CLUSTAL 2.1 multiple sequence alignment ENST00000344327.3 GGGATCTTGACGGAGAGTGCGGGGGATGAAGGCGGGAGCTGAGGGCTGGAGAGTCTCTGT ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 TGACATAGTAACTCTTCAGCTCCGTCTCCCTTGCTCTCCGCTCTTACGCTTCGCTACCAC ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CAGCGGCCCCGCCTGTGCCCTCTCTGCCCGGGCGCCCCAGACGCATCCTCGCGGGGTCTC ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CTCGGCCTGACCTGCTCAGGTCAAGATCCTCTTTGCACCCCCTTAAGTGGTGACTTTTCC ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CCGGGCCAGTGGGCGAGCCACTTGCGGCGGGCGTCTGCACCCCCTGCTTCACCGTCGTCC ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CCTGGGCACCGGTCTGCCCAGGTCCAGTTCGGCCGCTGACGCGAACCCTCCGCACCGGGT ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CCCCGCTGGAACTGCCCACTCGGCTCCCCCGGGAGCGGGGCCCAGGCCAGTCGGGCGTTC ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CCGCCATGAGCCAGAGCCCGGCGTTCGGGCCCCGGAGGGGCAGTTCTCCCCGGGGCGCTG ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CCGGAGCCGCTGCGCGGCGCAACGAGAGCCAGGACTATCTGCTCATGGACTCGGAGCTGG ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 GAGAAGACGGCTGCCCGCAAGCCCCGCTGCCTTGCTACGGCTACTACCCCTGCTTCCGGG ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 GATCTGACAACAGACTGGCTCACCGGCGGCAGACAGTTCTCCGTGAGAAGGGGAGAAGGT ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 TAGCTAATCGAGGACCAGCATACATGTTTAGTGATCGCTCCACAAGCCTATCTATAGAGG ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 AGGAACGCTTTTTGGATGCAGCTGAATATGGTAACATCCCAGTGGTGCGGAAGATGTTAG ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 AAGAATGCCACTCACTCAACGTTAACTGTGTGGATTACATGGGCCAGAATGCCCTACAGT ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 TGGCAGTGGCCAATGAGCATCTGGAAATTACAGAACTTCTTCTCAAGAAAGAAAACCTCT ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CTCGAGTTGGGGATGCTTTGCTTCTAGCTATTAGTAAAGGTTATGTTCGGATTGTGGAAG ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CAATTCTCAGTCATCCGGCTTTTGCTGAAGGCAAGAGGTTAGCAACCAGCCCTAGCCAGT ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CTGAACTCCAGCAAGATGATTTTTATGCCTATGATGAAGATGGGACACGGTTCTCCCATG ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 ATGTGACTCCAATCATTCTGGCTGCCCACTGCCAGGAATATGAAATTGTGCATACCCTCC ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 TGCGGAAGGGTGCTAGGATTGAACGGCCTCATGATTATTTCTGCAAGTGCAATGACTGCA ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 ACCAGAAACAGAAGCATGACTCGTTTAGCCACTCCAGATCTAGGATTAATGCCTATAAAG ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 GCCTGGCAAGTCCGGCTTACCTGTCATTGTCTAGTGAAGATCCAGTCATGACGGCTTTAG ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 AACTTAGCAATGAACTGGCAGTTCTGGCCAATATTGAGAAAGAGTTCAAGAATGACTACA ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 AAAAACTGTCAATGCAGTGCAAAGACTTTGTTGTTGGACTCCTTGATCTGTGCAGAAACA ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CTGAAGAAGTCGAGGCCATTCTGAATGGGGATGTTGAAACGCTCCAGAGTGGTGATCACG ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 GTCGCCCAAATCTCAGCCGTTTAAAACTTGCCATTAAATATGAAGTAAAAAAATTTGTAG ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CTCATCCAAACTGCCAACAGCAACTTCTCTCCATTTGGTATGAGAATCTTTCTGGTTTAC ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 GACAGCAGACAATGGCGGTCAAGTTCCTTGTGGTCCTTGCTGTTGCCATTGGACTGCCCT ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 TCCTGGCTCTCATTTACTGGTTTGCTCCATGCAGCAAGATGGGGAAGATAATGCGTGGAC ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 CATTCATGAAGTTTGTAGCACACGCAGCCTCCTTCACCATTTTTCTGGGACTGCTAGTCA ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 TGAATGCAGCTGACAGATTTGAAGGCACAAAACTCCTTCCTAATGAAACCAGCACAGATA ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 ATGCAAAACAGCTGTTCAGGATGAAAACATCCTGCTTCTCATGGATGGAGATGCTCATTA ENST00000421233.1 ------------------------------------------------------------ ENST00000344327.3 TATCCTGGGTAATAGGCATGATATGGGCTGAATGTAAAGAAATCTGGACTCAGGGCCCCA ENST00000421233.1 ---------------GCATGATATGGGCTGAATGTAAAGAAATTTGGACTCAAGGCCCCA **************************** ******** ******* ENST00000344327.3 AGGAATATTTGTTTGAGTTGTGGAACATGCTTGATTTTGGTATGTTAGCAATTTTCGCAG ENST00000421233.1 AGGAATATTTGTTTGAGTTGTGGAACATGCTTGATTTTGGTATGTTAGCAATTTTATCAG ******************************************************* *** ENST00000344327.3 CATCATTCATTGCGAGATTCATGGCATTTTGGCATGCTTCCAAAGCCCAGAGCATCATTG ENST00000421233.1 CATCATTCATTGCAAGATTCAGGGCATTCTGGCATGCTTCCAAAGCCCAGAGCATCACTG ************* ******* ****** **************************** ** ENST00000344327.3 ACGCAAATGATACTTTGAAGGACTTGACGAAAGTAACATTGGGAGACAATGTGAAATACT ENST00000421233.1 ATGCAAGTGATACTTTGAAGGACTTGACAAAAGTAACATTGGGAGATAATGTGAAATACT * **** ********************* ***************** ************* ENST00000344327.3 ACAATTTGGCCAGGATAAAGTGGGACCCCTCTGATCCTCAAATAATATCTGAAGGTCTTT ENST00000421233.1 ACAGTTTGGCCAGGAGGGAGTGGGACCCCTCGGATCCTCGTATGGTGTCTGAAGGTCTTT *** *********** ************* ******* ** * ************* ENST00000344327.3 ATGCAATTGCTGTAGTTTTAAGTTTCTCTAGGATAGCTTATATTTTACCAGCAAATGAAA ENST00000421233.1 GTGCAGTTGCTGTGGTTTTGAGTTTCTCTGGGATAGCTTGTATTTTGCCAGCAAATGAAA **** ******* ***** ********* ********* ****** ************* ENST00000344327.3 GCTTTGGACCTCTGCAGATATCACTTGGAAGAACAGTCAAAGACATCTTCAAGTTCATGG ENST00000421233.1 GCTTTGGACCTCTGCAGACGTCGCTTGGAGGAGCAGTCAAAGACATCTTCAGGTTCATGC ****************** ** ****** ** ****************** ******* ENST00000344327.3 TCATATTCATTATGGTGTTTGTGGCCTTTATGATTGGAATGTTCAATCTCTACTCCTACT ENST00000421233.1 TCATATTCATTATGGTGTTTGTGGCCTTTATGATTGGAATGTTCAACCTCTACTCCTACT ********************************************** ************* ENST00000344327.3 ACATTGGTGCAAAACAAAATGAAGCCTTCACAACAGTTGAAGAGAGTTTTAAGACACTGT ENST00000421233.1 