CLUSTAL 2.1 multiple sequence alignment ENST00000392033.4 ------AGTCTCGAGCTCTCGCTGGCCTTCGGGTGTACGTG-CTCCGGGATCTT--CAGC ENST00000445357.1 CTACTTGGTGTCGAG-----GCAGG--TAAAAACCAAGGTGACCCCAAGAAAATGGCTGC ** ***** ** ** * * *** * ** ** * * ** ENST00000392033.4 ACCCGCGGCCGCCATCGCCGTCGCTTGGCTTCTTCTGGACTCATC------TGCGCCACT ENST00000445357.1 TCCCCCAAAGGAGGCAGAAGGAGGAAGTGAAGATGAGGAAATGTCAGAAGATGAAGAAGA *** * * * * * * * *** ** ** * ENST00000392033.4 TGTCCGCTTC-----ACACTCCGCCGC-CATCATGGTGAAGCTCGCGAAGGCAGGTAAAA ENST00000445357.1 TGACAGCTGTGGAGAAGAGACTGTCACACCTCA-GGAGAAAGGCAAGAAGGCTGCTGCAA ** * *** * * * * * * * *** ** *** * ****** * * ** ENST00000392033.4 ATCAAGGTGACCCCAAGAAAATGGCTCCTCCTC---CAAAGGAGGTAGAAGAAGATA--- ENST00000445357.1 CCCCAG------CCAAGAAGGTGACAGTTTCCCGAACAAAAAAGGCTGCAGGTGCCACAC * ** ******* ** * * * * **** *** * ** * * ENST00000392033.4 --GTGAAGATGAGGAAATGTCAGA--AGATGAAGAAGATG--ATAGCAGTGGAGAAGAGC ENST00000445357.1 CCACCAAGA-AAGCAACTGTCACTCCAGGCAAAGCAGTCGCCACACCTGCCAAGAAGGG- **** ** ** ***** ** *** ** * * * * * ***** * ENST00000392033.4 TAAATGATGACTTTTATCAAACTACCATGCACACTCTTTGGAAGAAAGGCAAGAAGGCTG ENST00000445357.1 --AGCCATAGCAGGCAAAGCACTGGCA-GCA-GCTCCT---------GGCAAGAAGG--- * ** * * *** ** *** *** * ********** ENST00000392033.4 CTGCAACCTCAGCCATCCCAGCCAAGGGGGCAAAGAATGGCAAGAATGCCAAGAAGGAAG ENST00000445357.1 -----------GACACCCCAGCCAAGGGGGCAAAGAACGGCAAGAACGCCAAGAAGGAAG * ** ********************* ******** ************* ENST00000392033.4 ACAGTGATGAAGAGGAGGATGA---TGA-----CAGTGAGGA------------------ ENST00000445357.1 ACAGCGATGAGGAGGAGGATGACTCTGAACCAGCAGTGATGAAGGCAGCAGCGGGTGCCC **** ***** *********** *** ****** ** ENST00000392033.4 ----------GGATGAGGAGGATGACGAGGACGAGGATGAGGATGAAGATGAAATTGAAC ENST00000445357.1 CTGCCTCAGGGGATGAGGACGAGGACGATGAGGACGATGCTGAGGAAGATGGCTCTGAAG ********* ** ***** ** ** **** ** ******* **** ENST00000392033.4 CAGCAGCGATGAAAGCAGCAGCTGCT------------GCCCCTGC-----------CTC ENST00000445357.1 CAGCACCTATGGAAACAACACCAGCCAAAGGAAAGAAAGCTTCTACAAATGCTGTTCCTG ***** * *** ** ** ** * ** ** ** * ** ENST00000392033.4 AGAGGATGAGGACGATGAG-GATGACGAAGATGATGAGGATGACGATGACGATGAGGAAG ENST00000445357.1 GGAAAGCCAAGAGGATGGCTGGGAATGAAGATGAAGAGGATGATGAGGACAAGGACGAGG ** * ** **** * * ******** ******** ** *** * ** ** * ENST00000392033.4 ATGATGATGATGATGAAGATGATGAGGAGGAGGAAGAAGAGGAGGAGGAAGAGCCTGTCA ENST00000445357.1 GTGACGATGATGAAGAGGATGA-AGTGATGAAGACGACAAAGAGGAGGAAGGGTCTGTCA *** ******** ** ***** ** ** ** ** * ********** * ****** ENST00000392033.4 AAGAAGCACCTGGAAAACGAAAGAAGGAAATGGCCAAACAGAAAGCAGCTCCTGAAGCCA ENST00000445357.1 AAGAAGCACCTGGAAAAT----GAAGGAAATGACCAAACAG----CAGCTTCTGAAGCCA ***************** ********** ******** ***** ********* ENST00000392033.4 AGAAACAGAAAGTGGA-------AGGCACAGAACCGACTACGGCTTT------------- ENST00000445357.1 AGAAACACAAAGTGGAGAGTGAGAAGCACAGAACCAACTGTGCCTTTTTTTTTTTTTTAA ******* ******** * ********** *** * **** ENST00000392033.4 ----------CAATCTCT------------------TTGTTGGAAACCTAAACTTTAACA ENST00000445357.1 GACAGGGTCTCACTCTCTCGGAACGTCTTTCAATCTTTGTTGGAAACCTGAACTTTAACA ** ***** ************* ********** ENST00000392033.4 AATCTGCTCCTGAATTAAAAAC------TGGTATCAGCGATGTTTTTGCTAAAAATGATC ENST00000445357.1 AGTCTGCTCCTGAGTTAAAAACAAAAACTAGTATCCATGATATTTTTGCTAAAAATGATC * *********** ******** * ***** *** ****************** ENST00000392033.4 TTGCTGTTGTGGATGTCAGAATTGGTATGACTAGGAAATTTGGTTATGTGGATTTTGAAT ENST00000445357.1 TTGCTGTTGTGGATGTCAGAATGGGTATGACAAGGAAATCTGACTATGTGGATTTTCAAG ********************** ******** ******* ** ************ ** ENST00000392033.4 CTGCTGAAGACCTGGAGAAAGCGTTGGAACTCACTGGTTTGAAAGTCTTTGGCAATGAAA ENST00000445357.1 CTGCTGAAGACCTGGAAAGAGCCTTGGAACTCGCTGGTTTGAAAGACTTTGGCAATGAAA **************** * *** ********* ************ ************** ENST00000392033.4 TTAAACTAGAGAAACCAAAAGGAAAAGACAGTAAGAAAGAGCGAGATGCGAGAACACTTT ENST00000445357.1 TTAAACTAGAGAAACCAAAAGGAAAAGACAGTAAGAAAGAGCAAGATGTGAGAATACTTT ****************************************** ***** ***** ***** ENST00000392033.4 TGGCTAAAAATCTCCCTTACAAAGTCACTCAGGATGAATTGAAAGAAGTGTTTGAAGATG ENST00000445357.1 TGGCTACAAATCTCCCTTACAAAGTCACTCAGGATGAA----AAAAAGTGTTTGAAGATG ****** ******************************* ** *************** ENST00000392033.4 CTGCGGAGATCAGATTAGTCAGCAAGGATGGGAAAAGTAAAGGGATTGCTTATATTGAAT ENST00000445357.1 CTGTGGAGATTGGATTAGTCAGCAAGGATGGGAAGAGTAAAGGGACTGCTTATATTGAGG *** ****** ********************** ********** ************ ENST00000392033.4 TTAAGACAGAAGCTGATGCAGAGAAAACCTTTGAAGAAAAGCAGGGAACAGAGATCGATG ENST00000445357.1 TTAAGACAGAAGCTAATGCAGAGAAAACTTCTGAAGAAACGCAGGGAACAGAGATGGATG ************** ************* * ******** *************** **** ENST00000392033.4 GGCGATCTATTTCCCTGTACTATACTGGAGAGAAAGGTCAAAATCAAGACTATAGAGGTG ENST00000445357.1 GCCGATCTATTTCCCTGCACTATCATGGAGAGAAAGGTCTAAATCAAGACTAGAGAGAC- * *************** ***** ************** ************ **** ENST00000392033.4 GAAAGAATAGCACTTGGAGTGGTGAATCAAAAACTCTGGTTTTAAGCAACCTCTCCTACA ENST00000445357.1 ----------CACTTGGAGGGGTGAATCAAAAACTCTGGTTT-AAGCAACCTCTCCTACA ********* ********************** ***************** ENST00000392033.4 GTGCAACAGAAGAAACTCTTCAGGAAGTATTTGAGA--AAGCAACTTTTATCAAAGTACC ENST00000445357.1 GTGCAACAGAAGAAACTCTTCAGAAAGAATCTGAGACAAGGCAACTTTTATCAAAGTGCC *********************** *** ** ***** * ***************** ** ENST00000392033.4 