CLUSTAL 2.1 multiple sequence alignment ENST00000309035.6 AAACCCCCAGTTGGTTGTCCCTGCCGTCTCGGAAGGGTTAGCACACAGCCAGGTCTGTTT ENST00000422584.1 -------------ATGGCCCTTGT----------GGATAAGCACAAAGTCAAGA------ * * ** ** ** * ****** ** ** * ENST00000309035.6 TTGATGTATGTAATTGAA---GATTTATAAAGAAAAGCTTCTCCTCTGCCTCATCCGCAG ENST00000422584.1 --GACA---GCAATTGGACAGAATTTGTGAAGGTA---TCCGCCCCCAGATCATGAACGG ** * ***** * **** * *** * * * ** * **** * * ENST00000309035.6 TCATTTTTTTTCCAATGCCAGTTCCCAGCAGGCATATAAATATTGGTCGTTCTCAGAGCT ENST00000422584.1 CCCCCTGCACTCC--TGCC----CCCTGGTGGCGC-----TGCTGGACG--------GCC * * *** **** *** * *** * *** ** ** ENST00000309035.6 GGGATGCTGCTGGGTGGTACGAGGGCC--CCTGGGAGAACGCCGAGTCCCTGCGGCCTCT ENST00000422584.1 GCGA--CTGCACTGTGG--AGATGCCCATCCTGAAAGA---CCTGGCCACTGTGGCCTTC * ** **** **** ** * ** **** *** ** * * *** ***** ENST00000309035.6 GGGGAGGAGAAGCTCCCTGACGTATGGCACAGCAGAGGGGACTTGGTTTGAGCCAAACCA ENST00000422584.1 TGTGACGCGCAGTCC----ACGCAGG--AAATCCACGAGAA---GGTTCTAACGAAGCCA * ** * * ** * *** * * * * * * * * **** * * ** *** ENST00000309035.6 CCGACCACAGGACGCTGCCCTGCCCGTGGCCGCCGAGCCCTACCTGTACCGGGAGGCCGT ENST00000422584.1 TGGGTACCATGA---TGTACCAC-----ACCATC-ATCCTCAC-----CAGGGAGGACCT * ** ** ** * * ** * * ** ** * ****** * * ENST00000309035.6 TTATAACTCAGTGGCTGCAAGAAAGGGGTCTACTCCTGACTTCACCTTCTACGACAGCAG ENST00000422584.1 AGAAAAGTTTAAGGCCCCGAGAG-------------TGA--TCGT-----------GCAG * ** * *** * *** *** ** **** ENST00000309035.6 ACAGGCAGTGATGTCTGGTCGCAGCCCCCTGCTGCCA-CGGGAGTACTACAGTGATCCGT ENST00000422584.1 ATAGGCAGTGGC-TACGATAAC--------GTGGACATCAAGGCTGC--CAGCGA---GC * ******** * * * * * * ** * * * * *** ** * ENST00000309035.6 CTGGAGCTGCTAGGGTACCCAAAGAGCCTCCCCTCTATCGGGACCCAGGAGTCAGCCGGC ENST00000422584.1 TCGGAATTGCT-GTGTGC------AATATCCCGTCTGCAGCCGTGGAAGAGACA-CCGGA *** **** * ** * * **** *** * * *** ** **** ENST00000309035.6 CGGTCC-CCAGCTACGGAGTGCTTGGCAGCAGAACGTCATGGGATCCAATGCAAGGCCGG ENST00000422584.1 C--TCTACCATCTGCCACATCCTCAAT--CTGTAC--CAGAGGA----ACACATGGCTG- * ** *** ** * * ** * * ** ** *** * ** *** * ENST00000309035.6 TCACCT-GCCCTGCAGGACGCCGGTCACCTGTACCGGGATCCTGGAGGTAAAATGATCCC ENST00000422584.1 -TACCAAGCACTGCGGTA----AGGCACACGGGTTCAGAGCATGGAG-CAGAA-----CC *** ** **** * * * *** * ** * ***** * ** ** ENST00000309035.6 TCAGGGGCGGCAGACACAGAGCAGGGCTGCATCTCCCGGGCGGTATGGACGGGAGCAGCC ENST00000422584.1 GC-GAGTTGGC---CTCGGGATCGGCCAGCATC-CGTGGG-GAAATG--CTGGGCCTCAT * * * *** * * * ** * ***** * *** * *** * ** * ENST00000309035.6 CGACACCAGGTATGGGGCGGAGGTGCCTGCCTACCCCCTCAGCCAGGTCTTCAGCGACAT ENST00000422584.1 CGGCTTTGATCGCAGGGGGTAGGCGGTTGC--AGTTC--GAGCCAAGGCCTTTG-GAT-T ** * *** * *** * *** * * ***** * * * * ** * ENST00000309035.6 CAGCGAAAGACCCATTGACCCTGCCCCTGCCAGACAGGTGGCCCCGACGTGCCTGGTTGT ENST00000422584.1 CAGCGTCATATTTTATGACCCC-TACTTGCAGGATGGG--ATCGAGCGATCCCTGGGCGT ***** * * ****** * *** ** ** * * * ***** ** ENST00000309035.6 GGACCCCAGTTCAGCTGCTGC-CCCCGAAGG-----CAGCACAGGGGTGGCCCCAGGGGC ENST00000422584.1 G-----CAG---AGGGTCTACACTCTGTAGGATTTGCTGTATCAGAGCGACTGC-GTCTC * *** ** ** * * * * *** * * * * * * * * * * ENST00000309035.6 CCTGAATCGTGGCT---ACGGGCCTGCCCGGGAAAGCATCCCATCCAAGATGGCTT---- ENST00000422584.1 CTTGCACTGCAATCTCAACGAACATAACC-----ACCACCTCATC---AATGACTTTACC * ** * * *** * * ** * ** * **** *** *** ENST00000309035.6 ACGAGACTTACGAAGCTGA--------CCTGTC----CACCTTCCAGGGTCCTGGTGG-C ENST00000422584.1 ATAAAGCAGATGAGGCAGGGAGCATTCCTTGTGAACGCACCCCGTGGTGGCCTGGTGGAC * * * * ** ** * * *** **** * * ******** * ENST00000309035.6 AAGAGGACCGTGCTCCCTGAGTTCCTGGCCTTTCTGCGGGCGGAGGGGCTGGCAGAGGCC ENST00000422584.1 GAGAAAGCCTTAGCAC--AAGCTCTCAA--------------GGAGGGC------AGGAT *** ** * * ** ** * **** *** ENST00000309035.6 ACGCTGGG-AGCCCTACTGCA-GCAGGGCTTTGA-CTCCCCGGCCGTCCT--GGCTACCC ENST00000422584.1 ACGAGGGGCAGCCCT-CTATGTGCGTGAGTCGGAGCCCTTTAGCTTTGCTCAGGGTCCGT *** *** ****** ** ** * * ** * * ** * ** ** * * ENST00000309035.6 TGGAGGACGCGGATATCAAGTCT-GTC-GCACCCAACCTGGGCCAGGCCCGTGTTCTGAG ENST00000422584.1 TGAAAGATGC----ACCGAATCTTATCTGCACTC--CTCACACT--GCCTG-GTAC--AG ** * ** ** * * * *** ** **** * * * *** * ** * ** ENST00000309035.6 CCGCCTGGCCAATAGCTGCAGGACCGAAATGCAGCTGCGGAGGCAGGACCGGGGGGGCCC ENST00000422584.1 CAAGCAGGC--GTCACTGGAGATGAGGGAGGCAGCTGCCACTG-AGATCCGCCGAG--CC * * *** * *** ** * * ******** * ** *** * * ** ENST00000309035.6 