CLUSTAL 2.1 multiple sequence alignment ENST00000337109.4 AAACCCAAAGCGGCCGCCGTAGGCGAAGGTGAAGATGGCTGCCTCTGCCTTTGCTGGTGC ENST00000453682.1 ----------------------------------ATGGCTGCCTCTGCCTTTGCTGGTGC ************************** ENST00000337109.4 AGTGAGAGCAGCTTCAGGAATCCTACGGCCCCTGAATATTTTGGCATCTTCAACCTACCG ENST00000453682.1 GATGAGAGCAGCTTCAGGAATC-TATGGCTCCTGAATATTTTTGCATCTCCAGCCCACCG ******************** ** *** ************ ****** ** ** **** ENST00000337109.4 CAACTGTGTCAAGAATGCCTCTCTTATTTCTGCATTGTCCACTGGACGTTTTAGTCATAT ENST00000453682.1 AAACTGTGCCAGGAATGCCTCTCTTATTTCTGCATTGTCTACTGGACGTTTTAGTCATAT ******* ** *************************** ******************** ENST00000337109.4 TCAGACACCAGTTGTTTCCTCCACTCCCAGACTTACCACATCTGAGAGAAACCTGACATG ENST00000453682.1 TCAGACACCATTTGTTTCCTCCACTCCCAGGCTGATCACATCTGTCAGAAACCTGACATG ********** ******************* ** * ******** ************** ENST00000337109.4 TGGGCATACCTCAGTGATCCTTAATAGAATGGCCCCCGTGCTTCCAAGTGTCCTGAAGCT ENST00000453682.1 TGGGCATACTGCAGTGATCCCCAACAGAGTGGCCCCCTTGCTTCCAAGTGTCCTGAAGCT ********* ********* ** *** ******** ********************** ENST00000337109.4 GCCAGTCAGATCTCTAACATACTTCAGTGCAAGAAAAGGCAAGAGAAAGACCGTGAAAGC ENST00000453682.1 GCCAGTCAGAACTGTAATATACGTCAGTACACAAAAAGGCAAGAGAACAACTGTGAAAGC ********** ** *** **** ***** ** ************** ** ******** ENST00000337109.4 TGTCATCGATAGGTTTCTTCGACTTCATTGTGGCCTTTGGGTGAGGAGAAAGGCTGGCTA ENST00000453682.1 TGTTATCTATAGGTTTTTTCGACTTCATTCTGGCCTTTGGGTGAGGAGAAAGGCTGGTTA *** *** ******** ************ *************************** ** ENST00000337109.4 TAAGAAAAAATTATGGAAAAAGACACCTGCAAGGAAGAAGCGATTGAGGGAATTTGTATT ENST00000453682.1 TAAGAAAAAATTCTGGAAAAAGACACCTGCAAGAAAAAAGCAATTGAGGGAATTTGTGTT ************ ******************** ** **** *************** ** ENST00000337109.4 CTGCAATAAAACCCAGAGTAAACTCTTAGATAAAATGACGACGTCCTTCTGGAAGAGGCG ENST00000453682.1 CTGCAATAAAACCCAGAGTAAACTCTTAGATAAAATGACAGTGTCCTTCTGGAAGAGGTG *************************************** **************** * ENST00000337109.4 AAACTGGTACGTTGATGATCCTTATCAGAAGTATCATGATCGAACAAACCTGAAAGTATA ENST00000453682.1 AAACTTGTATGCTGATAATCCTTATCAGAAATATCTTTATGAAACAAACCTGAAAGTATA ***** *** * **** ************* **** * ** ****************** ENST00000337109.4 GATCAGAAGTTTCACTTGTTTCTCAGTTATTGGATATGTATCTTTGTGTACAT---ATCT ENST00000453682.1 GATCAGAAGTTTCACTTGTTTCTCAGTTATTGAATATGTATCTTTGTGTACATGACATCT ******************************** ******************** **** ENST00000337109.4 TTGCAAAAATGGATAAGTACAAAACTTGATGTAAATTGTACCAATGAATACGTAAACATA