CLUSTAL 2.1 multiple sequence alignment ENST00000327155.4 -------------------CGCG--TGACGTCGCGCGGGCTCCCGGGCGGGG-----CGG ENST00000449447.1 TCTGACAATTTTAAAAAAACATGGCTGGCGCTAAAAGAGCTCCATGATAAAGAGCTGCGG * * ** ** * ***** * * *** ENST00000327155.4 -GTCC---GGCCGCCTC--CGAGCCCGGC----CGGCAGCCCCCGGCCTTAAAGCG--CG ENST00000449447.1 CGTCTACAGGCAAAATTAACAAGTCTGAGGAAACAGCGATTGTCAGACGGGAGGCGGACG *** *** * * ** * * * ** * * * * *** ** ENST00000327155.4 GGCTGTCCGG---------AGGGGTCGGCTTTCCCACCGAGGATTTGGCA------CTCT ENST00000449447.1 GGCTCCACAGCCAAAATTAAAGAGTTGACTAAACAGCAGAGAGTCCTGCAGAGCACCATT **** * * * * ** * ** * * *** * *** * * ENST00000327155.4 GGTGAGGGAAAAGGGCG---AAAGAGAAAAGCGAGCAGCCGTCCTTTCACAGCCTCAGAA ENST00000449447.1 AATGACTTGAAAGATCAGTTAAAGGCAAAAACCTGTGACTGCTGTT---CAATGACAGAA *** **** * **** **** * * * * ** ** ***** ENST00000327155.4 A-GTGCTCGCTTCCCTTCGGG---GGCTTTCGCGAATCCCGA-GGCAA-------TCTCG ENST00000449447.1 ACATACAGGCTTGCGCTAGAGAAAGACTATTATGAAATCCAACAACAAAATCTTTTCTTT * * * **** * * * * * ** * *** ** * *** *** ENST00000327155.4 GAGGCGGTATTTGACCTGTCCAAAGACGACTTGATACCTCTATAATGTAACAGAAAAGGT ENST00000449447.1 ATTGCGGAACTCA--CTAA--AGAAACAAATAAAT--TACGAGAAGAAAATAAAAGGCTT **** * * ** * * ** * * ** * * ** ** * ** * ENST00000327155.4 CAGAAAATATTAAGCAAGTAGAAGTG--TGGAGCATATTAAGCAA-GATGAA--CATCTC ENST00000449447.1 TCTAAAATAATAATGAGGCAACAACAATTTCAG-ACTTCTGGTAGTGATGACTTCGTTTC ****** *** * * * * * ** * * * * ***** * * ** ENST00000327155.4 GGG-----AAGCAGCTGTGGAAG--CCCTAACTCTGCAGATACATCTAGTGACTTTAAGG ENST00000449447.1 TGGTAGTCAAATGACTATGTCAGATTTTTCAGTCAGGGAGCCTGCACAAGGAAGGCAGAG ** ** ** ** ** * * ** * * ** * * ENST00000327155.4 ACCTTTG---GACAAAACTAAAAGAATGTCATGATAGAGAAGTACAAGGTTTACAAGTAA ENST00000449447.1 GCATGTGCCTATCAAATCGATAAGCCAGTCACAAAGTAAGCAGATGAAACCTACGAGCAC * * ** **** * * *** **** * * * * *** ** * ENST00000327155.4 AA-------GTAACCAAGCTAAAA-----CAGG--------------AACGAATCTTAGA ENST00000449447.1 AAAGGAACTGCAACAAAGTTCAGAGTTTCCAGCTCCATCTTTTAGTCAAGGCCTCTTTGA ** * *** *** * * * *** ** * **** ** ENST00000327155.4 TGCAC-AAAGACTA-------GAAGAATTCTTC------------ACCAAAAATCAA--- ENST00000449447.1 AGTGCCAGAGACCTCTTTTGCGAAAAGTTCCTCTAATGACACTAAGCCTAACATAGAAGA * * * **** *** * *** ** ** ** ** * ENST00000327155.4 ------CAGCTGAGGGAACAGCAGAAAGTCCTTCATGAA--AC--CATTAAAGTTTTAGA ENST00000449447.1 CCCTGCCAGCC-AGAAGCCACTGGCAAGTTCTCTTTTAACAACTTCACTTAGTCCTCAAA **** ** ** * **** ** * ** ** ** * * * * * ENST00000327155.4 AGATCGGTTAAGAGC----AGGCTTATGTGATCGCTGTGCAG-----------TAACTGA ENST00000449447.1 AGA---GGTATGAATTTCAAGATTTTTTCAATCTTCATGAAGACAAGATTGGCCAGCCAA *** * ** ** ** ** * *** ** ** * * * ENST00000327155.4 AGAACATATGCGGAAAAAA----------CAGCAAGAGTTTGAAA-----ATATC-CGG- ENST00000449447.1 AAGGGACACTTGAAACAAAGGTCTCCCCGCAAAAAGAAACTCAGATTGGCACATCATGGA * * * * ** *** ** **** * * * * *** ** ENST00000327155.4 ------------------CAGCAGAATCTTAAACTTAT-TAC---AGAACTTA-TGAA-- ENST00000449447.1 ACCCTTCCGCTATCTCCCCAGGAGAATACCCAACTCATGTATCTGAAAGTTTACTGGAAA *** ***** **** ** ** * * *** ** * ENST00000327155.4 --TGAAAGGAATACTCTACAG--------------------GAAGAAAATAAAA--AGCT ENST00000449447.1 CTTTAGAGGATTATTCTATAACCTCATATAGCCCTCTTGCAAAGGAAAAGAAAATAATCC * * **** ** **** * * ***** **** * * ENST00000327155.4 TTCTGAACA------------ACTCCAGCAGAAAATTGAG-----AATGATCAACAGCA- ENST00000449447.1 CTTTGAATGTCTTGCCTTTAGACTCTACTTTAAAATCTAGTACAAAAAGAAGAGCAGTGG * **** **** * ***** ** ** ** * *** ENST00000327155.4 -----------TCAAGCAGCTGAGCTTGAATGTGAGGAAGACGTTATTCCAGATTCA--C ENST00000449447.1 TTGCTATTCCTTCTAACA-CCAAATTTGCA-GTGAGAGATAGCTCTAACCAGATACCTTC ** * ** * * *** * ***** * * * ****** * * ENST00000327155.4 CGAT-AACAGCCTTCTC------ATTTTCTGGCGTTAACCGGCTACGAAGAAAGGAG--- ENST00000449447.1 CAATGAACAGTCTGCTTCGGAGAATATTAATGAATCTACAAG-TGCAGGGTATGGTGCCG * ** ***** ** ** ** ** * * ** * * * * * ** * ENST00000327155.4 ---AACCCCCATGTCCGATACATAGAACA---------AACACATACTAAATTG------ ENST00000449447.1 ATAAGCCTCAATGT--GATACTGAGAGTGTCTTTTTGGAGTCTGGGCTAAAGAGAAAAGT * ** * **** ***** *** * ***** * ENST00000327155.4 GAGCACTCTGTGTGTGCAAATGAAATGAGAAAAGTTTCCAAGTCT------------TCA ENST00000449447.1 GAAGACACAGT---CACAAAGAAAGAGGAAGTAGCTTCCCCATCCCCCCCACCCCCCTCA ** ** * ** **** ** * * ** **** ** *** ENST00000327155.4 ACTCATCCACAAC--------ATAATCCTAA-TGAAAATGAAATTCTAGTAGCTGACACT ENST00000449447.1 CCCCCCCCCCCACCGCCCCCCACCACCTTCTCTCTTAAGGAAGCAACAATGTTTTACTTT * * ** * ** * * * * * ** *** * * * ** * ENST00000327155.4 TATGACCAAAGTCAATCTCCAATGGCCAAAGCACATGGAACAAGCAGCTATACCCCTGAT