CLUSTAL 2.1 multiple sequence alignment ENST00000374518.4 GCTGACCTGAGGAGTCGCGGCTGCGAGCAGGTTAGAGTTACTTGTTATTGGTAAATAGCC ENST00000417301.1 ----------------------------------------CATGT---------ACAGCT * *** * *** ENST00000374518.4 ACTATGGAGGCTAAGGACCAGAAGAAACACAGAAAGAAAAACAGTGGACCCAAAGCTGCA ENST00000417301.1 -----------------------GAATCAC------------------------------ *** *** ENST00000374518.4 AAGAAAAAGAAGCGGCTTCTGCAGGATCTCCAGCTAGGAGACGAAGAAGATGCCCGGAAG ENST00000417301.1 --------------------GTAGAATTT-------GAAGATCAAGATGATG-----AAG * ** ** * * *** **** **** *** ENST00000374518.4 AGAAATCCCAAAGCTTTTGCAGTTCAGTCTGCTGTGCGGATGGCTCGATCCTTTCACAGG ENST00000417301.1 -------CCAGAG---------TTCAGT-----ATGAGGGT----------TTTC----G *** ** ****** ** ** * **** * ENST00000374518.4 ACTCAGGATTTGAAGACAAAAAAGCATCATATTCCAGTGGTTGATCGAACTCCACTAGAG ENST00000417301.1 ACCTGGGATGT-----------------ATGTCCGCGTTGA-GATTGAA-------AATG ** **** * ** * * ** * *** *** * * ENST00000374518.4 CCCCCACCAATAGTGGTAGTGGTGATGGGACCTCCAAAAGTTGGAAAGAGCACTTTGATA ENST00000417301.1 TTCCC--------------------TGTG--------AATTTGTGCAGA--ACTTTGA-- *** ** * ** *** *** ******* ENST00000374518.4 CAATGCCTCATTCGGAACTTTACCCGGCAGAAGTTGACTGAGATCAGAGGCCCTGTGACG ENST00000417301.1 -----CCCC--------CTTTACCC--CA----TTATCCTGGGT-----GGCTTG-GGCA ** * ******** ** ** * * * * * ** * * ENST00000374518.4 ATTGTGTCAGGTAAAAAGCGCAGACTCACCATTATTGAATGTGGGTGTGACATTAACATG ENST00000417301.1 ACAGTG--AGGGAAA-----------------TGTTGGACATGTGCA------------- * *** *** *** * *** * ** * ENST00000374518.4 ATGATTGATCTGGCTAAAGTAGCAGATCTGGTACTGATGCTTATAGATGCCAGCTTTGGG ENST00000417301.1 ------GATGCGTCTGAAGAAACATCTCTGGTAT-------------------------- *** * ** *** * ** ******* ENST00000374518.4 TTTGAAATGGAAACGTTTGAGTTTCTAAACATCTGTCAAGTACATGGCTTTCCTAAAATT ENST00000417301.1 ------AAGAAAATCCTCAAGTCCC--AAGATC---CAATCATAT--TTTCTGTAGGGTG * * *** * *** * ** *** *** * ** ** ** * ENST00000374518.4 ATGGGAGTTCTCACCCACCTCGACTCCTTCAAGCATAATAAGCAACTGAAGAAGACAAAG ENST00000417301.1 GAGGAGGTTTCAGACCATCCTG-CTCTATTA--TATCGAAGACCACAATGGAAGACAAAG ** *** *** * * *** * * ** * * ** ********** ENST00000374518.4 AAGCGATTAAAACACAGGTTCTGGACGGAAGTTTACCCGGGTGCCAAGCTGTTCTACCTT ENST00000417301.1 --GCTTCTAAAGTATACGCC----ACAGCA---TATCCAT-TGTGGAGCCG------CCT ** **** * * * ** * * ** ** ** *** * * * ENST00000374518.4 