CLUSTAL 2.1 multiple sequence alignment ENST00000339644.5 ACTGC-AGCCGGAAGTTCTCGGC-----GG----TGGAGGAGCC------------CCGC ENST00000414425.1 AATGCCAGCAACAGACCCTCGTCACTTAGGCTCCTGAATGAGCCACAGAAGTGGGACTAT * *** *** * **** * ** ** * ***** * ENST00000339644.5 GGCAAAGTTG---------CCCACGGAGAGGCT-----CTGCTGCACGATCTCGCGCACC ENST00000414425.1 GGCAGCACTGGGGTGGCCACCAACAGTGACCCTAACATCTACTTCCTGATCCAGAAGATA **** ** ** ** * ** ** ** ** * **** * * ENST00000339644.5 TCCT---TGTCGGACA------------GCAGGT---AG--GGAGAGCGCACTGGGAA-G ENST00000414425.1 TTCTACATGTTCAACACCCTCAAGTCTAACAGGTCCCAGCTGCACAGCACAATGGACATA * ** *** *** ***** ** * * *** ** *** * ENST00000339644.5 CTC--------GGTGAA--------GGA-----------------------CCACCACCT ENST00000414425.1 CTCTCCCTGAAGGTGAACCCCACTGAGATGGTGGCCAAATTCCAGCTGCCCCCACCACCG *** ****** ** ******** ENST00000339644.5 CAT------CCAAGGG-----GATCTT--GCAGAAGTCCTTGCTGCTCCTCTCAGGGG-- ENST00000414425.1 CATAGCAGCTCATGGGCCGCAGAGCTCAAGCAGATGGTGGACCAGAGCCTGTCGGGTGGG *** ** *** ** ** ***** * * * *** ** ** * ENST00000339644.5 ----CAGCGGGGGACCCTCA-----AACTCCTCCCTGAACCTCTCAG----GATTGATTG ENST00000414425.1 GTCTTGGCAGGCTGCCCACTGGTGCAGCTCTTCCCCAAGCTCTTCAGCTGCAGTTGACTT ** ** *** * * *** **** * * **** **** * ENST00000339644.5 CAT---AGCTCCTCATGTTTCTACACTCGGGGCCA-GCACG---TGGA--CCTTGCAC-T ENST00000414425.1 CTCCCGAGGCTGCAGTGCCTGTAGCTTTGAGGCCAAGCGTAAGTTGGAGTCACTGCACCT * ** ** * ** * * ***** ** **** * ***** * ENST00000339644.5 GCTGCTGGTA-----------GGAG--------CGCCTCTGT-----------TCGTGTT ENST00000414425.1 GCAGCTCATCCACAACTACGTGGAGGTCTACTACCCCTCGGTGAAGGACATGGCCGTGTG ** *** * **** * **** ** ***** ENST00000339644.5 CCAGTGCAGGT---TGCCC-------ATGA-----------ACTCCAGGGTCCAGACG-- ENST00000414425.1 ACAGGCCGAGTGCTTGCCCCAGCTGAATAACTTCTTCAGCCACTTCTGGGCCCAGAGGGA *** * ** ***** ** * *** * *** ***** * ENST00000339644.5 ------------------CGATTG--------------TTTTTGGTGCAGAG--GTAGAG ENST00000414425.1 GATGGAGAACAGCCAGCCCGGTGGCCAGGCTGCCAGCTTCTTTGAGGCCGAGCAGTGGAC ** * * * **** ** *** ** ** ENST00000339644.5 CAGGTGCACTTAGTGG----------CGA------------------------------- ENST00000414425.1 CCCGGCCACTTCCTGGACCACAAAGACGAGGAGGACGGCCTGTCTCTGGACCGGAGCAGC * * ***** *** *** ENST00000339644.5 ---ATGAGCTTG---------------ATGCAGGAC------GGGTCC--AGCTG----C ENST00000414425.1 ACCATGGCCTCAGACCACGTGGTGGACATGCAGGACCTCACCGAGTTCCTGGATGAAGCC *** ** ********* * ** * * ** * ENST00000339644.5 TTCTTGCCCAGGGAGT-CGCTG-----CAGCTGTACTG-------CTTGTGCAGGTTG-T ENST00000414425.1 TCTTCGCCCAGCGAATATGCTGTCTTCCTCCTCCACTGGCTCTTCCCTGAGCTCTTTGAC * * ****** ** * **** * ** **** * ** ** *** ENST00000339644.5 