CLUSTAL 2.1 multiple sequence alignment ENST00000327451.5 GAGACT----CCTGCAGGTTCGAGAAAGCAT--GACATGCTC----CCAGAATCCTGGAT ENST00000449385.1 -AGGTCACAGCTTCCACCCACAAGTGGACCTCTACCACCCTCATTGCCGGGAAGGTGC-T ** * * ** * ** * * ** *** ** * * ** * ENST00000327451.5 TTGGACTTC-ATTCTGGACAGCATATGACAAGGAC--------------------GAGGA ENST00000449385.1 TTGCACTCAGAGCCTGGCTGGCCTCT-ACAAAGGCCTGGTGCTACTCTCCTTAGAGATAT *** *** * **** ** * * **** * * ** ENST00000327451.5 CCCCTATTCTAGCCAGTTAAAGCTGGACAG-----AATTTTTAAAAGCAATGA---AGCC ENST00000449385.1 TCCCTTCTCCAGC-ATCTACTTCCCACCATTTGCCAACTTTAACCACCCAGGGTTCAATG **** ** *** * ** * ** ** *** * * * * * * ENST00000327451.5 AGTTCCTTGGATA--TATCCACGGGCTTTGCTTTGAGAAGGAACTGAGTAGGCAGTGAGA ENST00000449385.1 AGCTTACTGGAAAGGCATCCTCTACTCATTCTTTCAGGTCAGGCTGTGCAGCAGGTTCCA ** * **** * **** * * **** ** *** * ** ** * ENST00000327451.5 -AG-----AGTCG-AGTGAAGC--CTGGCC----------CGTGAGTGC-----CTCAAC ENST00000449385.1 TAGTTTGCAGTCACGGTGACACTTCTGGACATTCTGAAAACTTGAGTCCAAACCCTCAAA ** **** **** * **** * * ***** * ***** ENST00000327451.5 AA----CTGAGATGA--ACGTC-------GACTCGCT----TGCAGGCAAGTTG--TCAC ENST00000449385.1 GAAGGCCTGGGATGAGGACATTTGTGGCAGGGTCACCACTGTGCCAGCAAACTTCTTCAT * *** ***** ** * * ** * *** **** * *** ENST00000327451.5 TCAGC-AGCGATCTG---AACTATATCCTGGG---TTCCAGAAAAGGCAGAGG---TTCT ENST00000449385.1 AAAGAGAGCAGGCTGCCAGGCCCCATCACAGCACCTCTCTGGGAATGCTCAGGACATCTA ** *** *** * *** * * * * ** ** *** * ENST00000327451.5 TACCGAAAGCAGGGGAGGAAGCCGCAGCCCAAGGAGGTCGTCACTTGCCGGGAAGGTGGC ENST00000449385.1 TTTCATTGGTATTGGAGAG---TATATCTTAAGGTGTTT-TGAGTAGATAGAGCTGGAGT * * * * **** * * **** * * * * * * * * * ENST00000327451.5 TCGGGCCAGGCTGCACTCAAAACCCGTGCTCT-------GTCCACACTGCT--------A ENST00000449385.1 TTGAGTCC--TTGTACTCATGGCTCTCTCTCTCTCTCCAGCCCATTTTACTCAGCCTGGA * * * * ** ***** * * **** * *** * ** * ENST00000327451.5 CGGGGCCAGAGCCAAGGAAGCTTCCA---------CTTCTTCCCC------CAG-ACAGC ENST00000449385.1 TGGGGCAAGAACAGGATAGGCCACCTGTAGCATGTCTTCTTCTCCAACTTGTAGTGCTAC ***** *** * * ** ** ******* ** ** * * ENST00000327451.5 CCCAAC-----AGCGGCTACCCCA-----AGGAGCC-----AGCA--GCCTTGT------ ENST00000449385.1 CTCTACTCAGAAGTAACAACCCTATTCTAATAAGCATGTTGAGCATGGCCTTATTCTCCC * * ** ** * **** * * *** **** ***** * ENST00000327451.5 ---GTCCTGGGATCCCCAGCCCCTGCAGAATGACCCACCAGGATCT----GAGCATCACA ENST00000449385.1 TTCATACCTGCATTTATTTCCTTTGTGGGTACAGCTACCAGGGGCTTTCAGAAACCCCCA * * * ** ** ** * * * ****** ** ** * ** ENST00000327451.5 GCCAA-ACTCATCAATGGA---GGTGTAGCAG------GGCTCGTG----GGGGTG---- ENST00000449385.1 ACCACCACTAGATAGTGTATTTACTGTAGTAATAAAGAAACACATATATTAAAATATTAA *** *** * ** * ***** * * * * * ENST00000327451.5 ---------ACCTGCGTGTTCCCCATCGACTTGGC-CAA--GACTCGCCTGCAGAACCAG ENST00000449385.1 AAAGTCCACACTTGGGATATATTAACTGTTTTAGTATAATTGATTTCCTTTGTAAACCTG ** ** * * * * ** * ** ** * * * **** * ENST00000327451.5 