CCAGAACCAAAATGGCAAATCTAAAGGGTATGCATTTA--TAGAGTTTGCTTCATTCGAA ENST00000445357.1 CCAGAACCAAAATGGCAAATCTAAAGGGTGTGCATGCACTTACAGTTCGCTTCATTTGAA ***************************** ***** * ** **** ******** *** ENST00000392033.4 GACGCTAAAGAAGCTTTAAATTCCTGTAATAAAAGGGAAATTGAGGGCAGAGCAATCAGG ENST00000445357.1 GATGATAAAGCAGCTTTAAATTCCTGTAATAAAAGGGAAACTGGGGGCAGGGCAATCAGG ** * ***** ***************************** ** ****** ********* ENST00000392033.4 CTGGAGTTGCAAGGACCCAGGGGATCACCTAATGCCAGAAGCCAGCCATCCAAAACTCTG ENST00000445357.1 CTGGAGTTGCAAGGACC---------ACCTGATGCCAGGAGCCAGCCATCTAAAAC--TG ***************** **** ******* *********** ***** ** ENST00000392033.4 TTTGTCAAAGGCCTGTCTGAGGATACCACTGAAGAGACATTAAAGGAGTCATTTGACGGC ENST00000445357.1 TCTGTCAAAGGCCTGTCTGAGGACACCACTGAAGAGGCTTTA-----GTCATTCGACAGC * ********************* ************ * *** ****** *** ** ENST00000392033.4 TCCGTTCGGGCAAGGATAGTTACTGACCGGGAAACTGGGTCCTCCAAAGGGTTTGGTTTT ENST00000445357.1 TTTGTT-GGGCAAGGGTAGTCACCAACCAGGAAACCGGGTGCCCCAAAGGCTTTGGCTCT * *** ******** **** ** *** ****** **** * ******* ***** * * ENST00000392033.4 GTAGACTTCAACAGTGAGGAGGATGCCAAAGCTGCCAAGGAGGCCATGGAAGACGGTGAA ENST00000445357.1 GTAGATGGCAACAGTGAGGAGGATGCCAAAAGCGCCAAGGAGGCCGCGGAAGATGGTGAA ***** ********************** ************ ****** ****** ENST00000392033.4 ATTGATGGAAATAAAGTTACCTTGGACTGGGCCAAACCTAAGGGTGAAGGTGGCTTCGGG ENST00000445357.1 ATTGAGGGAAACAAAGGTAACTTGGACTGGGCCAAACCTAAGGGCGAAGGTGGCTTTGGG ***** ***** **** ** ************************ *********** *** ENST00000392033.4 GGTCGTGGTGGAGGCAGAGGCGGCTTTGGAGGACGAGGTGGTGGTAGAGGAGGCCGAGGA ENST00000445357.1 G-TTGTGATGGAGGTAGAGGAAGCTTTGGAGGATGAGGTGGTGG---------------- * * *** ****** ***** *********** ********** ENST00000392033.4 GGATTTGGTGGCAGAGGCCGGGGAGGCTTTGGAGGGCGAGGAGGCTTCCGAGGAGGCAGA ENST00000445357.1 -----------CAGAAGCCAGGAAGGCTTTGGTGGGCGAGGCAGCTTCTGGGGAGGCA-- **** *** ** ********* ******** ***** * ******* ENST00000392033.4 GGAGGAGGAGGTGACCACAAGCCACAAGGAAAGAAGACGAAGTTTGAATAGCTTCTGTCC ENST00000445357.1 -------GAGGTGACCACAAGCCACAAGGAAAGAAGACAAAGTTTGAACGGCTTCTGTCC ******************************* ********* ********** ENST00000392033.4 CTCTG-CTTTCCCTTTTCCATTTGAAAGAAAGGACTCTGGGGTTTTTACT--GTTACCTG ENST00000445357.1 CTTTGTCTTTCCCTCTCCCATTTGAAAGAAAGGACGCTGGGGTTTTTATTCCGTTACCTG ** ** ******** * ****************** ************ * ******** ENST00000392033.4 ATCAATGACAGAGCCTTCTGAGGACATTCCAAGACAGTATACAGTCCTGTGGTCTCCTTG ENST00000445357.1 ATCAATGACAGAGCTCTCTGAGGACATTCCAAGACAGTCTACAGTCCTGTGGTCTCCTTG ************** ********************** ********************* ENST00000392033.4 GAAATCCGTCTAGTTAACATTTCAAGGGCAATACCGT----GTTGGTTTTGACTGGATAT ENST00000445357.1 