ENST00000449447.1 TCCAACAGAA--CAGTCTTC--TTGTCAATTCAGACTTCGTAA-CTGGTA-ACTCCTGAC * ** ** ** *** * * * *** ** * ** * * ** ** ***** ENST00000327155.4 AAGTCATCTTTTAATTTAGCTACAGTTGTTGCTGAAACACTTGGACTTGG---TGTTCAA ENST00000449447.1 TCTTATTCCTTTTCTCACGATATAATAA--ACT-AAGCAGTAAGGCCTGAAAATGTTTGG * ** *** * * ** * * ** ** ** * * * ** **** ENST00000327155.4 GAA--GAATCTGAAACTC-AAGGTCCCATGAGCCCCCTTGGTGATGAGCTCTACCACTGT ENST00000449447.1 CAAATGAATCTAAGACTTTGAAATAGCAAA----TTTTTGTCAATTAA-TAAAATGCAG- ** ****** * *** * * ** *** ** * * * * * ENST00000327155.4 CTGGAAGGAAATCACAAGAAACAGCCTTTTGAGGAATCTACAAGAAATACTGAAGATAGT ENST00000449447.1 CTATAAGTAGAGAATGAAATTTATTCTCC---AGAATCCATATAAAAGTGTAGAGATAG- ** *** * * * * * * ** ***** * * *** * ****** ENST00000327155.4 TTAAGATTTTCAGATTCTACTTCAAAG-----ACTCCTC----CTCAAGAAGAATTACCT ENST00000449447.1 --AACATCTTTTCATTG-ACATTAAAGTTGCTACTGTTTATGACTCAATAAAAAAGAA-- ** ** ** *** ** * **** *** * ***** ** ** * ENST00000327155.4 ACTCGAGTGTCATCTCCTGTATTTGGAGCTACCTCTAGTATCAAAAGTGGTTTAGATTTG ENST00000449447.1 AGCCAAGAGAGGACCTCAAGATTGTGGAC-----------TTGAAAGAGATAAATATTTA * * ** * * * *** * * * **** * * * **** ENST00000327155.4 AATACA---AGTTTGTCCCCTTCTCT-TTTACAGCCTGGGAAAAAAAAACATCTGAAAAC ENST00000449447.1 AATGCATATAGAGTAACTAAAACAATATTTAC---CGGACAAGACAAAGTAATT-AGAAT *** ** ** * * * * ***** * * ** * *** * * * ** ENST00000327155.4 ACTCCCTTTTAGCAACACTT-GTATATCTAGATTAGAAAAAACTAGATCAAAATCTGAAG ENST00000449447.1 ACATCCATTGAGAAGGATCTAGAAGACATTTCTTAGAACAAAATGAATATGACTTTACAG ** ** ** ** * * * * * * * ****** *** * ** * * * ** ENST00000327155.4 ATA-GTGCC----CTTTTCACACATCACAGTCTTGGGTCTGAAGTGAACAAGATCATTAT ENST00000449447.1 ATATACAGCATGACTTTATACATATAAAAGAT---AAACAGATGTGACATAGACTGTATA *** * **** *** ** * ** * ** **** *** * ENST00000327155.4 CCAGTCATCTAATAAACAGATACTTAT--AAAT--AAAAATATAAGTGAATCCCTAGGTG ENST00000449447.1 CTAGTTAT----TGAAAATGTGCTTTTTAAAATCAAAAAGCAAGAGCAGAAGACTACA-A * *** ** * ** * * *** * **** **** * ** * *** ENST00000327155.4 AACAGAAT-----AGGACTGAGTA--CGGTAAAGATT-CTAACACTGA-TAAACATTTGG ENST00000449447.1 AACCTAATTAACAAAGACTGAATATTCGGCACAGAGTACTGCCACTGAGCAAGCATGGTC *** *** * ****** ** *** * *** * ** ****** ** *** ENST00000327155.4 