CLUSTAL 2.1 multiple sequence alignment ENST00000375284.4 TTCTTTGCTGTGCTGGCGATCCTCACCATCCTCGGCGTTCTCAATGGGCTGGT-TTTGCT ENST00000521874.1 ---------------GTGTTCTCCATCACC------------ACTGTGATGGCATCCGCT * * ** ** ** * * ** * *** * *** ENST00000375284.4 TCCCGTGCTTTTGTCTTTCTTTGGACCATATCCTGAGGTCAGTAGTGACACGGGGATGTC ENST00000521874.1 TCC-----------------------------------------GTGAC-------TGTC *** ***** **** ENST00000375284.4 CCACGTGTAGGCCGGCTGAATGCTGTGTTTCCTGTGCCGCTCTTCACTTCGATACTTAGG ENST00000521874.1 ---------------------ACTGTGCACCCT---CCGCCTGTC----------CTGGG ***** *** **** ** * ** ENST00000375284.4 TGCCTCCCCACTTGCTGGTGGTTCTTCAGTAAACATCTCAGAGTCATGTCTGTTTTCCTC ENST00000521874.1 ------CCCAC--GCAGG----------------ACCCCCAAGCGGGG---------CTC ***** ** ** * * * ** * *** ENST00000375284.4 TTCGGTGTACTGGCTTTGAGGGCTAGAGGGCGGGTTCGGTTTGGTTCCTCTAAATCAACT ENST00000521874.1 T-----GCACAGGCCAGGAGGGCTA-----------------------CCCAGG------ * * ** *** ******** * * ENST00000375284.4 GATTGGCAGCCTGGGTCTTACAGATCTTTATACAGTAAATGAAGACTTTCCCCTTGAGAT ENST00000521874.1 GACTGAC--CACGGGT--------TGTTCATG---------------------------- ** ** * * **** * ** ** ENST00000375284.4 GCATAATTGGACTTCACAAGAGTAAAAAGTACACATCCTGCCTTTCCAG-TGTGGAGC-A ENST00000521874.1 --------GGTCCTCAC--------------------CTGCTTTTCCAGGTCCAGGGTGA ** * **** **** ******* * * * * ENST00000375284.4 GAGGACAGTTCTTCTGCTCCAGCTGCGGGACCTGAAGGTCCTCCAGGTGGTAGAGAAGGG ENST00000521874.1 GAGGAC---------------------GAATTTGAAGGT-----AGAAGTCACAGAGTTG ****** * * ******* ** * * *** * ENST00000375284.4 GAGGTTAATACGGCACAGTGCGCAGGGCCCCAGGGCAGGGAACAGAGGCCCCTGAAAAAT ENST00000521874.1 CAGG---ATGTGG---AGTGCG--------------AGG----AGTGGCCCCGGGGAAGC *** ** ** ****** *** ** ****** * ** ENST00000375284.4 ACCGTGCTTTGAGCTTTGAGTGTGGCCAGCAGGTAAATGGACAAGAACACTTTTAACATG ENST00000521874.1 A----GCTCCAA---CTGAGGGTGATTA------AAAT---------------------- * *** * **** *** * **** ENST00000375284.4 GAATCCCCTTAAATAGGTGTCTCCAGCCAACGGCTTGAACCGCCTGCCCACACCCTCCCC ENST00000521874.1 -------CTGAAGCAGG------------------------------------------- ** ** *** ENST00000375284.4 TGAGCCACCCCCCAGCGTGGTCCGCTTCGCCATGCCGCCCGGCCACACGCACAGCGGGTC ENST00000521874.1 --------------------------------------CCGG------GCGCAGTGGCTC **** ** *** ** ** ENST00000375284.4 TGATTCCTCCGACTCGGAGTATAGTTCCCAGACGACAGTGTCAGGCCTCAGCGAGGAGCT ENST00000521874.1 ACATC--------------TGTAATCCC-------------------------AGCACTT ** * ** * ** ** * * ENST00000375284.4 TCGGCACTACGAGGCCCAGCAGGGCGCGGGAGGCCCTGCCCACCAAGTGATCGTGGAAGC ENST00000521874.1 TTGG-------AGGCC-------------GAGGC-----------AG-----GTGGA--- * ** ***** ***** ** ***** ENST00000375284.4 CACAGAAAACCCCGTCTTCGCCCACTCCACTGTGGTCCATCCCGAATCCAGGCATCACCC ENST00000521874.1 -----------------TCACCT---------------------------GACGTCAG-- ** ** * * *** ENST00000375284.4 