CLUSTAL 2.1 multiple sequence alignment ENST00000305786.2 GTAGCCGCCAGCTCGGCCGCACGTCAGGGCGCGGGAGCGCGGAGCGAGTTTGGTTGCACT ENST00000451978.1 ------------------------------------------------------------ ENST00000305786.2 TACACCGGTACTTAAGCGCGGACCGGCGTGTCCTTGGACTTAGAGAGTGGGGACGTCCGG ENST00000451978.1 ------------------------------------------------------------ ENST00000305786.2 CTTCGGAGCGGGAGTGTTCGTTGTGCCAGCGACTAAAAAGAGAATTAAATATGGGTGATG ENST00000451978.1 ----------------------------------AAAAAAAAAAAAAAACA--------- ***** * ** *** * ENST00000305786.2 TTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACCGTTGAAAAGG ENST00000451978.1 ----AACAAACAAAAA----------ACG--GTGCACCCCTTGCCACACCATGGAAAATG * * *** ** * * *** *** ********* * ***** * ENST00000305786.2 GAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAGACAGGTCAGG ENST00000451978.1 GAGGCAAGCACATAACTGGGCCAAATCCCCATGGTCTCTTTGGGCAGAAGACAAGTCAGG ************ ************* ***************** ******* ****** ENST00000305786.2 CCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGGGGAGAGGATA ENST00000451978.1 CAGCTGGATCCTCTCACACAGAGGCCAGTAAGAACAAAGGCATCACCTGGGGAGAGGAGA * ****** **** ****** **** ***************** ************ * ENST00000305786.2 CACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAAATGATCTTTG ENST00000451978.1 CACCGATGGGGTCTTAGGAGAATCCCAAGAAGTACATCCCTGGAACAGAAATCATCTTTG *** ***** ** ** ******************************* **** ******* ENST00000305786.2 TCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAAAAAGCTACTA ENST00000451978.1 CTGACATTGAGAGGTC---AGAAAGGGCAGACTTGATAGCTTATCTCAAAAAAGCTGCTA * **** *** * *************** ********************* *** ENST00000305786.2 ATGAGTAATAATTGGCCACTGCCTTATTTATTACAAAACAGAAATGTCTCATGACTTTTT ENST00000451978.1 ATGGATAATAATTGGCCACTGCCTTGTTTATTACAAAACAGAAATGTCTCATGACTTTTC *** ******************** ********************************* ENST00000305786.2 TA-TGTGT-ACCATCCTTTAATAGATCTCATACACCAGAATTCAGATCATGAATGACTGA ENST00000451978.1 AAATGTGTTACCATAATTT----GATCTCATACACCAGAATTCAGATCATGAATGAC--- * ***** ***** *** ********************************** ENST00000305786.2 CAGAATATTTTG-TTGGGCAGTCCTGATTTAAAACTAAGACTGGCTTGTGGTTAAATGAA ENST00000451978.1 -AGGATATTTTGGTTGAACAGTCCTGATTTAAA--TAAGACTGGCTTATAGCTAAATGAA ** ******** *** *************** ************ * * ******** ENST00000305786.2 TATGTTCAG--TTTTTGAATTTTAATAGTAACTCCAATTCAGTAAATGGTATCACTGTTT ENST00000451978.1 TATGATCAGCTTTTTTGAATTTTGATAGTAA------TTCA--AAGTACTATTACCATTT **** **** ************ ******* **** ** * *** ** *** ENST00000305786.2 ACCCCTTTTAAAGATATGATTAGACTTCGTTAGTAATGTTCAACTTTTCACAAAGATGGT ENST00000451978.1 TCCCCTTCTAAAGATATGATTGGACTTCACTAGTAATGTCCAACTTCTCACAGAGATGGC ****** ************* ****** ********* ****** ***** ****** ENST00000305786.2 GAGTGCCATCTTAAAACTTACTGGAGATTGGTTTTATATTTAGATTTATATAACTGGTTA ENST00000451978.1 AAATGTTGTCTCAAAACATATTGGAGGTCAGTTTTATATTTACATTTATACAACTGGTTA * ** *** ***** ** ***** * ************ ******* ********* ENST00000305786.2 TGTGAATATATTTAAATACTGGGGAAATTGCTTCACTGTCTTAGAACCAAGCAAGATTCA ENST00000451978.1 TATGACTATATTTAAATACTGGGGAAATATCTTCACTGTCTCAGAACCAAGTAACACTCA * *** ********************** *********** ********* ** * *** ENST00000305786.2 CCTGTGTTTTGTGTTCATGTTCATTTGCCTCTTAAAGGCAAGGGTTGAAGATAAATAAGG ENST00000451978.1 CCTGTGGTTTA-ATTTGTGTTCATTGGCGTATTAAGGGCAAGGGTTGAAGAT----AAGA ****** *** ** ******** ** * **** **************** *** ENST00000305786.2 TAGCAATGTCTA-----TAGTTTTGGCCTTAACTATGCCAATCTAATTATAATTCCCTGT ENST00000451978.1 TAGCAATGTCTACTTTATATTTTTGGTCCTGACTATGCTAATCTAATCAGAATTCCCTGT ************ ** ****** * * ******* ******** * ********** ENST00000305786.2 ATTTAAAATGGTTTCTTTTACTTATTGAAAGGCATTTTAGTGTGGTTTATGTGTAATATT ENST00000451978.1 ATCTAAAATGC------------------AGGCTTTTT---------------------- ** ******* **** **** ENST00000305786.2 AAAGATTATTCAACACCTCTCACATCTTACAGATCTATAAGGTCACATGCTTTTAAAATA ENST00000451978.1 ----------------------------------------GGCCAGGTGC---------A ** ** *** * ENST00000305786.2 GTAGCAAGTTAAACTTCACTCTTGAATTCTTTACAATCTAAGTCAAACTAAGTTATAATT ENST00000451978.1 GTGGC----------TCACACCTG---------TAATCC--------------------- ** ** **** * ** **** ENST00000305786.2 TAGGATTGTCTTTAAACAGCCATTCAGAAACAAAACTGTAGAACTGTGTATTTGATTGGG ENST00000451978.1 ------------------------------CAACACT------------------TCGGG *** *** * *** ENST00000305786.2 AATGGTGCTTTTGCCAACTTAAAAGGATTAAAGTAACGGAGATATACACAAATTTTAAAA ENST00000451978.1 AG----------GCCAA-------GG----------------------CAGGT----AGA * ***** ** ** * * * ENST00000305786.2 TTATGTGTGATCACAAGACTAAAGATAATTAAAAAGAAAACCACAGATCATGACTTTTTG ENST00000451978.1 TCACTTGAGATCAGGAGATCGAGG----------------CCA----------------- * * ** ***** *** * * *** ENST00000305786.2 ACTGTGCTTGATTTCATGACTGATGCACAAATTTTAATGATTAAAAAGTGCAGGAGCCCT ENST00000451978.1 -------------TCCTGGCTAACAC------------GGTGAAACCATGT-----CTCT ** ** ** * * * * *** ** * ** ENST00000305786.2 AAATGTCAGTGCAGCAGCCCTAAATGTCAGTGCAGCAGTGTTAACCAGTCATGGTGCTAG ENST00000451978.1 A------------------CTAAA----AATACAAAAAC-TTAGCCAGGTGTGGTGGCA- * ***** * * ** * *** **** ***** * ENST00000305786.2 ATTGTTTACTTGGTTTTCTAGGACTGCCTCAACTAGAATAACACTTCACTAATTGACTCT ENST00000451978.1 ----TGCACCT-----------ATAGTCCCAGCTA------------------------- * ** * * * * ** *** ENST00000305786.2 TAGTTTCTTTGCTCAGATTGAGAACTGCAGCATTTATGCCAGACATGGACAGAGGAATGC ENST00000451978.1 -----------CTCGG---GAGG-CTG-------------------GGGCAGGAGAATCT *** * *** *** ** *** **** ENST00000305786.2 CTGTGGTCATAGTTTTGTGATGTGTAACAGTGTATAATTACATACTGAATTATTTCATGC ENST00000451978.1 CT-------------------------------------------TGAAC---------- ** **** ENST00000305786.2 ATAGTCTGTGCCATACACATTTAGAGTAGTCCTTGGAGATTTTATGGAGATGGTGAGCAC ENST00000451978.1 ----------CCG--------------------------------GGAGGCGG--AGCTT ** **** ** *** ENST00000305786.2 AAGGTAAGTCATAAAGAATAATGAGAAAATAAATCTATGCTGGTGCAGCTGAGAACTGTA ENST00000451978.1 GCAGTGAGCCA-------------------AGATC-GTGCCATTGCACTCCAG------- ** ** ** * *** *** **** ** ENST00000305786.2 TCTTTGTGGGACAGTGAGAAGACTGAGAAGATGTGAATCCATGGTCTCAAAGGTGATAGG ENST00000451978.1 --CCTGGGTGACAGAGAGG---------------GACTCCAT---CTCAAAAAAAAAAAA ** * ***** *** ** ***** ****** * * ENST00000305786.2 GACGATTAGATAGGTGTTTTAAGGCCTGAAAGCAATTTATAACATATGAGTCTTATTTTT ENST00000451978.1 AA------------------AA------AAAGCAGGCT------------------TTTT * ** ****** * **** ENST00000305786.2 ATTTATAGAAATGTGGAAAGCTTGCTGTAATTCATATTTGAAGTCCTAGTCTGAGTTCTG ENST00000451978.1 ACTTAC-------TGAAAGGC--------------ATTT-------TAGTGTGGTTTCTG * *** ** ** ** **** **** ** ***** ENST00000305786.2 GTGGGGAATTTAAAAATGCATCCTGGAAATCCTTTAAAGATTTCAGACTTTGAAAGGCCT ENST00000451978.1 -TGTAATACCAAAAAATATTT------AATACTTT-------TCACATTTTATA------ ** * ****** * *** **** *** * *** * ENST00000305786.2 TGTAGCAGAGGACTTGGTGACTGTATAAAGTTAGTGGTATTCAGGGACAGTGTAGCAAGT ENST00000451978.1 ---------------GATGATC-TATAAGGTCAG---------------GTGC------- * *** ***** ** ** *** ENST00000305786.2 AGCTTACAAGGGGACAATTCTGGACTAATGAGAAAGACCTGAAGTGAAGGCTAGAGAGTT ENST00000451978.1 ------------------------------------------------------------ ENST00000305786.2 GATTTTTTTTTTTTTTGGCATCCTGGAAATGATACAGGAAACATATTAAGATAGATACAG ENST00000451978.1 --TTTTTTTTT---------------AGATGGT------------------------CAA ********* * *** * ** ENST00000305786.2 AAATGTGTTCAACCTTCCATCTTGGCTAGTTGTGGCGTTTAGTTTGTTTTTTGAGACATG ENST00000451978.1 AA-----------------TCTCGCCT--------------------------------- ** *** * ** ENST00000305786.2 GTCACGCTGTGTCGCCAAGGCTGGAGTGCAGTGGTGCGATCTCGGCTGGCTGCAACCTCT ENST00000451978.1 ----------GTCACCCAGACTGGAGTGCAGTGGCGCACTCTC----------------- *** ** ** ************** ** **** ENST00000305786.2 ATTTCCCAGGCTCAAGCGATTCTCTCACTTCAGCTTCCCAAGTAGCTGGGACTACAGGTG ENST00000451978.1 ACTCCC--------ACCGATCTCCCTACT-CAATCTCCCCAGC-GCCTGGCCTGGAGAGA * * ** * **** * *** ** **** ** ** ** ** ** ENST00000305786.2 TTCGCCACCATGCCCAGCTAATTTTTTTGTAGAGATGGAGTTTTGCCATGTGGTCCCAGG ENST00000451978.1 GCAA--ATTATAATTAG--GATTGTCTTG---AAACAG-------CTAT----TCAAAAA * ** ** *** * *** * * * * ** ** * ENST00000305786.2 