TCTGGAATGGTGCATGGAGAATATCAAAACCAAGAAATCCACAATCTGGGCCGTTTTATT ENST00000417301.1 TTTGGGAC---------------------CCTATCACTCCACAGG--GAACTGGTTTCTT * *** * ** * * ****** * * * *** ** ENST00000374518.4 ACAGTTATGAAGTTTAGGCCTCTCACATGGCA-AACTTCTCACCCTTATATC-CTGGCAG ENST00000417301.1 G--GCAATACAGT------CTGTCA-GTGGCATAATGCCTGATTTTCAGATAGCTGCCAC * ** *** ** *** ***** ** ** * * * ** *** ** ENST00000374518.4 ACAGGATGGAA--GATTTG-ACAAACCCAGAGGATATCCGAACAAACATCAAATGTGACC ENST00000417301.1 AGGAGTTGTCCTTGATCTGGATAAATCCATAAAAATTGTGAAGAA--ATTAAAGCTAACT * * ** *** ** * *** *** * * * *** ** ** *** * ** ENST00000374518.4 GGAAGGTGTCACTTTATGGTTATTTAAGAGGAGCACACTTGAAAAATAAAAGCCAAATTC ENST00000417301.1 G---GTTTTCCATATAAAATT-TTCAAGAACACTTCATTTATTAAGGGAATGTTTAATTC * * * ** * ** ** ** **** * ** ** ** ** * ***** ENST00000374518.4 ACATGCCAGGGGTAGGAGATTTTGCCGTGAGTGACATCAGTTTCCTCCCAGACCCTTGCG ENST00000417301.1 ---TGCC-----TTGGA------------AGTGGC-CAAATTT----GAAGATGCT---G **** * *** **** * * *** *** ** * ENST00000374518.4 CTCTTCCTGAACAACAAAAGAAGCGCTGTTTAAATGAGAAGGAGAAGCTGGTTTATGCGC ENST00000417301.1 TGATTC--GAAC--------------TGTC--AGTGGGATAAGGGGGCAGATCAAGAGAG *** **** *** * ** ** * ** * * * ENST00000374518.4 CTCTTTCTGGAGTTGGGGGTGTGCTGTATGACAAAGACGCTGTCTATGTTGACCTTGGTG ENST00000417301.1 CACTCT---GAGCTCCAG---------------AAGGAGCTTTCCAGGATAGCTTTG--- * ** * *** * * *** *** ** * * * * *** ENST00000374518.4 GCAGCCACGTTTTTCAGGATGAAGTGGGGCCCACCCATGAGCTGGTCCAGAGTCTCATCT ENST00000417301.1 ---------------AGGATAAGCTGCGG-------ATGAGC--------GATATTGTCT ***** * ** ** ****** * * *** ENST00000374518.4 CTACCCACTCCACCATTGATGCCAAGATGGCTTCAAGTCGAGTGACGCTGTTTTCTGATT ENST00000417301.1 TCA----------------TGCGAACTTGGTATC-------------CTGTTTCC--ATC * *** ** *** ** ****** * ** ENST00000374518.4 CCAAGCCACTTGGGTCAGAGGATATAGATAATCAAGGGCTAATGATGCCAAAGGAGGAAA ENST00000417301.1 CCAGCCTTCT--------ATAACCCAG-TAAC--ATCTTTGTTGAAACCAGTGGGTGAGA *** * ** * * ** *** * * *** *** ** ** * ENST00000374518.4 AACAAATGGACTTGAACACTGGTCGAATGCGTCGGAAAGCCATTTTCGGAGATGAAGATG ENST00000417301.1 AA------GAC----AC-CTGGTCAGGAATGT-GGA---CCAC------------GGGCC ** *** ** ****** ** *** *** * ENST00000374518.4 AATCTGGAGATAGTGATGATGAAGAAGATGATGAAATGTCTGAAGATGACGGGTTGGAAA ENST00000417301.1 AACTCAGGCTCGCCCATGGTG----------TCAGA---CTAAAGACAA--------ACA ** * *** ** * * * ** **** * * * ENST00000374518.4 