GCTGCCCCGGGCGCGGTCCAGCA-GCTTCAGCCACCG---AAGCGAACTGCTCCATGGTG ENST00000422584.1 ATCACA--GGTCACATCCCAGAAAGCTTAAGAAACTGTGTGAACAAGGAATTCTCTGTCA * ** * * **** * **** ** ** * * * * ** ** ENST00000309035.6 ACTTGGCTTCTCTGGGCGCTGCGGCTCCTCTGCAGACAGCATCCCCCCGAGCTGGA-GAC ENST00000422584.1 CATCAGCGCCT-TGGTCA--GTAATAGACCAGCAAGCAAT-TCATCCTGAGCTCAATGGT * ** ** *** * * * *** ** ** ** ***** * * ENST00000309035.6 CCGGCTCGCCGTC--CCTCCAGCGCACCATCTCAGCACCTCCTGGAGA-----CGGCAGC ENST00000422584.1 GCCACATACAGATATCCGCCAG-GCATCGTGGGCGTGGCTCCAGGAGGACTTCCTGCAGC * * * * ** **** *** * * * **** **** * ***** ENST00000309035.6 CACCTATT---CTGCCCCTGGCGTGGGCACCC--ATGCCCCACACTTCCCCTCCAACTCC ENST00000422584.1 CGTGGAAGGGATCATCCCTGG---AGGCATCCCAGTGACTCACAACCTCCCAACAGT--- * * ****** **** ** ** * **** *** ** ENST00000309035.6 GGGTACAGCTCTCCCACCCCTTGCGCCCTGACAGCGCGTCTGAGCCCCACGTACCCCCTG ENST00000422584.1 -GGCACATCCTTCCCAG-----GCGCCCT----------CT----CCCAACCAGCCCACA ** *** * ***** ******* ** **** * *** ENST00000309035.6 CAGGCAGGGGTGGCCTTGACTAACCCGGGCCCCTCAAACCCCCTTCACCCAGG--CCCCA ENST00000422584.1 -AAACACGGG-------GAC-AATCGAGAGCACTCCAACGAGCAATAGCAGAGAATGCCG * ** *** *** ** * * * *** *** * * * * ** ENST00000309035.6 GAACAGCCTACTCCACGGCATACACGGTGCCCATGGAGCTGCTAAAGAGGGAGCGCAACG ENST00000422584.1 GAAGGTAATCATTCA-GATACATTTGG-GACCAAGAGATAGTGAAAAATGATGAACTAAG *** * * ** * * * ** * *** * * *** * * * * * * ENST00000309035.6 TGGCCGCCTCTCCGCTGCCCAGCCCTCACGGCAGCCCCCAGGTCT-TGCGGAAGCCAGG- ENST00000422584.1 AGAAAAAGAATATGATG----GTCTTTGTAACTGATTCTGGACTTATGCATCATTGATGC * * * ** * * * * * * * * *** * * * ENST00000309035.6 TGCACCCCTGGGGCCATCCACCCTGCCGCCGGCCAGCCAGAGCCTCCACACGCCT----- ENST00000422584.1 TGCAGTGTTAAAACTA------CAAGAGCTAGAAAACTGAAGATGTCGTCTGCTTACGGA **** * * * * ** * * * ** * ** * ENST00000309035.6 --CACTCACCGTACCAGAAGGTGGCCCGGCGCACAGGGGCACCCATCATCGTGTCCACCA ENST00000422584.1 AGCGCTGAAAG-ACTAGGATGTGATTTATTAACGACCAACTTCTGTTATTGTGT--GTTA * ** * * ** ** * *** * * * * ** **** * ENST00000309035.6 TGCTTGCACCAGAACCAAGTATCCGCCCCCAGATCATGAACGGCCCCCTGCACCCCCGCC ENST00000422584.1 AGTTTTTC----ATCTGTGCATCAAATCACAAAGAATAAATAG--------AGCTTTTTC * ** * * * *** * ** * ** ** * * * * ENST00000309035.6 