ACCCTCGAACCCGAGACAGCAGCCCCACCTGGACTCAGGGTCCCTGCCTCCCGGACGGCA ENST00000521874.1 ------GAGTTCGAGAC--CAGCCT---------------------------GGGCAACA ** ****** ***** ** * ** ENST00000375284.4 AGGCCAGCAGCCCCGCAGGGACCCCCCCAGAGAAGGCTTGTGGCCACCCCCCTACAGACC ENST00000521874.1 TGGTGA--AACCCCGT-----CTCTGCTAAAAA-------------------TACA---- ** * * ***** * * * * * * **** ENST00000375284.4 GCGCAGAGACGCTTTTGAAATTTCTACTGAAGGGCATTCTGGCCCTAGCAATAGGGCCCG ENST00000521874.1 -----------------AAGT------------------------TAGCCA---GGCATG ** * **** * *** * ENST00000375284.4 CTGGGGCCCTCGCGGGGCCCGTTCTCACAACCCTCGGAACCCAGCGTCCACTGCCATGGG ENST00000521874.1 ATGGCG-------AGCGCCTGT--------------AATCCCAGC------TACTA-GGG *** * * *** ** * ****** * * * *** ENST00000375284.4 CAGCTCCGTGCCCGGCTACTGCCAGCCCATCACCACTGTGACGGCTTCTGCCTCCGTGAC ENST00000521874.1 AGGCT----------------------------------GAGG-----------CACGAG *** ** * * ** ENST00000375284.4 TGTCGCCGTGCACCCGCCGCCTGTCCCTGGGCCTGGGCGGAACCCCCGAGGGGGACTCTG ENST00000521874.1 AATCGCT--------------------TGAACCTGGG-----------AGGGGGAGGTTG **** ** ****** ******* ** ENST00000375284.4 CCCAGGCTACCCTGAGACTG-ACCACGGCCTGTTTGAGGACCCCACGTGCCTTTCCACGT ENST00000521874.1 C---AGTCACC-TGAGATTGGACCATTGC----------ACTCCA-------------GC * * *** ***** ** **** ** ** *** * ENST00000375284.4 CCGGTGTGAGAGGAGGGATTCGAAGGTGGAAGTCATTGAGCTGCAGGACGTGGAATGCGA ENST00000521874.1 CTGG-GCAACAAGAG-----CGAAACT-----CCAT----CT-CAGAA---AAAAAAAAA * ** * * * *** **** * *** ** *** * ** * ENST00000375284.4 GGAGAGGCCCCGGGGAAGCAGCTCCAACTGAGGGTGATTAAAATCTGAAGCAAAGAGGCC ENST00000521874.1 AAAAAAA--------------------------------AAAATCTAAAGTAAAGAGGTC * * ******* *** ******* * ENST00000375284.4 AAAGATTGGAAACCCCCCACCCCCACCTCTTTCCAGAACTGCTTGAAGAGAACTGGTTGG ENST00000521874.1 AAAGATCGGAAACCCCT-GCCCCTACACCTTTCAAGAACTGCTTGGTAAGAACTGCTCGT ****** ********* **** ** ***** *********** ******* * * ENST00000375284.4 AGTTATGGAAAAGATGCCCTGTGCCAGGACAGCAGTTCATTGTTACTGTAACCGATTGTA ENST00000521874.1 AGTTACGGTAAAGATGCCTTGAGCCAGGATAGCAGTACATTGTTGCTGTAGCTGGTTGTA ***** ** ********* ** ******* ****** ******* ***** * * ***** ENST00000375284.4 TTATTTTGTTAAATATTTCTATAAATATTTAAGAGATGTACACATGTGTAATATAGGAAG ENST00000521874.1 TTATTTTGTTAAACATTTCCATAAAGATTTAAGAGGTGTACACATGTGTAATATAGGAAG ************* ***** ***** ********* ************************ ENST00000375284.4 GAAGGATGTAAAGTGGTATGATCTGGGGCTTCTCCACTCCTGCCCCAGAGTGTGGAGGCC ENST00000521874.1 GAAGGATGTAAAGTAGTATGATCTGGGGCTTCTCCACTCCTGCCCCAGATTGTGGAGGCT ************** ********************************** ********* ENST00000375284.4 ACAGTGGGGCCTCTCCGTATTTGTGCATTGGGCTCCGTGCCACAACCAAGCTTCA-TTAG ENST00000521874.1 GCAGTGGGGCCTCTCCTTATTTTTGCATTGGTCTCTGTGCCACAACCAAGCTTCACTTCG *************** ***** ******** *** ******************* ** * ENST00000375284.4 