CA--------TGGGTGA-----AGAGCT----TGGGGA--ACAG-GGGCACCAGCAGGCG ENST00000414425.1 CACTGCAAGCTGGGCGAGTACTACAGCTGCTATGGGGATGGCAGCAAGCAGGAGCTGGAG ** **** ** * **** ****** *** *** *** ** * ENST00000339644.5 C----GAGG-TGAAG-----TTGCCGATGGACAGG---CTGCT-CTCCTAGATACTGC-- ENST00000414425.1 CCGCAGAGGCTGCAGATCATCTGCAACTACACAGAGGTCTACTTCTCCCATATGCAGGAG * **** ** ** *** * **** ** ** **** * ** * * ENST00000339644.5 GAAGATGCTCGTTGCTG-AGCAG-GCAGTCGGCGC-----CGGGCAACTCCAAG---TTG ENST00000414425.1 GAGGAGGCCTG--GCTGCAGCAGTGTGCCCAGCGCATCAACGACAAGCTCCAGGGCCTGA ** ** ** * **** ***** * * **** ** * ***** * * ENST00000339644.5 GGCTGGG-----------------------------GAT-----CTCCAATTTGTCCAAG ENST00000414425.1 GGCTGGATGCGGGCAGTGAAGACGAGCCCCCCACGTGATGACTGCTACAACTCCTCCAGC ****** *** ** *** * **** ENST00000339644.5 T---CGATAG-GTACCAGT---CAG----------ATCTTCTTGG---AGCGGCACCGCT ENST00000414425.1 CTCCCGATGACATCTCAGTAATCAGGGTGGAGGATAGCTCCAAGGGCGAGCAGCGCCGCT **** * **** *** * ** * ** *** ** ***** ENST00000339644.5 C------------------GCCCTTGAAGCTG-------------TCCTCCACCCTGATT ENST00000414425.1 CCAAGAAGATCTGGCTGGTACTCATCAACCTGGACAAATTGGAGATCCCCCAGCCCAATT * * * * ** *** *** *** ** *** ENST00000339644.5 ACTGAGATGTC----ATCGG--GCAGGCT------GGAGGAGTTGTAGCAGTTGTTGCGT ENST00000414425.1 -TGGAGGTGCCTGGCACCGACTGCCTGCTCAGCAAGGAGCATCTGCA-CAGCATCTATGA *** ** * * ** ** *** **** * ** * *** * * ENST00000339644.5 GGGGGGCTTGCC----------TTCGC--TGCCCGCGTCCA-GCCCCAGGCCCTGGAGCT ENST00000414425.1 GAGCAGCCTGTCCATTGGCAACTTCGCCTTGCACCTGCTGGTGCCCCTGTTCCCCAAGCT * * ** ** * ***** *** * * ***** * ** **** ENST00000339644.5 TGTCGT---TGA-----TGCACTGGGCGCACCGCT----------------------GCA ENST00000414425.1 CTTCACCCATGAGAACCTGCACAAGCAGTACAGCTCCAGCGGTTCCCTGGGCAAGAAGCA ** *** ***** * * ** *** *** ENST00000339644.5 GCCAGGCCT---------------CCTCCTCCTGCATGTGGGGGAAGTAGACCTCCGTGT ENST00000414425.1 GCTGGACCTGTCCTGCATCAAGCTCATTCGCCAGTATGTGTGTCTGCTCTACCTCCATGC ** * *** * * * ** * ***** * * ****** ** ENST00000339644.5 AGTTGCTGATGATCTGCAGCCTCTGCGGGTCCA---GCT-CCTGCTTGCCGCCGTCCCCG ENST00000414425.1 CAAAAACGACCGCTTCTGGACCCTG-GAGTTCATGGGCAACCTGC--GCCGGGACACGAG ** * * * *** * ** ** ** ***** **** * * ENST00000339644.5 TAGCAGCTGTCCTGCTCACC-CAGCTTGCTGTA---GTGGAAGAGCTCAGGGAAGAGCCA ENST00000414425.1 CAGAGGCGCTCCTACCAGCAGCAGTGCAAGGTCCACGTGCTGGCCCCCAGTGCAGAGACA ** ** **** * * *** ** *** * * *** * **** ** ENST00000339644.5 GTGGAGGAGGAAGACGGCAAACTCACCGGG---TGAAGAGG-----------------CT ENST00000414425.1 --TGAGGAGCTATGCAATCAACCCTGAGAGGTTTGAGGAGGAGTTTGAGGGTCCCCCGCT ****** * * *** * * * *** **** ** ENST00000339644.5 TCATCCAGGA--ACTAGGTGAGGGCCTACATGTCCACCACGTGGTCTGAGGCGATGGTGC ENST00000414425.1 GCCCCCAAGAGGAGCAGG-AAGGACTTTTGCAAGATCCCCTTGGAC-AAGGTGGTGGT-- * *** ** * *** *** * * ** * *** * *** * **** ENST00000339644.5 TGCTCCTGTCCAGAGACAGGCCCTCCTCCTCATCTTTGTGGTCC----AGGAAGTGGCCG ENST00000414425.1 --CCCTCGCCCAGCTTCCCGGTGCCCTCTCCCTACCTGCTGTCCGACAAGGAGGTGCGCG * * * **** * * **** * * ** **** **** *** ** ENST00000339644.5 GGGTC-CACTGCTCAGCCTCAA-GCTGGCAGCCTGGCCACCAGGCTG----GCTGTTCTC ENST00000414425.1 AGATCATGCAGCAGAGCCTCTCCGTGGGCAACTTGGCTGCAGGGCTCCTCCACTGCCAAG * ** * ** ****** * **** * **** * **** *** ENST00000339644.5 CATCTCCCGCTG-----------------GGCCC------AGAAGCGGCTGAAGAACTTA ENST00000414425.1 AACCTCCCGCTGCAGTACAATCATTCCCGGGCTTGCAACAAGAAGCAGCTG--GACCCTA * ********* *** ****** **** ** * ** ENST00000339644.5 CTCAGCTGGGGCA----------------AGCAC----TCGGCCTG-TCAC-------AC ENST00000414425.1 CGCAGCTGTGGCTCATCTGCAGACTTTTTAGTACACTTTTAGTGTGCTCACTTTTAGTAC * ****** *** ** ** * * ** **** ** ENST00000339644.5 -----AGCCCTCTCCTT-----------------------CACCG------------AGG ENST00000414425.1 CTTTTAGTTCCCTTTTTTTGGTTGAAAGTGAGACATGATACACTGGGCAAAAGGAACAGA ** * ** ** *** * ** ENST00000339644.5 GGTA--GTAGACCTCCATGTAG-----TTGTGGATG---AGCTG-CAGGTGCAGTGACTC ENST00000414425.1 GGTAAAGAGGTCTTTTGTGTAAGGCTCTTGTGTTTATCTGGCTGGTAGTTAGACTGTCTT **** * * * * **** ***** * **** ** * * ** ** ENST00000339644.5 CA--GCTTAAGCTTG------GCCTCAAAGCTGCAG-GCACT---GCAGCCTTGGGAGAA ENST00000414425.1 CACTGTTTGGTGTTGCTGTAGGTGTCAGAGGCAAAATGTACTCAGGTGTCCTTGTTAGTA ** * ** *** * *** ** * * *** * ***** ** * ENST00000339644.5 GTT----GACTGTGGCTGA--------AGAG-------CTTGGGGAAGAGCTGCACCAG- ENST00000414425.1 TCTCCCCGCTTGTCTTTGAGTTTCCCTAGAGACTCCTTCTTAAATAAGTGCTGAGACAGT * * *** *** **** *** *** **** *** ENST00000339644.5 CAG------CCAGCAGGC-------------CAGGACCCCACCTGAC---------AGGC ENST00000414425.1 CAATTCCTTCCATTATAATTCCCTTATTATACAAAAGTCCTACTGATGTGGTGAGGAGGC ** *** * ** * ** **** **** ENST00000339644.5 TCTGGTCCAAGA------------------TCTGC--TTGAGCTCCATGCCCGTGAGCTG ENST00000414425.1 ACTTATGTGGGAGAGGAAATGTTCGATAATCCTGTAATTAGGTTCCAGGCACA-GTGC-A ** * ** *** ** * **** ** * * ** ENST00000339644.5 CTATGGGGTGGTGGGGGTCGGCTGGAATTTGGCCAC---CATCTCAGTGGG--GTTCACC ENST00000414425.1 CAGTGAGCCTATGCTCCTAGGCTGTGACCTGCACATGTGCTTCTCAGTAGCCCGTGTCCC * ** * ** * ***** * ** ** * ******* * ** ** ENST00000339644.5 TT------CAGGGAGA-GCAGG-----------------TCCACTTT--GCTGTGCAGCT ENST00000414425.1 TGGTGGGACAGGAAGGCACAGGGAACTGGAGTTTGACACTTCTCTTTCCGCAACTCAGTT * **** ** **** * * **** ** *** * ENST00000339644.5 GGGACCTGTTGGA-CGTGAGCGTGTTGAGCAT--GTAGAA-CATCTCCTGGATCAGGAAG ENST00000414425.1 AGACTCTGATAAAACCCCAATACATTAGGCTCTGGTAAAAATATTTTCTG--TTAAGGA- * *** * * * * ** ** *** ** ** * *** * * * * ENST00000339644.5 TAGATGTT---AGGGTC--ACTGTTGGTGGCTGCCCCAGTGCTGCCACAGTCCCATTTCT ENST00000414425.1 TAGGTTTTTGCAAAGTAGAACTAATGTT--CTGCTTTTATTTCAAAATGGTTACTTTTCC *** * ** * ** *** ** * **** * * ** * **** ENST00000339644.5 -ATGGCTCATTCAGGAGCCTAAGCAGCAAGGGGCTGTTG-CTGGCATTTGCCTT------ ENST00000414425.1 CATCGTCCTGCCAA------AATCAGGAGGGGGTTTTTCTCTGATCTACACCCTGAGAAT ** * * ** ** *** * **** * ** *** * ** * ENST00000339644.5 CTGGAAGAGCTCATATGTGTTTAGC-------------AGGTCCCCTGAG---GGA---- ENST00000414425.1 CTGGTAAGGCTACTGAAGGTAAAACTCCTGAAAGTTGGGGCTCTCCTAAGACTGGACATG **** * *** * ** * * * ** *** ** *** ENST00000339644.5 GGGTTCTT----------CTTCTCCATG----ACCTTGTGCAAGATGCCA--TACAG--- ENST00000414425.1 GAGTTTTTAACTGTCAAGCTCATCCACATTGAACCCTCAGCACTTTGTCAATTACAGTTT * *** ** ** **** *** * *** ** ** ***** ENST00000339644.5 AGGCTTCTTGTAGTAAGGGGTGGTGGC----ATGG-------TTGCG---GGGCTCCTCC ENST00000414425.1 AGGTTTTTC-TACCCTGGGAT--TGGCTCCAATAGCCAGCTTTTACATCTGAGCTTCCCT *** ** * ** *** * **** ** * ** * * *** * * ENST00000339644.5 TT-GCCTGCCCACA-----CAGAGCCTG---AGCTCCTGCCTTGC------CAGCCTGCT ENST00000414425.1 TCAGATTAACCGTGATTCTCTGTATCTGCCTGTCTCCAGTTTTGAGGGTAGTAATCTGCC * * * ** * * *** **** * *** * **** ENST00000339644.5 CT------CCATTGCCTTGGCAGGGC---GAGCTGTTCTTGGGTTCCA-------CA--- ENST00000414425.1 CTGTGACCTCAATTCTCTGACAGATCTAAGAAGAGTTGTTGACTTTCAGTTTGTTCAGCT ** ** * * ** *** * ** *** *** ** ** ** ENST00000339644.5 -------TGCCTGCT--AGGAGCGCCTCTGG-GATC----AGCTACCTCCTCTCCACACT ENST00000414425.1 TTTTTTTTTCTTGTTTTGAGAATGGGAGTGATGACTTCCAAGCTTCTTATACTCCAGACT * * ** * ** * ** ** **** * * ***** *** ENST00000339644.5 GGGGA-TGGAG---TCTGGCTGGCCATTGCTGAC--CAGCTGAGTCCT----------TG ENST00000414425.1 GGAAACTGGAAGTCTTTAATTGATCTTGGTTCATTTCATTTCACTCCCATAGCTTGTCTG ** * **** * * ** * * * * * ** * * *** ** ENST00000339644.5 AGG---------GCAGTAAAGAC-GCTGTCCAGAGGGTGCTTCTCAGAAGTCCTGGAATT ENST00000414425.1 GGGATGACTTTGGCAACAAAAGCAGCAGCCCA-----TGCCCGTGCACCATCTGGGAG-- ** *** *** * ** * *** *** * ** *** ENST00000339644.5 CACGGAGCAGCCTAGAGCAGCATCTTTGG--CCTCTGT-CTCCACTC---TCACTTCTTA ENST00000414425.1 AACAGGGGGGCCCTGATGATGACTCTAGGGCCCTCCATGCCCTACTCGTCTCTCTCTTCA ** * * *** ** * * * ** **** * * * **** ** ** * * ENST00000339644.5 GAAGTTCTTCTACATC---AATTTTTTTTGGAGATGGTTCTGA------CTCTGTCA--- ENST00000414425.1 