AGCCCCTGAAATCATTGGGAGGCCGAACA--TCCAAAAGGAAGAAAACTG----AGGAAG ENST00000449447.1 AACATTTGCAAGAATAAGAGGAACTATCAAGTTCACAAGAAATAAAACAGTCATGGGCCG * * ** ** ** * * * * ** * ** *** ** ***** * ** * ENST00000327155.4 AAAGTG---------------------AACAT-----------GAAGTAAGCTGCCCCCA ENST00000449447.1 GGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACG *** * ** ** ** ** * * * ENST00000327155.4 AGCT-------TC-------TTTTGATAAAGAAAATGCTTTCCCTTTTCCAATGGA--TA ENST00000449447.1 AGGTCAGGAGATCGAGACCATCCTGGCTAACACCGTGAAACCCCATCTCTACTAAAAATA ** * ** * ** ** * ** *** * ** * * * ** ENST00000327155.4 ATCAGTTTT-CCATGAATGGAGACTG-----TGTGAT----------------------- ENST00000449447.1 AACAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAAA * ** ** ** * *** * * * *** * ENST00000327155.4 --GGATAAACCTCTGGATCTGTCTGATCGATTTTC-----AGCT---ATTCAGCGTCAAG ENST00000449447.1 CAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATCCTGCCACTGC *** ** * ** * *** * * ** ** **** ** * ** * ENST00000327155.4 AGAAAAGCCAAGG-----AAGTGAGACTTC----TAAAAACAAATTTAGGCAAGTGACTC ENST00000449447.1 ACTCCAGCCTAGGCGACAGAGTGAGACTCCATCTTCAAAACAAAAACAGTCA--TGGTTT * **** *** ********* * * ******** ** ** ** * ENST00000327155.4 TTTATGAGGCTTTGAAGACCATTCCAAAGGGCTTTTCCTCAAGCCGTAAGGCCTCAGATG ENST00000449447.1 TACCCATGACATTAAAAATAACAACCAGAGACTTGTCTCTGGTTAGTATAGAATGTGATG * * * ** ** * * * * * *** ** *** * * **** ENST00000327155.4 -GCAACTGCACGT---TGCCCAAAGATTCCCCAG----------GGGAGCCCTGTTCACA ENST00000449447.1 TATATGTGTGTGTATGTGTGTGTGAGACCTACAGTGGAGGAGGGGAGAGAACTAGTCA-- * ** ** ** * *** * *** ** *** ENST00000327155.4 GGAATGCA-------TCATCCTTCAGCC--------CTTGAATAAATGCTCT---CCA-- ENST00000449447.1 GCAATGCAGCTTTTCCCCTCCTCCTACCTTCTCTCTCTTTCCCTCATTCTTTGGGCTGTG * ****** * **** * ** *** ** ** * * ENST00000327155.4 --GACAATAAACCA---------TCATTACAAATA-------AAAGAA------GAAAAT ENST00000449447.1 GTGGTATTCAACCGCTTTTTTGTTCACTTCTGCTTTTTTTCTAATGTATCTCTTGGACCT * * * **** *** * * * ** * * * * * ENST00000327155.4 GCTGTCTTTAAAATTCCTCTA-CGTCCACG----TGAAAGTT---TGGAGACTGAGAATG ENST00000449447.1 ATTTTTTTTAAGGCTAGTCAAGTGGCAATGGGAGTGGAGAACAGATAAAGATTGGGCCTC * * ***** * ** * * * * * ** * * *** ** * * ENST00000327155.4 TTTT----AGATGACATA----AAGAGTGCTGGTTCTCATGA----GCCAATAAAAATA- ENST00000449447.1 