ENST00000453682.1 TTGCAAAAATAGGTAAGTATAAAACC-GATGTAAATTGTACCAGTTAATATGTAAACATC ********** * ****** ***** **************** * **** ******** ENST00000337109.4 CAGTGACAACATTAAACTTAGAAAAGTTTTAAAACTTAATGGATCAGACTTTGCCAGATT ENST00000453682.1 CAATGCCAACATTAAACTTATAAAAGTATTTAAACTTAA--------------------- ** ** ************** ****** ** ******** ENST00000337109.4 TGGTTAGGGAAACAGAAATTTAGAATGGTGCATTATTTTTAACAAATGGTATTGGCTTAA ENST00000453682.1 -------AAAAAAAAAAACTTGGCATCATACAT-ATTCT----------------CCCAA *** * *** ** * ** * *** *** * * ** ENST00000337109.4 CTAGTTGTTTCAGTTATGCTCTTTTAGTTGCAAGGAATCTCAAGTGGGACAAACATAAAA ENST00000453682.1 --AGCTGG---AAAAACACCTCTTTA-CTGATAGGAACCTAA------ATAAACCC---- ** ** * * * **** ** ***** ** * * **** ENST00000337109.4 AGACTCAAAAGCTACAAGTTAGCTCAAGCAATGTGACATTATTTCAAGGATATGT-GCCA ENST00000453682.1 ---CTTAAA-----CAAGTT-GCCCGAGT---------CTAGTT-AATGCTGTGTTGCCA ** *** ****** ** * ** ** ** ** * * *** **** ENST00000337109.4 GGGAATTCAGGAACCACCTCACCAACCCCATCTCCCACTCAGAAATCACCTCCCAGCCTC ENST00000453682.1 GCATGT---GGAAGTAT------AA-----------------------------AGTCTC * * **** * ** ** *** ENST00000337109.4 AGGAAGAGTAGAAATTGGGTGGTGCTCCTCAGCAGGGGAAGGTGGATGTTTAGGCTTGGG ENST00000453682.1 AGG-----------TTGCTTTATGCAACTTGCTTGGTTTGGATGAACGTGTGAGTGAGAG *** *** * *** ** ** * ** * ** * * * * ENST00000337109.4 CTCTGCATGCATGTGACTTGCTTCTTTTTGCATTGTTAACTCCATTCTCTCTATTCACCA ENST00000453682.1 ----GTAGGTATG------------------------AATCCCACT-------------- * * * *** ** *** * ENST00000337109.4 ACTTCTCTACACAGCTTTTGCATACTTACAGTTTCTGTTCCTTTGTAATAACTTTAACTT ENST00000453682.1 -------------GC---------CTTACGGTTCATGCT--------------------- ** ***** *** ** * ENST00000337109.4 GCACCTTTGAGGTTCTTTTCTACATGATGACCTTCAGCTCCTGCTGCTAGTCTCCAATTG ENST00000453682.1 ----------AGTTTTTTCC---------ACTCTCAGATGCTG----------------- *** *** * ** **** * *** ENST00000337109.4 CCAAGGGAATTTAACTGGGCCAGACTACCTTTTTATACTAGGTCTGGTTGGGTCATTGTC ENST00000453682.1 ---------------TAAGTCAG-----------------GGTCTGCTTG----AT---- * * *** ****** *** ** ENST00000337109.4 TAGAGTAGGGATTGGCTGTCCTTAAGTCAGGAGCCCGCTTTGTATTAGCAGGTTTGCATG ENST00000453682.1 --GAAAAGG-------------------AGGA-----CTTTGA--TGACAAGTAT-CATG ** *** **** ***** * ** ** * **** ENST00000337109.4 CAGCAAAAAAACAGTTATGTGAGCAGTTTCACTTGGAGGTTCACATGGGGTGGCAGCACA ENST00000453682.1 ----------GTATTTGTATAACAAGTCT-----AAAAGTTTTAAT------------CC * ** * * * *** * * *** ** * ENST00000337109.4 CTTAACATCTAACACACCAGGTTCATTGTGTTCATAACACTTGTCATTTACTGTAACAAC