ACGGCTCTAGTGATGAGGAAGCAGAAGAGGAGGAAAATGCTGAGATGACTGATCAGTATA ENST00000417301.1 AGGACTCT-------------CTGTA--------------TAAGGT-ACTGGTC-GTGTG * * **** * * * * ** * **** ** ** * ENST00000374518.4 TGGCTGTTAAGGGCATCAAACGACGGAAACTTGAGTTGGA-AGA-AGACAGTGAAATGGA ENST00000417301.1 TG--TGTTAGTGG----AGATGA----AGCCTGTGCTCTACAGACAGGGAGTCACACAGA ** ***** ** * * ** * * ** * * * *** ** *** * * ** ENST00000374518.4 ---TTTGCCAGCATTTGCTGACAGTGACGATGACCTTGAGAGGAGCTCAGCGGAAGAAGG ENST00000417301.1 CACTTTTCTATAATTT-CTTACAT--------ACTTTGAATG---TTCAA--GTATAAAG *** * * **** ** *** ** **** * *** * * ** * ENST00000374518.4 GGAAGCGGAGGAAGCTGATGAAAGCAGTGAAGAAGAGGACTGCACTGCAGGAGAGAAGGG ENST00000417301.1 TCTAATGTTA-AATTTGAT--------TGAACAA----------TTGTATATTTGTGGGA * * ** **** **** ** ** * * ** ENST00000374518.4 CATTTCAGGATCAAAGGCTGCTGGAGAAGGTAGTAAAGCAGGGCTGTCACCAGCTAATTG ENST00000417301.1 TATTTTGGAATGGAACACC-----AAAAAATGGTAA--TAGTGGT-TC---------TTT **** * ** ** * * ** * **** ** * * ** ** ENST00000374518.4 CCAGAGTGACCGTGTGAATCTGGAGAAGTCTTTGCTGATGAAGAAAGCAGCTCTCCCCAC ENST00000417301.1 CTGGATTGAA-----------GGAAAACTTTTCTTTTTTAAAATAA------------AT * ** *** *** ** * ** * * ** ** * ENST00000374518.4 TTTCGATTCTGGGCATTGCACAGCTGAAGAGGTGTTTGCATCTGAAGATGAATCTGAAGA ENST00000417301.1 TTT--ATTTTATATATT-------TGAG-----GTTGACAAC-----ATGATCTTAAAGG *** *** * *** *** *** ** * **** * *** ENST00000374518.4 AAGCTCCTCACTCAGTGCAGAGGAAGAAGACTCAGAAAATGAAGAGGCTATTAGAAAAAA ENST00000417301.1 A--------------TACATA-----------TAGATAGTAAACTGGTTACTATAGTGAA * * ** * *** * * ** ** ** ** * ** ENST00000374518.4 GCTTTCAAAGCCTTCTCA-AGTGAGCAGTGGTCAGAAACTGGGGCCACAGAACTTCATTG ENST00000417301.1 GC----AAA---TTAACATAGCTACCATC--TCACATAGT-------TAGATTTTTGTTT ** *** ** ** ** * ** *** * * * *** ** ** ENST00000374518.4 ATGAGACCAGTGATATAGAAAATTTACTCAAAGAGGAAGAAGATTACAAGGAAGAAAATA ENST00000417301.1 GTGTGAC-AGGAACAGCTAAAATCTACTTATTTAACA--AAAATCCCAA---AGACAATA ** *** ** * * ***** **** * * * ** ** *** *** **** ENST00000374518.4 ATGATTCCAAAGAAACGTCAGGTGCCCTCAAG-TGGAAGGAAGACCTTTCCAGAAAGGCA ENST00000417301.1 --TATTTTTATTAACTAT----TGCCCTCATGATGTACACTAGATCTCT----------A *** * ** * ******** * ** * *** ** * * ENST00000374518.4 GCTGAGGCCTTTCTGAGGCAGCAGCAAGCAGCTCCAAACCTCCGAAAGCTTATTTATGGG ENST00000417301.1 