TTTTTAAAAAAAAACATTTACTGAGAGATTCATTTATCATAAAAATGCCCACATAAATAG **** * * **** **** ** **** * *** * * ***** ENST00000327155.4 ----CAA-ACCAGGTCAGACCATGG--------AGGAT---GTGAACTTGCATCAGTTCT ENST00000449447.1 CCCACAATATTACAATAGTTTATAGTTTATTCAAAGACTAAGGAAACCTTCACCACAGTT *** * * ** ** * * ** * *** * ** ** * ENST00000327155.4 TCAGTTAAATCCATGTAGAACTGGTAAAATAAAGTCTCTACAAA-ACAACCAAGATGTAT ENST00000449447.1 TTAGA-ACATTTTCATTGCCTTA--AGAAGAAA--CTCCATAAATGTTAGCAA----TTT * ** * ** * * * * ** *** *** * *** * *** * * ENST00000327155.4 CC---TTTGAAAATATCCAGTGGAGTATAGATCCGGGAGCAGACCTTTCTCAGTATAAAA ENST00000449447.1 CCAGATTCCACAACATAATGTTTGATATTTATGCTAAATCGTACATTCCT----AGAACT ** ** * ** ** ** *** ** * * * ** ** ** * ** ENST00000327155.4 TGGATGTTACTGTAATAGATAC------AAAGGA---TGGCAGTCAGTCAAAATTAG--- ENST00000449447.1 TGAATATTCCAGTTATTTTTATTTTATTAATGAACTTTAGAATTTACTCATATCTAGCTA ** ** ** * ** ** ** ** * * * * * * * *** * *** ENST00000327155.4 --------GAGG-----AGAGACAGT-GGACATGGACTGTACATTG-GTTAGTGAAACC- ENST00000449447.1 TTTATTTTAATGTTTCTATAGCTACTTAGATATCAACT-TATTTTATGTCTTTACATCCT * * * ** * * ** ** *** ** ** ** * * ** ENST00000327155.4 --GTTCTCTTAAAA-----ATGAAGAAGCAAGAGCAGAAGGGAGAAAAA-AGTTCAAATG ENST00000449447.1 GCATTATTATAAAATATTTAAAACGAAATAATTACTAAAAATAAAAAAATAGA--AAATG ** * ***** * * *** ** * ** * ***** ** ***** ENST00000327155.4 AAGAAAGAAAAATGA-----ATGATAG-CTTGGAAGAT---ATGTTTGATCGGACAACAC ENST00000449447.1 AGTAAAAGATAGCAATCACTATGATGATCCCAGGTGCTTTTATGTTT--TCCATTTTTGC * *** * * * ***** * * * * ****** ** * ENST00000327155.4 ATGAAGAGTATGAATCCTGTTTGGCAGACAGTTTCTCCCAAGCAGCAGATGAAGAGGAGG ENST00000449447.1 AT--------TTTTTTTTTTTAAGCAAA-AGTAT-TGCGAAAAGGAAGA-GAAGGGAGGG ** * * * ** *** * *** * * * ** * *** **** * ** ENST00000327155.4 AATTGTCTAC-------TGCCACAAAGAAACTACACACTCATGGTGATAAACAAGACAAA ENST00000449447.1 AACTGTCTAAGTAAATGTGGTATTTGGAAATAACCTGCTTTTACTTCCCGAGGACATGCA ** ****** ** * **** ** ** * * * * * * ENST00000327155.4 GTCAAGCAGAAAGCGTTTGTGGAGCCGTATTTTAA-AGGTGATG-AAAGAGAGACTAGCT ENST00000449447.1 GTTTAT--GAAAGTCCTT---CGGTTGTATTCCATCATATAGTGTAAAGAGGAACTGG-T ** * ***** ** * ***** * * * ** ****** *** * * ENST00000327155.4 TGCAAAATTTTCCTCATATTGAGGTGGTTCGGAAAAAAGAGGAGAGAAGAAAACTGCTTG