CLUSTAL 2.1 multiple sequence alignment ENST00000378289.4 CGGAACGAAGAATGATTTCTAAGCGCAGTTCCGCAGCCCACTCACCTCGTCGGCTGGGGC ENST00000454630.1 ------------------------------------------------------------ ENST00000378289.4 CACCTGCTCTGGGAGTTTCGATTTCCCTTCCCGCGACTGCACCTCCACAGACATGGGCAA ENST00000454630.1 ------------------------------------------------------------ ENST00000378289.4 CGCCTTACCAGAGCAACACCTGTGTTTGTTGGGCGGGAATGAGCCTTGCACTGGGCAGGG ENST00000454630.1 ------------------------------------------------------------ ENST00000378289.4 CTCAGGGCCCATCGCGTGCAGCGAAGCGCGGGTGATTTAAACCCAAGCAGCGGGCGCCTA ENST00000454630.1 ------------------------------------------------------------ ENST00000378289.4 GAACCCGACCGGATGCTCCTTGACTTTGCCCCCGGTCTCCGGACTCCTCTGATTGGACGT ENST00000454630.1 ------------------------------------------------------------ ENST00000378289.4 GGCTGCGTTCGGCCGCCCAATGGCGAGGCAGCGCGCGGCTTCCCGGAAGTGGCGGCGCGG ENST00000454630.1 ------------------------------------------------------------ ENST00000378289.4 TCAGGGCTGGCCTTGGCTTCAGCTGCGGTTTTGGGGTCCCGGACTCTGGGATCGGCGGCG ENST00000454630.1 ------------------------------------------------------------ ENST00000378289.4 CTATGAGTTCTTTCGAGGGGCAGATGGCCGAGTATCCAACTATCTCCATAGACCGCTTCG ENST00000454630.1 ------------------------------------------------------------ ENST00000378289.4 ATAGGGAGAACCTGAGGGCCCGCGCCTACTTCCTGTCCCACTGCCACAAAGATCACATGA ENST00000454630.1 ------------------------------------------------------------ ENST00000378289.4 AAGGATTAAGAGCCCCTACCTTGAAAAGAAGGTTGGAGTGCAGCTTGAAGGTTTATCTAT ENST00000454630.1 ------------------------------------------------------------ ENST00000378289.4 ACTGTTCACCTGTGACTAAGGAGTTGTTGTTAACGAGCCCGAAATACAGATTTTGGAAGA ENST00000454630.1 ------------------------------------------------------------ ENST00000378289.4 AACGAATTATATCTATTGAAATCGAGACTCCTACCCAGATATCTTTAGTGGATGAAGCAT ENST00000454630.1 --------ATATCTATTGAAATCGAGGCTCCTACCCAGATATCTTTAGTGGATGAAGCAT ****************** ********************************* ENST00000378289.4 CAGGAGAGAAGGAAGAGATTGTTGTGACTCTCTTACCAGCTGGTCACTGTCCGGGATCAG ENST00000454630.1 CAGGAGAG---------------------------------------------------- ******** ENST00000378289.4 TTATGTTTTTATTTCAGGGCAATAATGGAACTGTCCTGTACACAGGAGACTTCAGATTGG ENST00000454630.1 ----GTTTTTATTTCAGGGCAATAATGGAACTATCTTGTACACAGGGGACTTCAGATTGG **************************** ** ********** ************* ENST00000378289.4 CGCAAGGAGAAGCTGCTAGAATGGAGCTTCTGCACTCCGGGGGCAGAGTCAAAGACATCC ENST00000454630.1 TGCAAGGAGAAGCTGCTAGAATGGAGCTTTTGCACTCCGGGGGCAGA--------CATCC **************************** ***************** ***** ENST00000378289.4 AAAGTGTATATTTGGATACTACGTTCTGTGATCCAAGATTTTACCAAATTCCAAGTCGGG ENST00000454630.1 AAAGTGTATATTTAGATACTATGTTGTGTGATCCAAGATTTTACCAAATTCCAAGTCAGG ************* ******* *** ******************************* ** ENST00000378289.4 AGGAGTGTTTAAGTGGAGTCTTAGAGCTGGTCCGAAGCTGGATCACTCGGAGCCCGTACC ENST00000454630.1 AGGAGTGTTTATGTGGAGTCTTAGAGCTGGTTCAAAGCTGGATCACTCAGAGCCTGTACC *********** ******************* * ************** ***** ***** ENST00000378289.4 ATGTTGTGTGGCTGAACTGCAAAGCGGCTTATGGCTATGAATATCTGTTCACCAACCTTA ENST00000454630.1 ATGTTGTGTGGCTGAACTGCAAAGCGGCTTATGGCTATGAATATTTGTTCACCAACCTTA ******************************************** *************** ENST00000378289.4 GTGAAGAATTAGGAGTCCAGGTTCATGTGAATAAGCTAGACATGTTTAGGAACATGCCTG ENST00000454630.1 GTGAAGAATTAGGAGTCCAGATTCATGTCAATAAGCTAGACATGTTTAGGAACATGCCTG ******************** ******* ******************************* ENST00000378289.4 AGATCCTTCATCATCTCACAACAGACCGCAACACTCAGATCCATGCATGCCGGCATCCCA ENST00000454630.1 AGATCCTTCATCATCTCACAACAGACCGCAACACTCAGATCCATGCATGGTGGCACCCCA ************************************************* **** **** ENST00000378289.4 AGGCAGAGGAATATTTTCAGTGGAGCAAATTACCCTGTGGAATTACTTCCAGAAATAGAA ENST00000454630.1 AGGTACATGTGTG-----AGTGGCTCGAG---------------ACCTCCAAAAGT---- *** * * * * ***** * * ** **** ** * ENST00000378289.4 TTCCACTCCACATAATCAGCATTAAGCCATCCACCATGTGGTTTGGAGAAA---GGAGCA ENST00000454630.1 TTCC-CACCAGAGACCTAG-GCTGCGTGTTGCTCTG-GTAGGTTGATGAGCTTTGGCTGG **** * *** * * ** * * * * * ** * *** ** ** ENST00000378289.4 GAAAAACAAATGTAATTGTGAGGACTGGAGAGAGTTCATACAGAGCTTGTTTTTCTTTTC ENST00000454630.1 GACACCCCACGGCAGTCGGGTGCACCA-AGGGA------ACGGA--TTGCCCTACGCC-C ** * * * * * * * * * ** ** ** ** ** *** * * * ENST00000378289.4 ACTCCTCCTACAGTGAGATTA-AAGATTTCTTG--AGCTACCTCTGTCCTGTGAACGCAT ENST00000454630.1 ACACCTGGAGGACTGTGGGTATAAGGTGTCCAAGAAAAAAGCTCAGATCTGCTGACAG-- ** *** * ** * ** *** * ** * * *** * *** ** ENST00000378289.4 ATCCAAATGTCATTCCAGTTGGCACA-ACTATG-GATAAAGTTGTCGAAATCTTAAAGCC ENST00000454630.1 ---CAGGTAT-GTTCC--TTGGGATATACTATCTGACAGGG-----GGAAT---GCAGCC ** * * **** **** * * ***** ** * * * *** **** ENST00000378289.4 