ACTT-GTTCATCCTA---------CATGT--CTGCTA--CTTTGTA---TTATTT----- ** * * * ** ** * ** * * ** * * ****** ENST00000374518.4 ACAGTGACAGAAGATAATGAAGAAGAAGATGATGATACTCTAGAAGAGCTTGGAGGGTTG ENST00000417301.1 --------------TAATGTACATC----TCCCCATTTCCTA-------TTGG----TCA ***** * * * ** *** **** * ENST00000374518.4 TTTCGTGTC-AACCAGCCTGACAGAGAGTGTAAGCACAAGGCTGACTCTTTGGACTGCTC ENST00000417301.1 TTTCCTATTTGGCCCATTTTTCA------------ACTGGGTTG--TTTTT---CTGCTC **** * * ** * ** ** ** ** * *** ****** ENST00000374518.4 CAGATTTCTTGTGGAGGCCCCCCATGACTGGGATTTAGAGGAGGTTATGAACAGT--ATC ENST00000417301.1 TTAAG---TTGTAAGAGTTCTTTA---CTGATTTTTGGA------TATTAACACTTTATC * **** * * * *** *** ** *** **** * *** ENST00000374518.4 AGAGATTGCTTCGTGACTGGAAAGTGGGAAGATGATAAAGATGCAGCCAAGGTCTTAGCA ENST00000417301.1 AGATAT------GTGGTT------TGCAAATAT--------TTCTTCCA--GTCT--GTA *** ** *** * ** ** ** * * *** **** * * ENST00000374518.4 GAAGATGAGGAGCTCTACGGTGACTTTGAAGACTTGGAAACAGGGGACGTGCACAAGGGA ENST00000417301.1 G----------GTTCCCCTTTCATTTTGTTGGTT---GTTCCTTTGCTGTGCAGAAG--- * * ** * * * **** * * * * ***** *** ENST00000374518.4 AAATCAGGCCCCAATACTCAGAATGAAGATATAGAGAAAGAAGTTAAGGAAGAAATTG-A ENST00000417301.1 ---------CTTTTTAGTTTGA-TGCAGTCCTCCTTGTTTATGTTTAC-----ATTTGTA * ** * ** ** ** * * *** * * *** * ENST00000374518.4 CCCCGACGAAGAAGAAAGTGCCAAGAAAAAGCATTTGGATAAGAAGAGAAAATTGAAGGA ENST00000417301.1 GCCTGGCTTGTGGTGCGATATCCA-AAAAATTATT--GCTAAG----GCCAATGTCAAGA ** * * * * * ***** *** * **** * *** * ** ENST00000374518.4 GATGTTTGATGCAGAATATGATGAAGGAGAAAGCACATATTTTGATGATCTTAAAGGAGA ENST00000417301.1 GGCTTTCCCCCTATGTTTTCTTCTAGGAGT---TTTATGGTTTCA-GGTCTTATTTGGG- * ** * * * * ***** ** *** * * ***** * * ENST00000374518.4 AATGCAGAAACAAGCACAGCTGAATCGCGCAGAATTTGAAGATCAAGATG-ATGAAGCCA ENST00000417301.1 --TCTTTGGTCTTGTAT--CTGTTTTGAGTTGATTTTTGTG--TATGGTGTATGA--TCA * * * * *** * * * ** *** * * * ** **** ** ENST00000374518.4 GAGTTCAGTATGAGGGTTTTCGACCTGGGATGTACGTCCGCATTGAGATTGAAAATGTTC ENST00000417301.1 GGGTCCAATTTTATTCTTTTGCATGTGAAA-----ATCC-TATT---ATTGAAGAGACTA * ** ** * * * **** * ** * *** *** ****** * * ENST00000374518.4 CCTGTGAATTTGTGCAGAACTTTGACCCCCATTACCCCATTATCCTGGGTGGCTTGGGCA ENST00000417301.1 TCT----------------TTTTTACC---ATTGT---GTTGTCTTGTTTGCCCTTGTCA ** *** *** *** ** ** ** ** * * * ** ENST00000374518.4 ACAGTGAGGGAAATGTTGGCTACGTGCAGATGCGTCTGAAGAAACATCGCTGGTATAAGA ENST00000417301.1 