GGAGTGG----ATATCTGAGGCTCACTTTGGGGACAGGTCAGAGTAAGCCTCCCTCAGGT * *** * *** * ***** ** * ** ** *** *** ENST00000339644.5 --CCCAGGCTGGAGT-----GCA--------GCAGTTGATCAGAGCTCACTGCA---TCC ENST00000414425.1 GTCTGAGGCTTGGATAAAAGGCATCTTGGGTGCAGTCTGTGGGTGTGGAAAGAACAGTGA * ***** * * *** ***** * * * * * * * ENST00000339644.5 TTGACCTCCCAGACTCAAAAGAG--CCTAGCT--------------ACTTAGGAGTAGCT ENST00000414425.1 TTGAGCTCT----CTCAAGAGAGATCTCAGTTTGAATTTCTGTTCCACTACATACTACCT **** *** ***** **** * ** * *** * ** ** ENST00000339644.5 AGGA---CT---ACAGGCCACGGCCACCATGCC---------TGGCTAA------TCTTT ENST00000414425.1 ATGATATCTTTAAAAAGCCACT-CAACCCTGGCCGGGTGTGGTGGCTCACGCCTGTATTC * ** ** * * ***** * *** ** * ***** * * ** ENST00000339644.5 TAAATTTTTTGTAGAGGCAGAGG----TCTCTCACTGTGTTGCCCAGACAAGTCTCAAAT ENST00000414425.1 CCAGCACTTTG-GGAGGCTGAGGCGGGTGGATCACGAGGTCAGGAGAGTGAGACC---AT * **** ***** **** * **** ** ** * ** ENST00000339644.5 TCTCGGGCTCAAGTGGT-----------CCTCCCAAAGTGCTGGGA--TTAAT--GGCGT ENST00000414425.1 CCT--GGCTAACATGGTGAAACCCCGTCTCTACTAAAAATTTAAAAAATTAGCTGGGCAT ** **** * **** ** * *** * * *** *** * ENST00000339644.5 GA-GACACCGTACCTG--GCCATATTTTTTTT------TTTTTTCAAAAAATTCATTTGT ENST00000414425.1 GGTGGCGG-GTGCCTGTAGTCCCAGCTACTCGGGAGAATGAGGCGGGAGAATGAGGCAGT * * * ** **** * * * * * * * *** ** ENST00000339644.5 AGA---GTTTAAA------AAGT--ATCTTTCGATCAA--GAGTTC---TTATTGTATTT ENST00000414425.1 AGAACGGTGTGAATCCGGGAGGTGGAGTTTGCGATGAGCGGAGATTGCGCCACTGCACTC *** ** * ** * ** * ** **** * *** * * ** * * ENST00000339644.5 ATGTTTGC-----------AAATTTCATTT--------------CCCATTC--------- ENST00000414425.1 CAGCCTGGGCGACAGAGCGAGACTCCATCTAAAAAAAAAAAAAACCTACTCAACCCTAAT * ** * * * *** * ** * ** ENST00000339644.5 ----TGTTGCTTGCCTTTTCACTCAGTGAGTTATTTTATGATTACAAATCCCTATTTTTT ENST00000414425.1 AGGCTGCAGTTTATCTTTAAA---AATAAACTAAACCAGGATAA-GGATACTGAGCACTT ** * ** **** * * * * ** * *** * ** * * ** ENST00000339644.5 ATGTTATTTT--------------ATTA-CTATTTATTAACCTA--TCTATCT-ATCTAT ENST00000414425.1 ACATTGGTTTCAAGAAACAGGGAAACTAACTGTGCAGGAACTGAGATTTGTTTGATCTGT * ** *** * ** ** * * *** * * * * * **** * ENST00000339644.5 CTACCTACCTATCTATCTATCTAT---CTATCATCTA----TCT------ACCTAGATAG ENST00000414425.1 CGCGTGGACTAGGTATGTATCCCCACCCTTTGGTTTAGAGGCCTGAGAGCATCCAGGAGG * *** *** **** ** * * ** ** * * ** * ENST00000339644.5 ACAGAGA--TATCTA-TAGATAGC-TATGGTAAATTTTGAAACACGTTCCAAATACATTA ENST00000414425.1 ACAGGAAATCACCTAACCCCTGGCATAAGGTGTATAAC-AGGCAGGCCCTCAGGACACAG **** * * *** * ** ** *** ** * ** * * * *** ENST00000339644.5 TAATAAATTGTGTGTTTTGCT----- ENST00000414425.1 C--CAGCCTGTGGCTGCCACAAAGGA * **** * *