ACATTGATGTAAAACAAAATGAAGCCTTCACAACAGTTGAAGAGAGTTTTAAGACACTGT ****** ** ************************************************** ENST00000344327.3 TCTGGGCTATATTTGGACTTTCTGAAGTGAAATCAGTGGTCATCAACTATAACCACAAAT ENST00000421233.1 TCTGGGCTACATTTGTGCTTTCTGCAGTGAAATCAGTGGTCATCAACTATAGCCACAAAT ********* ***** ******* ************************** ******** ENST00000344327.3 TCATTGAAAACATTGGTTACGTTCTTTATGGAGTCTATAATGTTACGATGGTCATTGTTT ENST00000421233.1 TCATTGAAAACATTGGTTATGTTCTTTATGGAGTCTATGATGTTACAATGGTCATTGTTT ******************* ****************** ******* ************* ENST00000344327.3 TGCTAAATATGTTAATTGCCATGATCAACAGTTCATTCCAGGAAATTGAGGATGACGCTG ENST00000421233.1 TGCTAAATATGTTAATTGCAATGATCAACAGTTCACTCCAGGAAATTGAGGATGACGCTG ******************* *************** ************************ ENST00000344327.3 ATGTGGAGTGGAAATTTGCAAGGGCCAAACTCTGGTTTTCCTACTTTGAGGAGGGC-AGA ENST00000421233.1 ATGTGGAGTGGAAATTTGCAAGGGCCAAACTCTGGTTTTCCTGCTTTGGGGAGGGGGAGA ****************************************** ***** ****** *** ENST00000344327.3 ACACTTCCTGTACCCTTCAATCTGGTGCCGAGTCCAAAGTCCCTGTTTTATCTCTTACTG ENST00000421233.1 GCACTTCCTGTTCCTTTCAATCTGGTGCCGGGTCCAGAGTCCCTGTTTTATCTCTTGCTG ********** ** *************** ***** ******************* *** ENST00000344327.3 AAGCTTAAAAAATGGATTTCTGAGCTGT-TCCAGGGCCATAAAAAAGGTTTCCAGGAAGA ENST00000421233.1 AAGCTTAAAGGGTGGATTTCTGAGCTCTATCCAGGGTCATAAAAAAGGTTTCCAGGAAGA ********* ************** * ******* *********************** ENST00000344327.3 TGCAGAGATGAACAAGATAAATGAAGAAAAGAAACTTGG--AATTTTAGG-AAGTCATGA ENST00000421233.1 GATAGAGCTAAGTAAGTAGAGCTAAGTAAGTAGAGCTAAGTAAGTACAGCTAAGTAGGGA **** * * *** * *** ** * * * ** * ** **** ** ENST00000344327.3 AGACCTTTCAAAATTATCACTTGACAAAAAACAGGTTGGGCACAATAA--ACAACCAAGT ENST00000421233.1 AAG----ACAGGA-----ACTTG-CAGGAACTAA--CAGGTACCATAGGGACAGACAGGG * ** * ***** ** ** * ** ** *** *** ** * ENST00000344327.3 ATAAG--GAGCTCAGAAGATTTCCATCTAAATAGTTTCAATAATCCTCCAAGACAATATC ENST00000421233.1 ACAGATAGAGAT-AGATGAAGGCTAGCAATATAAGGTCAGTG---CCCTAAAGAGGTACT * * *** * *** ** * * * * *** *** * * * ** ** ENST00000344327.3 AGAAAATAA--TGAAAAGGCTCATTA--AAAGATATGTACTGCAGGCCCAGATAGATAAG ENST00000421233.1 GATCAGTGCCCTAAAGAGGTACAAAAGTAAAGACTAGTAATATAAGGTCAGTGCCCTAAA * * * ** *** ** * ***** *** * * * *** *** ENST00000344327.3 GAGAGTGATGAAGTGAAC---GAAGGGGAACTGAAGGAAATTAAGCAGGACATCTCAAGT ENST00000421233.1 GAG-GTACTGGTCTGTGCCCTAAAGAGGTACAAAAGCAAA--GACTAGCA-ATATAAGGT *** ** ** ** * *** ** ** *** *** * ** * ** * * ** ENST00000344327.3 CTCCGCTATGAA------CT--------CCTTGAAGA-----AAAATCTCAGAATACAGA ENST00000421233.1 CAGTGCCCTAAAGAGGTACTGGTCAGTGCCTTAAAGAGGTACAAAAGTAGAGAGTAGTGA * ** * ** ** **** **** **** *** ** ** ENST00000344327.3 AGACCTAGCAGAACTTATTAGAGAACTTGGAGAGAAATTAT---CCATGGAACCAAATCA ENST00000421233.1 AGAC-TAGCAGAGATTTGCAG-GGACAGACAGGAACATTCTGAATTATGGAAATTAGCTA **** ******* ** ** * ** ** * *** * ****** * * ENST00000344327.3 AGA---GGAAACCAATAGATAA-TGCGAAGACTTCCTTAGAAATTCATATTTATTTGTCC ENST00000421233.1 TGGCTCAAAGTCCAATCAAAATCTGAGAGGGCAAATATAAAAGGA-ATAGAGAGGAGGAG * * ***** * * ** ** * * ** ** *** * * ENST00000344327.3 ACTTGAAGCCATATTATTTTCTGATTTATTTTCTTAAGTGCCAATGGGCCCACCTTTTAA ENST00000421233.1 GCAAGGAAGGATAAAAATGCTC--TTTCTTTTCT----CTCCGACAGG---ACCTTTTGG * * * *** * * *** ****** ** * ** ******* ENST00000344327.3 A--CAAGAAAACGTTA--AATAACTTGGGCCATCCTATCATCTGGA-----GCCCTAGTA ENST00000421233.1 ATTCAAGGTTGTGCTAGCAATAGGAAATGTTACTCT-TGATATAAATACACGTTTTATTA * **** * ** **** * * ** * ** * * * ** ** ENST00000344327.3 TCTAATTT---TTTTGGTGATTAAACTCCATTG-TTCAG-----GGTAAAGGCTGTAGAT ENST00000421233.1 CATGCTCTGAATGTTGCTTGTTTACCTGCATTAATTCAACCTTTGATAAAAAT--CAAAT * * * * *** * ** * ** **** **** * **** * ** ENST00000344327.3 AATGAGGAAAATTATGCCCAGTT-----GTTTGGTGCT-TGTTTTATAAACTGCTTTCTT ENST00000421233.1 TATCTTGATAATTAAAGCCAGGGAAGGAGTTTGGTTCCCTGTGTCACTAAATAGACCATG ** ** ***** **** ******* * *** * * ** * * ENST00000344327.3 GGATATAACTAACTCTTGTGATGATGTCATTG----CCATGTAG-----TGTCTGCCTGA ENST00000421233.1 GGAGACATCACCCTCTATTTATATTGTAACTGAGATCCTTAAAAACTCTTATCCCATTCC *** * * * **** * ** *** * ** ** * * * ** * ENST00000344327.3 AAATGGGTCCCAGCGGACAGGGGCTGACCCACGTTACTCCCCATGCGGTTTTTCCTCTGA ENST00000421233.1 AAAAGATTTACAGTTGA---AGGCCATTGGAGGCT-CTACATTTGTGGATTTTGTTCTGG *** * * *** ** *** * * * ** * ** ** **** **** ENST00000344327.3 AGTTTATTT-------CAGGTTCCTTCTTGCCTGCTC-TGTGGAT----CCCCTGCTGGG ENST00000421233.1 TGGTTGTGTGCTTGTGCTGTCTCCTTTTAGTCTGCAGATGTGGAAGCTGCCTCTGAAGAG * ** * * * * ***** * * **** ****** ** *** * * ENST00000344327.3 GACTCCCAGCTCTGAAATTTGGGAAAAAGTAGCC--CATGGGCCTTTA--GAATGCTTTA ENST00000421233.1 GAAGCC-ACCTCTGAA------GAGAAAGCTGCCACCAAGAACAAGCAATGAGAGCTGTG ** ** * ******* ** **** *** ** * * * ** *** * ENST00000344327.3 ATCCTTTCTTTAGAATGCTGTTTAAACACCATTT------ACCCTACTTATCCCTCAATG ENST00000421233.1 GCGGTTTTACAAAAAAG--AAAAGGGGGGCATGTTGGGAGAAGCTGAGTGTTGGGAGAAA *** * ** * *** * * ** * * * ENST00000344327.3 CA----CATGATTGATA---CCGT--TCATACAAAATGGTCTTACATC-TATGTAAAATT ENST00000421233.1 CAGAGGCAGGGCTTGCAAGTCTGAAATGATGTAAAAGAGTCTTGGAACATGTCCAAGGTC ** ** * * * * * * ** **** ***** * * * * ** * ENST00000344327.3 T----TCTGA-----TTCATCTATTTGAAAACATTACACTTAACAATGAAAA----AAGT ENST00000421233.1 CAGGGTCTAAAACCCCTCATGGCCTTTGGAACACCAAGCTCTGTGCTAAAAGGTGGAAGG *** * **** ** **** * ** * *** *** ENST00000344327.3 TTTTCCT------CCA----CTGAACCCTGGAAACATGGTCCAGTTTTGTGTGTGTGCGT ENST00000421233.1 CTACCCTGATGCACCATAATCTAAGCCCAGGGCATAAAACCC---CTCATG-----GCTT * *** *** ** * *** ** * * ** * ** ** * ENST00000344327.3 GTGTGTAAATGTGTACACACAGACATAAAGTACTTGCCCTAGTTTGTGGCTAATGT-GGA ENST00000421233.1 GGATAGAATCCAGGGCTCAGAG-CACAAA--ACCCCTCATGGCTTGGATAGAATCCAGGG * * ** * * ** ** ** *** ** * * * *** *** ** ENST00000344327.3 CACACA----AAAGCTCTTTATGTTAT---AAATTTTTATTG--TCACTAAAAAATT--- ENST00000421233.1 CTCAGAGCATAAAACCCCTCATGGTCTCTGAAATGTGTCTAGACTTGCTGGCTCCTTGCT * ** * *** * * * *** * * **** * * * * * ** ** ENST00000344327.3 --TTACTGTCTAAA---TAA--GTACCTTTTATTGGAGAAAAAT------CAAAACCCCA ENST00000421233.1 CCTTGCTCTCCCAGGATTGATTGTATCTTGAGTTAAAAGAACCTGCTCTCCATTATCTCA ** ** ** * * * *** *** ** * ** * ** * * ** ENST00000344327.3 AACAAACACTGTGGTTGTTTGGTTCCATTATAGCAC--AATTTTGTGCC-ATTTCTGGGA ENST00000421233.1 AGTAG---CAGAGCATATTCTAAACCATTACAGCTGTAAATCTTGTGCTTAATGCAATGC * * * * * * ** ****** *** *** ****** * * * * ENST00000344327.3 GCATTTACAGATGAATCCCCACACT-TAGCCATTGAATGTAAAGGGGAAAAATAAG--GT ENST00000421233.1 GCCCTTTCAA------CCCCACATTCTCACCACCTGTTTCTTTGATCACCAATAAATAGT ** ** ** ******* * * *** * * * ***** ** ENST00000344327.3 GAGAATTTGTAAATACTTAT--CTGTTATTTTCAATATGTTC----TATCCTTCT--ACC ENST00000421233.1 CTGGGCTTCCAGA-GCTCAGGGCCTTCACAGCCTCCATACTCACATTGGCCCCCTGGACC * ** * * ** * * * * * ** ** * ** ** *** ENST00000344327.3 CAAATA---TATAAAACAGGAATTTG-CATTCATGTGCATTTACCAAGAGGTTGTTGTTG ENST00000421233.1 CAGTTTCTCTCTCTAACTGTCTTTTCTCATTCCTTTGACTCCACCA-GACTTCGTCACCC ** * * * *** * *** ***** * ** * **** ** * ** ENST00000344327.3 TTACTTACTGATCATGTGAAGTGGTGTCTTAAACAACTA-----AAAGCGA--------- ENST00000421233.1 CCATGACCTGGTGTTG-GGTCTGATCACCCCAACATCTGCCCCTGCAGCAGATTTATGCC * *** * ** * ** * * **** ** *** ENST00000344327.3 TGAAGGTTCATATGTTTACTCAAAGACCATTGGCATTCAG----AGGATGCTGGACATTA ENST00000421233.1 TGGACGTCCAGGTGTTTCCATATAT-CCTCTGAAATCTAGGTGGAGGCTTCCAAGCCTTA ** * ** ** ***** * * * ** ** ** ** *** * * * *** ENST00000344327.3 ACTGGAAC----TGC-TACTTCCA-ATTCAATA----ATGGGAGATTTCAA-ATGCAAAT ENST00000421233.1 ACTCTTGCCTTCTGCATACCTGCATGCCCAATACCATGTGGAAGCCACCAAGACTTGGGG *** * *** *** * ** ***** *** ** *** * ENST00000344327.3 CTTTAACTTCATCTTAAAG--ATGAAATG-GTTGCAGAA-AATCTGTTT-AGCTCCAACT ENST00000421233.1 CTTTCACCTC----TGAAGCAATGGCCTAAGCTGTACCTTGGTCCGTTTTAGCCACAGCT **** ** ** * *** *** * * ** * ** **** *** ** ** ENST00000344327.3 TTGGCT----TAATTTAAAT-CAAAGAAC-AT---TTA----TGTAACCAGATCAGAAAA ENST00000421233.1 GAAGCTGGAGCAGCTGGGATGCAGGGTACCATGCCTCAAAGCTGCA--CAGACCAGCAGG *** * * ** ** * ** ** * * ** * **** *** * ENST00000344327.3 ----TA----CAGC---TGAAA--ATTTATATTCAGT--GATTTTGTATTTGTG----GA ENST00000421233.1 GCCCTAGGCCCAACCCATGGAACCATTTTTTCTTCCTCGGCCTCTGGGCCTGTGATGGGA ** ** * ** ** **** * * * * * ** **** ** ENST00000344327.3 T-----------ACTACTTATGGAA-------AAG-----TTAC--------TTGGTGAT ENST00000421233.1 TGGGCTGCCACAAATATCTCTGAAATGTCCTGAAGACTTTTTTCCCATTGTGTTGGCTAT * * ** * ** ** *** ** * **** ** ENST00000344327.3 --ACATAAAGATCGATTTT-------CAAATA- ENST00000421233.1 TGGCATTTGGCTCCTTGTTACTTATGCAAATTT *** * ** * ** *****