CTGGTCTCAAACTCCTGAGCTCAAGCAATCCGTCCACTTGCCTTGGCTCCCCAAAGTGCT ENST00000451978.1 C--ACATAAAACTACAGAACT-----ATTGTGTATGTGTGCTTTGGCAACTCAT--TAGA * * ***** * ** ** * * ** *** ***** * ** * ENST00000305786.2 GGGATTACAGGCGTGAGCCACCAGGCCCTGCCTGGTTTTCAAATTCAGAAATCTTATTAT ENST00000451978.1 AGGATTA-AAGTAGAAG-----AGAC--------ATACACGAGTTTATAAAT-----TAT ****** * * ** ** * * * * ** * **** *** ENST00000305786.2 TTAACCCAGAAGTAATCAGCCCAGTAGTAACTTAGGTTTAATTTTTTTTCAGGTTTAAAA ENST00000451978.1 CT---------GTGATCA------------------------------TAAGATTTAAGA * ** **** * ** ***** * ENST00000305786.2 TTTTTCTCATTTATTTTTTCTGAGACGGAGTTTCGCCCTTTTCGCCCAGGCTGAGTACAG ENST00000451978.1 T-------AATCA---------AAATAAAAT---------------CAGGCGGGGCATGG * * * * * * * * ***** * * * * ENST00000305786.2 TGGTGCAATCTCACTGCAACCTCCGCCTTCCAGTTGCAAGTGATTCTCCTGCCTCAGCCT ENST00000451978.1 TGG------CTCAC----ACCT-----------------GTAAT--------CTCAGCAT *** ***** **** ** ** ****** * ENST00000305786.2 CCTGAGTAGCTGGGATTACAGGCACCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAG ENST00000451978.1 TCTGGGAGGCCA-------AGGCA------------------------------------ *** * ** ***** ENST00000305786.2 TGGAGATGGTGTTTCACCATGTTGGCCAGACTGGTCTTGGACTCCTGACCTCGTGATCCA ENST00000451978.1 --GAGG----------------------GATCG--CTTGAGC------------------ *** ** * **** * ENST00000305786.2 CCCACCTTGGCCTCCCAAAGTTCTAGGATTACAGGTGTGAGCCACCACGTCCGGCCAATT ENST00000451978.1 --------------CCAGGATTTCAAGATCA---GCATCGGCAACATAGT--GG------ *** ** * *** * * * ** ** ** ** ENST00000305786.2 TTTCTCATTTCTATGCCTCCTATATTAAGGTCTGTGTTGGCACAGATGAGTAACTGCCAT ENST00000451978.1 TACCTCAT-----------CTATATAAA-------------------AAATAA------- * ***** ****** ** * *** ENST00000305786.2 GTTCTAGGTCAGTTATACCCAAGCACTTCTGGTGGTTTAAAATGTGATTCTGTAACTTTT ENST00000451978.1 -----AAG------ATAGCCAGGCA----TGGTGGT-----GCGTGCCT----------- * * *** *** *** ******* *** * ENST00000305786.2 TTATTTTTATTTTTTTGAGATAATTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGT ENST00000451978.1 -------------------ATAGTCCCA-----GCTACTTGGA--AGGCTGCGGTAGGAG *** * ** * * * * * *** * * ENST00000305786.2 GATCGCTGCTCACCGCAACCTCCGCCTTCCAGGTTCAAGCGATTCTCCTGACTCAGCCTC ENST00000451978.1 GATCACT--TGAGCCCAG------------GAGTTCAAG--------------------- **** ** * * * ** ******* ENST00000305786.2 TCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCCAGCTTATTTTGTGTTTTTAGTA ENST00000451978.1 ----GTTGCAGTGAGT-CAAGGTTGTGCCACTGCAC------------------------ ** ** * ** * **** ** ***** * ENST00000305786.2 GAGACAGGGTTTCTCCATGCTGGACAGGCTGGTCTTGAACTCCCGACGTCAGGTGATCTA ENST00000451978.1 -------------TCCAGCCTGGGCAA----------------CAGTG-CAG-------- **** **** ** * * *** ENST00000305786.2 CCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCTGGCCAATT ENST00000451978.1 --TGTCTCAA-----AAAAAAAAAAGAAAGAAAGAAAAAAG---------------AA-- ** *** *** * * * ** ** ** ENST00000305786.2 ATGTAATTTTTTAAAAAGGACATTTCTATCAGGGATATATACCTTCAG-AAATAAGGAAA ENST00000451978.1 AAATAA------AAAAACGA----------AAAAACCC-TGTCTCCAACAAAAAAAGAAA * *** ***** ** * * * ** ** *** ** **** ENST00000305786.2 TAGGGGAAAAAAAGAGCACTATAAACCACATGTTTTCATTTCTAGTGCTTCGCTGTAAGT ENST00000451978.1 AAAAAGAAAAAAAAAAC-CCACAA-TCACAGATTACGA---------------------- * ******** * * * * ** **** ** * ENST00000305786.2 GGCTAGGTTGGTAGAATCAAAAACAAGGGCCAGATGTATTTAAGGGGTATTCAGATGCCA ENST00000451978.1 ------------------AAAAATAAG-------TGTAT---------------ATGCCA ***** *** ***** ****** ENST00000305786.2 CCTACATGCTTATTTTGTCTAGAACAGTGCTGTCTAATAGAACTTTCTGTGACGATGGAT ENST00000451978.1 GG-ACATG--------------AACAGTG-------ATTACATTTTCT-------TATGT ***** ******* ** * ***** * * ENST00000305786.2 ATTTTGTAGACTTTTGCTGTCCAGTGTGGTAGCCACTAACCACATGTGGCTGTTAAGCCC ENST00000451978.1 ATTTTCCATATTTTTTTT--------TG------------CATAAGTTACTTTAGGAATC ***** * * **** * ** ** * ** ** * * ENST00000305786.2 TTGAAATATAGCTAGTGTGACTAGAAAGTATTTTA-TTTTAAATTTACATAGGCACAAGT ENST00000451978.1 AGAAAAAATAGTTAACATAAT---AAAATATTTAAGTTTCAAAAT--CAGAGATA-ATTC *** **** ** * * *** ***** * *** *** * ** ** * * ENST00000305786.2 GGCTAGTGGCTACTGTA-TTGACATTCTGGGTCTAGGACTAGAACCAGTGGTCTGTAACA ENST00000451978.1 AGTTGATGG--GCTGAAGTTAGCCTCTTGGG-----GGCCAG------------------ * * *** *** * ** * * **** * * ** ENST00000305786.2 AAAGTACTTTCTCTTTACTCTATTAAATCTAGAATTAGCCGGGCATGGTCGCTCATGCCT ENST00000451978.1 ----------CTCTT-AC------AAATTCCAAGCTGGCCAGGAGCGGTGGCTCATGCTT ***** ** **** * * *** ** *** ******** * ENST00000305786.2 GTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTCAGGCGTTTGAGA ENST00000451978.1 GTAATCCTGGCACTTTGGGAGGCCAAGACGGGCAAATCACTTGAGGTCAGGAGTTAAAGA ******* ****************** * **** **************** *** *** ENST00000305786.2 CCAGCCTGGTCAACATGGCGAAACCCTGTCTCTACAAAAAACATAAAAATTAGCCAGGTG ENST00000451978.1 CCAGCCTGGCCAACATAGTGAAAACGTGTCTCTACCAAAAATACAAAAATTGGTCAGACG ********* ****** * **** * ********* ***** * ******* * *** * ENST00000305786.2 TGGTGGTGGGCACCTGTAATCTCAGCTACTTGGGAGGCTGAGGCACAAGAATCACTTGAA ENST00000451978.1 CAGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCA--------------- **** * *** ***** **** ********* ***** ENST00000305786.2 CTTGGGAGGTGGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCAAGCCTGGGTGAC ENST00000451978.1 -------GGTGGA--------------------------------TC------------- ****** ** ENST00000305786.2 GAGTGAAACTGTCTCCAAAAAAAAAAAAAAA ENST00000451978.1 -------------------------------