CLUSTAL 2.1 multiple sequence alignment ENST00000381218.3 GCGCGTGTGGCCTCCCCGCCTGTCCCGGGTCGGGCTCCAACCAAGCAGCCCCCGTGCAGC ENST00000502364.1 ------------------------------------------------------------ ENST00000381218.3 CGCCCCCCCGCGCACCCTGACACCTCCGGGCCATGGCCGGGGACCCGGGGGCTCGCACGC ENST00000502364.1 ------------------------------------------------------------ ENST00000381218.3 CCCGCGCCCAAGACATCAGGCGGCTCTGCCTGCCGCCTGCGGTCGGCCAGTGACCGCGCG ENST00000502364.1 ------------------------------------------------------------ ENST00000381218.3 CCCCCGCCAGGCCCCGGAGGGGAGGAGCGGGCGTCCCAGGGACCTCGACCCCTACCCACC ENST00000502364.1 ------------------------------------------------------------ ENST00000381218.3 CCAGGCAGGTCCCCACGCATGAGCAGCCGTCCAGCAGGCAGGCTCCGGTGGAGAAGCAAT ENST00000502364.1 ------------------------------------------------------------ ENST00000381218.3 GGAGAATAAAAGCCTGGAGAGCTCCCAGACAGACCTGAAGCTGGTGGCCCACCCCCGCGC ENST00000502364.1 -GAGAATAAAGGCCTGGAAATCTCCCAGATAGACCTGAAGTTACAGGCCCACCTCTACAC ********* ******* * ******** ********** * ******** * * * ENST00000381218.3 CAAGAGCAAGGTGTGGAAGTATTTCGGCTTCGACACCAACGCCGAGGGATGCATCCTGCA ENST00000502364.1 CCATGGCAAGATGTGGAAGTATTGCAGCTTGGACACCGATACCAAGTCATGAGTCTTGCC * * ***** ************ * **** ****** * ** ** *** ** *** ENST00000381218.3 GTGGAAGAAAATCTACTGCCGCATCTGCATGGCCCAGATCGCCTACTCCGGAAACACCTC ENST00000502364.1 ATGGAATAAAATC---TGCTGCATCTGCCTGGTGCAGATCACCTATTCTG-AAACACCTC ***** ****** *** ******** *** ****** **** ** * ********* ENST00000381218.3 CAACCTGTCCTACCACCTGGAGAAGAACCACCCCGAGGAATTCTGCGAGTTCGTCAAGAG ENST00000502364.1 CAACCTGTCCTGCCACCTGAAGGAGA-TGACCTCTAAGAGTTTTAC-AGT---------- *********** ******* ** *** *** * * ** ** * * *** ENST00000381218.3 CAACACGGAGCAGATGCGTGAAGCCTTCGCCACCGCCTTCTCCAAGCTGAAGCCCGAGTC ENST00000502364.1 ---CACCCAGCAGATGTGGGAAGCCTTCACTCCCACCTCCTCCAAACCGAAGCCCAAGTC *** ******** * ********* * ** *** ****** * ******* **** ENST00000381218.3 GTCCCAGCAGCCCGGGCAGGACGCGCTGGCCGTCAAGGCCGGCCACGGCTACGACAGCAA ENST00000502364.1 ATCCCAGCAGTTGTCGCAGGACCCACTGGCCACAAAGGCTGGCCACAGTGATGAGAGCAA ********* ******* * ****** ***** ****** * * ** ***** ENST00000381218.3 GAAGCAGCAGGAGCTGACGGCCGCCGTGCTGGGCCTCATCTGCGAGGGGCTGTACCCAGC ENST00000502364.1 GCAGTAGCAGGAACTGATGGCCAC-GTCCTTGGGCTCATATGCAAGGGGCAAGG----AT * ** ******* **** **** * ** ** ** ***** *** ****** ENST00000381218.3 CTCCATCGTGGACGAGCCCACCTTCAAGGTGCTGCTGAAGACGGCCGACCCCCGGTATGA ENST00000502364.1 ATCCAGTGAGGACGAGCCCACTTTCAAGGTGCTG---------GCCGACCCCAGGTACCA **** * ************ ************ ********* **** * ENST00000381218.3 GCTGCCCAGCCGGAAGTACATCTCTACCAAGGCCATCCCTGAGAAGTACGGGGCCGTCCG ENST00000502364.1 