CLUSTAL 2.1 multiple sequence alignment ENST00000355354.7 TGGGCAGTGGGTCCTGCCTGTGACGCGCGGCGGCGGTCGGTCCTGCCTGTAACGGCGGCG ENST00000529418.1 ------------------------------------------------------------ ENST00000355354.7 GCGGCTGCTGCTCCGGACACCTGCGGCGGCGGCGGCGACCCCGCGGCGGGCGCGGAGATG ENST00000529418.1 ------------------------------------------------------------ ENST00000355354.7 TGGCCCCTGGTAGCGGCGCTGTTGCTGGGCTCGGCGTGCTGCGGATCAGCTCAGCTACTA ENST00000529418.1 ------------------------------------------------------------ ENST00000355354.7 TTTAATAAAACAAAATCTGTAGAATTCACGTTTTGTAATGACACTGTCGTCATTCCATGC ENST00000529418.1 ------------------------------------------------------------ ENST00000355354.7 TTTGTTACTAATATGGAGGCACAAAACACTACTGAAGTATACGTAAAGTGGAAATTTAAA ENST00000529418.1 ------------------------------------------------------------ ENST00000355354.7 GGAAGAGATATTTACACCTTTGATGGAGCTCTAAACAAGTCCACTGTCCCCACTGACTTT ENST00000529418.1 ------------------------------------------------------------ ENST00000355354.7 AGTAGTGCAAAAATTGAAGTCTCACAATTACTAAAAGGAGATGCCTCTTTGAAGATGGAT ENST00000529418.1 ------------------------------------------------------------ ENST00000355354.7 AAGAGTGATGCTGTCTCACACACAGGAAACTACACTTGTGAAGTAACAGAATTAACCAGA ENST00000529418.1 -----------------------------------TTATGAAGTAACAAAGTTAAGCAGA ** ********** * **** **** ENST00000355354.7 GAAGGTGAAACGATCATCGAGCTAAAATATCGTGTTGTTTCATGGTTTTCTCCAAATGAA ENST00000529418.1 AAAGGCAAAACAATCTCAGAACTAAAACACAATGTTGTTTCATGGCTTTCTCCAAATGTA **** **** *** ** ****** * ************* ************ * ENST00000355354.7 AATATTCTTATTGTTATTTTCCCAATTTTTGCTATACTCCTGTTCTGGGGACAGTTTGGT ENST00000529418.1 AGTAGCCTCATTGTTATTTTCCCAATTTTAGCTGTACTTATGTATTAAAGACAAATTTGT * ** ** ******************** *** **** *** * **** ** ** ENST00000355354.7 ATTAAAACACTTAAATATAGATCCGGTGGTATGGATGAGAAAACAATTGCTTTACTTGTT ENST00000529418.1 G-----ACACTTCACTATAAATCCAATAG----GGTGAGAAAACCATTATTTT---TATT ****** * **** **** * * * ********* *** *** * ** ENST00000355354.7 GCTGGACTAGT----GA-TCACTGTCATTGTCATTGTTGGAGCCATTCTTTTCGTCCCAG ENST00000529418.1 ATTGAATTATTTCTGGACTCACTGTGGTTGTCATTGTTC-AACCATTCTTTTCATCTCAG ** * ** * ** ******* *********** * *********** ** *** ENST00000355354.7 GTGAATATTCATTAAAGAATGCTACTGGCCTTGGTTTAATTGTGACTTCTACAGGGATAT ENST00000529418.1 GTAAATATTTAATAAAGAATACTTCTGCAATTCGTTTAATTGTAATTCCTCCCAGCATAT ** ****** * ******** ** *** ** ********** * * ** * * **** ENST00000355354.7 TAATATTACTTCACTACTATGTGTTTAGTACAGCGATTGGATTAACCTCCTTCGTCATTG ENST00000529418.1 TG-TAT--CTGTAGTTCTGTATGTTTAAGATAGC----------------TTTTCCATTG * *** ** * * ** * ****** * *** ** ***** ENST00000355354.7 