AAAATTAGTTGACAGTA---TATGTTTGGATTTATTTC---AAAGGTCTCTG-------- * * * ** * ** ** ** *** * * *** ** *** ENST00000374518.4 AAATCCTCAAGTCCCGAGATCCAATCATATTTTCTGTAGGGTGGAGGAGGTTTCAGACCA ENST00000417301.1 ------TTACGTTCC---ATTGGTCTAT-TTTTTTGT-------------TTTTATGCCA * * ** ** ** ** **** *** *** * *** ENST00000374518.4 TCCCACTGTATTATATCGAAGACCACAA---TGGAAGACAAAGGCTTCTAAAGTATACCC ENST00000417301.1 G--CACCATACTGTTTTGATTACTATAGCTTTGTAATGCAA----TTTTAAAT------- *** ** * * * ** ** * * ** ** *** ** **** ENST00000374518.4 CACAGCACATGCATTGCGGAGCAGCCTTTTGGGGCCCTATCACTCCACAGGGAACTGGTT ENST00000417301.1 --CAAGAGGTGTGATGCCTC-CAACTTTTT------CT-----TTCACAG-----TGATC ** * ** *** ** * **** ** * ***** ** * ENST00000374518.4 TCTTGGCAATACAGTCTGTCAGTGGCATAATGCCTGATTTTCGGATAGCTGCTACAGGAG ENST00000417301.1 TGTTGGC---------TGTTTGGGGT-----------TTTTTG--TGGTT-CCATATGAG * ***** *** * ** **** * * * * * * * *** ENST00000374518.4 TTGTCCTTGATCTGGATAAATCCATAAAAATTGTGAAGAAATTAAAGCTAACTGGTTTTC ENST00000417301.1 TT----------------------TCAGGATTGT-------TT--------TTTCTTTTC ** * * ***** ** * ***** ENST00000374518.4 CATATAAAATTTTCAAGAACACTTCATTTATTAAGGGAATGTTTAATTCTGCCTTGGAAG ENST00000417301.1 TTTTC----TTTTT-------TTTTTTTTTTTGAGGTGAAGTCTCACTCTGTC------- * **** ** *** ** *** * ** * * **** * ENST00000374518.4 TGGCCAAATTTGAAGGTGCTGTGATTCGAACAGTCAGTGGGATAAGGGGGCAGATCAAGA ENST00000417301.1 --ACCCAAGCTGGAG-TGC----------------AGTGGCATAATC--TCGGCTCACTA ** ** ** ** *** ***** **** * * *** * ENST00000374518.4 AAGCACTCCGAGCTCCAGAAGGAGCTTTCAGGGCCAGCTTTGAGGATAAGCTGCTGATGA ENST00000417301.1 AAAC-CTCTGC-CTCCTGGA------TTCA-----------------------------A ** * *** * **** * * **** * ENST00000374518.4 GCGATATTGTCTTCATGCGAACTTGGTATCCTGTTTCCATCCCAGCGTTCTATAACCCAG ENST00000417301.1 GCAAT----TCTTC-TGC----------------------CTCAGCCTCCCA------GG ** ** ***** *** * **** * * * * ENST00000374518.4 TAACATCTTTGTTGAAACCAGTGGGTGAGAAAGACACCTGGTCAGGAATGCGGACCACGG ENST00000417301.1 TAGC--------TGGGACTAC----------AGGCACATG--CCACTATGC------CCG ** * ** ** * ** *** ** * **** * * ENST00000374518.4 GCCAACTCAGGCTCGCCCATGGCGTCAGACTAAAGGCGAACAAGGACTCTCTGTATAAGC ENST00000417301.1 GCCAATTT--------TTGTAGTTTTAG--TAGAG----ACAGGGTTTCACTATGTTGGC ***** * * * * ** ** ** *** ** ** ** * * ** ENST00000374518.4 CAATCCTGAGGCAAAAGAAACATTTTAATTCACTGCACATTCCAAAAGCCTTGCAGAAGG