TTTATGCCGGTCTTCCCAAAGTACGGAGCCAAAGTATAAACCA-CTGGGAAAACTGAAGA ENST00000454630.1 T----------CGTATCAGAA-ACAAAGC-AGGTCATTTGCCATCTAGCAGAGCCTAAGA * * * ** * ** *** * ** *** ** * * * * **** ENST00000378289.4 G-AGCTAGAACAGTTCACCGAGACTCAGGGTCTCACTCTGTCACTCAGGCTAGAATGCGG ENST00000454630.1 GCAG--AAGGCAGGTGA--GAGA-----------ATTCT-----------TAGGA-GCTG * ** * *** * * **** * *** *** * ** * ENST00000378289.4 TGGTGCCATCATGACTCCCTGTATCCTTTAACTCCTGGGATCAAGCGATCTTCCTGCCTC ENST00000454630.1 TGAGGTTTTGTAGACTG--TGGATCCCA-AACTTT---------GCAGTAT---TAGCTA ** * * **** ** **** **** ** * * * ** ENST00000378289.4 AGCCTCCTGACTAGCTGGATCACAGGTGCATACCGCCATGCCCAGCTAATGATTTAGTTT ENST00000454630.1 AGCCTT-TGTTTGA---GGTCACAAAGGAG----GCGGGGACCGG-----GA---ACCTT ***** ** * * ***** * ** * ** * ** * ** ENST00000378289.4 TTATAGAGATGTGGGGTCTCACTATGTTGCCCACA-CTGGTCTGGAACTCCTGGGCTCAA ENST00000454630.1 TTG----AATG-GGGATCCCAACA--------ACAGCAAGTCT----TTCACGAGTTAAA ** *** *** ** ** * *** * **** ** * * * ** ENST00000378289.4 GTGAGCCTCCAGCCTTGACCTCCCCAAGTGCTGGGATTAACTGTAACTGGTTGATTTATG ENST00000454630.1 G-GAGA----AACTTATGTCAGCCCCAGCCCTGGGGCTACCTG-ATCTGAC------AAA * *** * * * * *** ** ***** ** *** * *** * ENST00000378289.4 ACTTTTTAAACAGGATTTGAGCAGTACATTGGAACACTGCATTACTTTCATTATAATTAG ENST00000454630.1 GCCTTTTACATCGTATGTGT-CAGAGAGAGAAAAGATGGCA--GCC-------------G * ***** * * ** ** *** ** * *** * * ENST00000378289.4 GATGTTCAAAAAGCTATACAACTATAGCTCTCTACAGGACACAACTGAATGTTAAGGACT ENST00000454630.1 GACTTT---GAACCCA---AACTGTGGGGCCCT---GGCCGAGGCTG---GT---GGCCT ** ** ** * * **** * * * ** ** * *** ** ** ** ENST00000378289.4 AAATCT----GCAAGTATATG----CTCTAAAT-ATGATCCAGGCACATTTTTCCTATAA ENST00000454630.1 ACGTCTCTAAACAAGTAGACGGGGTCTCTAAAGGATGGCCCC----CATGTTTG--AGGG * *** ****** * * ******* *** ** *** *** * ENST00000378289.4 CTTATATATATGCAGTTACAAATGGAAAATTGTTAAAAATACAGGGGAGAAGCTATGTTA ENST00000454630.1 CCTTGGCA---GCAACTGCC---------CTGCTAG---TACAAGA-AGCAAATAAGCTG * * * *** * * ** ** **** * ** * ** * * ENST00000378289.4 ACTTTGGAATGGAAGGTTTTGTTTTTGTAGAATATGTTATTTTCATGCAATTCTGTAAGT ENST00000454630.1 ACTCTTGGGTAGAA-------CCTGAACAGAAAAGGCC--CCCCATGCTGTG--GTGACT *** * * * *** * **** * * ***** * ** * * ENST00000378289.4 CTAAGATCGTCATCTACAGTTCTGCTCTTAAGAACACAAGT--TTTATGACACGCTCGGC ENST00000454630.1 TTAA--------TGAATA--------CTAAAGGACATGATTGGCTAACGA-ATGCGAGAC *** * * * ** *** *** * * * * ** * ** * * ENST00000378289.4 