CLUSTAL 2.1 multiple sequence alignment ENST00000358015.3 GAGTCACGATGATGGCGGCCACCATCCTGTGGTGAGCTAGCGGATTCCCTGCTTGTCTCG ENST00000421404.1 ------------------------------------------------------------ ENST00000358015.3 CCGACCCCCTCGCGCCTTCTGCAGACTCCGTGGCTGGCGCTCGGCGCGTGAGGAAGCACG ENST00000421404.1 ------------------------------------------------------------ ENST00000358015.3 GCGGCCCGAGTTCGCGGGGAAGGCCGCAGTCGCGGAGGCAGCGGCGCGGTCCGGGGCACG ENST00000421404.1 ------------------------------------------------------------ ENST00000358015.3 GGCTGGGGGAGAGGCCGCTCCGCTGGGCGAATGTGACAAGCCCCCACCCCCACCGCCTTC ENST00000421404.1 ------------------------------------------------------------ ENST00000358015.3 CTCCCCAGAGCGCGAGGAGCGCGGGCGACCCCGGGGCCCCGCCAGGCCACAGACCCCGCC ENST00000421404.1 ------------------------------------------------------------ ENST00000358015.3 CAGCGGCCAGCACCCGGCGCAGGCCCGGCAGCCGAGCTGCGCGGCGGCACCATGCAGGTC ENST00000421404.1 ---------------------------------------------------ATGCAGGTC ********* ENST00000358015.3 ACCCTGAAGACCCTCCAGCAGCAGACCTT------CAAGATAGACATTGACCCCGAGGAG ENST00000421404.1 ACCCTGAAGACCCTCCAGCCGCAGACCTTGACCTGCAAGATAGACATTGACCCCGAGGAG ******************* ********* ************************* ENST00000358015.3 ACGGTGAAAGCACTGAAAGAGAAGATTGAATCTGAAAAGGGGAAAGATGCCTTTCCAGTA ENST00000421404.1 ACAGTGAAAGCACTGAAAGAGAAGACGGAATCTGAAAAGGGGAAAGTTGCCTCTCTGGTA ** ********************** ******************* ***** ** *** ENST00000358015.3 GCAGGTCAAAAATTAATTTATGCAGGCAAAATCCTCAATGATGATACTGCTCTCAAAGAA ENST00000421404.1 GCAGGTCAAACATTAATTTATGCAGGCAAAATCCTCAATGATGATACTGCTCTCAAAGAA ********** ************************************************* ENST00000358015.3 TATAAAATTGATGAGAAAAACTTTGTGGTGGTTATGGTGACCAAACCCAAAGCAGTGTCC ENST00000421404.1 TATAAAATTGATGAGAAAAACTTTGTGGTGGTTATGGTGACCGAACCCAAAGCAGTGTCC ****************************************** ***************** ENST00000358015.3 ACACCAGCACCAGCTACAACTCAGCAGTCAGCTCCTGCCAGCACTACAGCAGTTACTTCC ENST00000421404.1 ACACCAGCACTAGCTACAACTCAGCAGTCAGCTCCTGCCAGCACTACAGCAGTTACTTCC ********** ************************************************* ENST00000358015.3 TCCACCACCACAACTGTGGCTCAGGCTCCAACCCCTGTCCCTGCCTTGGCCCCCACTTCC ENST00000421404.1 TCCACAACAACAACTGTGGCTCAGGCTCCAACCCCTGTCCCTGCTTTGGCTCCCCCTTTC ***** ** *********************************** ***** *** *** * ENST00000358015.3 ACACCTGCATCCATCACTCCAGCATCAGCGACAGCATCTTCTGAACCTGCACCTGCTAGT ENST00000421404.1 ACACCTGCATTCATCACTCCAGTATCAGTGACAGTGTCCTCTGAACCTGCAACTGCTAGT ********** *********** ***** ***** ** ************ ******** ENST00000358015.3 GCAGCTAAACAAGAGAAGCCTGCAGAAAAGCCAGCAGAGACACCAGTGGCTACTAGCCCA ENST00000421404.1 GCAACTAAACAAGAGAAACCTGCAGAAAAGCCAGCAGAGACACCAGTGGCTACTAGCCTG *** ************* **************************************** ENST00000358015.3 ACAGCAACTGACAGTACATCGGGTGATTCTTCTCGGTCAAACCTTTTTGAAGATGCAACG