ENST00000449447.1 GACA--------CTAGTA--AATACGGCTCTATACCAAGGAGAAAAAACAGA---GCCCG ** ** ** * ** ** * *** ** * ** * * ** * ENST00000327155.4 GGCACACGTGTAAGGAATGTGAAATT------TATTATGCAGATATGCCAGCAGAAGAAA ENST00000449447.1 A---------CAAAGAACGCGATACCAGACAATATCATACAGTGTTGCTGCAAAGATAAT ** *** * ** * *** ** *** *** * * ** ENST00000327155.4 GAGAA---------------AAGAAAT-----TGGCTTCCTGCTCAAGAC--ACCGATTC ENST00000449447.1 GATGACATTCCCTACCCTTCAAGAACTCTTCCTGTCTTTTTGTTTCTTATTTGTCAAATC ** * ***** * ** *** ** * * * * ** ENST00000327155.4 C---GCTACATTCCACCCAACACACCAGA---GAATTTTTGGGAAGTTGGT-TTTCCTTC ENST00000449447.1 CTGGGTTAAATAAAAGCTGAAGTATTAAATATGAATTCT--GGTGGTTATTATTTCCTTT * * ** ** * * * * * * ***** * ** *** * ******* ENST00000327155.4 CACTCAGACTTGT------ATGGA--AAGAGGT-TATATTAAGG-AAGATCTT------- ENST00000449447.1 CAGTTACATTGGTCATTTAATGAATTAAATGCTCTGCATGAAAACAAAATGTTTAGCACT ** * * * * ** *** * ** * * * ** ** ** ** ** ENST00000327155.4 -----GATCCTTGTCCTCGTCCAAAAAGACGTCAGCCTTACAACGC-AATATTTTCTCCA ENST00000449447.1 TCTAAAACCATTGCCTCATTTTAGAAATTCATTTGCAAAATTATGTTAAAATTATTTCAA * * *** * * * *** * * ** * * * ** *** * ** * ENST00000327155.4 AAAGGCAAG---GAGCAGAAGACATAGACGT----TGAAACAGAAAC--AGAAGGATG-- ENST00000449447.1 AGACTCGAACTTGTGTGACTGACATGAACCTATTTTGAAGTTCAATTTAAGAAACATTTT * * * * * * ***** ** * **** ** **** ** ENST00000327155.4 AAGGACAGTTTTTTCCTTCTTAGTTATTTATAGT----------------TAAAGTTGGT ENST00000449447.1 AAAGTCAGAGTCTCCAA--ATAACTGTTTATAATGTGCATGTGCTCTGCCTCCAGATGAT ** * *** * * * ** * ****** * * ** ** * ENST00000327155.4 -ACTAAACATTGATT------TTTTTGATCTTCTGTAAATGGATTTATAAATCAGTTTTC ENST00000449447.1 GATCAAATATTGTTGCATGAATTTGTGAACCTGTGAGGGTGTATGTCTAGTACAGTCCA- * *** **** * *** *** * * ** ** ** * ** **** ENST00000327155.4 TATTGAAAATGTTTGTGAT---------------ATTTTGCTTTTGCACCTTTAAAACAA ENST00000449447.1 TGCTTAATATGATGGTAACTCACCTTCTGAAATCATTTTTACTATATACAGGTAGCACAT * * ** *** * ** * ***** * * ** ** *** ENST00000327155.4 TAAGGCGCTTTCATTTTGCACTCTAACTTAAGAGTTTTTACTTT-ATGTAGTGATACCTA ENST00000449447.1 CAGGAGGCTTCTGATTT-CATACTGATCCAGGCGGTTATACTGGGATACACT-ACTCCTT * * **** *** ** ** * * * * ** **** ** * * * *** ENST00000327155.4 ATACAATTTTGAAAATACAA- ENST00000449447.1 GTAGAACTCTGTCGGGTCTGT ** ** * ** *