CLUSTAL 2.1 multiple sequence alignment ENST00000356654.3 GACGCCATACTGGACGCCAAGTGGGAGGAACTTCAAGGCTGTCCCCTGCGGGCCTCCCGC ENST00000421884.1 --------------------------------------------CCCACAGCCCACC--C ** * * ** ** * ENST00000356654.3 TCTGCTTCTGCGAAGGTTTCATTGAAAACAGATCCTGCAAAAGTTCCAGGTGCCCACACT ENST00000421884.1 TCTGCCCC------GGCTCC--------------CTGC-----TTCC------------- ***** * ** * * **** **** ENST00000356654.3 GGAAACTTGGAGATCCTGCTTCCCAGACCACAGCTGTGGGGAACTTGGGGTGGAGCAGAG ENST00000421884.1 --------------TCTTCTTCC---GCCCCA-CTG------------------------ ** ***** ** ** *** ENST00000356654.3 AAGTTTCTGTATTCAGCTGCCCAGGCAGAGGAGAATGGGGTCTCCACAGCCTGAAGAATG ENST00000421884.1 AGGTTTCTTTACTCA--TGCTCTAGTAGCAG----------CTCTGCGGC---------- * ****** ** *** *** * * ** * *** * ** ENST00000356654.3 AAGACACGACAGAATAAAGACTCGATGTCAATGAGGAGTGGACGGAAGAAAGAGGCCCCT ENST00000421884.1 -----------------AGCCTCCTCTTCCA-----------------------GTTCTT ** *** ** * * * * ENST00000356654.3 GGGCCCCGGGAAGAACTGAGATCGAGGGGCCGGGCCTCCCCTGGAGGGGTCAGCACGTCC ENST00000421884.1 ---CCTC--------CT-----------------CCTCCTCTG------------CCTCC ** * ** ***** *** * *** ENST00000356654.3 AGCAGTGATGGCAAAGCTGAGAAGTCCAGGCAGACAGCCAAGAAGGCCCGAGTAGAGGAA ENST00000421884.1 --CAGTA----CCCTGCT------TCC---CAGGCATT-------GCCCAGGTA------ **** * *** *** *** ** **** *** ENST00000356654.3 GCCTCCACCCCAAAGGTCAACAAGCAGGGTCGGAGTGAGGAGATCTCAGAGAGTGAAAGT ENST00000421884.1 -TCCCCACTCC--------------------------------TTCC------------- * **** ** * * ENST00000356654.3 GAGGAGACCAATGCACCAAAAAAGACCAAAACTGAGCAGGAACTCCCTCGGCCACAGTCT ENST00000421884.1 -------CTCTTGCAACAAG-------------------------CCTC--------TCT * **** *** **** *** ENST00000356654.3 CCCTCCGATCTGGATAGCTTGGACGGGCGGAGCCTTAATGATGATGGCAGCAGCGACCCT ENST00000421884.1 GTCCCCAATC--------------AGGC----------------------------CCCC * ** *** *** *** ENST00000356654.3 AGGGATATCGACCAGGACAACCGAAGCACGTCCCCCAGTATCTACAGCCCTGGAAGTGTG ENST00000421884.1 AAGTATACT--------CAATC--------TTCTCT------TCCAGCCCAGGCTGTGTA * * *** *** * * * * * ****** ** **** ENST00000356654.3 GAGAATGACTCTGACTCATCTTCTGGCCTGTCCCAGGGCCCAGCCCGCCCCTACCACCCA ENST00000421884.1 GAG-----------------------------CCAGGG---------------------- *** ****** ENST00000356654.3 CCTCCACTCTTTCCTCCTTCCCCTCAACCGCCAGACAGCACCCCTCGACAGCCAGAGGCT ENST00000421884.1 -----------------TCCCCCACAACC------------------------------- * **** ***** ENST00000356654.3 