CCCTGGTGGCGCTGCTGGACGGCCGCGACTGCACTGTGGAGATGCCCATCCTGAAGGACC ENST00000422584.1 CTTTATCAGT-CCCTTGG------------GCACAGCAGG--------TCCTGAACACCC * * * * *** **** * * ******* ** ENST00000309035.6 TGGCCACTGTGGCCTTCTGTGACGCGCAGTCGACGCAGGAAATCCACGAGAAGGTTCTAA ENST00000422584.1 TG--CTCTACAATGTTGCATCAAG---AGTTCAAACAACAAAAT----AAAAAATATTAA ** * ** ** * * * *** * ** *** * ** * *** ENST00000309035.6 ACGAAGCCGTGGGCGCCATGATGTACCACACCATCACCCTCACCAGGGAGGACCTGGAGA ENST00000422584.1 --GAGGATAT---CCCCATCCTGTG--ACTTGAGT-CCCTTA--------AGTCTACAGG ** * * * **** *** ** * **** * ** ** ENST00000309035.6 AGTTCAAGGCCCTGAGAGTGATCGTGCGGATAGGCAG-TGGC--TATGACAACGTGGACA ENST00000422584.1 GGCTGGTGACCTCC-------TTTTGCTAATAGGAAAATTACATTACTACAAAATGGGGA * * * ** * *** ***** * * * ** **** *** * ENST00000309035.6 TCAAGGCTGCCGGCGAGCTCGGAATTGCCGTGTGCAACATCCCGTCTGCAGCCG-TGGAA ENST00000422584.1 G-AAAACTGTTTGC-------------CTGTGGTAGACA-CTTGCTCGCATAGGATTGAA ** *** ** * *** *** * * *** * * *** ENST00000309035.6 GAGACAGCGGACTC---TAC-------CATCTGCCACATCCTCAACC-TGTACCGGAGGA ENST00000422584.1 GACAGTACAGGCTCCTGTACAGAGAAGCATCTCTCACATC-TGAACTGCATACTGAGTGG ** * * * *** *** ***** ****** * *** *** * * ENST00000309035.6 ACACGT-GGCTGTACCAGGCACTGCGGGAAGGCACGCGGGTTCAGAGCGTGGAGCAGATC ENST00000422584.1 GCAAGTTGGTTGTA--AG---TTCAGTAAAAACCCTCTGATGCAAAA---AAAAAGTATT ** ** ** **** ** * * ** * * * * * ** * * ** ENST00000309035.6 CGCGAGGTGGCCTCGGGAGCGGCCCGCATCCGTGGGGAGACGCTGGGCCTCATTGGCTTT ENST00000422584.1 AAC-------TTTCACAAGCTGTTTGTACTCAAATACATTTTCTCAGTTTCAGATCCTCT * ** *** * * * * * ** * *** ** * ENST00000309035.6 G--GTCGCACGGGGCAGGCGGTTG--------CAGTTCGAGCCAAGGCCT-TTGGATTCA ENST00000422584.1 GCTGTTTTATTGAGTGGAAAGTTGAGCTAAAACGGTTCAAGAAGAATAATGTTGCATTT- * ** * * * * **** * **** ** * * *** *** ENST00000309035.6 GCGTCATATTTTATGA--CCCCT---------ACTTGCAGGATGGGAT-CGAGCGGTCCC ENST00000422584.1 -CCTTATGTCTCAGGAAACACTTTTTATGGTAACTTGTCAGATTGTCTATGAACAAACCC * * ** * * * ** * * * ***** *** * * ** * *** ENST00000309035.6 -------TGGGCGTGCAGAGGGTCTACA---CCCTGCAGGATTTGCTGTATCAGAGCGAC ENST00000422584.1 ACTTTTTTAGACATTGATAAAGTCTTCTTTTCTTCACGTGATATTTTATACAAGAGC-AC * * * * * * **** * * * *** * * ** ***** ** ENST00000309035.6 