ENST00000421404.1 ACATCAACTCATAGTACATCAGGAGATTCTTCTTGGTCAAACCTTTTTGAAGATGCAACG *** ***** * ******** ** ********* ************************** ENST00000358015.3 AGTGCACTTGTGACGGGTCAGTCTTACGAGAATATGGTAACTGAGATCATGTCAATGGGC ENST00000421404.1 AGTGCACTTGTGATGGGTCAGTCTTACGATAATATGGTAACTGAGATCATGTCAATGGGC ************* *************** ****************************** ENST00000358015.3 TATGAACGAGAGCAAGTAATTGCAGCCCTGAGAGCCAGTTTCAACAACCCTGACAGAGCA ENST00000421404.1 TATGAACGAGAGCAAGTAATTGCAGCCCCAAGAGCCAGTTCCAACAACCCTGACAGGGCA **************************** ********** *************** *** ENST00000358015.3 GTGGAGTATCTTTTAATGGGAATCCCTGGAGATAGAGAAAGTCAGGCTGTGGTTGACCCC ENST00000421404.1 GTGGAGTACCTTTTAATGGGAATCCCTGGAGATA----AAGTCAGGTTGTGGTTGACCCC ******** ************************* ******** ************* ENST00000358015.3 CCTCAAGCAGCTAGTACTGGGGCTCCTCAGTCTTCAGCAGTGGCTGCAGCTGCAGCAACT ENST00000421404.1 CACCAAGCAGCTAGTACTGGGGCTCCTCAGTCTTCAACAGTGGCTGCAGCTGCAGCAACT * ********************************* *********************** ENST00000358015.3 ACGACAGCAACAACTACAACAACAAGTTCTGGAGGACATCCCCTTGAATTTTTACGGAAT ENST00000421404.1 ACGACAGCAACAACTACAGC---AAGTTCTGGA--ACATCCCCTTGAATTTTTATGGAAT ****************** * ********** ******************* ***** ENST00000358015.3 CAGCCTCAGTTTCAACAGATGAGACAAATTATTCAGCAGAATCCTTCCTTGCTTCCAGCG ENST00000421404.1 CAGCCTCAGTTTCAACAGATGAGACAAATTATTCAACAGAGTCCTTCCCTTCTTCCAGTG *********************************** **** ******* * ******* * ENST00000358015.3 TTACTACAGCAGATAGGTCGAGAGAATCCTCAATTACTTCAGCAAATTAGCCAACACCAG ENST00000421404.1 TTACTACAGTAGATAGATTGAGAGAATCCTCAATTACTTCAGCAAATTAGCCAACACCAG ********* ****** * ***************************************** ENST00000358015.3 GAGCATTTTATTCAGATGTTAAATGAACCAGTTCAAGAAGCTGGTGGTCAAGGAGGAGGA ENST00000421404.1 GAGCATTTTATTCAGATGTTAAATGAAACAGTTTGAGAAGCTGGTGGTCAAAGAGGAAGA *************************** ***** **************** ***** ** ENST00000358015.3 GGTGGAGGTGGCAGTGGAGGAATTGCAGAAGCTGGAAGTGGTCATATGAACTACATTCAA ENST00000421404.1 GGTGGAGGTGTCAGTGGAGGAATTGCAGAAGCTGGAAATGGTCTTATGAACTACATTCAA ********** ************************** ***** **************** ENST00000358015.3 GTAACACCTCAGGAAAAAGAAGCTATAGAAAGGTTAAAGGCATTAGGATTTCCTGAAGGA ENST00000421404.1 GTAATGCCTCAGGAAAAAGAAGCTACAGAAAGGTTAAAGGCATTAGGATTTCCTGAAGGA **** ******************* ********************************** ENST00000358015.3 CTTGTGATACAAGCGTATTTTGCTTGTGAGAAGAATGAGAATTTGGCTGCCAATTTTCTT ENST00000421404.1 CTTGTGATACAAGCATATTTTGCTTGTGAGAAGAATAAGAATTTGGGTGCCGATTTTCTT ************** ********************* ********* **** ******** ENST00000358015.3 CTACAGCAGAACTTTGATGAAGATTGAAAGGGACTTTTTTATATCTCACACTTCACACCA ENST00000421404.1 CTACAGCAGAACTTTGATGAAGATTGAAAGGGAGTTTTTTATATCTCACACTTCGCACTA ********************************* ******************** *** * ENST00000358015.3 GTGCATTACACTAACTTGTTCACTGGATTGTCTGGGATGACTTGGGCTCATATCCACAAT