AGCTTTGAACCCCATCCTTCTGTGACACCCACTGGATATCATGCTCCCATGGAGCCCCCC ENST00000421884.1 -----------------TCCTGTGGC-------GG------------------------- * ***** * ** ENST00000356654.3 ACATCTCGAATGTTCCAGGCTCCTCCTGGGGCCCCTCCCCCTCACCCACAGCTCTATCCT ENST00000421884.1 ---------------------CCTCTTAGGCTTCCTCCTTCTC---------------CT **** * ** ***** *** ** ENST00000356654.3 GGGGGCACTGGTGGAGTTTTGTCTGGACCCCCAATGGGTCCCAAGGGGGGAGGGGCTGCC ENST00000421884.1 GGAGGC-------------------------CAAT-----CCA------------CTGCC ** *** **** *** ***** ENST00000356654.3 TCATCAGTGGGGGGCCCTAATGGGGGTAAGCAGCACCCCCCACCCACTACTCCCATTTCA ENST00000421884.1 C----------------------------ACATCACCCCCAACACATCAC---------- ** ******* ** ** ** ENST00000356654.3 GTATCAAGCTCTGGGGCTAGTGGTGCTCCCCCAACAAAGCCGCCTACCACTCCAGTGGGT ENST00000421884.1 -CATCA---------------------CCACCAGCAG-------CAACACT--------- **** ** *** ** * **** ENST00000356654.3 GGTGGGAACCTACCTTCTGCTCCACCACCAGCCAACTTCCCCCATGTGACACCGAACCTG ENST00000421884.1 -GTGGAA-----------GCTCCA---------GGCCCCCTCCACCTG-----GAGCATT **** * ****** * ** *** ** ** * * ENST00000356654.3 CCTCCCCCACCTGCCCTGAGACCCCTCAACAATGCATCAGCCTCTCCCCCTGGCCTGGGG ENST00000421884.1 TCCCCACCACCTG----GAGAGCTGTAGCCA---CAT-AGCCCCATACCATG-------- * ** ******* **** * * ** *** **** * ** ** ENST00000356654.3 GCCCAACCACTACCTGGTCATCTGCCCTCTCCCCACGCCATGGGACAGGGTATGGGTGGA ENST00000421884.1 ---CA--CACTCTTTTTTTTTTTTTTTTTTT---------TGAGACGGAGTTT-----CA ** **** * * * * * * ** *** * ** * * ENST00000356654.3 CTTCCTCCTGGCCCAGAGAAGGGCCCAACTCTGGCTCCTTCACCCCACTCTCTGCCTCCT ENST00000421884.1 CTT--TTGTCACCCAGGTTGGAGTGCAGTAGTGGCACTA---------TCTTGGCTCACT *** * * ***** * * ** **** * *** ** ** ENST00000356654.3 GCTTCCTCTTCTGCTCCAGCGCCCCCCATGAGGTTTCCTTATTCATCCTCTAGTAGTAGC ENST00000421884.1 GCAACCTCT-----------GCCTCCTAGG-----------TTCA---------AGTGAT ** ***** *** ** * * **** *** ENST00000356654.3 TCTGCAGCAGCCTCCTCTTCCAGTTCTTCCTCCTCTTCCTCTGCCTCCCCCTTCCCAGCT ENST00000421884.1 TCT------------------------------TCTGCCTCAGCCT-------CCCAAGT *** *** **** **** **** * ENST00000356654.3 TCCCAGGCATTGCCCAGCTACCCCCACTCTTTCCCTCCCCCAACAAGCCTCTCTGTCTCC ENST00000421884.1 TCCTGGG-ATT-------------------------------ACAGGCGC---------- *** ** *** *** ** ENST00000356654.3 AATCAGCCCCCCAAGTATACTCAGCCTTCTCTCCCATCCCAGGCTGTGTGGAGCCAGGGT ENST00000421884.1 --TCACCACCATAAGTG-GCTAATTTTTGTAT----TTTTAG------TAAAGACAGGGT *** * ** **** ** * ** * * * ** * ** ****** ENST00000356654.3 CCCCCACCACCTCCTCCCTATGGCCGCCTCTTAGCCAACAGCAATGCCCATCCAGGCCCC ENST00000421884.1 T-------------TCACCATG--------TTGGCCA--GGC--TGGTCAT--GAACTCC ** * *** ** **** ** ** *** * ** ENST00000356654.3 TTCCCTCCCTCTACTGGGGCCCAGTCCACCGCCCACCCACCAGTCTCAACACATCACCAT ENST00000421884.1 TGACCTC-------AGGTG---------------ATCCACCTGCCTCGGC---------- * **** ** * * ***** * *** * ENST00000356654.3 CACCACCAGCAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG ENST00000421884.1 --CTACCAA----------------------------------------------AGTGC * **** ** ENST00000356654.3 CAGCATCACGGAAACTCTGGGCCCCCTCCTCCTGGAGCATTTCCCCACCCACTGGAGGGC ENST00000421884.1 TGGGATTACAGG---CGTGAGCCAC----------AGCG----CCCGGCCA--------- * ** ** * ** *** * *** *** *** ENST00000356654.3 GGTAGCTCCCACCACGCACACCCTTACGCCATGTCTCCCTCCCTGGGGTCTCTGAGGCCC ENST00000421884.1 -------------ATGCACACTCTTATGCCATGTGTTCCTCCCTGGGGTCTCTTTGGCTC * ****** **** ******* * **************** *** * ENST00000356654.3 TACCCACCAGGGCCAGCACACCTGCCCCCACCTCACAGCCAGGTGTCCTACAGCCAAGCA ENST00000421884.1 TATCCATCAGGGCCAGCATACCTGGCCCCATCTCACAGCCAGATGTCCTACAGCCAAGCA ** *** *********** ***** ***** *********** ***************** ENST00000356654.3 GGCCCCAATGGCCCTCCAGTCTCTTC---CTCTTCCAACTCTTCCTCTTCCACTTCTCAA ENST00000421884.1 GGCCCCAATTGCCCCCTACCTCCCACGGTCTCTTCTT-CTCTTTTT-TTCCTCCTCTCAA ********* **** * * * * ****** ***** * **** * ****** ENST00000356654.3 GGGTCCTACCCATGTTCACACCCCTCCCCTTCCCAGGGCCCTCAAGGGGCGCCCTACCCT ENST00000421884.1 GGGTCCTACCCACTTTCACACACCTCCC------AGGGC------------CCCTACCTC ************ ******* ****** ***** ******* ENST00000356654.3 TTCCCACCGGTGCCTACGGTCACCACCTCTTCGGCTACCCTTTCCACGGTCATTGCCACC ENST00000421884.1 TTCCTGCTGGTGCCTACGGTCACCACCTCCTTGGCTGCCCTTTCCACTGCCATTGCTATT **** * ********************* * **** ********** * ****** * ENST00000356654.3 GTGGCTTCCTCGCCAGCAGGCTACAAAACGGCCTCCCCACCTGGGCCCCCACCGTACGGA ENST00000421884.1 GTGGCTTCCTCACCAGCAGACTACAAAACAGCCTACTCGCCTGGGCCCACGCCATAGGGA *********** ******* ********* **** * * ********* * ** ** *** ENST00000356654.3 AAGAGAGCCCCGTCCCCGGGGGCCTACAAGACAGCCACCCCACCCGGATACAAACCCGGG ENST00000421884.1 GAGAAAGCTGCATCCCCAGGGAC-TAGAAGACAG----GCCACACAGATACAAGCCAGGG *** *** * ***** *** * ** ******* **** * ******* ** *** ENST00000356654.3 TCGCCTCCCTCCTTCCGAACGGGGACCCCACCGGGCTATCGAGGAACCTCGCCACCTGCA ENST00000421884.1 