ENST00000453682.1 CTTCA-GTTAGATACAAC-----CATGG--------ACATTTTTCAA-----GTAATAAT *** * * * *** * *** * *** ** *** **** ** ENST00000337109.4 ATTTTTTCATAGGAGA---GTAAATAGCCCTTCAGCATGCTCATTC--ATGAAACAGAAG ENST00000453682.1 ATTTTT--ATTAGAAATTTGCAGATA--CCTTGAGCCTGTTCTTTGTAATGACATGGAAA ****** ** ** * * * *** **** *** ** ** ** **** * *** ENST00000337109.4 AGGCTGTACAAGTGAAGACAAGGGCTTTTTATGCAAGTTTTGAAAGATAGGTATTTATTT ENST00000453682.1 AAG-------------AACACAGCCTACATATCC---CTTTGTAT-ATAGGA---TATTT * * *** * ** *** * **** * ***** ***** ENST00000337109.4 TTTCTAGAGACAGGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCAATCATAG ENST00000453682.1 TT------------AGCATTG---TAAAGCCC-----------CGGTG------TCATAA ** ** *** * **** * *** ***** ENST00000337109.4 CTCATTGAAGCCTCGCACTCCTGGGCTCAAGTGGTCCTCCTGCCTCAGCTTACTGAGTAA ENST00000453682.1 TT------AACCTTGTCTTT-----------TGTTTCTCATTCCCC----TTTTAAATGA * * *** * * ** * *** * ** * * * * * * ENST00000337109.4 GGATATGTATTTCTTAAAAG-TTAGTTTATCCACTTCAGATTTCATGTTTTCATTTGTAA ENST00000453682.1 AAGTATGAAGCACTTCACTGCTTAGTTCTTCCGT---AAGTTTCAT-TTTAC---TGTGA **** * *** * * ****** *** * ****** *** * *** * ENST00000337109.4 GGATAAACTTTTCCCACAA-ATTTTCAACAATCATTGTAGAAACTAAGGGGGAGAAAGTA ENST00000453682.1 AATGAAAGTGTTCTGAAGATATCCTTGACAG--GATATGCAAACGAATGTAACAAAAAC- *** * *** * * ** * *** * * **** ** * *** ENST00000337109.4 ATCTCAGTTGTTTTAGAAACGAAAAAGTTAAGCATTGTTTACTTGAAGTGGGCAGGGAAG ENST00000453682.1 -CTTCCTTTGTGTTGAAGGCTGGT--CCTAAGTACA---TACTAGATTTCACCAGACGAG ** **** ** * * **** * **** ** * *** ** ENST00000337109.4 CAGCACTGAGTAAAGTTCAATTGAGTGGTTACAGTCTAGGGCAGTGGTTCCCAACTCTCC ENST00000453682.1 TC-CA------AAAGGTCAGATG-----------CTTTGAAAAAAGGCCCCCAGTGC--- ** **** *** ** * * * ** **** * ENST00000337109.4 GATCAGAATCATCTGGGAAGCATTTTCAAACAGCAAAGTACTTTGAAAACCATTATTAAA ENST00000453682.1 -----AAATAATCGAGTAGTTGACCTGGTGAAAAAAAGGA-----AAGACTATT------ *** *** * * * * **** * ** ** *** ENST00000337109.4 TAGAATTATGCATGAATTACTGTTTCAGATCCTTTAATGTGGTAGTTGGTAATAATAAGA ENST00000453682.1 ------TATGCATGCATTGGTCTTTGAG-CTGTTCCGCCTGCTGTCTTGTAA-ACTCAGA ******** *** * *** ** ** ** * * **** * * *** ENST00000337109.4 TGAAATTCCTCTGTTGTTAGTAAAATTATGAAATTGAAGTTCTGCAGCATGTCAGGCCAG ENST00000453682.1 AGCAGTTTTCCTGAGGTGGGT---ATTAC-----TGACCATCT--AGCTCACCAT-CTGA * * ** *** ** ** **** *** *** *** ** * ENST00000337109.4 GATTATTAGGGAGATTCCTCGAAACTAGTGTGTGTTTATTAAAAGGAGAAAGGATAACAA ENST00000453682.1 GACTCATAAGTAGATTT----------GTGAGTGGT------GAGGTGTAGTGAAGACCA ** * ** * ***** *** *** * *** * * ** ** * ENST00000337109.4 TAGAATGTTCTAAAACCAGAAGTCCAAGTGCGTGTCTACTTATGGGACCAATAAATAAAG ENST00000453682.1 CT---TGTTT-------GGGATTCAACATACATGGCCA--------GCCAATGAA-AATG **** * * ** * * * ** * * ***** ** ** * ENST00000337109.4 --AACAGACATTTGATTTGAGGTGAGGTAAAAGCCTGAAACATGGAATGGCATTCTGTTT ENST00000453682.1 TTAACTCACATCTG-------------CATATGCCTTCATCTTGTTATGGAA--CTG--- *** **** ** * * **** * * ** **** * *** ENST00000337109.4 TGATGGATTTTCATTTCTTCGCACTTCTGAGACGGCAAAGCCAACCACTTAGAAGCCTTC ENST00000453682.1 -GAGGCACCATCATT----CATAATGCTTA------AAAATAAAACACCTGCAAGGCAGC ** * * ***** * * * ** * *** ** *** * *** * * ENST00000337109.4 CACATCTTTGTCACCTGCCTGGCTCCTGCTCTCTGATGTACCTCTGGGTAGTGAGATGGA ENST00000453682.1 TA-----TTGTTAAA-ACCTAACTC--GCCCAC-------------------AAGA--AA * **** * *** *** ** * * *** * ENST00000337109.4 AATGGTGCCTGCAGAAGTTGGGGAGAAGGATACTTTTGCACAGCCTCCATGATGTCTTTA ENST00000453682.1 GCTGATGCTCAACGAAGTC------AAATCTCTAGTAATAAAAC-----TGG-GTTACTA ** *** ***** ** * * * * * ** ** ** ENST00000337109.4 TTGCAAATATGGATGACAAGGGTCTCTGTTACAGGGGCCTCAGAGCACCTTCGTTTCTCC ENST00000453682.1 TT-CATATCTTGA----------CTCTACTAC-------CCAA---------GTTCTTTC ** ** ** * ** **** *** ** *** * * ENST00000337109.4 TCTAGACCAGGGACAGGTGTAGAGATAAGGACTGGCAACCAGAGCCTCAGCATCCAAAGA ENST00000453682.1 TGTAAGTCA--------TCTAAA------------CAGCCAGGACCTCAGCA-------A * ** ** * ** * ** **** ******** * ENST00000337109.4 TGGACTGAAGTGGGATGGCTGACAGGCACATAACTTACGGGAAAGGGAATTTCATACATA ENST00000453682.1 T-----------------CTGAC---TAGATAA--------------------AAACAAA * ***** * **** * *** * ENST00000337109.4 CGATTTTTGTTTTGTGGGTAGGAGGGCTTATCATCAACACTGATTTTATAATCTGACAAT ENST00000453682.1 AAATTCTTCTT------------------------------GAGTTTATGATCC-----T *** ** ** ** ***** *** * ENST00000337109.4 AAATGTCTTTCATTAAAGAGTTTACCTAAATGATGTTCGATTATATGTATAATTTATAAA ENST00000453682.1 AAGGGTTTCTTTTTCA------TATCTAAGGGTTTCTTTTTCATATCTAAAGC-----AG ** ** * * ** * ** **** * * * * **** ** * * ENST00000337109.4 ATATTTATGTATAGTTTGTTTATTCAGGTATATGTATAATTTATTGAACACCTACTATGT ENST00000453682.1 GTATTCATAT-TAG-------ATGCTGTCACAT------TTTGCTTATCTCTTGCTGTGT **** ** * *** ** * * * ** *** * * * * * ** *** ENST00000337109.4 CCCAGCATATCTACAAAACTGGGTACATACATACTGTCTAACTGCTAATCCACATTTCCA ENST00000453682.1 ---AACAAACC-----AACCCAAAACATATCTGCT-TAAAACAG-TAA-CCACTTT---- * ** * * *** ***** * ** * *** * *** **** ** ENST00000337109.4 GTCTTACAAAGGACATAATGATTAGTTAAGCCCTAATTTAGATTTGAGGAAACTGAAGCT ENST00000453682.1 --------------------ATTTGTTCA----TGATTC---TTTGG-----TTG--GCT *** *** * * *** **** ** *** ENST00000337109.4 GAGAGAGGGTTAAGTAAATTACCCAAAGTACAGCTAATAAGACCCAGAATCTCAGTCTCA ENST00000453682.1 G-----GGGCT----------------------CTGCTGGG----------------CTG * *** * ** * * ENST00000337109.4 CTCCTTGGGATCCTGTGTATTTCCCTGAGTCTTCTAACATATGAAAATTCATATCTAAAT ENST00000453682.1 TTCTTTGG----TTG---GTTTC----AGT-----------TGGGGTCTC---------- ** **** ** **** *** ** ** ENST00000337109.4 CAACAAGTGACTGTAATCTGGTACTATAAATACTAAATAAACACTTCTTCATAACACTGT ENST00000453682.1 ----------CTGTGA---GGT--TGTAA------------------------------- **** * *** * *** ENST00000337109.4 ACCAATTCAGCTTTTAAATTTTATTACTTTGCTTTCCTGTCCTTTGCCAACTCTTAACCT ENST00000453682.1 ------TCAG------------ATGGCTTTGTTCACATGTC------------------T **** ** ***** * * **** * ENST00000337109.4 AGTTAATCCTAGTTCTGTTGACATTGGACCAGGCTCAGTAAATAAACGAATGGATTTCCA ENST00000453682.1 AGTT--CCCCAGT------------GGGGAAGGTTGAG--AGGGAGTGATC---TTTTCC **** ** *** ** *** * ** * * ** *** * ENST00000337109.4 GCCTTTTTTTCCCATCTGTTCCTGCTTTTAGTCCTCTGAATCTGCTTCTTTTCTTACTGC ENST00000453682.1 TCTTTTCTTCCCCATGTG-----GC---TAGC---TTGGGT----TTCTTTTCATGGTG- * *** ** ***** ** ** *** ** * ******** * ** ENST00000337109.4 TGCTTTATTTT-ACAGTGATTTTGTCAA---ACATAGAATACAG---GACTAAAAATGCA ENST00000453682.1 -GTTTGATCCTGAGAGTGAGCATTTCAAGAGACATAAGCTCCAGTGTGCCAGCACTTATC * ** ** * * ***** * **** ***** * *** * * * * ENST00000337109.4 AAGAAATTGGGTCTGTGTTTAATTTTGATGTTTCAAATTTTGAGCTTCCAAGTCTTTGTG ENST00000453682.1 AAGCATTTGCTTACATCATTCTTGCTAATGTCCTATTTATTGG----CCGAGCC--CGAG *** * *** * * ** * * **** * * *** ** ** * * * ENST00000337109.4 GCCACCCAATGAAGTTTGAGTCTGCCTGTTCAGATGTGAAAGGTAAGGGCTGCAGCAGGT ENST00000453682.1 GTTAAT--ATGGAA---GGATACACCA---CAGAAGTG-----TGAATAC--CAGGAG-- * * *** * * * ** **** *** * * * *** ** ENST00000337109.4 TTAAGGGTGGCCCTTCACCACCCTGTTGTCACCTGCACAGGCACTCCCCCATTTGCAG-A ENST00000453682.1 TTATGG-------TTCATCG----GGAACCACCAAAGTAG-CAATCCACCACTTGTAGTA *** ** **** * * **** ** ** *** *** *** ** * ENST00000337109.4 TGAAGAAATGTTCAGAGAAGAAAAATGATGGACCAAACGTCTGTTTGCACAATTGAAACT ENST00000453682.1 TATACAA-----CAGAAATGTAAAA---------AAA--------TTCATATTTAAG--- * * ** **** * * **** *** * ** * ** * ENST00000337109.4 CTACCAGTGGACTATTCTATTTTCACAGCTACCTAGTTTCTGCCGATGATTTTTTTAAAT ENST00000453682.1 ---CCA--AGA----TCTGTT--------------GTTCC-------------------- *** ** *** ** *** * ENST00000337109.4 GTGAAATAAACAGTGATACTTTCAGGTT ENST00000453682.1 ----------------------------