ENST00000421404.1 GTGCATTACACCAGCTTGTTCACTGGATTGTCTGGGATGACTTGGGCTCATATCCACAAT *********** * ********************************************** ENST00000358015.3 ACTTGGTATAAGGTAGTAGATTGTTGGGGGTGGGGAGGGAGGGATCTAGGATACAGGGCA ENST00000421404.1 ACTTGGTATAAGGTAGTAGACGGTTGGGGGTGGGGAAGGAGGGATCTAGGATATAGGACA ******************** ************** **************** *** ** ENST00000358015.3 GGGATAAATACAGTGCATGTCTGCTTCAATTAGCAGATGCCGCAACTCCACACAGTGTGT ENST00000421404.1 GGGATAAATACAGTGCATATCTGCTTCAATTAGCAGATGCTGCAACTCCACACAGTACGT ****************** ********************* *************** ** ENST00000358015.3 AAAATAT---ATACAACCAAAAATCAGCTTTTGCAGGTCTTTATTTCTTCTGTAAAACAG ENST00000421404.1 AAAATATTATATACAACCAAAAATCAGCTTTTGCAGGTATTTATTTCTTCTGTAAAACAG ******* **************************** ********************* ENST00000358015.3 TAGGTAACTTTTCCTAGGTTTCACTC-------------TTTTTAGTGTACTAGATCCAG ENST00000421404.1 TAGATAACTTTTCCTTGGTTTCACTTGGTTTCCTTGGTTTTTATAGTGTACTAGATCCAG *** *********** ********* *** ***************** ENST00000358015.3 AAACTTAGTGTAATGCCCTGCTTTATATTTCTTTGACTTAACATTGGTTTCAGAAAGAAT ENST00000421404.1 AAACTTAATATAATGCCCTGCTTTATATTTCTTTGACTTAACATTGGTTTCAGAAAGAAT ******* * ************************************************** ENST00000358015.3 CTTAGCTACCTAGAATTTACAGTCTCTGTTTCATGGCAACACTGGATAATGGCTTTGTGA ENST00000421404.1 CTTAGCTACCTAGAATTTACAGTTTCTGTTTCATGGCAACACTGGATTATGACTTTGTGA *********************** *********************** *** ******** ENST00000358015.3 AATTTAAAAAATTTTTGTAGCGACTGTAAACAGAAATGCCAA---ATTGATGGTTAATTG ENST00000421404.1 AATGTAAAAGAATTTTGTAGTGACTGTAAACAGAAATGCCAACTTATTGATAGTTAATTG *** ***** * ******** ********************* ****** ******** ENST00000358015.3 TTGCTGCTTCAAAAATAAGTATAAAATTAATATGTAAGGAAGCCCATTCTTTCATGTTAA ENST00000421404.1 TTGCCGCTTCAAAAATAAGTATAAAATTAATGTGTAAAGAAGCCCATTCTTTCATGTTAA **** ************************** ***** ********************** ENST00000358015.3 ATACTTGGGGTGGGAGGGGAGAAAGGGAACCTTTTCTTAAAATGAAAATAATTACTGCTA ENST00000421404.1 ATACTTGGGGTGGGAAGGGAGAAAGGGAACCTTTTCTGAAAATGAAAATAATTACTGCTA *************** ********************* ********************** ENST00000358015.3 TTTTAAAATTTCTTGATCATTGAATGTGAGACCCTTCTAACATGATTTGAGAAGCTGTAC ENST00000421404.1 TTTTAAAATTTCTTGATCATTGAATGTGAGACCCTTCTAACGTGATGTGAGAAGCGGTAC ***************************************** **** ******** **** ENST00000358015.3 AAGTATAGGCAGAGTTATTTTCCTGTTTACATTTTTTTTTTGTTTTGGGGAAAAAATTGG ENST00000421404.1 AAGTATAGGCAGAGTTATCTTCCTATTTACATTTTTTTTT-GTTTTGGG-AAAAAATTAG ****************** ***** *************** ******** ******** * ENST00000358015.3 TAGGTGTCTAATTACTGTTTACTTCATTGTTATATTGCAGTAAAAGTTTTAAAACAACCA ENST00000421404.1 TAGGTGTCTAATTACTGTTTACTTCATTGTTACATTGCAGTAAAAGTTTTAAAACAA--- ******************************** ************************ ENST00000358015.3 TTGCATGTTTGCTTTTGATGTATCCCTTTGTGAAATTAGCACTTTTGGGGCCAATGGAGA