T-GCCTCTCTCCATCTGAA-GGGGACCCCATCGGG------------------------- * ***** **** ** *** ********** **** ENST00000356654.3 GGCCCAGGGACCTTCAAGCCGGGCTCGCCCACCGTGGGACCTGGGCCCCTGCCACCTGCG ENST00000421884.1 -------------TCAAACCAGTCTTGCCCACTGTGGGACCTG--------TCACTTGTG **** ** * ** ****** ********** *** ** * ENST00000356654.3 GGGCCCTCAGGCCTGCCATCGCTGCCACCACCACCTGCGGCCCCTGCCTCAGGGCCGCCC ENST00000421884.1 AG-CCCTCAGG--TGTCATCTCTGCCACCACCACCTGTGGCCCCTGCCTCAGGGTTACCC * ******** ** **** **************** **************** *** ENST00000356654.3 CTGAGCGCCACGCAGATCAAACAGGAGCCGGCTGAGGAGTATGAGACCCCCGAGAGCCCG ENST00000421884.1 CTAAGCACCAGACAGATCAAACAGGAGCTTGCTGAGGAGTATGAGACCACTAAGAGTCCA ** *** *** **************** ****************** * **** ** ENST00000356654.3 GTGCCCCCAGCCCGCAGCCCCTCGCCCCCTCCCAAGGTGGTAGATGTAC---CCAGCCAT ENST00000421884.1 GTGCCCCCAGCCTACAGCCTC-CAACTCCTCCTAAGGTGGTGGTAGTCCTTTCCAGCCAT ************ ***** * * * ***** ******** * ** * ******** ENST00000356654.3 GCCAGTCAGTCTGCCAGGTTCAACAAACACCTGGATCGCG-GCTTCAACTCGTGCGCGCG ENST00000421884.1 GCCAGTCAGTCAGCCAGGTG-AGTGGGTACG-GGAGGGTGAGCCTGGAAGGGGGT-TATG *********** ******* * ** *** * * ** * * * * * ENST00000356654.3 CAGCGACCTGTACTTCGTGCCACTGGAGGG-CTCCAAGCTGGCCAAGAAGCGGGCCGACC ENST00000421884.1 AAGGGGCG-ACAGAGAGTGGCACAAGAGGGGCTTT---CTGTTTATGTGGTGGTTTTTGT ** * * * *** *** ***** ** *** * * * ** ENST00000356654.3 TGGTGGAGAAGGTGCGGCGCGAGGCCGAGCAGCGCGCGC-GCGAAGAAAAGGAGCGCGA- ENST00000421884.1 TGTTGTTGTTGTTTT--TTTGAGATGGTTTCGCTCTTGTTGCCCAGGCT-GGAGTGCAAT ** ** * * * *** * ** * * ** ** **** ** * ENST00000356654.3 -GCGCGAGCG-GGAACGCGAGAAAGAGCGC-----GAGCGCGAGAAGGAGCGCGAGCTTG ENST00000421884.1 GGCGCGATCTTGGCCCACTGCAATCTCCGCCTCCTGGGTTCAAGCGATTCTGCT-GCCTC ****** * ** * * ** *** * * * ** ** ** * ENST00000356654.3 AACGCAGCGTGAAGTTGGCTCAGGAGGGCCGTGCTCCGGTGGAATGCCCATCTCTGGGCC ENST00000421884.1 AGCCTCCCAAGTAGCTAGGATTACAGGCATGTGCCACCACACC-TGGCTAACTTTGTATT * * * * ** * * *** **** * ** * * ** ** ENST00000356654.3 C--AGT-GCCCCATCGCC-CTCCATTTGAACCGGGC-AGTGCGG------TGGCTACAG- ENST00000421884.1 TTTAGTAGAGACAGGGTTTCTCCATGTTGATCAGGCTGGTCTTGAACTCCTGACCTCAGG *** * ** * ****** * * * *** ** * ** * *** ENST00000356654.3 TGCCCC-CCTACCTGGGTCCTGACACT-CCAGCCTTGCGCACTCTCAGTGAATATGCCCG ENST00000421884.1 TGATCCACCCACCTCAGCCTCCAAAGTGCTGGGATTACAGGCG-TGAGCCACCATGCCCA ** ** ** **** * * * * * * * ** * * * ** * ****** ENST00000356654.3 GCCTCATGTCATGTCTCCTGGCAATCGCAACCATCCATTCTACGTGCCCCTGGGGGCAGT