TGCGTCTCCTTGCACTGCAATCTCAACGAACATAACCACCACCTCATCAATGACTT-TAC ENST00000422584.1 TTCA----GATGTATTA-GATGTGACTGATTTTAACAA--ATCCTATTA--GATTTGTAT * * ** * * ** * * ** **** * * * ** * ** ** ** ENST00000309035.6 CATAAAGC-AGATGAGGCAGGGAGCATTCCTTGTGAA-CGCAGCCCGTGGCGGCCTGGTG ENST00000422584.1 CAACTAGTTACATGTTCTATTCACAGTCTTTTGTGAATCATTGCCTTT------TTGTTT ** ** * *** * * * ******* * *** * ** * ENST00000309035.6 GACGAGAAAGCCTTAGCACAAGCCCTCAAGGAGGGCAGGATACGAGGGGCAGCCCTCGAC ENST00000422584.1 GAAAAGATGGCCTCT-TTTGAGCCTTT------GTTTGGATACA-----TTCCTGTTTTT ** *** **** **** * * ****** * * ENST00000309035.6 GTGCATGAGTCAGAGCCCTTCAGCTTTGCTCAGG------------GTCCGTTGAAAG-A ENST00000422584.1 GTG-ACAAAAGAAAAACTTTAAAATTGTCCCAAGCAGAAAAATAATGGCTATCAGAAGTA *** * * * * * ** * ** * ** * * * * *** * ENST00000309035.6 TGCCCCGAATCTCA-TCTGCACTCCTCACACTGC-CTGGTACA--GTGAGC--AGGCGT- ENST00000422584.1 TGTTTTG--TTTCAGTGTGAGTTACTGTTACTGTATTTGTTTATTGTAAACGTAGACATT ** * * *** * ** * ** **** * ** * ** * * ** * * ENST00000309035.6 -------CACTGGAGATGAGGGAGGCAGCTGCCACCGAGATCCGCCGAGCCATCA----C ENST00000422584.1 TAGCATTCACTGCAGTTTTCAGTAAAAAGTA--ATTAAAATTTGTTGAGTTCTGAAATTC ***** ** * * * * * * ** * *** * * * ENST00000309035.6 AGGTCGCATCCCAGAAAGCTTAAGAAATTGTGTGAACAAGGAATTCTTTGTCACATCAGC ENST00000422584.1 AAGT-ACATCTCACTAATGT--AAAAGTTCTCTACTTGAGA---TGTTTAAGGCA--AGT * ** **** ** ** * * ** ** * * ** * *** ** ** ENST00000309035.6 GCCTTGGTCAGTAATAGACCAGCAAGCAATTCATCCTGAGCTCAATGGTGCCACATACAG ENST00000422584.1 GCGTTG-TCAAT--TAG-CCAATTTCCAACTCTTGTTA--CTACAGGGTTCTATCTGCCT ** *** *** * *** *** *** ** * * ** * *** * * * * ENST00000309035.6 ATATCCG---CCAGGCATCGTGGGTGTGGCTCCAGGAGGACTTCCTGCAGCCATGGAAGG ENST00000422584.1 AT-TCCATAACCAGAC-TCAAGAATG---CT----GACAATTACCTCATGTGATACAAAG ** *** **** * ** * ** ** ** * * *** * ** ** * ENST00000309035.6 GATCATCCCTGGAGGCATCCCAGTGACTCACAACCTCCCGACAGTGGCACATCCTTCCCA ENST00000422584.1 TTTAAT---TGAAA-----------ACTCAAAACCTC---ACACAAGTCCATCATTATCA * ** ** * ***** ****** *** * **** ** ** ENST00000309035.6 AGCGCCCTCTCCCAACCAGCCCACAAAACACGGGGACAATCGAGAGC--ACCCCAACGAG ENST00000422584.1 AGT---------CATGCCGTCCTTAAGTTGTAATGGTGGGTTAGAGCTAAGTCAATTAAA ** ** * * ** ** * ***** * * * * ENST00000309035.6 CAATAGCAGAGAATGCCAGAAGGTAATCACTCAGATAC-ACTTGGGACCAAGAGACAGTG ENST00000422584.1 AAAAAACAAAGT-TGCTCAACTTTTAGAATTCTGATTTTAATTTACCCCAAAGCAAAATG ** * ** ** *** * * * * ** *** * ** **** * * ** ENST00000309035.6 AAAAATAGATGAACTAAGAGAAAAAGAATCGGATGGTCTTTGTAACTGATTCTGGACATA ENST00000422584.1 ACCTGGACCTGGTTCAAGGGAGGGA------AGTGAACCTTGAAACTG-TTTTG------ * * ** *** ** * ** * *** ***** ** ** ENST00000309035.6 TGCATCATTGATGTTGCAGTGTTGAAACTACAAGAGCTAGAAAACTGAAGATGTCGTCTG ENST00000422584.1 ----CCAATAACCTAACAAAATGATATTTACAA-----AGAAGTGTTCCAAAATAGTCC- ** * * * ** * * ***** **** * * * *** ENST00000309035.6 CTTACGGAAGCGCTGAAAGACTAGGATGTGATTTATTAACGACCAACTTCTGTTATTGTG ENST00000422584.1 ----CATGAG---TTAAGAACTTGAAGTTGATTTAATG--GACTTTCTTTT-TAAATA-G * ** * ** *** * * ******* * *** *** * * * * * ENST00000309035.6 TGTTAAGTTTTTCATCTGTGCATCAAATCACAAAAAGAATAAATAGAGCTTTTTCCTTTA ENST00000422584.1 AATTAAACCTT-----TATAC-TCAAAAAAAAAAAAAAAAAAAAAAGACTTCTCTGCTCT **** ** * * * ***** * ***** ** *** * *** * * ENST00000309035.6 TCAGTCCCTTGGGCACAGCAGGTCCTGAACACC-CTGCTC--TACAATGTTGCATCAAGA ENST00000422584.1 TGAACTTGCTCATCATAGTATAAAACAGACAAAATTAATAGGTGCAATGTTTTATTAA-- * * * ** ** * *** * * * ******* ** ** ENST00000309035.6 GTTCAAACAACAAAATAAAAAATATTAAGAGGAAATC--CCCATCCTGTGACTTGAGTCC ENST00000422584.1 -TCT---CATCTCCTTAATGAGTTCTGTGGTGAGTTTAACTCATTC-GTGG-TCCAGTCC * ** * *** * * * * ** * * *** * *** * ***** ENST00000309035.6 CTTAAGTCTACAGGGGC-TG-GTGACC--TCTTTT-TGCTAATAGGAA--AATCACAT-T ENST00000422584.1 ---ACACATATGGAAGTATGTGTGAACATTCATTTGTGCAATTATGTATTATTCCTATCT * ** * * ** **** * ** *** *** * ** * * * ** ** * ENST00000309035.6 AC-TACAA------AATGGGGAGAAAACTGTTTGCCTGTGGTAGACACCTGCACGCATAG ENST00000422584.1 GTGTATAAGTCTTTAATTTTGGAAAAACACTTTGCCTTTTACAT-TAACTTCATCCACAA ** ** *** * ***** ******* * * * ** ** ** * ENST00000309035.6 GATTGAAGACAGTACAGGCTGCTGTACAGAGAAGCGCCTCTCACATCTGA--ACTGC--A ENST00000422584.1 TAT-GAAGG-GATTTTGACTTTTGGA-AAAGTAGCAAATCCTATATTTGAGAACTTTCGG ** **** * * ** ** * * ** *** ** * ** *** *** ENST00000309035.6 TACTGAGCGGG- ENST00000422584.1 GAATAAGTTTGA * * ** *