ENST00000421404.1 ----------------AACAGAC----------AAACAAAAGTTAT----CTAACGAAGA * * ** * * ** * * ** * *** ENST00000358015.3 AATGCAGCATTCACTCTCCCTGTCTTTTCCCCTTCCCTCAGCAGAAACGTGTTTATCAGC ENST00000421404.1 CATG-----TTTAC---AACTGT--------------TCAG--GAAAC---TTTAT---- *** ** ** **** **** ***** ***** ENST00000358015.3 AAGTCGTGAGTCAAACTGCTGCCTTTTAAAAAACCCACAAAATGCTGATTCAGTTCAAAA ENST00000421404.1 ---TCATAATT---------------------ACCCCCAAATTG--------------AA ** * * * **** **** ** ** ENST00000358015.3 TTAATGCAAATGTTTCAAAACTGGGTTTCTGATATTTGTAAATGTGTTTCTTTATTAGAT ENST00000421404.1 ATAACCTAAATATC----AACTGA--------------TAAATG-------------GAT *** **** * ***** ****** *** ENST00000358015.3 AAGAGTGTATTACCATTAAAGTCAT-TAGTATAATATTGCTTT-CAAAAAGAAATGGTAG ENST00000421404.1 AAAGAAACCATGCTAT---AGCTATATAATGTAATACTACTCAGCAATAAAAAA----GA ** * * ** ** ** ** * ***** * ** *** ** *** ENST00000358015.3 ACAAAACTATAATCCA-GCATCTTTTATTGCATTGGAAAGACTGGCAAAGTCTTTTGGAT ENST00000421404.1 ATGAAATGCTGATACAAGCA------ATAGTATAG--ATGGCTCTCAAAAACACTAGACT * *** * ** ** *** ** * ** * * * ** **** * * * * ENST00000358015.3 GGGTTGGGAGATGTGGCTGGAAAGTACTTTGGAAAATATACA-ATCAAGATATCTCATGG ENST00000421404.1 GTGC----AAAAGTAGTCAGA-------TCAAAAAAAGTACATACCAAATGATTCCATT- * * * * ** * ** * **** **** * *** ** *** ENST00000358015.3 CATATTAAAAGAAAAATCTTAATAGCAGTGTTGGCTTTTATTTGGATTTTTTCATCTCAG ENST00000421404.1 TATATAAAACTAGAAA---GAACA--AGTCTAA---TTTACATGGA---------CGGAA **** *** * *** ** * *** * **** **** * * ENST00000358015.3 TTTTTTCTGTGGAATCTCCTTCATTGGCATTGTTATTTAATCATAAACGGGGCAGATGTC ENST00000421404.1 AGCAAACCGTTGACTCTCTGGGGCTGGAGGTGTTG-----------ATGGGGTTG----- * ** ** **** *** **** * **** * ENST00000358015.3 TACTTGTTCAGTTTTTCAAATCTGTTTTCCTGAGTATAAATAAGAGTATTTAAAGAAATA ENST00000421404.1 -----GCTCGG------AAAA----------------AGGTAGGGAAGCTTTCTGGGATG * ** * *** * ** * ** * ** ENST00000358015.3 ATTTGGATTGCTTTTGTTTTTTGTTTCCTTTTTTTTAACCATCTGATACTAAGAAGATGA ENST00000421404.1 ATGAAAAT-------GTTCTATATCTTC------------ATTTGATGATGGTTGCATGA ** ** *** * * * * * ** **** * **** ENST00000358015.3 ATTTGCACAGATTTCTCTGCATAATTTCTCAATATCTTTAGCACAGTATGGTGATGATGA ENST00000421404.1 GTT--AATAAATTAGCC---AAAACTCATCAAAAT-----GTACACTTCAA--ATGGGTA ** * * *** * * ** * **** ** * *** * *** * ENST00000358015.3 CTTTTAA-GCATTTACATCACGTACTCATA-ACCTATTATGAAAATAAATGAAACTGGCT ENST00000421404.1 CATTTGGTGTATGTTAATTACATATCAATAGAGTTGATTTTAAAATAATCTAGA--AGCT * *** * ** * ** ** ** *** * * * * ******* * * *** ENST00000358015.3 GGGTATGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCAC ENST00000421404.1 CAAT--------TTACTTCTTTATTCTC-----TTTGGA------------------CTC * * * ** ** ** * ***** * * ENST00000358015.3 TTGAGGCCAGGAGATTGAGACCAGCCTGACCGTCATGGCGAAACCCCGTCTATACTAAAA ENST00000421404.1 TTTTGGTC---------------------CTCCCATGG-GAAAC---------------- ** ** * * ***** ***** ENST00000358015.3 