GCTCCTGAGCAGGAAGTACATCTCCACCAAGGCCATCCCTGAGAAGCATGGAGG-GTCAG *** * *** ************* ********************* * ** * *** * ENST00000381218.3 GGAGGTGATCCTGAAGGAGCTGGCCGAGGCCACCTGGTGTGGCATCTCCACCGACATGTG ENST00000502364.1 AGAGGTGATCCTGAAGAAGCCAGCCAACGCCTTTTGGTGTGGCATCTCCAGGGGCAAGTG *************** *** *** * *** **************** * ** *** ENST00000381218.3 GAGGAGTGAGAATCAGAACCGCGCCTACGTCACGCTGGCCGCCCACTTCCTGGGCCTGGG ENST00000502364.1 GAGGAGTGAGAACCAGAATCGAGTCTTGGTGATATTGGCTGTCCAGTTCCTCGGTGTTAG ************ ***** ** * ** ** * **** * *** ***** ** * * ENST00000381218.3 CGCCCCCAACTGCCTGTCCATGGGCTCCCGCTGCCTGAAGACCTTCGAGGTGCCCGAAGA ENST00000502364.1 CTCCCCCGACAGCCTGTATGTGGGTTCC-GGTGCCTGAAGACATTTGAGGTGCTCGAAAA * ***** ** ****** **** *** * *********** ** ******* **** * ENST00000381218.3 GAACACGGCGGAGACCATCACGCGAGTGCTCTATGAGGTCTTCATCGAGTGGGGCATCAG ENST00000502364.1 GAACACAGCGGAAACCATCATGCCGGTGCTCT---------TCATCAAATGGGGCATCAA ****** ***** ******* ** ******* ***** * ********** ENST00000381218.3 CGCCAAGGTCTTCGGGGCCACCACCAACTATGGCAAGGACATCGTGAAGGCGTGCTCCCT ENST00000502364.1 CATCAAGGAGTGCAGGGCCACCACCGACTATGGCAAGGACATCATGAAGGTGTGCCCCTT * ***** * * *********** ***************** ****** **** ** * ENST00000381218.3 GCTGGACGTCGCAGTGCACATGCCCTGCCTGGGCCACACCTTCAATGCCGGCATCCAGCA ENST00000502364.1 GCTCAACATTGCTGTTCAAATGCCTTACTTGTGC-AGACCTCCTATGCTGGCATC-AGCA *** ** * ** ** ** ***** * * ** ** * **** * **** ****** **** ENST00000381218.3 GGCCTTCCAGCTCCCGAAGCTGGGGGCGCTGCTGTCGCGCTGCCGCAAACTGGTGGAGTA ENST00000502364.1 GGCTTTCCAGCTCCCTAAACTGGAGAGCCTGCTCTCTTGGTGCTGTCCACCGGTGGACTA *** *********** ** **** * ***** ** * *** * ** ****** ** ENST00000381218.3 CTTCCAGCAGTCTGCCGTGGCCATGTACATGCTCT-ATG-AGAAGCAGAAGCAGCAGAAC ENST00000502364.1 CTTCCAGCAGCCCACCATGGCCTTTGACATGCTCTTGTGGAGAAGCAGACACAGCAAAAC ********** * ** ***** * ********* ** ********* ***** *** ENST00000381218.3 GTGGCCCACTGCATGCTGGTGAGCAACCGCGTCTCCTGGTGGGGGAGCACGCTGGCCATG ENST00000502364.1 A-GGGACACTGCATGCTGGTGAGCAATCA--TCTCCTGGTGGGGAAGCATACTGGCCATG ** ******************** * ************* **** ********* ENST00000381218.3 CTGCAGCGCCTCAAGGAGCAGCAGTTCGTCATCGCCGGGGTCTTGGTGGAGGACAGCAAC ENST00000502364.1 CTGCAGCCGCTCAAAGAGCAGCAGTGCGTCATCCCTGGTGTATCTG---AAGACAGCAAC ******* ***** ********** ******* * ** ** * * * ********* ENST00000381218.3 AACCACCACCTCATGCTGGAGGCCAGCGAGTGGGCCACCATCGAGGGGCTGGTGGAGCTC ENST00000502364.1 AATCACAACCTGATGTTGGAGGCTACCAAGTGGTCCACCATCCAGGGGCTGGTGGAATTC ** *** **** *** ******* * * ***** ******** ************* ** ENST00000381218.3 CTGCAGCCCTTCAAGCAGGTGGCCGAGATGCTGTCGGCCTCCAGGTACCCCACCATCAGC ENST00000502364.1 CTGCAGCTCTGCAAGCAAGTGGCCAAGATACTGTCTGCCTTGAAGTATCCCACCATCAGC ******* ** ****** ****** **** ***** **** * *** ************ ENST00000381218.3 ATGGTGAAGCCGCTGCTGCACATGCTCCTGAACACCACGCTCAACATCAAGGAGACCGAC ENST00000502364.1 ACAGTGAAACTGCTGTTTCACATGCTGCTAAATACCACGTTCAACAACAAGGAGACTGAC * ***** * **** * ******** ** ** ****** ****** ********* *** ENST00000381218.3 TCCAAGGAGCTCAGCATGGCCAAGGAGGTCATCGCCAAGGAGCTTTCCAAGACCTACCAG ENST00000502364.1 TCCAAGGAGATCCCCATGGCCAAGAGGGTGATTGCCAAGGAGCTCTACAAGACCTGCTAG ********* ** ********** *** ** *********** * ******** * ** ENST00000381218.3 GAGACGCCCGAGATCGACATGTTTCTCAACGTGGCCACCTTCCTGGACCCCCGCTACAAG ENST00000502364.1 GAGACGCCTGAAATGGGCATGTTTCCAAATGTCACCATCTTCCTGGACCCACGCTACAAG ******** ** ** * ******** ** ** *** ************ ********* ENST00000381218.3 AGGCTGCCCTTCCTCTCCGCCTTCGAGCGGCAGCAGGTGGAGAATCGCGTGGTGGAAGAG ENST00000502364.1 AGGCTGCCCTTCCTGCTTGTCTTCGAGAGGCAGCAGATGGAGAACTCTGTGGTC--AGGG ************** * ******* ******** ******* ***** ** * ENST00000381218.3 GCCAAGGGCCTGCTGGACAAGGTCAAAGACGGCGGCTACCGGCCGGCTGAGGACAAGATC ENST00000502364.1 GCCAAGG-CCTCCTGGACAACGTCAAAGACGGCAGCTACCGGCTGGCCAATG-CAAGATC ******* *** ******** ************ ********* *** * * ******* ENST00000381218.3 TTCCCGGTGCCCGAGGAGCCTCCCGTCAAGAAGCTCATGCGGACATCCACGCCGCCGCCC ENST00000502364.1 TACCCTTTGCCGGAAAAACGTCCCGTGAAGAAGCTCACGGGGACGTCGGTGCCTCAGCCC * *** **** ** * * ****** ********** * **** ** *** * **** ENST00000381218.3 GCCAGCGTCATCAACAACATGCTGGCCGAGATCTTCTGCCAGACAGGCGGCGTGGAGGAC ENST00000502364.1 TCCTGCATGATCAACAGCATGCTGGCTGAGATCTGCCGCCAGACCAGCGGCCTGGAGGAC ** ** * ******* ********* ******* * ******* ***** ******** ENST00000381218.3 CAGGAAGAGTGGCATGCCCAGGTGGTGGAGGAGCTGAGCAACTTCAAGTCCCAGAAGGTG ENST00000502364.1 CAGGAGGAAGGGCATGCCCAGGTGGTGGAGGAGATGAGGGACTTCAAGTTTTAGAAGGTG ***** ** *********************** **** ********* ******** ENST00000381218.3 CTTGGCCTC---------AACGAAG-ACCCCCT------------CAAGTGGTGGTCA-- ENST00000502364.1 CTTGGCCACCTGCGTTGTGCTGGAGCATCTCTTTGGCTCCGCAGCCAAATGGTCAACACC ******* * * ** * * * * *** **** ** ENST00000381218.3 ------GACCGCCTGGCCC------------TCTTCCC---CCTG------CT------- ENST00000502364.1 AAGAGGAACCGGCTGGCCCCTAACAAGCAGGTCTTTCTGTACCTGAACGAGCTTAACCAG **** ******* **** * **** ** ENST00000381218.3 -----------------GCCCAAGGTGCTGCA---GAAGTACTGGTGC------------ ENST00000502364.1 GCAGAGGCGGAGGCAGAGCCCGAGGCCCAGGACAAAAAGCAGTGGGGCTTGGATAGAGAG **** *** * * * *** * *** ** ENST00000381218.3 ---------------------GTGACGGCCACGC-------GCGTC----------GC-- ENST00000502364.1 CAGGTGTTCCCTTGGGAAACGGTGTCAGCCAAGCTTCTTTGGCATCTGGGATAGTGGCTT *** * **** ** ** ** ** ENST00000381218.3 ---------------CCCTG-------------AGCGTC-------TCT-TCGGATCCGC ENST00000502364.1 