CCATATTGGTTATTCAGGTGATAGCCTATATCCTCGCTGTGGTTGGACTGAGTCTCTGTA ENST00000529418.1 TCATAATCATTCTGCAGTTTCTTGTTTATCTTCT-------------------------- **** * ** * *** * * * *** * ** ENST00000355354.7 TTGCGGCGTGTATACCAATGCATGGCCCTCTTCTGATTTCAGGTTTGAGTATCTTAGCTC ENST00000529418.1 TTGTGAC--------------ATAGCCCTCTTGTGACCACAGGTTAAGGTATCTTAGCTC *** * * ** ******** *** ****** ************ ENST00000355354.7 TAGCACAATTACTTGGACTAGTTTATATGAAATTTGTGGCTTCCAATCAGAAGACTATAC ENST00000529418.1 TGGTAGAGTTACTTGGACTGGT------AAAATTTGTGACTTACAGT--AAAGACTA--- * * * * *********** ** ********* *** ** * ******* ENST00000355354.7 AACCTCCTAGGAATAACTGAAGTGAAGTGATGGACTCCGATTTGGAGAGTAGTAAGACGT ENST00000529418.1 ----------ATATAA-----------------------ATTTTATAAGCAGCC------ **** **** ** ** ENST00000355354.7 GAAAGGAATACACTTGTGTTTAAGCACCATGGCCTTGATGATTCACTGTTGGGGAGAAGA ENST00000529418.1 --------TACAC-------------------CCTTCA--ATACATTG-----------A ***** **** * ** ** ** * ENST00000355354.7 AACAAGAAAAGTAACTGGTTGTCACCTATGAGACCCTTACGTGATTGTTAGTTAAGTTTT ENST00000529418.1 AATAATGAAA-------------------------------TGATAAGTAATTAAG---- ** ** *** **** ** ***** ENST00000355354.7 TATTCAAAGCAGCTGTAATTTAGTTAATAAAATAATTATGATCTATGTTGTTTGCCCAAT ENST00000529418.1 ---------------------AGTTGAAGAAAAGAT----ATT------------CTGAT **** * *** ** ** * ** ENST00000355354.7 TGAGATCCAGTTTTTTGTTGTTATTTTTAATCAATTAGGGGCAATAGTAGAATGGACAAT ENST00000529418.1 TGAAGACTAGT--------------------------GCGACAA----------GACGA- *** * *** * * *** *** * ENST00000355354.7 TTCCAAGAATGATGCCTTTCAGGTCCTAGGGCCTCTGGCCTCTAGGTAACCAGTTTAAAT ENST00000529418.1 -------GATTATATTTGT---------------------------------GTTTAAAC ** ** * * ******* ENST00000355354.7 TGGTTCAGGGTGATAACTACTTAGCACTGCCCTGGTGATTACCCAGAGATATCTATGAAA ENST00000529418.1 T---CCATAGT--------CTCA---------------TTACCTGTAGAGAA----GAAA * ** ** ** * ***** *** * **** ENST00000355354.7 ACCAGTGGCTTCCATCAAACCTTTGCCAACTCAGGTTCACAGCAGCTTTGGGCAGTTATG ENST00000529418.1 ACAAG-----------AAA-----ATTAACTT------------GCTTT---CATCTATG ** ** *** **** ***** ** **** ENST00000355354.7 GCAGTATGGCATTAGCTGAGAGGTGTCTGCCACTTCTGGGTCAATGGAATAATAAATTAA ENST00000529418.1 GGAGAAAAAAATCAA---------GTCTTCCATTATTGTGT-----------TAAATT-- * ** * ** * **** *** * ** ** ****** ENST00000355354.7 GTACAGGCAGGAATTTGGTTGGGAGCATCTTGTATGATCTCCGTATGATGTGATATTGAT ENST00000529418.1 -------------TTTATTTGAAA---TATTGTA--------------------ACT--- *** *** * * ***** * * ENST00000355354.7 GGAGATAGTGGTCCTCATTCTTGGGGGTTGCCATTCCCACATTCCCCCTTCAACAAACAG ENST00000529418.1 -----TAGCTGTT-TAATTATTATGTGTTGCG----------------TGCA--AAACAG *** ** * *** ** * ***** * ** ****** ENST00000355354.7 