TCTTAAATTTCAGCATATGTTGCTGCTGCTTAAATATTGTATAATTTACTTGTATAATTC ENST00000521874.1 TCTTGAATGTCAGCATATGTTGCTGCTGCTTAAATATTTTATAATTT------------- **** *** ***************************** ******** ENST00000375284.4 TATGCAAATATTGCTTATGTAATAGGATTATTTTGTAAAGGTTTCTGTTTAAAATATTTT ENST00000521874.1 ----CAAA---------------------------------------------------- **** ENST00000375284.4 AAATTTGCATATCACAACCCTGTGGTAGTATGAAATGTTACTGTTAACTTTCAAACACGC ENST00000521874.1 AAATTAGCTGGGC--------GTGGTGGTG---GGCGCCAGT----AGTCCCA-----GC ***** ** * ***** ** * * * * * ** ** ENST00000375284.4 TATGCGTGATAATTTTTTTGTTTAATGAGCAGATATGAAGAAAGCACGTTAATCCTGGTG ENST00000521874.1 TACTCGGGA----------GGCTGA--GGCAG-----GAGAATGGCCGTTAACCTGGG-- ** ** ** * * * **** **** * ****** * ** ENST00000375284.4 GCTTCTCTAGGTGTCGTTGTGTGCGGTCCTCTTGTTTGGCTGTGCGTGTGAACACGTGTG ENST00000521874.1 --------AGGTG----------------------------------------------- ***** ENST00000375284.4 TGAGTTCACCATGTACTGTACTGTGATTTTTTTTTTGTCTTGTTTTGTTTCTCTACACTG ENST00000521874.1 -GAGCT-----TGCAGTGAGCCGAGATT------------------GCGCCACCGCACT- *** * ** * ** * * **** * * * **** ENST00000375284.4 TCTGTAACCTGTAGTAGGCTCTGACCTAGTCAGGCTGGAAGCGTCAGGATATCTTTTCTT ENST00000521874.1 -------------------------CCAGCCTGGGTGAAAGAG-CAAGA--------CTC * ** * ** ** *** * ** ** ** ENST00000375284.4 CGTGCTGGTGAGGGCTGGCCCTAAACATCCACCTAATCCTTTCAAATCAGCCCGGCAAAA ENST00000521874.1 CGT-CTCAAGAA----------AAA--------TAATA-----AAATAAA----ATAAAA *** ** ** *** **** **** * **** ENST00000375284.4 GCTAGACTCTCCTCGTGTCTACGGCATCTCTTATGATCATTGGCTGCCATCCAGGACCCC ENST00000521874.1 -------------------TAAAATATATTGTATAAT--TT------------------- ** ** * *** ** ** ENST00000375284.4 AATTTGTGCTTCAGGGGGATAATCTCCTTCTCTCGGATCATTGTGATGGATGCTGGAACC ENST00000521874.1 -ACTTGT-----------ATAAT--------------TCTATGTGA---ATGTTG----C * **** ***** ** ***** *** ** * ENST00000375284.4 TCAGGGTATGGAGCTCACATCAGTTCATCATGGTGGGTGTTAGAGAATTCGGTGACATGC ENST00000521874.1 T-----TATG--------------------TAATAGG-ATTA-----TTTTGTAA----- * **** * * ** *** ** ** * ENST00000375284.4 CTAGTGCTGAGCCTTGGCTGGGCCATGAGAGTCTGTATACTCTAAAAAGCATGCAGCATG ENST00000521874.1 ---------AGCTTT--CTG-----------TTTAAATATTTTAAA-------------- *** ** *** * * *** * **** ENST00000375284.4 GTGCCCCTCTTCTGACCAACACACACACGACCCCTCCCCCAACACCCCCAAATTCAAGAG ENST00000521874.1 ----------TTTG-----CATAT-CACAACCC--------------------------- * ** ** * *** **** ENST00000375284.4 TGGATGTGGCCCTGTCACAGGTAGAAAAACCTATTTAGTTAATTCTTTCTTGGCCCACAG ENST00000521874.1 ----TGTGGT---------AGTATGAAATGTTACTGGTTTTTTTTTTTCTT--------- ***** *** *** ** * ** ** ****** ENST00000375284.4 TCTCCCAGAAATGATGTTTTGAGTCCCTATAGTTTAAACTCCCTCTCTTAAATGGAGCAG ENST00000521874.1 ----------------TTTT----------------------CTTTTTT----------- **** ** * ** ENST00000375284.4 