGCTAGAGGTCATGGAGGACTGCGGG *********** **** **** * ** ** ***************** ************ ENST00000304546.1 GGCTGGGACCTGGGCGGCGCGGAGGAGCGTCCGGGGGTCGCGGCGC--------GATGGG ENST00000373592.2 GGCTGGGACCTGGGCGGCGCGGCGGAGCGTCCGGGGGTCGCGGGACCTCAACCAGCTGGG ********************** ******************** * * **** ENST00000304546.1 ACCTCAACCGGCTGCTGTACAAGGCGCAGGGCGTGTACAGCGCCGCCGCGCTCTTCTCGC ENST00000373592.2 ACCTCAACCAGCTGCTGTACAAGGTGCAGGGCGTGTACAGTGCCGCCGCGCTCTTCTCTC ********* ************** *************** ***************** * ENST00000304546.1 TCACGGTCAGCCTGGACGACAGGAACTCCTCGCGCTACGTCATCCGCATTGACCAGGATG ENST00000373592.2 TCTAGATCAGCCTAGATTACAGGAACTCCTCGCGCTACGTCATCCGCATTGACCAGGATG ** * ******* ** ****************************************** ENST00000304546.1 GGCTCACCCTGCCAGAGAGGACCCTGTACCTCGCTCAGGATGAGGACAGTGAGAAGATCC ENST00000373592.2 GGCTCAATCTGCTAGAGAGGACTCTGTACCTCGCTCAGGATGAGGAGAGTGAGAAGATAC ****** **** ********* *********************** *********** * ENST00000304546.1 TGGCAGCATACAGGGTGTTCATGGAGCGAGTGCTCAGCCTCCTGGGTGCAGACGCTGTGG ENST00000373592.2 TGGCAGCACACAGGGTGTTCATGGAGCGAGTGCTCAGCCTCCTGGGTGCTGATGCTGTGG ******** **************************************** ** ******* ENST00000304546.1 AACAGAAGGCCCAAGAGATCCTGCAAGTGGAGCAGCAGCTGGCCAACATCACTGTGTCAG ENST00000373592.2 AGCAGAAGGCTAAGGAGACCCTCCCTG-ATTGCTAC-GCCCACCCAGATCACTGTGTCAG * ******** * **** *** * * ** * ** ** * ************* ENST00000304546.1 AGCATGACGACCTACGGCGAGATGTCAGCTCCATGTACAACAAGGTGACGCTGGGGCAGC ENST00000373592.2 AGTATGATGATTTCCAGCGAGATGTCAGCTCCATGTACAGAAAGATGACGCTGGGACAGC ** **** ** * * *********************** *** ********** **** ENST00000304546.1 TGCAGAAGATCACCCCCCACTTGCG-GTGGAAGTGGCTGCTAGACCAGATCTTCCAGGA- ENST00000373592.2 TGCAGAAGATCACCCCCCCCCCCCATGTGAGTATGGC--CCAGGCC---CCTCCCCTGCC ****************** * * *** **** * ** ** ** ** * ENST00000304546.1 ----GGACTTCTCAGA-GGAAGAGGAGGTGGTGCTGCTGGCGACAGACTACATGCAGCAG ENST00000373592.2 CCCTGGACTTGCTGGCTGGGTGCGGGGGTGGTGCCCTTGGTGGC---CCATATG-AATGT ****** * ** * ** ******** *** * * * * *** * ENST00000304546.1 GTGTC---GCAGCTCATCCGCTCCACAC--CCCACCGGGTCCTGCACAACTACCTGGTGT ENST00000373592.2 CTTTCTGGACACCCCACTGGCTTCATCTGGCCCCCAGGGTCCTGCATAACTACCTCGTGT * ** ** * ** *** ** *** * ********** ******** **** ENST00000304546.1 GGCGCGTGGTGGTGGTCCTGAGTGAACACCTGTCCCCGCCATTCCGTGAGGCACTGCACG ENST00000373592.2 GGGACGTGGTGGTGGTCCTGAGTGAGCACCTGTTCTTACCATTCCATGAGGTGCTGCACA ** ********************* ******* * ******* ***** ****** ENST00000304546.1 AGCTGGCACAGGAGATGGAGGGCAGCGACAAGCCACAGGAGCTGGCCCGGGTCTGCTTGG ENST00000373592.2 AGCTGGCACAGGAGATGGAGGGCAGCGGCAAGCTGCAGGAACTGGCCCGGGTCAGCCTGG *************************** ***** ***** ************ ** *** ENST00000304546.1 GCCAGGCCAATCGCCACTTTGGCATGGCGCTTGGCGCCCTCTTTGTACATGAGCACTTCT ENST00000373592.2 GCCAGGCCAACCACCACTATGGCATGGCGCTTCGTGCCCTCTTTGTACATGAACACTTGT ********** * ***** ************* * ***************** ***** * ENST00000304546.1 CAGCTGCCAGCA-AAGCCAAGGTGCAGCAGCTAGTGGAAGACATCAAGTACATCCTGGGC ENST00000373592.2 CAGCTACCAAGGTGGGCCGCCCTGGTTTAGCTGGTGGAAGACACCAAGTACATCCTGGGC ***** *** *** ** **** ********** **************** ENST00000304546.1 CAGCGCCTGGAGGAGCTGGACTGGATGGACGCCGAGACCAGGGCTGCTGCTCGGGCCA-- ENST00000373592.2 CAGCGCCTGGAGGAGCTGGACTGCATGGA------GACCAGAACAGCTACTGGGGCCGTG *********************** ***** ****** * *** ** ***** ENST00000304546.1 ------AGCTCCAGTACATGATGGTGATGGTCGGCTACCCGGACTTCCTGCTGAAACCCG ENST00000373592.2 GTGAGGGGCCCCCATACATGGTGGTGATGGTCGGCTACCCAGACTTCCTTTTCAAACTGG ** ** ****** ******************* ******** * **** * ENST00000304546.1 ATGCTGTGGACAAGGAGTATGAGTTTGAGGTCCATGAGAAGACCTACTTCAAGAACATCT ENST00000373592.2 GT-CTGTGGACAAGGAGTATGAGTTTAAGGTCCATGGGAAGACCTATTACAAGAACATCT * *********************** ********* ********* * *********** ENST00000304546.1 TGAACAGCATCCGCTTCAGCATCCAGCTCTCAGTTAAGAAGATTCGGCAGGAGGTGGACA ENST00000373592.2 TGAACAGCATCTGCTTCAGCATCCAGCTCTCAGTCAAGAAGACTGGGCAGGAGATGGACA *********** ********************** ******* * ******** ****** ENST00000304546.1 AGTCCACGTGGCTGCTCCCCCCACAGGCGCTCAATGCCTACTATCTACCCAACAAGAACC ENST00000373592.2 AGTCCATGTGGTTGTTCCCCCGACAGGTGCTCATTGCCTTCTATCTACGCAGCAAGAACC ****** **** ** ****** ***** ***** ***** ******** ** ******** ENST00000304546.1 AGATGG----------TGTTCC---------------------------------CCGC- ENST00000373592.2 AGATGGGTTTGGGGTGTGTTTCTATACCTATTGGGTCCATATATAGGTGGGTCTCCCACT ****** **** * ** * ENST00000304546.1 ------------------------------GGGCATCCTGCAGCCCACCCTGTACGACCC ENST00000373592.2 TGACCACACCCTCCCTATAGTGTAACCACAGAATGTCCTGCAGTCCAGGCTCTATGACC- * ******** *** ** ** **** ENST00000304546.1 TGACTTC-------------CCACAGTCTCT---CAAC-----TACGGGGGCATC----- ENST00000373592.2 TGACTTCAGTGATCAAGACATAACATACTCTGGCCAATGCATGCCCGGTGGCATCCTAGG ******* *** **** *** *** ****** ENST00000304546.1 -GGCA-----CCATCATTGG--ACATGAGCTGACCCACGGC--------------TACGA ENST00000373592.2 TGGCAAGCTTCTATCAAGAGGAACTTCAGCTGCTTCTTGGTGTTGGGGTCCAGTGTGTGG **** * **** * ** * ***** * ** * * ENST00000304546.1 C---------------GA----CTGG-----GGGGGCCAGTATGACC------------- ENST00000373592.2 CCTGGTAGCAAAGGGGGAAGCTCTGGTCGGAGGGAGTCAGTAGGTCCTGGGGCCGCCTTA * ** **** *** * ***** * ** ENST00000304546.1 GCTCAG----------------------------------------------------GG ENST00000373592.2 GCTCAGAGGGTACAATTACAAGTCCCACATAGTAAGTCCCACACACTGTAGACATCTTGG ****** ** ENST00000304546.1 AACC----------------------------------TGCTGCACTGGTGGACGGAGGC ENST00000373592.2 GACCCCCTTGGGATGGGGGCAAAGGCCAGTTATGCAGATGCTAACCCGGTGG--GGAGGC *** **** * ***** ****** ENST00000304546.1 CT---CCTACAGCC---------------------------------GCTTCCTGCGAAA ENST00000373592.2 CTGTTCCTAGAACCAGTGGGACCAGGGCATCATCAGATGCAACATCAGCACCCAGCAGAA ** **** * ** ** ** ** ** ENST00000304546.1 GG-------------------------CTGAG----TGCA----------TCGTCCGTCT ENST00000373592.2 GGGCACAGCTGGGATCCCCCTTGAGTCCTGAGAGGCTGCAGGGAGCATACTCCTCTTCCC ** ***** **** ** ** * ENST00000304546.1 CTATGACAA--CTTC-----------------ACTGTCTA------------CAACCAGC ENST00000373592.2 CGATCATGAGGCTTCCTGTGCCAATCACTGGAACTGTGTAGGGGCTCACGGGCACTCAAT * ** * * **** ***** ** ** ** ENST00000304546.1 GGG----------------TGAACGGGA---AACACACGCT------TGGGGA--GAACA ENST00000373592.2 GGGCAGGGGGCCTCGGATCTGGTGGGGACTGAACTTGTGGTGCCATCTGGGGTCTGAATT *** ** **** *** * * ***** *** ENST00000304546.1 TCGCAG-----------------------------------ATATGGGCGGCCT---CAA ENST00000373592.2 TTGCAGGGAGTGAGACGCCCCTGCTCACAAGGAGTTGCTCAATTTGAATGGCCTGCCCAG * **** ** ** ***** ** ENST00000304546.1 GCTG---GCCTACCACGCCTATC----------AGAAGTGGGTGCGGGAGCAC--GGCCC ENST00000373592.2 GCTGCAAGCACCTCAAGACTAACCTGGACCTTGGGGTTTGGTTAAAGGAACATCAGGCCC **** ** ** * *** * * *** * *** ** ***** ENST00000304546.1 A---GAGCACCCACT---TCCCCGGCTCA-----------AGTACACACATG-------- ENST00000373592.2 TCCTGAGTGCTTACTGTTTGCTGGGCTCATCACATGCCTCAGCACAGCCCTGGGCAGTGA *** * *** * * ****** ** *** * ** ENST00000304546.1 ---ACC----AGCTCTTCTTCATT------------------GCCTTTGCCC-------- ENST00000373592.2 GCGACCCAAGAGCTCATGTTTAATATTGAGCTGAATGCTGGTGCCTTCACCCTTCATGCA *** ***** * ** * * ***** *** ENST00000304546.1 ----------------------------------------AGAACTGG-TGCATCAAGC- ENST00000373592.2 GGCACCCACCCCATGTGGTTCCCGGGTGCCCCGGAGGAAGGGAATTGGGTGCCTCAGGCC *** *** *** *** ** ENST00000304546.1 ---GGCGGTCGCAGTCCATCTACCTG----CAGGT-----GCTGACTG------ACAAGC ENST00000373592.2 AGGGGTTGACACAGTACGCCCTCCAGATCACAAGCTTTCAGCAAATTGTGGAGTATTAGT ** * * **** * * ** * ** * ** * ** * ** ENST00000304546.1 ATGCC--CCTGAGCA-------------------CTA----------------------- ENST00000373592.2 GTGTCTGCCTAAGTAGATTGACAGATTATATGATCTAGTTTTCTTTTTTTTTTTTTTTTT ** * *** ** * *** ENST00000304546.1 --------CAGGGT-----------------GCTGG---GCAGTG-TG---TCCCAGTTT ENST00000373592.2 TTTTGAGACGGAGTCTCACTCTTTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTC * * ** ***** ****** ** ** * * * ENST00000304546.1 GAGG--AGTTTGGCC----GGGCT-------TTCCACTGTCCCAA--------------- ENST00000373592.2 ACTGCAAGCTCCGCCTCCCGGGTTCATGTCATTCTCCTGCCTCAGTCTCCCGAGTAGCTG * ** * *** *** * *** *** * ** ENST00000304546.1 GGACT-----CACCCATGAAC---CCTGCCCA---------------------------- ENST00000373592.2 GGACTACAGGCGCCCACCACCATACCTGGCTAATTTTTTTTTTTTTTTTGTATTTTTAGT ***** * **** * * **** * * ENST00000304546.1 -----CAAGTGTT---CCGTGT-------GGTGAGCCTGG-----------------CTG ENST00000373592.2 AGAGACGGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCATGATCTG * * *** ****** * ** * ** *** ENST00000304546.1 CCCGCCTGCACGCCCC--------------------------CACTGC------CCCCGC ENST00000373592.2 CCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCGCAGCCTTAT ** **** * *** ****** ** ENST00000304546.1 ACGA-------------------ATCACC----------------------------TCC ENST00000373592.2 ATGATCTAGTTTTAACCGACCTAATCCTCCAAAAGGGCCAAGAGGCTCACACAAGATTCC * ** *** * *** ENST00000304546.1 TG--------CTG--GCTA-----------CCGGGGCAGGCATGCACCC----------- ENST00000373592.2 TGTAAAGAATCTGCAACTAACAACAGAAATCCAGAGCAG--ATGAACCACAGCAGAAGGG ** *** *** ** * **** *** *** ENST00000304546.1 GGTGCC---AGCCCC-----GCTCTGGGCA---------CCACCTG---------CCTT- ENST00000373592.2 GGAGCTGAGAATTCCTTATTACTCCTGGCAGAGCGCACGTCACCCGGGGTACGGACCTGA ** ** * ** *** **** **** * *** ENST00000304546.1 CCAG------CCCCTC-------------------CAGGACCC---GG---TCCCCC--- ENST00000373592.2 CCAGACGTTACCCCTAATAATAAAAAATCAGCAAACAAAACTCTTTGAATTTCCCCCACT **** ***** ** ** * * ****** ENST00000304546.1 -----TGCTGCC-----------------CCTCACTTCAGGAGG---------------- ENST00000373592.2 CTGATTACTGCTGAAGTTTGCCCCGGGTGCCTTGTTCCTGGAGGTATTACTTAATTACTT * **** *** * * ***** ENST00000304546.1 ------GGCCTGGA-------------GCAGGGTG----AGGCTGGACTTT--------- ENST00000373592.2 ATGAGCAGTGTGAAATCCTCATGGTTGGCAAGGTGTCTAAAACTAAGCTTTTTGTTTTTT * ** * *** **** * ** **** ENST00000304546.1 --GGGG----------------------GGCTGTGAG------GGAAATAT--------A ENST00000373592.2 CTGAGACAGAACGTCGCTCTGTCGCCCAGGCT-TGAGTGCAGTGGCAAGATCTTAGCTCA * * **** **** ** ** ** * ENST00000304546.1 CTGGGGTCCCCA----------------GATTCTGCT-----------CTAAG-----GG ENST00000373592.2 CTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCCTCCTCAGCCTCCTAAGTAGCTGG *** * ** ****** * ***** ** ENST00000304546.1 GGC--CAGAC---CCTC----TGCCAGGCTGGATT-GTAC---------------GGGCC ENST00000373592.2 GACTACAGGCATGCATCACCATGCCTGGCTAATTTTGTATTTTTTAGTAGAGACAAGGTT * * *** * * ** **** **** ** *** ** ENST00000304546.1 CCACC---TTCGCTG---TGTTCTTG--CTGCAAAGTC----TGGTCAATAAATCACTGC ENST00000373592.2 TCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCTGCCTCTGC **** ** ** ** ***** ** * * ** ** * * **** ENST00000304546.1 -------ACTGTT------------------ ENST00000373592.2 CTTCCAAAGTGCTGGGATTACAGGCGTGAGC * ** *