TGTAACAGGTCCTTCCCAGATTTAGGGTACTTTTATTGATGGATATGTTTTCCTTTTATT ENST00000529418.1 TTTAAAA------CCCTAGA--------ACT---------------GCCTCTCAGTTATT * *** * ** *** *** * * * ***** ENST00000355354.7 CACATAACCCCTTGAAACCCTGTCTTGTCCTCCTGTTACTTGCTTCTGCTGTACAAGATG ENST00000529418.1 ------GCCCATTGAA------TTTTA----------ATTAAATTAGGTTATA------- *** ***** * ** * * ** * * ** ENST00000355354.7 TAGCACCTTTTCTCCTCTTTGAACATGGTCTAGTGACACGGTAGCACCAGTTGCAGGAAG ENST00000529418.1 --------TTTCAGTTC-----ATGTAACCTAGTTACATGAT------------------ **** ** * * ***** *** * * ENST00000355354.7 GAGCCAGACTTGTTCTCAGAGCACTGTGTTCACACTTTTCAGCAAAAATAGCTATGGTTG ENST00000529418.1 GAGCCAA------TATCA----ACT------ACAATATT-----AAAGAAGCTC--ATCA ****** * *** *** *** * ** *** **** * ENST00000355354.7 TAACATATGTATTCCCTTCCTCTGATTTGAAGGCAAAAATCTACAGTGTTTCTTCACTTC ENST00000529418.1 CAAAAT--------------TCTGAT------------------GGTCTTTGCTAGCTCC ** ** ****** ** *** * ** * ENST00000355354.7 TTTTCTGATCTGGGGCATGAAAAAAGCAAGATTGAAATTTGAACTATGAGTCTCCTGCAT ENST00000529418.1 TGTT----------GGATGGAAGAACTAATGCAGATCTTCACA----GGGTATGCT---- * ** * *** ** ** ** ** ** * * ** * ** ENST00000355354.7 GGCAACAAAATGTGTGTCACCATCAGGCCAACAGGCCAGCCCTTGAATGGGGATTTATTA ENST00000529418.1 ----------TGTGTATACACATCAGGTAA---GGCTATATCCTGA--------TCAGTA ***** * ******* * *** * * *** * * ** ENST00000355354.7 CTGTTGTATCTATGTTGCATGATAAACATTCATCACCTTCCTCCTGTAGTCCTGCCTCGT ENST00000529418.1 CAACC---------TTACA-GA-AAACACAGAGGAACTGCTCTTTGTGA----GCCTAGC * ** ** ** ***** * * ** * *** **** * ENST00000355354.7 ACTCCCCTTCCCCTATGATTGAAAAGTAAACAAAACCCACATTTCCTATCCTGGTTAGAA ENST00000529418.1 A-------------------GCAAAGCAAACAAT-----CATT--CTACTTCA--TAAAA * * **** ****** **** *** ** ** ENST00000355354.7 GAAAATTAATGTTCTGACAGTTGTGATCGCCTGGAGTACTTTTAGACTTTTAGCATTCGT ENST00000529418.1 GGGATGTGATAT------AATT--GATCAC---AACTACCCTGAAGTTTATGG-AGCCA- * * * ** * * ** **** * * *** * * ** * * * * ENST00000355354.7 TTTTTACCTGTTTGTGGATGTGTGTTTGTATGTGCATACGTATGAGATAGGCACATGCAT ENST00000529418.1 -----ATGTGTTTGCATAAGAGCAATCATCTGAGCTCTATTATAA---------ATGAAA * ****** * * * * * ** ** *** * *** * ENST00000355354.7 CTTCTGTATGGACAAAGGTGGGGTACCTACAGGAGAGCAAAGGTTAATTTTGTGCTTTTA ENST00000529418.1 CATCTGC-TGGGCTC---TGGAGAACCCACA----AGCAAA-----------------TA * **** *** * *** * *** *** ****** ** ENST00000355354.7 GTAAAAACATTTAAATACAAAGTTCTTTATTGGGTGGAATTATATTTGATGCAAATATTT ENST00000529418.1 GCGAGA-CACAGGCATGCAAA----TTTA------GGAATTACA------GCAGGTACTT * * * ** ** **** **** ******* * *** ** ** ENST00000355354.7 GATCACTTAAAACTTTTAAAACTTCTAGGTAATTTGCCACGCTTTTTGACTGCTCACCAA ENST00000529418.1 ---CACTT---------------CCTAG--------------------------TACAAA ***** **** ** ** ENST00000355354.7 TACCCTGTAAAAATACGTAATTCTTCCTGTTTGTGTAATAAGATATTCATATTTGTAGTT ENST00000529418.1 AACA--GCAGAGCTA---AATTC-----ATTTGT-----------CTCA-ACCAATGG-- ** * * * ** ***** ***** *** * * * ENST00000355354.7 GCATTAATAATAGTTATTTCTTAGTCCATCAGATGTTCCCGTGTGCCTCTTTTATGCCAA ENST00000529418.1 --GCCAATAA-----ATTTCTAAATCCTTTCAA-GTTCTCA-GCGCTGCTTTAAAAAAAA ***** ****** * *** * * **** * * ** **** * ** ENST00000355354.7 ATTGATTGTCATATTTCATGTTGGGACCAAGTAGTTTGCCCATGGCAAACCTAAATTTAT ENST00000529418.1 A---------------------------AAG---------------AAACTT---TTTAA * *** **** * **** ENST00000355354.7 GACCTGCTGAGGCCTCTCAGAAAACTGAGCATACTAGCAAGACAGCTCTTCTTGAAAAAA ENST00000529418.1 TGTTTG-------------------TGGGTACA-TAGCAGGT------------------ ** ** * * * ***** * ENST00000355354.7 AAAATATGTATACACAAATATATACGTATATCTATATATACGTATGTATATACACACATG ENST00000529418.1 -AGATATATTTATG-GGGTATGTGTG-ATATTTTGATACAGGCATGCA---------ATG * **** * ** *** * * **** * *** * * *** * *** ENST00000355354.7 TATATTCTTCCTTGATTGTGTAGCTGTCCAAAATAATAACAT-ATATAGAGGGAGCTGTA ENST00000529418.1 TGTA----------------------------ATAATCACATCATGTAAAACGGG--GTA * ** ***** **** ** ** * * * *** ENST00000355354.7 TTCCTTTATACAAATCTGATGGCTCCTGCAGCACTTTTTCCTTCTGAAAATATTTACATT ENST00000529418.1 T---------------------------CAG------TCCCCTC---AAGCATTTGTCCT * *** * ** ** ** **** * ENST00000355354.7 TTGCTAACCTAGTTTGTTACTTTAAAAATCAGTTTTGATGAAAGGAGGGAAAAGCAGATG ENST00000529418.1 TTG-----------TGTTAC-----AAACCA----------------------------- *** ****** *** ** ENST00000355354.7 GACTTGAAAAAGATCCAAGCTCCTATTAGAAAAGGTATGAAAATCTTTATAGTAAAATTT ENST00000529418.1 -------------TCCAA--TTATACT----------------CTTTTAT-------TTA ***** * ** * ***** ** ENST00000355354.7 TTTATAAACTAAAGTTGTACCTTTTAATATGTAGTAAACTCTCATTTATTTGGGGTTCGC ENST00000529418.1 TTTAAAATGTACAGTTAAAGGCCTGAACATG--GTGG-CTCACACCTAT----------- **** ** ** **** * * ** *** ** *** ** *** ENST00000355354.7 TCTTGGATCTCATCCATCCATTGTGTTCTCTTTAATGCTGCCTGCCTTTTGAGGCATTCA ENST00000529418.1 -----AATCCCAGC--------------------ATACTGG---------GAGGC----- *** ** * ** *** ***** ENST00000355354.7 CTGCCCTAGACAATGCCACCAGAGATAGTGGGGGAAATGCCAGATGAAACCAACTCTTGC ENST00000529418.1 ----------------------------TGAGGCAGG---CAGATGA--------CTTG- ** ** * ******* **** ENST00000355354.7 TCTCACTAGTTGTCAGCTTCTCTGGATAAGTGACCACAGAAGCAGGAGTCCTCCTGCTTG ENST00000529418.1 -------AGGT----------CTGGA------ATTAAAGA------------CCAGCCTG ** * ***** * * *** ** ** ** ENST00000355354.7 GGCATCATTGGGCCAGTTCCTTCTCTTTAAATCAGATTTGTAATGGCTCCCAAATTCCAT ENST00000529418.1 