ENST00000421884.1 GCCT-ATGTGGTGTTTTTT----ATC----TTATT--TTTTA--------TTGAGACAA- **** **** *** * * *** ** ** ** * * * ** ENST00000356654.3 GGACCCGG---GGCTCCTGGGTTACAATGTCCCGGCCCTGTACAGCAGTG--ATC-CAGC ENST00000421884.1 GGTCTTGCTCTGTCACCCAGGCTGGAAGG--CTGG---AGAGCAGTAGTGTGATCATGGC ** * * * * ** ** * ** * * ** * *** **** *** ** ENST00000356654.3 TGCCCGGGAGAGGGAACGGGAAGCCCGTGAACGAGACCTCCGTGACCGCCT-CAAGCCTG ENST00000421884.1 TCACTGCAACCGTGAACTCCTGGGCT-CAAGCGATCCTCCCACCTCAGCCTACATGCCTG * * * * * **** * * * *** * ** * **** ** ***** ENST00000356654.3 GCTTTGAGGTGA-AGCCTAGTGAGCTGGAACCCCTACATGGGGTCCCTGGGCCGGGCTTG ENST00000421884.1 GAGCTGGGATGACAGGC--ACAGGTAGGAGCAACTGGCTAATTTTTTTATTTATATTTTT * ** * *** ** * * *** * ** * * * ** ENST00000356654.3 GATCCCTTTCCCCGACATGGGGGCCTGGCTCTGCAGCCTGGCCCACCTGGCCTGCACCCT ENST00000421884.1 TGTATATTTTTTTTGTA-GAGAATATA----TATATTTATATATATTTA---TATATATT * *** * * * * * * * * * * * ENST00000356654.3 TTCCCCT----TTCATCCGAGCCTGGGGCCCCTGGAGCG-AGAACGTCTAGCGCTGGCAG ENST00000421884.1 TTTGTAGAGAATATATATAAATATATA-TTTTTATAATATAAAATATAAAAATATAAAAA ** * ** * * * * * ** * * * * ENST00000356654.3 CTGGGCCAGCCCTGCGGCCTGACATG----TCCTATGCTGAGC-GGCTGG----CAGCTG ENST00000421884.1 ATATAT--ATTTTTTTTCTAGAGAAGGGGTCTCTATGTTGCCCAGGCTGGTCTCCAACTC * * * ** * * ***** ** * ****** ** ** ENST00000356654.3 AGAGGC---AGCA---CGCAGAAAGGGTGGCGGCCCTGGGCAATGACCCACTG-GCCCGG ENST00000421884.1 CTGGGCTCAAGTGAACCTCCCGAAGTGTGGAGATTACAGGCA-TGAGCCACCGTGCCTGG *** ** * * *** **** * **** *** **** * *** ** ENST00000356654.3 CTGCAGATGCTCAATGTGACTCCCCATCACCACCAGCACTCCCACATCCA---CTCGCAC ENST00000421884.1 CCT------TTTGGTGAAATTTTGAGTCAAAAAAATTTTTTTTGAGACAAGGTCTGGC-T * * ** * * *** * * * * * ** ** ENST00000356654.3 CTGCACCTGCACCAGCAAGATGCTATCCATGCAGCCTCTGCCTCGGTGCACCCTCTCATT ENST00000421884.1 CTGT---TGCCCCAGCTGGATTGCAGTGGTGCGATCTCGGC-TCACTGCAGCCTCT---- *** *** ***** *** * *** *** ** ** **** ***** ENST00000356654.3 GACCCCCTGGCCTCAGGGTCTCACCTTACCCGGATCCCCTACCCAGCTGGAACTCTCCCT ENST00000421884.1 -GCCTCCTGGGTTCAAGCAATCCTCCCACCTCAGCCTCCTGAGTAGCTGGGATTAC---- ** ***** *** * ** * *** * *** ****** * * ENST00000356654.3 AACCCCCTGCTTCCTCACCCTCTGCACGAGAACGAAGTTCTTCGTCACCAGCTCTTTGCT ENST00000421884.1 AGGTCCATGCCACCACACCC----------AGCTAA--TTTTTGTA------TTTTTAGT * ** *** ** ***** * * ** * ** ** * *** * ENST00000356654.3 GCCCCTTACCGGGACCTGCCGGCCTCCCTTTCT--GCC---CCGATGTCAGCAGCTCATC ENST00000421884.1 