GAAATTCGTATAGACAACATTTCAAGGGTAATACCTTCCTTGTTTGTTTTGACTGGATAT ***** *** *** ************* ****** * *** *************** ENST00000392033.4 TCATATAAACTTTT------------------TAAAGA--------------GTTG---- ENST00000445357.1 TCATATAAACTTTTCTTTCTTTTCTTTTTTTTTTAAGACGAAGTCTCACTCTGTCGCCCA ************** * **** ** * ENST00000392033.4 -----------AGTGATA-GAGCT-----------AACCCTTATCT-----GT--AAG-- ENST00000445357.1 GGCTGGAGCGCAGTGGTGTGATCTTGGCTCACGGCAACCTCTGCCTCCCGGGTTCAAGCG **** * ** ** **** * ** ** *** ENST00000392033.4 ----TTTTG--------------------------------------------------- ENST00000445357.1 ATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATACGCCACCACACCTGGC * ** ENST00000392033.4 -AATTT--ATATT--------------GTTTCATC------------------------- ENST00000445357.1 TAATTTTCATATTTTCAGTAGAGATGAGTTTCATCATGTTGGCCAGGTTGGTCTTGAACT ***** ***** ******** ENST00000392033.4 -------CCATGTA--------------------CAAAA--------------------- ENST00000445357.1 CCTGACCTCATGTAATCCGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAG ****** **** ENST00000392033.4 ------------------------CCATTT------------------------------ ENST00000445357.1 CCACCGTGCCCGGCCTGCTAAGTCCCATTTCTAAATTCGCACCAGTGTCTACTCAGAGAG ****** ENST00000392033.4 ------------------------------------------------------------ ENST00000445357.1 GACTCTGGTTGTCCGAGCTCCTGGGCCAGGCCAGTATCAGAGCTGCACAATAATGCTCAC ENST00000392033.4 ------------------------------------------------------------ ENST00000445357.1 TCAGGAGCAACTCCACAGAAAAATTCTGCACCAAATACAACTGATATTTTGTGTCCAGTC ENST00000392033.4 ------------------------------------------------------------ ENST00000445357.1 ACAGTAGAAAGGGACAGACCAACTCAGGCAACAATCTTTCTTCCAAATAATTTCAAATAA ENST00000392033.4 -TTTCCTA-------------CAAATAGTTT----------------------------- ENST00000445357.1 TTTTCCTAATAATTTTATATGCAAATAATTTCAAAATTGTGTAAACCAAAATTAAAATCC ******* ****** *** ENST00000392033.4 ------------------------------------------------------------ ENST00000445357.1 CAAGGCCTGCCAACCATCTGAATGGACTTCCTCTTCTAGGCCAGGGCCATCCAAATTTCA ENST00000392033.4 ---------------------------------------------GGGTTTTGTTGTTGT ENST00000445357.1 TCTGAAAGACTGGTTCAGGCCATTATGGGAAGAGGGGAGTCAGACAGGCCTCATTGTGGC ** * **** * ENST00000392033.4 TTCTTTTTTT-------------------------------------------------- ENST00000445357.1 CTCCTCCCTTCTGGAATTCAGGAAAAGCTCACCAGCATTTAACATCAACACTGACTTTAA ** * ** ENST00000392033.4 ------------------------------------------------------------ ENST00000445357.1 GTCTGATAAGAAACATAATCTGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTT ENST00000392033.4 ----------------------TGTTT--------------------------------- ENST00000445357.1 