GACAACATAGTGA-AATCCCATCTCT---ACTAAAAATTAAAA--------AAATT---- * ** *** * * * * ** ***** * * * * ** ** ***** ENST00000355354.7 CACATCACATTTAAATTGCAGACAGTGTTTTGCACATCATGTATCTGTTTTGTCCCATAA ENST00000529418.1 -------------AGCTGGATGTGGTGGA--GCGCACC-TGTA--------GTCCCA--- * ** * *** ** ** * **** ****** ENST00000355354.7 TATGCTTTTTACTCCCTGATCCCAGTTTCTGCTGTTGACTCTTCCATTCAGTTTTATTTA ENST00000529418.1 ----------GCTACTTGG----AG-----GCTG---------------AG--------- ** * ** ** **** ** ENST00000355354.7 TTGTGTGTTCTCACAGTGACACCATTTGTCCTTTTCTGCAACAACCTTTCCAGCTACTTT ENST00000529418.1 ------------GCAGGAGAATCACTTG--------------AACCT-----GGGA---- *** * ** *** ***** * * ENST00000355354.7 TGCCAAATTCTATTTGTCTTCTCCTTCAAAACATTCTCCTTTGCAGTTCCTCTTCATCTG ENST00000529418.1 -GGCAAAGGCT-------------------------------GCAGT-------GAGCTG * **** ** ***** * *** ENST00000355354.7 TGTAGCTGCTCTTTTGTCTCTTAACTTACCATTCCTATAGTACTTTATGCATCTCTGCTT ENST00000529418.1 AG--ATTGC------------------ACCACTC------TACTCCA---------GCCT * *** **** ** **** * ** * ENST00000355354.7 AGTTCTATTAGTTTTTTGGCCTTGCTCTTCTCCTTGATTTTAAAATTCCTTCTATAGCTA ENST00000529418.1 GGGT----------------------------------------------------GACA * * * * ENST00000355354.7 GAGCTTTTCTTTCTTTCATTCTCTCTTCCTGCAGTGTTTTGCATACATCAGAAGCTAGGT ENST00000529418.1 GAGACTGTCT---------------------CA---------AAACAGCAACAACAAAAT *** * *** ** * *** ** * * * * ENST00000355354.7 ACATAAGTTAAATGATTGAGAGTTGGCTGTATTTAGATTTATCACTTTTTAATAGGGTGA ENST00000529418.1 A-AAAAATTAAATG-------------------TAGAGTTATTA---------------- * * ** ******* **** **** * ENST00000355354.7 GCTTGAGAGTTTTCTTTCTTTCTGTTTTTTTTTTTTGTTTTTTTTTTTTTTTTTTTTTTT ENST00000529418.1 ------------------------------------------------------------ ENST00000355354.7 TTTTTTTTTGACTAATTTCACATGCTCTAAAAACCTTCAAAGGTGATTATTTTTCTCCTG ENST00000529418.1 -------TTGACTATAGTCAC--------------------------------------- ******* **** ENST00000355354.7 GAAACTCCAGGTCCATTCTGTTTAAATCCCTAAGAATGTCAGAATTAAAATAACAGGGCT ENST00000529418.1 -----------CCCATTGTGTT---ATC-------------------AAATTATAGATCT ***** **** *** **** * ** ** ENST00000355354.7 ATCCCGTAATTGGAAATATTTCTTTTTTCAGGATGCTATAGTCAATTTAGTAAGTGACCA ENST00000529418.1 TATTCATTATT---TCTATTTGTTTTTT-----AGCTATTAACAATTC---------CCA * * *** ***** ****** ***** ***** *** ENST00000355354.7 CCAAATTGTTATTTGCACTAACAAAGCTCAAAACACGATAAGTTTACTCCTCC--ATCTC ENST00000529418.1 C------------------------ACTC----CACCACTACCCTACCTTTCCCAACCTC * *** *** * * *** *** * *** ENST00000355354.7 AGTAATAAAAATTAAGCTGTAATCAACCTTCTAGGTTTCTCTTGTCTTAAAATGGGTATT ENST00000529418.1 TG----------------GTAACCATCCTTCTA---CTCTCT-ATCCCAACATG----TT * **** ** ******* ***** ** ** *** ** ENST00000355354.7 