CCTATAGAGAGGAAGCCTTGTCTTATGAGTCATAGCCTCGAGGTAGTCTGTTGGATGCAT ** ** *** ** *** * **** * ENST00000381218.3 CGCC------------------AACGTGGTC----AGCGCCAAGAGGAACCGGCTGGCTC ENST00000502364.1 TGCTTGTAAATACTGTAAATATAGCTTGGTTTTGAACCTCAAAGACCAACCG--TGGCCT ** * * **** * * * **** ***** **** ENST00000381218.3 CCGCG---CACGTGGACGAGC-------------AGGTGTT------------------- ENST00000502364.1 TTGAAATCTAAAGGGAAAGGCGGAAAACAGAAAGAGATGTTAGAAGAAAGAGATAAAGGC * * *** ** ** **** ENST00000381218.3 -------------------------TCTG---TATGAG--AACGCCCG---GAGTGGGGC ENST00000502364.1 TTTGGGTTGATGGGTCCTCTTCTCCTCTGGTCCATCAGGCAACTCCTGCTTGGGAGTTGC **** ** ** *** ** * * * * ** ENST00000381218.3 AGAGGCGGAAC---CCGAGGAC--CAGGACGAGGGGGAG-------------------TG ENST00000502364.1 CAAGGGGAAACTCCCCAAGGACAGCAGAACCTGGAGGAGGTTTTGGATCACAGACACTTG *** * *** ** ***** *** ** ** **** ** ENST00000381218.3 GGGCCTGGACCAGGAGCA-------------------GGTGTTCTCCTTGGG-------- ENST00000502364.1 GGACATGGCACAGGCACACCATTTGCGATTTCTGATTGAAGTTCTTCCTGGGAGGGTTTA ** * *** **** ** * ***** * **** ENST00000381218.3 ---------------------GGATGGCGTCAGCGGCGG--------------------- ENST00000502364.1 GAATAAATCCAAGAAAATTCTGGGTGGAATCATCTGAGGGATTTTGGAGATCTCTAGATG ** *** *** * * ** ENST00000381218.3 -----------------TTTCTTTGGCATTAGGGACA------GCAGCTTC--CTGTAGC ENST00000502364.1 AATGAATTCATGTTTACTTTTTTTTGAAATGGGGTCTCACTCTGTAGCCCAGGCTGGAGT *** *** * * * *** * * *** *** ** ENST00000381218.3 GAGGAAGCGTGTTGT---CTTAC-----------------------AAGTCATCCCC--G ENST00000502364.1 GCAGAGATGTGTTCTTGGCTCACTGCAAGCTTCGCCTCCAAGGTTGAAGTGATTCTCATG * ** ***** * ** ** **** ** * * * ENST00000381218.3 CAGCAGCCCATTGGAT-GCT----------------------------------TTGCTG ENST00000502364.1 CCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTGTACCACCACACCTGGCTAATTTTTG * ***** ** * *** ** ** ENST00000381218.3 TA-----AATA----------CTTACC----CGGTCAGCTTGGTTTTGAACCTCAGAGAC ENST00000502364.1 TATTTTTAGTAGAGGTGGGGTTTCACCATGTTGGCCAGGTTGGTCTCGAACTCCTGACCT ** * ** * *** ** *** ***** * **** * ** ENST00000381218.3 CA-----TCCAC-TGTCTTTGACACCTAGA-------------AGG-------------- ENST00000502364.1 CAAGTGATCCACCTGTCTCAGACTCCCAAATTGCTGGGATTACAGGCATGAGTCACCGCG ** ***** ***** *** ** * * *** ENST00000381218.3 ----------------------TGGAAAAAGGAA-----------AGAGATTTGAGA--- ENST00000502364.1 CCCGGCGATGTTTACATTTTAATGGAAGCAGAGACCATGCTTCTGGGAGATTTGAAAGAG ***** ** * ********* * ENST00000381218.3 -------------AGTG-------------AGAGAG------------------------ ENST00000502364.1 ATCCTTTAGCCCAAATGTCCTTCCTGCAAAAGAGAGATCAGTTTTATGTTTGGTTAAACG * ** ****** ENST00000381218.3 ------------------------------------------------------------ ENST00000502364.1 TGTGAATAATGAGCAAAAAATGCAGGCACTTTTAAAACACAGGGGAAAAAAGGCCTTGAA