A---------GAGA--TG--GGTTTCACTACGTTGGCCAGGCTGGTCTCAAC--CTC-CT * ** ** ** ** ** * *** * * * *** * *** ENST00000356654.3 AGCTGCAGGCCATGCACGCACAGTCAGCTGAGCTGCAGCGCTTGGCGCTGGAACAGCAGC ENST00000421884.1 GGCT-CAAGTGATCCACCCGC------CTTGGCCTCA---CAAAGTGCTGGGATTACATC *** ** * ** *** * * ** ** ** * * ***** * ** * ENST00000356654.3 AGTGGCTGC-ATGCCCATCACCCGCTGCACAGTGTGCCG-CTGCCTGCCCAGGAGGACTA ENST00000421884.1 ATGAGCCACTATTCCTGGCCTTCACT-CAAATCTTTTTGTCCATTTTTCTATTGGGGTT- * ** * ** ** * * ** ** * * * * * * * ** * ENST00000356654.3 CTACAGTCACCTGAAGAAGGAAAGCGACAAGCCACTG--TAGAACCTGCGATCAAGAGAG ENST00000421884.1 -TTCTTTTTCTTATTGTTCAGTTTTGA-GGGTTCTTAAATATATTCTG-GATTGAATGGG * * * * * * ** * * ** * *** *** * * * ENST00000356654.3 CACCATGGCTCCTACATTGGACCTTGGAGCACCCCCACCCTCCCCCCACCGTGCCCTTGG ENST00000421884.1 C-TCATGGATATT-TATGAAATCAT---GCCCCCCAAGAGT----TAAAGATACCAGTGA * ***** * * ** * * * ** **** * * * * ** ** ENST00000356654.3 CCTGCCACCCAGAGCCAAGAGGGTGCTGCTCAGTTGCAGGGCCTCCGCA-GCTG-GACAG ENST00000421884.1 C-TGTTACCAAGCAAAAGGAGCTCACTGCCCGGTGGTACAGAAGTCAAATGCTATGGCAC * ** *** ** * *** **** * ** * * * * * *** * ** ENST00000356654.3 AGAGTGGGGGAGGGAGGGACAGACAGAAGGCCAAGGCCCGATGTGGTGTGCAGAGGTGGG ENST00000421884.1 TAGGTTTTTGA--GAAGAAAAAAAAAAAAGC----------TTTATTGTG---------- ** ** ** * * * * * ** ** * * **** ENST00000356654.3 GAGGTGGCGAGGATGGGGACAGAAAGCGCACAGAATCTTGGACCAGGTCTCTCTTCCTTG ENST00000421884.1 -AGTCAGCCAACAAAGAGACAGGAGGC---CAG---CTCAAATT-GGCCTCCCTGTGCAA ** ** * * * ***** * ** *** ** * ** *** ** ENST00000356654.3 TCCC-----CCCTGCTTTTC---TCCTCCCCCATGCCCAACCCCTGTG-GCCGCCGCCC- ENST00000421884.1 TTCTTAAGTCAGTGCTTTTTAAACTTTTTATTGTATTTTATTTTTTAGAGACAGAGTCTT * * * ******* * * * * * * * * * ENST00000356654.3 -CTCCCCTGCCCCG-TTGGTGTG--ATTATTTCATCT--GTTAGATGTGGCTGT----TT ENST00000421884.1 GCTTTTTTGCTCAGGCTGGAGTGCAGTGGCTTGATCTCAGCTCAG-GTCACTGCAACACC ** *** * * *** *** * ** **** * * ** *** ENST00000356654.3 TGCGTAGCA---TCGTGTGCCACCCCTGCC----CCTCCCCGATCCCTGTG--TGCGCGC ENST00000421884.1 TGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTAAATGT *** * ** ** * * ****** ******* * *** * * * ENST00000356654.3 CCCCTCTGCAATGTATGCCCCTTGCCCCTTCCCCACACTAATAATTTATATATATAAATA ENST00000421884.1 GCA---TGCCACG-ATGCCC---GGCTCTTTTTTGTATTTTTTTTTAGTACAGATGGAGT * *** * * ****** * * *** * * * ** ** * ** * ENST00000356654.3 TCTAT-ATG------ACGCTCTT- ENST00000421884.1 TTCACCATGCTGGCCAGGCTGGTC * * *** * *** *