CATGGGAAAGCCATGTAC--AAAGGAATGATC------------GACTGCCTGATGAAGA ENST00000449385.1 TGCATGTATTTTATGCATTTAAAGACATTATCTTTTGATAATAAAACTGCC--ATGAAGA * * *** * **** ** *** ****** ******* ENST00000327451.5 C-----GGCTC---GGGCGGAG----------GGCTTCTTCG--GCATGTACCGAGGGGC ENST00000449385.1 CTTCATGTCTTTATGAAGGGAGCAGGCTGCCAGGCCCCATCACAGCACCTCTCT-GGGAT * * ** * **** *** * ** *** * * *** ENST00000327451.5 TGCAGTGAACCTCACTCTGGTCACTCCAGAG--AAGGCCATCA--AGCTGGCGGCCAACG ENST00000449385.1 TGCTATTACTATTATTATTATTATATTACTATTACTATTATTATAAACTATTCAACAACA *** * * * * * * * * * * ** * * ** **** ENST00000327451.5 ACTTT--TTCCGGCGGCTGCT-CATGGAAGATGGGATGC-AGCGGAACCTGAAGATGGAG ENST00000449385.1 AAAATAGTACTTGCTTTTGTTGTATTAATTGCAGGACCTTAACAGATAGTCAAGATAGAA * * * * ** ** * ** * *** * * ** * ***** ** ENST00000327451.5 ATGCTTGCCGGGTGTGGGGCTGGGATGTGCCAGGTCGTGGT--GACCTGTCCCA--TGGA ENST00000449385.1 GGGCTGTTTCTGTATT---TTAATAT-TTCTATTTCACACTCAAACTCAGCACAGTTGAG *** ** * * ** * * * ** * ** * ** ** ENST00000327451.5 AATGCTCAAG-ATTCAGCTGCAG-GATGCTG-----GACGCCTGGCCGTCCATCATCAGG ENST00000449385.1 TCCGTTTGAGGATTTAATTTCGTTAATCTTGAATTAGACAACTTATGATGAATCCTCATG * * ** *** * * * ** ** *** ** * *** *** * ENST00000327451.5 GCTCGGCCTC----------AGCACCC----TCCA------CCTC--CAGGTCCTA--CA ENST00000449385.1 --CTGACTTTGGGGAAAAGGAGGATCAGAAGTTCAAGGGGACCATGACAGCCCCTAGTCA * * * ** * * * ** ** *** **** ** ENST00000327451.5 -CAACTGGTTCGGCTTCCACCCACAGGCGCCC---CTCTGCCACCCTCATTGCCTGGGAG ENST00000449385.1 GCACCTAGTTTGAAG-CCAAGCACAGCCTTTCAAACCCTGGAAGGCAGAT-GAATGAGGC ** ** *** * *** ***** * * * *** * * ** * ** * ENST00000327451.5 CTGCTCCGCACTCAG-GGCCTGGCTGGGCTCTACAGGGGCCTGGGTGC-CA--CTCTCCT ENST00000449385.1 CAGCTCTG-ACTGAGCAGCCTGGGCAAAGTC-AGAGCAGCCACCCTTCTCAATCCCTCCT * **** * *** ** ****** ** * ** *** * * ** * ***** ENST00000327451.5 C--AGAG-----------ACATTCCTTTCTCCATCA---TCTACTTCCCACTGTTTG--- ENST00000449385.1 CCTAGAGCACAGGCCCTCACAGACCCCTCCCTATCAATGTTCAAGGAACACTATTTGAAA * **** *** ** ** * **** * * **** **** ENST00000327451.5 CCAACCTTAACAACCTGGG-----GTTCAACGAGCTCGCCG-----GTAAGGCGTCC--- ENST00000449385.1 TAAACATGAATGGTTAAAGAAAATGTACATGGAGCTTAACGAAAATGAAATGCATCAAAA *** * ** * ** ** ***** ** * ** ** ** ENST00000327451.5 TTTGC---ACATTCCTTCGTGTCAGGCTGTGTGGCAGGTTCCATAGCTGCGGTCGCAGTG ENST00000449385.1 TTTGTGGGACACAGCTA-GAGCAATGCTGGGAGGCAAATTT-ATAGCAGTAAATACAT-- **** *** ** * * * **** * **** ** ***** * ** ENST00000327451.5 ACGCCTCTAGATGTTCTGAAAACTCGAATCCAA-----ACCCTCAAG----AAAGGCCTG ENST00000449385.1 ACAT-TAGAAAAGAGAAAAAATATCCAATCAACCGTTTACTCTCCCACCTCAAAGATCAA ** * * * * *** ** **** * ** *** **** * ENST00000327451.5 GGCGAGGACATGTACAGTGGGATCACCGACTGTGCCAGGAAACTCTGGATTCAGGA-GGG ENST00000449385.1 GAAAAAGAAGAGCAAAATAAACCCACC-ACTAACAGAAGAAAGACAACAATAAAGATAAG * * ** * * * * **** *** * **** * * * * ** * ENST00000327451.5 