ENST00000381218.3 ------------------------------------------------------------ ENST00000502364.1 TGTGTTGTATTTTTGGCATGTTGCAGGCAATTAGTCTTTTTATCTCAAAATTCACTTTGT ENST00000381218.3 --------------------------GGTCGGGGGCGGTGGCTCCTGTCTATAATCGCAG ENST00000502364.1 AGACTTGGTTCCTGAAAGACAAGTCAGGCCAGGCGCAGTGGCTCATGCCTGTAATCCCAC ** * ** ** ******* ** ** ***** ** ENST00000381218.3 CACTTTGGGAGGCCGAGGTGGGCAGATCAGCTGAGGTCAGGAGATCGAGACCAGCCTGGC ENST00000502364.1 CAGTTTAGGAGGCTGAGGCGGGCGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGC ** *** ****** **** **** ***** ************* **************** ENST00000381218.3 CAACATGGCGAAACCCCGTCTCTACTAAAAA-TACAAAAATTAGCCAGGACTGATGGCAT ENST00000502364.1 TAATATGGCGAAACCCCGTCTCTACTAAAAACTACAAAAATTAGCTGGGCGTGGTGGCGA ** *************************** ************* ** ** **** ENST00000381218.3 GTGCCTGTAATCCCAGCTTCT--GGAGGCTGAGGCCAGAGAATCGCTTGAACCTGGGAGG ENST00000502364.1 ACGCTTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGG ** * *********** ** ************ ******* *************** ENST00000381218.3 TGGAGGTTGCAGTAAGCTGAGATCGC-----TGCACTCCAGCCTGGGCGACAAGAGCGAG ENST00000502364.1 CAGAGGTTGCAGTGAGCCAAGATCGCGCCATTGTACTCTAACCTGGATGACAAGAGTGAA *********** *** ******* ** **** * ***** ******** ** ENST00000381218.3 A--CTC--TCTCAAAAAGAAAAAAGAA--------------------------------- ENST00000502364.1 AAACTCCATCTCAAAAAAATAAATAAATAAATAAAGTCTCTTAAGAGTTCCTGGTTTTCT * *** ********* * *** ** ENST00000381218.3 ------------------------------------------------------------ ENST00000502364.1 TGTGTGTCTGGTGCCTGAATGCTTCAGTGTCCCAAGAATCACATTTTTTGGGGGGTTGGA ENST00000381218.3 ------------------------------------------------------------ ENST00000502364.1 GGTGGCTGTGTGAGAATAAGACCCCTCCTTTCAAGTGCTATTTTAAAACTTGCACACAGC ENST00000381218.3 ------------------------------------------------------------ ENST00000502364.1 AGGCTTTTTGGCATCAATAGGGGTGTTTTAGATTTGATTGCTGGAAAGAATTCTTGAATT ENST00000381218.3 ------------------------------------------------------------ ENST00000502364.1 CTCTCTTTTCAACTCAATACTATAGGGGAAAACTACCACTGATAGTTTCACTATGGGGGT ENST00000381218.3 ------------------------------------------------------------ ENST00000502364.1 CCTTATGGGTTGCTTCTAATGATTCAGGGAAACAGACAATTTCCAATACTTAGAAATACT ENST00000381218.3 ------------------------------------------------------------ ENST00000502364.1 TTTTAATCTGGAGAAAAAAATACTTCCACTGAGTGACAGCCTTGCTCCACCAGAATCAGC ENST00000381218.3 ------------------------------------------------------------ ENST00000502364.1 ACATCTCTTCAATTTCCATGTGGGATGATTCTGTGCCTCCGTGAATACAAGCCAGGTTGG ENST00000381218.3 -------------------------- ENST00000502364.1 AAAGGTCAGTGTATAGAGAGGAATGA