CTGGTTGAGGCTTTCTAGATCTGTTTGCATCTTCTTTAAAACTAAGTGGTGAGCATGCAT ENST00000521874.1 ----------CTTTTTA--------------TTTTTTA-------------------TAT **** ** ** **** ** ENST00000375284.4 TGTGGTGTAGAGGCAGGCATTATGTAGGATAAGAGCTCCGGGGGGATTCTTCATGCACCA ENST00000521874.1 TAT--------------TATTATA------------------------CTTTA------A * * ***** *** * * ENST00000375284.4 GTGTTTAGGGTACGTGCTTCCTAAGTAAATCCAAACATTGTCTCCATCCTCCCCGTCATT ENST00000521874.1 GT-TCTAGGGTAC----------------------------------------------- ** * ******** ENST00000375284.4 AGTGCTCTTTCAATGTGATGTGGGAAAGCAGGAGGATGGACACACCCCACTGAAAGATGT ENST00000521874.1 ------------ATGTG-----------------------CACA------------ACGT ***** **** * ** ENST00000375284.4 AGGCAGGGGCAGGTCTCTCAACCAGGCATATTTTTAAAAGTTGCTTCTGTACTGGTTCTC ENST00000521874.1 --------GCAGTTTTGTTACATAGGTATACATGTG----------CCATATTGGTT--- **** * * * * *** *** * * * ** ***** ENST00000375284.4 TTCTTTTGCTCTGAGGTGTGGGCTCCC-TCATCTCGTAACCAGAGACCAGCACATGTCAG ENST00000521874.1 ------TGCT-----------GCACCCATCAACTCGT---------CCTTTACAT--TAG **** ** *** *** ***** ** **** ** ENST00000375284.4 GGAAG-CACCCAGTGTCGGCTCCCCATCCAAATCCACACCAGCACCTTGTTACAGACAAG ENST00000521874.1 GTATTTCTCCCAATG--------CTATCC----CTCCCCCAGC----------------- * * * **** ** * **** * * ***** ENST00000375284.4 AAGTCAGAGGAAAGGGCGGGGTCCCTGCAGGGCTGAAGCCTAAGCTACTGTGAGGCGCTC ENST00000521874.1 ---------------------CCCCCAC----CCGAAAT----GTTACTGTTA---ACTT *** * * *** * ****** * ** ENST00000375284.4 ACGAGTGGCAGCTCCTGTTACTCCCTTTTAAATTACCTGGGAAATCTTAACAGAAAGGTA ENST00000521874.1 TCAA--------TCATGTTATGCATCATAACGTTTTTTG------TTTAATGAA------ * * ** ***** * * * ** ** **** * ENST00000375284.4 ATGGGCCCCCAGAAATACCCACAGCATAGTGACCTCAGACCCTGATACTCACCACAAAAC ENST00000521874.1 ---------CAGATATG-----AGCAAAG-GACGTTA-ATCCCGGTAT-----------C **** ** **** ** *** * * * ** * ** * ENST00000375284.4 TTTTAAGATGCTGATTGGGAGCCGCTTGTGGCTGCTGGGTGTGTGTGTGTGTGTGTGCGT ENST00000521874.1 TTCT------CTAGTTGT-AGTTGTGTGTGGTTCTCGAGTGGCTGCGCATGTGAACACGT ** * ** *** ** * ***** * * *** ** * **** *** ENST00000375284.4 GCGTGCGTGTGTGTGTGTCTCTGCTGGGGACCCTGGCCACCCCCCTGCTGCT-GTCTTGG ENST00000521874.1 GTG-ATTTCTCAGTGTA-CTGTACTGTGA--TTTG------TTTTTATTGCTTGTTTTGT * * * * **** ** * *** * ** * **** ** *** ENST00000375284.4 TGCCTGTCACCCACATGGTCTGCCATCCTAACACCCAGCTCTGCTCAGAAAACGTCCTGC ENST00000521874.1 TTCCCCTCAGT------GTCTGTAACCCT--TAGCAGGCTCTGACCTA-----GTCAGGC * ** *** ***** * *** * * ****** * *** ** ENST00000375284.4 GTGGAGGAGGGATGATGCAGAATTCTGAAGTCGACTTCCCTCTGGCTCCTGGCGTGCCCT ENST00000521874.1 -TAGAAGAAGCATAA----GGAT----------------------CTTTTA--------T * ** ** * ** * * ** ** * * ENST00000375284.4 CGCTCCCTTCCTGAGCCCAGCTCGTGTTGCGCCGGAGGCTGCGCGGCCCCTGATTTCTGC ENST00000521874.1 TGCT-----------------TTGTGCTGGGT-GAGGGCTG----GCCCTAAACATCTGC *** * *** ** * * ***** **** * ***** ENST00000375284.4 ATGGTGTAGAACTTTCTCCAATAGTCACATTGGCAAAGGGAGAACTGGGGTGGGCGGGGG ENST00000521874.1 CTAAT--------CCTTTCAACGG--------GCCCAGGAAAAGCCAGA----------- * * * *** * ** *** * * * * ENST00000375284.4 GTGGGGCTGGCAGGGAATTAGAATTTCTCTCTCTCTTTTAATAGTTTTATTTTGTCTGTC ENST00000521874.1 ------CTGGCA-----TCATG--TCCACAGCATCGCTTAATA--------TCGT----- ****** * * * * * ** ****** * ** ENST00000375284.4 CTGTTTGTTCATTTGGATGTTTTAATTTTTAAAAAAAAAAAAACTTTGCTGATATTTATA ENST00000521874.1 -TGGTTGT-CATCCAGACACCTCAACTTGTGCTGCAGAGGAAA----------------- ** **** *** ** * ** ** * * * *** ENST00000375284.4 ATTTTGTATCATAAGAATGTTTTCCTCTACAGTATTTGTCATGCCAGTTTATAACAAAAA ENST00000521874.1 -----------TAAG------TTCCTTCTCACGGATCATCATG----------------- **** ***** ** * ***** ENST00000375284.4 AAAATGCAGGGATTTTATTTCTATTGGAAACATTACAGCTATGTTTTACTTTTGGACAGA ENST00000521874.1 -------ATGGATATT----------GAAACCTCAGGGT----------------GCAGA * **** ** ***** * * * **** ENST00000375284.4 ATTTTTATTTGTATAGAGTGCTTACTAATGTTAAATAGTTCAGAGTATATAACATTTACA ENST00000521874.1 ACTAACACCTGTTCA---TCATCGTGGATGTTAAAGAATTGGG------TAACAT----G * * * *** * * * ******** * ** * ****** ENST00000375284.4 TTAAGGACTCATGGTAGGTTTTAGGGTAAGGAGTTTAAAGGAAATAAATATTCAAACTGG ENST00000521874.1 CCAAG------CGGTAAGCCTTGG----ATGGGCC--ATGAGAATA--TCCTCTAAAAAG *** **** * ** * * * * * * **** * ** ** * ENST00000375284.4 GTCTCATTGCCAATTTTGGTGGAAATGAGTTTGTGTCATTTCAATTACAAAGATAAAAGT ENST00000521874.1 CACGCAGTA---------------------TTGTGCCCCTCTCACAACCAACACA----- * ** * ***** * * * ** ** * * ENST00000375284.4 ATGCCATATAATTTATTTATATGAAGATTTATTTTTGTAGTGTACATAGTAGTCATCAAG ENST00000521874.1 ----CACATGACCTGTCCCCTGGCACCCCCAAATTTA-AGAGTGGATTG-------CAAA ** ** * * * * * * *** ** ** ** * *** ENST00000375284.4 TCTTTTGACAGAAGTATATTTTTAAAGAATTTATATGTGATGAATCCATAATGTCTGGAA ENST00000521874.1 TCTTTTG--GAGACCATGGCCCTG------CTACATGTAGAAAAACC----TGT------ ******* * ** * ** **** ** ** *** ENST00000375284.4 CTTTGCTGAGACATGAGTGGGCACAGTTTTCATTGTAAATTACAGCAAGGAAAGAAAATG ENST00000521874.1 -TCTGCT-----ATTCCTGGGCCCA----------------------------------- * **** ** ***** ** ENST00000375284.4 TTTAACAGTGTTAAGAGAGTCAGAGCAGAGTGGATATTCATGCGATTATGAAGTGTTTAT ENST00000521874.1 -----------CAATAAACCCAGAA-------------------ATTATG------TTTT ** * * **** ****** ** * ENST00000375284.4 TAGTTACCATTGGCGACCTAGCATGCTTCTCATTTCAAACCTTGGAAGGTGAAAATGTAC ENST00000521874.1 GAGTTACTGT----GATTTAAACTCCCTCTCTTCTTAAA---TGGAAC------------ ****** * ** ** * * **** * * *** ***** ENST00000375284.4 AAACTCTCTAAATAATTAATGTTCAAACACTGATAGAAATTCTAACATGAATAAAAAATA ENST00000521874.1 -AGCTC--------ATTGGGGCT----------------TTCTGG--------------- * *** *** * * **** ENST00000375284.4 ATATAACTTGTTGGTT ENST00000521874.1 -----ATCTGT----- * ***