ACCATCTGCCTTCATGAAAGGCGCTGGCTGCCGGGCACTGGTCATAGCACCTCTCTTTGG ENST00000449385.1 AGCA---GAAATCAATAAAAG---TGAAAACAGAAAAACAACTTTAAAACCCCT-----A * ** * *** *** * ** * * * ** *** ** ENST00000327451.5 GATTGCTCAAGGGGTCTATTTTATTGGGATTGGAGAGCGCATCTTAAAGTGTTTT--GAC ENST00000449385.1 AAACACAGAACTGGTTC--TTCGAAAAGATCAATAAAC-TGTATGAACATCTAGCAAGAC * * ** *** ** *** * * * * ** * * *** ENST00000327451.5 T--AGACAGAGCTGGAGGT-CAAGTCCCTGCGCTTGCC-GCCCTCTCTCTAGCTGTTTCA ENST00000449385.1 TGAAAACAAAAA-GAAGATACAAAT---TACACATATCAGGAATGAAACAGGGTGTATCA * * *** * * ** * *** * * * * * * * * * * *** *** ENST00000327451.5 CTT---AGCCTAGAGGGGGCAAGGGCAGGT---GGGGCCACTCTGGCCTGCCTGGTCCTC ENST00000449385.1 CAACAAACCCTGTAGACATCAAAAGAATACTAAGGAAATACTATGAACAAC-------TC * * *** ** *** * * ** *** ** * * ** ENST00000327451.5 TGCGT-TGTAGTGCTACCTCAATC---TCGGGAGAAACAGCCCTATATTCTA-ACAAGTT ENST00000449385.1 TACACACATAAATTTAACA-AATTGGATGAAAGGAACCACTTCCATGAAAAATACAAACT * * ** ** * *** * *** ** * ** * **** * ENST00000327451.5 GAGCACAGCCTTCTTCCCCTTCGTGTCTACACTCGTTTTCCTTTGTGGGCAC---AGCTA ENST00000449385.1 -ACCACAAC-TAGTCCCTTATGAAATAAATAAT--------TTAAAAAGCCCTAAAACTA * **** * * * ** * * * * * ** ** * * *** ENST00000327451.5 CCAGGGGCTTTTGGAAGCCCCTAACCACCTA---CTTTTCAACAAAAATGGTACTTTCGT ENST00000449385.1 TTAAGGAAATT---GAATTTGTAATTTTTAAAAACTTCTCCAAAAAGAAAATCTCCTGGC * ** ** * *** * *** ** * *** * * * * ENST00000327451.5 -----TGTATTAATTGCAGGACCTTAACAGGTAGTCACAATAGAAGGGTTGTTTCTGTAT ENST00000449385.1 CCAAATATTTTCACTGGAGACTTCTACCAAACACTTA---AAGAAGAATTAATAC-AAAT * * ** * ** ** ** ** * * * ***** ** * * ** ENST00000327451.5 TTTA-ACATTTCTATTTCACAGTCAAACTCGG---CATTCTTCAGTCAGCTTGAGGATTT ENST00000449385.1 TCTACACAATCTCATTCAGAAAACAAGAGGAAGAACGCTTTCCAATAAATTCATGAGGCC * ** *** * *** * *** * * * ** * * * * ENST00000327451.5 AGCATTGTTAATCTTGGACTCCA-TAACTTATGAGTCCTAGCACTGATTTTGAGGA-AAA ENST00000449385.1 AGTA---TTACTCTGAGACAAAAATCAGACAAGGATACTACAAATCTTTTTAAGAACAGA ** * *** *** *** * * * * * * *** * * **** ** * * * ENST00000327451.5 GGAGGATCAGAAGTTCAAGGGACCGTGAAAGCCCTCAGAGTCAGCACCTAGTT--TGAGA ENST00000449385.1 CCAGCATCCTTCACTAACATAGATGCAAAAATTCTTAGTG-CAATAT-TAGCAGATATAA ** *** * * * *** ** ** * ** * *** * * ENST00000327451.5 CCAAGCACCCTTTCGAATCC----CTGGATGGCTGAG-GGGGCT--------------GA ENST00000449385.1 CTCAGCAATATATAAAAAATAATACGCCATGACCAAGTGGGGCTTATTCCAGATATGCGA * **** * * ** * *** * ** ****** ** ENST00000327451.5 GGCCGGCTCTG-ACTGGGCAGCTCAGC------CCCTCCCCC----AGAGCCCAGGG--- ENST00000449385.1 GGCTGGGTCAGTATTTGAAAATTAATCAATGTACTCTACCTTGTTAACAAGCTAGAGAAT *** ** ** * * * * * * * * * ** ** * * * ** * ENST00000327451.5 -----TCTTGCA--CACCCCTCCCTGTAACCAAGGAACACTCTGAAATAAAGGTGAATGG ENST00000449385.1 AAAAATTTTATAATCATGTCATCTGATGCATAAAAGGCATTT---GACAAAATTCAACAC * ** * ** * * * ** ** * * *** * ** ENST00000327451.5 CT------------ ENST00000449385.1 CCATTTTTACGACA *