CAAAAATGGGGATCTGTGGTGTATGTATGGAAACACATACTCCTTAATTTACCTGTTGTT ENST00000529418.1 CAA--------------------------------------------------------- *** ENST00000355354.7 GGAAACTGGAGAAATGATTGTCGGGCAACCGTTTATTTTTTATTGTATTTTATTTGGTTG ENST00000529418.1 --------------------------------TTATTTT--------------------- ******* ENST00000355354.7 AGGGATTTTTTTATAAACAGTTTTACTTGTGTCATATTTTAAAATTACTAACTGCCATCA ENST00000529418.1 ---AATTTTTT----AAC--TTTTATTT---TCAG---TTAGGAGTAC-AACTGC----- ******* *** ***** ** *** *** * *** ****** ENST00000355354.7 CCTGCTGGGGTCCTTTGTTAGGTCATTTTCAGTGACTAATAGGGATAATCCAGGTAACTT ENST00000529418.1 -------AGGT---TTGTTA---CAT---------------------------------- *** ****** *** ENST00000355354.7 TGAAGAGATGAGCAGTGAGTGACCAGGCAGTTTTTCTGCCTTTAGCTTTGACAGTTCTTA ENST00000529418.1 -----AGGTAAACTGTG-----TCATGGAGGTTTGTTGT-----------ACAG------ ** * * * *** ** * ** *** ** **** ENST00000355354.7 ATTAAGATCATTGAAGACCAGCTTTCTCATAAATTTCTCTTTTTGAAAAAAAGAAAGCAT ENST00000529418.1 ------ATTATT--------------TCACAGGGTT------------------------ ** *** *** * ** ENST00000355354.7 TTGTACTAAGCTCCTCTGTAAGACAACATCTTAAATCTTAAAAGTGTTGTTATCATGACT ENST00000529418.1 --ATAGTAAAC--------AAAACAGCAT-------------GGT------------ACT ** *** * ** *** *** ** *** ENST00000355354.7 GGTGAGAGAAGAAAACATTTTGTTTTTATTAAATGGAGCATTATTTACAAAAAGCCATTG ENST00000529418.1 GGT-AGAGAAAGAGACACGTAGACC------AATGGAACAGAAT----AGAGAACC---- *** ****** * *** * * ****** ** ** * * * ** ENST00000355354.7 TTGAGAATTAGATCCCACATCGTATAAATATCTATTAACCATTCTAAATAAAGAGAACTC ENST00000529418.1 -TGGGAATAAGACCACAAACC-TACAACTATCTA------ATCTTAGATAAAACTGAC-- ** **** *** * ** * * ** ** ****** ** ** ***** ** ENST00000355354.7 CAGTGTTGCTATGTGCAAGATCCTCTCTTGGAGCTTTTTTGCATAGCAATTAAAG-GTGT ENST00000529418.1 -AAAATTGTTTTA------ATTTTT------AGCTCCCACAAATA--AGTGAGAACATAT * *** * * ** * **** *** * * * * * * ENST00000355354.7 GCTATTTGTCAGTAGCCATTTTTTTGCAGTGATTTGAAGACCAAAGTTGTTTTACAGCTG ENST00000529418.1 AAAGTTTG---------ACTCTCT----GTG---------CCTGGCTTATTTCAC----- **** * * * * *** ** ** *** ** ENST00000355354.7 TGTTACCGTTAAAGGTTTTTTTTTTTATATGTATTAAATCAATTTATCACTGTTTAAAGC ENST00000529418.1 --TTAACAT-AATGACCTCTAGTTCCATATATGTTGTTGCAA---ATGAC-----AAAAC *** * * ** * * * ** **** * ** *** ** ** *** * ENST00000355354.7 TTTGAATATCTGCAATCTTTGCCAAGGTACTTTTTTATTTAAAAAAAAACATAACTTTGT ENST00000529418.1 CTC--ATTCTTTTTATGGCTGC-ATAGTACTCCATTGTGTATAAGTA--CCAGGTTTTCT * ** * ** *** * ***** ** * ** ** * * *** * ENST00000355354.7 AAATATTACCCTGTAATATTATATATACTTAATAAAACATTTTAAGCTA ENST00000529418.1 -----TTATCC------ATT-TATCTG-TTGATG--------------- *** ** *** *** * ** **