TTAAGAAAC-CAAAAGTGTCTAAAGTACTTTATGTTACCAACCAAATTTG--GC-TGCTG ENST00000454630.1 TCACCAAGTACCAAAGTG---AAAAT-CCCCATATAACCATTGAAGTTTGTAACATCCTA * * ** * ****** *** * * ** * **** ** **** * * ** ENST00000378289.4 CACTCATTAAGAATGCAACTTAAAAAATTTTGGTTAACAAAAAGA---GT--AATTTGAT ENST00000454630.1 CACCC--------TGCAACCTTG----CTCCCACTATCAGAGAGCCCTGTCAAGCATGAT *** * ****** * * ** ** * ** ** * **** ENST00000378289.4 TATACA-AGATCTTGTATACTGAATAATTTATAATA-ATCT-ACCACTGTCTAAAAGTGT ENST00000454630.1 TGTGTAGAAATGTTGGACTC-GGTTGACTC-TAGCAGACCTGACCTCCGGGTCCAGCCTT * * * * ** *** * * * * * * ** * * ** *** * * * * * ENST00000378289.4 AAGAATCAAAACAGCCATCTAATTTAGTTTCAGAATTATAGATGAATACAGATAATTATA ENST00000454630.1 GGGCATCAG---------------TAGACTGGGAACTATAGGTGGACGGGAGCAGCTTCA * **** *** * *** ***** ** * * * * ENST00000378289.4 GGTGACCCAATTCCAACTAAAAAATCCAGAGTTGACAACTCCAGATATGTAGCCATG--C ENST00000454630.1 ------TCA--TCCCGCAAGGAGA--GAGAGGTG------CAGGGTATGCAGTGGTAACC ** *** * * * * **** ** * * **** ** * * ENST00000378289.4 TTGTGTCTTTCTAGTCACAGCTCAACCTACCCTTCAGTTTGAAGCAGTGTGGTGCCATGG ENST00000454630.1 CTG-GACACTGTTGTTGAAGCCAGATCGATGCCCCAG------GCCACTTCAC-CCA--- ** * * * * ** *** * * * * *** ** * *** ENST00000378289.4 TGAAGACTACTGATTTTAGAGCTTTGAATCTCGGTTCTTATTACTATGTGACCTGTGTGA ENST00000454630.1 -GAAAGCT---GAACTCATTGCTTTCA--TTCAGGCCTTAGAACTCAGTGA--------- *** ** ** * * ***** * ** * **** *** **** ENST00000378289.4 CCTTGGGCAAGGTACTCAATTTCTCTAC-AATAATGGACATAACAGTACTACTTCTCAAA ENST00000454630.1 ----GGGTGAGACTGTCAACATTTACACTGATTCTCGGTATGTCTTTTTAACCCTTCAAG *** ** **** * * ** ** * * ** * * ** **** ENST00000378289.4 AAAAAAAAAAAAAAAAAAAAAAAAAGAAACAGTACTACCTCACTGAGTTTTGGAGAGGAT ENST00000454630.1 TGCATGGAGCGTGATAGAAGGAAAAGGG----------CCTATTGAACTCTGGGGGAAAA * * * * ** ***** * * *** * *** * * ENST00000378289.4 --TAGTGAATTAATACATCAAG-----TGC-----TTAGAA-TAGTATGTGACACACGGC ENST00000454630.1 GGCAGAAAAT-AACA-ACCAGAAATCTTGCATTTATTAGAAGCAGTATG-GAAACCCCAC ** *** ** * * ** *** ****** ****** ** ** * * ENST00000378289.4 AAATACTTTTTACATTTATATATATATATACATATATATGATTTGTATACAAATAAATTT ENST00000454630.1 AAGG-----TGGCAGTTATGCAT-----TGCAGA----------GGACACCAGCGAGCTT ** * ** **** ** * ** * * * ** * * ** ENST00000378289.4 GCTAGTATTTGTATGGTAGTTTTGAGAATGGTCTTCACAGTTCAAAAGTAAGTTACAGAT ENST00000454630.1 CC----ACCT---TGGTGGGCTTGGGGA--ATTCCCGCGCT--------GACTCAGAGGC * * * **** * *** * * * * * * * * * ** ENST00000378289.4 TATGGATGCAATAAATG----CTTGTGTATATTTTACAAAACTCAT----------AAAT ENST00000454630.1 TGCAAAAGCAGCATCTGTCCCCTTCCGGGCATCAGTCATAGCCCCTCTGCTCCCTCAAGC * * *** * ** *** * ** ** * * * * ** ENST00000378289.4 ATAGTATCTTTCA--TGTTGATCC---AAAATAGAG----TTCTGCCAACTACATTTAAT ENST00000454630.1 ACCTGATCTTGGACCTGCTTATTCTAAAGAATAAAAGGACTTTCTCCAGGTAGAGGGAAG * ***** * ** * ** * * **** * ** *** ** * ** ENST00000378289.4 CATATTTGGTCAAATA--GATGAAGTAAATTAAAACTTTCAAGTTTCAAAGCAGCATGTG ENST00000454630.1 GACAAGTGATGGAGGAAGGATGGAGTCAGTTA------CCAGATGGGAGCGTAGC-TGTG * * ** * * * **** *** * *** ** * * * *** **** ENST00000378289.4 TTACATCTGAGTTTCTTCTTAGGACTTTTGG--GTAAAAACAGTTGTCATATTTTAAATT ENST00000454630.1 CCACAGCTGTG---------AGGAACTGCAGTTGTACTGGCACCCATC-TATGTCAGGAG *** *** * **** * * *** ** ** *** * * ENST00000378289.4 TTAC---AAATCCTAGGTTTGACTAGTAGGAATGTGT-----ATTTGTTGAAAGATGACT ENST00000454630.1 TCACTTGAAAAGTT--GTTAGGCTGGTATTTCTACATCTCACATTTGTC---AGCT--CT * ** *** * *** * ** *** * * ****** ** * ** ENST00000378289.4 ATATCAATTTGTTTTAACGTATATTTTTTATTCATATAAAAGTTTTTTATTTCTAAATAT ENST00000454630.1 -TGCCAAAACGGTGAGGCAGTGGTGTGTCACCTGCCTACAG----CCTAATGCGAGGCAA * *** * * * * * * * ** * ** * * * * ENST00000378289.4 G--CCAGTGAACTCTTCTCCTAAATCTGAATAAATTTCTACA-TATCTGCAAATGAAAAT ENST00000454630.1 GGTCCAG----CCGTTCAGCCCAG--TGTACAAGCTTATGGAGCAGTCCCCTTTGAAGAT * **** * *** * * ** * ** ** * * * * **** ** ENST00000378289.4 ATCAAAATGTACCAAGTATCTCTTAAAGAGATAAAAAGGTAATTTTCCAA-AAGTATAAA ENST00000454630.1 CT---------CCAGGTAGACTTCACAGAGATGCCAAAGTGTGGAGGTAACAAGTATTTA * *** *** * * ****** ** ** ** ****** * ENST00000378289.4 CCT-TGCATGTCCATCATTTACTACGTGGCAAATGAAACATACCTCTCCAACAT------ ENST00000454630.1 CTTGTTCTTGGGCGT-ACCTACTCTG-GGTGGGTGGAG---GCTTATCCAACACGAACTG * * * * ** * * * **** * ** ** * * * ******* ENST00000378289.4 ----ATTCCATGACAAAACTCATTCTTTTAATCTTCACAAGGGTCTTTACACCCCAGCCA ENST00000454630.1 GGAAACCTCGTGAAGAAACCCGTGTGCTT---CTTCG---AGGTCTG-ATTCCTAGATTG * * *** **** * * ** **** ***** * ** ENST00000378289.4 CGTCCATTGCTAGTTCGAAAGATGCAAAGCGAATACTGTGTGCCTTTTTGTACAATCCTA ENST00000454630.1 GG---ACTGCCCTTCCG---GAT-CGGCTCAGATA--ACGGGCCTGCATTTGTAGCTGAC * * *** * ** *** * * *** * **** * * * ENST00000378289.4 TTGGGACAATCAGGACCACACTGACACCTTGA- ENST00000454630.1 TTGCTACAG--AAGACAGCAAAGGTA--TTGGG *** *** * *** ** * * ***