ENST00000417301.1 CGGGCT---GGT----------CTCCAACTC-CTG---ACCTCATGATCC-------ACC * * ** * ** ** *** * ** * ** * ENST00000374518.4 CCCTGCCATTTAAGAACAAGCCCAAGACCCAAGCAAAGGCAGGCAAGGTGCCAAAG-GAC ENST00000417301.1 CGCTGCAGTCT---------CCCAAAGTGCTGG-AATTACAGGCGTGA-GCCACTGTGCC * **** * * ***** * * ** ***** * **** * * * ENST00000374518.4 AGGCGGAGACCGGCCGTCATACGCGAGCCTCATGAAAGAAAGATCCTTGCACTGCTGGAT ENST00000417301.1 TGGCCAGGATT----GTTTTATTCT-GTTCTGTGAA--GAATGTCATCAGAACTTTGAG- *** ** ** ** * * **** ** ** * * ** ENST00000374518.4 GCTCTGAGTACGGTGCATAGTCAGAAGATGAAGAAGGCCAAGGAGCAGCG---GCACCTG ENST00000417301.1 -----GAGGATTGTGTTAAATCTGTATATTT-----GCTTTGG-GTAGTGTGAACATTTT *** * *** * ** * * ** ** ** * ** * ** * ENST00000374518.4 CACAATAAAGAGCACTTCAGAGCCAAGCAGAAGGAGGAGGAGGAGAAGCTGAAGCG-GCA ENST00000417301.1 AACAATATT-AATTCTTCTGATCCA--TAAACATAGGATGTCTTTTCATTTGTTCATGTC ****** * **** ** *** * * **** * * * * ENST00000374518.4 GAAGGACCTCAGGAAGAAGCTCTTCAGAATTCAGGGGCAGAAGGAAAGAAGAAACCAGAA ENST00000417301.1 TAAATTTCTTTCATCAATGTTTTATGGTTTTTAAGTGTA----------------CACAT ** ** * * * * * ** * * * * ** * ENST00000374518.4 GTC-CAGTTTGAAGGGGGCTGAGGGCCAATTGCAGTGAGCCTTTGGACTGGAGGGACTGT ENST00000417301.1 CTCTCACCTTCTT---GGTTAA--ATTTATTCC--TAAGTTTTTG-----------TTTT ** ** ** ** * * *** * * ** **** * * ENST00000374518.4 CCCTGGAT-CTG-CGGAGGT-AGACAGTTTCAAACATCACAGTTTGAATGCCT-GTGAAT ENST00000417301.1 TCTTTGATGCTATCGTAAATGAGATTATTTT-----------CTTGATTGCTTCATCAGC * * *** ** ** * * *** *** **** *** * * * ENST00000374518.4 GACAAGTCAGTGGGA---AAGAGCTCAAGAGATGTCTCTAC--TCAAACTGTGCCT-GCA ENST00000417301.1 --TAGGTTATTTGTATACAGAAATGCAACTGATTTTTATATGTTGAGTTTATACCTTGCA * ** * * * * * * *** *** * * ** * * * * *** *** ENST00000374518.4 GGAGGAGGAACAGAGAAGCCTGGGCTGCTGGGACTGGGTTCATTCTC-ATGACTTGGGGC ENST00000417301.1 GC----TTAACTGAATTGATTTAGTAGTTCTCAC--AGTTTTTTGTGGACTCTTTGGAGT * *** ** * * * * * ** *** ** * * **** * ENST00000374518.4 TGTCGAGATTTAAAGTGATGTAAGCTGTGGTTATGTGGATTCTCTTACTTTCCTCTGCCT ENST00000417301.1 TTTTTACGTAAAGGATCTTGTCATCTGCAA--ATAGAGATAATTTTACTT---------- * * * * * * *** * *** ** *** * ****** ENST00000374518.4 GCCTCAGTTTAATTATTTTGTCCTACAGAAATATCATTAAAATATTTTTTTGTTACTTTT ENST00000417301.1 -CTTTAATTTAGTTGCCTTTTTTTTC-------TCATCTGA--------TTGC------- * * * **** ** ** * * * **** * *** ENST00000374518.4 G ENST00000417301.1 -