ATACAAAAAATAGCCAGGCATGGTGGCGCACGCCTGTGGTCCCAGCTACTTGGGAGGCTG ENST00000421404.1 ----AAAAAAT------GCATGA------ATGCCTTTGACTTTTGTGA-TCAGGAG--CA ******* ***** * **** ** * * * **** ENST00000358015.3 AGGCATGAGAATTGCTTGAACCCGGGAAGTGAAGGTTGCCGTGAGCTGAGATCACACCAC ENST00000421404.1 AAGTTGCAGAAT--CT---ACACAGGAA---AA------CCTAAGTTAATATCTC----- * * ***** ** ** * **** ** * * ** * * *** * ENST00000358015.3 TGCCATAAACATGACAGGCTTTTGGACTTTGTATTACCTGTATGTTTTATAATGGATCAT ENST00000421404.1 -----CAAATTTCATATGCTTT---ATTCTG----------ATG----AAAGTGAG---- *** * * * ***** * * ** *** * * ** ENST00000358015.3 GCATAATTTCTCAGGAGAATAAAATGAGAATTCATATATACGTTCATCTTTCAAGTCAGA ENST00000421404.1 ------------AGGTGA-TATAAGGAGA------------GACCATTTTGCAAGT---- *** ** ** ** **** * *** ** ***** ENST00000358015.3 GCAATGAGTTGGGAAAAGAGGTGGCATTTCTGATCGGATAATGGAATACTCTCATTTATT ENST00000421404.1 ---ATAAG-----ATATAATGTAATAGGTCCAA-------ATAGAG-ACACTCATTAATC ** ** * * * ** * ** * ** ** ** ****** ** ENST00000358015.3 TTATGACATTCTCTGTCTACTCAGATCATAGTGAAAACTGGAAACAAAAAAAAAAAACAG ENST00000421404.1 TT--------CCCAATATGC-CAAAGAGTGTTAAGTGTTGAGA----------------G ** * * * * * ** * * * * ** * * ENST00000358015.3 CCTCTTCTTGGAAAGTGACAGCAGAAGGTGGCATGGAGCTTGTGTCCTTGGACAACAAAT ENST00000421404.1 TCCATCC---AAGAGTAA-----------GACAT-----TTGA----CTG---AATGCAT * * * * *** * * *** *** ** ** ** ENST00000358015.3 CTGGATATACTAGGATTAATTATCAGAAGACAGCTCAGGCCAAGTTTTGATCGTTCCATA ENST00000421404.1 CTGAGTATA--GGAACC--TTGCCTG--------TCTGTTCTA-TGTTG--CATTCC--- *** **** * * ** * * ** * * * * *** * **** ENST00000358015.3 CAGTACCTTGT-TTATCTGCTTCTTAAAGAATCAGCCGAGACACCATAAAAGAAATAGGC ENST00000421404.1 CAGTGCCTAGCACTGTATGCCTGCTACATGCTTA-TTGAATTGTTG-AATGAAGACATGC **** *** * * * *** * ** * * * ** ** * * * ** ENST00000358015.3 TTTTTGTGCCTTTTGCTGTTAATGTTTAATTTACAAACTGTTTTGGTAAATCTCTTAATG ENST00000421404.1 TTA------CTTTTATCATAGATGTTAAA------ATCTAGT---GCAAGTG-------G ** ***** * ***** ** * ** * * ** * * ENST00000358015.3 TAAGTAGCTATTTGACTTTGGAATTTTGCATTCGAGGTATACTGTCATTTCTTGAAATCT ENST00000421404.1 CAGGCAGAGATTCA----TGTAATTTTA-AT---AGACAGATAATTGCTGGGTGA----- * * ** *** ** ****** ** ** * * * * *** ENST00000358015.3 TTTTCTCGTTTAGTTGCTCTGTGGGAAATGTGAGGA---------AGCCTAAGTTT--GT ENST00000421404.1 -TGACACATTCAGTG---CTATGAGAATAGAGAGGAGGAACAATTAGCCCAAACTGAAGT * * * ** *** ** ** *** * ***** **** ** * ** ENST00000358015.3 ATTTGTAAATTTCTTATGCCATCCTCTAGTCAAATTTTTTTTCATTGTTTAAAAATACGG ENST00000421404.1 TTCTGGAAAGTCCTTATG---------AAGGAGATGTATC--CAT-GCTGAGAAAAGTGA * ** *** * ****** * * ** * * *** * * * *** * ENST00000358015.3 AAGTGTTCCAATATAATTTTTTCCTGTACTGGATGGCTAGGATTCTAGAGAATTGATTAT ENST00000421404.1 A----TTTGAGCAAAA-------CAAGAGAAAAGGTGTAATATGTCAGACA---GA---- * ** * * ** * * * * ** ** *** * ** ENST00000358015.3 AAAATATTTTCAATACATCCAA ENST00000421404.1 AAAATATAGTCTATATAGGG-- ******* ** *** *