TGGGAGGCCAAGGGGTTCGGACTGCTTGAGTAGAGGGGTCTGAGCCCAGCTGGGCAACGT ** ** ENST00000392033.4 ----------TGTTT----------------------------------------TTGTT ENST00000445357.1 GGTGAAACCCTGTCTCTCTAAAAAATACCAAAATTAGCTGGGTGTGGTGGTGCAATTGTT *** * ***** ENST00000392033.4 TTTTTTTTTTTT---------GCGTTCG----------------TGGGGT---------- ENST00000445357.1 TTTTTTTTTTTTTTTGAGACAGGGTCTGACTCTGTCACCCAGGCTGGAGTGCAGTGGCAC ************ * ** * *** ** ENST00000392033.4 -------------TGTAA------------------AAGAAA------------------ ENST00000445357.1 AATCTCAGCTCACTGTAACTTCTGCCACTTGGGCTCAAGCGATTCTCCCGCCTCAGCCTC ***** *** * ENST00000392033.4 ---AGAAAGCAGAAT------------------------GTT--TTATCATGGTTTT--- ENST00000445357.1 CTGAGTAGCTGGGATTACAGGCACCCACCATCACACCCGGTTAATTTTTATAGTTTTAGT ** * * ** *** ** * ** ***** ENST00000392033.4 ------------------------------------------------------------ ENST00000445357.1 AGAGACGGGGTTTCGACATGTTGGCCAGGCTGGTCTTGAACTCCTGGCCTCAGGTTGTCC ENST00000392033.4 ---TGCTTCAGC----------------------GGCTTTAG-----------GACAAA- ENST00000445357.1 GCCTGCCTCGGCCTCTCAATGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCGGCAAAA *** ** ** *** * ** * **** ENST00000392033.4 -------------TTAAA------------------------------------------ ENST00000445357.1 AAACACAATTTTTTTAAACTACCTCCGACCTGGAAGCCCCCACTTCAAGTTGTCCCGCCT ***** ENST00000392033.4 ----------AGTCAAC----------------TCTG----------------------- ENST00000445357.1 TTGTGGACCAAATCAACATATATCTTAAATGTATTTGATTACTGTCTCATGTCTAAAATG * ***** * ** ENST00000392033.4 --------------GTGCC----------------------------------------- ENST00000445357.1 TATAAAACCAAGCTGTGCCCTCCACCTTGGGCACATGTCCTCAGGGTCACCTGAGGGCTA ***** ENST00000392033.4 ------------------------------------------------------------ ENST00000445357.1 TGTCACGAGCCATGGTCACTCATATTCAGCTCAAAAATAAATCTCTTCAAATATTTGACA ENST00000392033.4 ------------------------------------------------------------ ENST00000445357.1 GAGTTTGACTTTTTCATCCATTATGGTCCAATGTCTCATTCGAGTTTTTATTCTAAAACC ENST00000392033.4 ------------------------------------------------------------ ENST00000445357.1 AGTGGGTGTCCCACACGTCTACCGGGACCACTAGCAACTCCGAGCAAATGCAGGGCCCAG ENST00000392033.4 ------------------------------------------------------------ ENST00000445357.1 GAGGAGAGCCCAGACTCCTGGAAACCCGCAGCAGTTCCCAGAAACTCTCACCCCCAAAAC ENST00000392033.4 ------------------------------------------------------------ ENST00000445357.1 CCTCGACTCTGTCTTGATCACATTGCTGGTCTGTTACGCTCTGTAAAATATTTGAGAAAA ENST00000392033.4 ------------------------------------------------------------ ENST00000445357.1 TAAATACCAGAAAGCCGGGCATGGTGGCTTACGCCTGTAATCCCAGCACTTTGAGAGGCT ENST00000392033.4 ----- ENST00000445357.1 GAGGC