CLUSTAL 2.1 multiple sequence alignment ENST00000393552.2 ------------CGAACCTTT--GCGAATCAGAGGAGGCTGGTGCAGGGAGAC-AGCAAG ENST00000478377.1 ATCAGCCATGGTCCAACATTTATGTGCAACATCTCAGGCTG-TGCTGTGAGCCCGGCTAT * *** *** * * * ** ****** *** * *** * ** * ENST00000393552.2 CTGTT----CTTCA------ATAACGTT---------TTCA---------CTGTGGAGCC ENST00000478377.1 CCATTTCTCCTTCACCAGCTACAACTTTGGGACCTGCTTTATCTATCAAGCTGGGATGCC * ** ***** * *** ** ** * *** * *** ENST00000393552.2 CCTGGA-AGGTGATGTCTGGC-----CCAAC-------------TCATCAGCTGAAATCA ENST00000478377.1 CCCATACAAACAAACCCTGGTAATTACCAACAAGGAAGAAACACCTATGAGCATAGATTG ** * * * **** ***** ** *** * ** ENST00000393552.2 CCGTGTACTTTAAC-CCACTA-----GAAGCCAA--GCTCTATCAAC------------- ENST00000478377.1 TC-TGTACACCAACACCACTCACCTCGAGGTGAACTGCCGTGTTGATGTGGTAAAGCCAG * ***** *** ***** ** * ** ** * * * ENST00000393552.2 -AGAC-CATT------TACTGCGACATTTTAGGC-CGAGAAA------------------ ENST00000478377.1 GAAACACATTGGAGATTCCAATAACTTTTTATCCTCGAGAAAGTATCAACTATCAAGAAC * ** **** * * ** ***** * ******* ENST00000393552.2 ----TCCGTCTG-----------CCCC------------TCCGAATCAAAGGGGAAGGCA ENST00000478377.1 TCATTCCCTTTGAAATCAATGGGCTCTCACAACAAACAGTCGAAATCAAAGGGAAGGGTA *** * ** * * ** ********** * ** * ENST00000393552.2 TGGGACCTAAGATTC--------ACTTCAACT--TTGAATTGCTGGATATTGGGAAAGTT ENST00000478377.1 CCGAAATGAAGATTTTAGTCCTAGATCCAGCCAACAGGATTGT--GAAGTTGGGAGCTGT * * ****** * ** * * **** ** ****** * ENST00000393552.2 TTCACTGGATCTGCACATTGTTATGAGGCGATACTGTACAACAAAGGCAGCATC--GAT- ENST00000478377.1 CCTACCAGG---GCAGGTTGTGAAAAGA--ACAGTTTCCATCATGAACAACAGCCTGGCC ** * *** **** * ** * * * * ** ** ** ** * * ENST00000393552.2 --GCTCTC-TTCAACATGACCCCTC------CAACTTCAG--CTTTGGGGGCCTG----C ENST00000478377.1 CAGCTCACATTTAATCAGTCCATTCTGTTCACAATTCCAGAACTCCAGGAACCCAAGGTC **** * ** ** * ** ** *** * *** ** ** ** * ENST00000393552.2 TTTGTTTTCAGTCCCAAGGAAGGCATCAT--TGAA-CCAAGTGGAGTCC--AAGCT---A ENST00000478377.1 CTCACCCTGGCGCCCTTCCACAACATCACACTGAAGCCCAAAGAAGTCTGTAAACTGGAA * * *** * ***** **** ** * * **** ** ** * ENST00000393552.2 TCCAGATCTCCTTC-----AGC-TCTACCATCCTGGGAAACTTTGAAGAAGAGTTCCTGG ENST00000478377.1 GTCATCTTTGCCCCGAAGAAGCGTGTCCCTCCCTT-----CTCTGAGGAAGTGTTCATGG ** * * * * *** * * ** *** ** *** **** **** *** ENST00000393552.2 TCAATGTCAATGGGTCACCTGAGCCTGT------------GAAACTGACCATTAGAGGCT ENST00000478377.1 --AATGC--ATGGGGCTCCTGCGCCCCCTCTTCCTCCTTAGCGGCTG-CTGCCAGGCCCT **** ***** * **** *** * *** * ** ** ENST00000393552.2 G----TGTCATTGGACC-----TACCTTCCATTT-------TAATGTTCCAG-------- ENST00000478377.1 GGAGATCTCACTGGACCAGGAACATATTCCCTTTGGACCCGTGGTGTATCAGACGCAAGC * * *** ****** * **** *** * *** *** ENST00000393552.2 ----CTCTGCACTTT-------------GGTGATGT----------TTCCTTTGGGTTTC ENST00000478377.1 CACGCGTCGCATCCTCATGTTGAACACAGGCGATGTGGGTGCAAGGTTTAAATGGGACAT * *** * ** ***** ** **** ENST00000393552.2 CTCATACCTTGA--TATGTTCCCTCAATAATAC---------CTCTTTGATCCC---CAT ENST00000478377.1 CAAAAAATTTGAGCCTCATTTCTCCATTAGCCCAGAAGAAGGCTATATTACCTCAGGCAT * * * **** ** * ** ** * ** * * * * * *** ENST00000393552.2 GA------CTTACAAACTG-CGTA---TCCC-------TGGGGATGG----CCTTGGCCA ENST00000478377.1 GGAGGTTTCTTTTGAAGTGACCTACCATCCCACCGAGGTGGGAAAGGAGAGCCTT---TG * *** ** ** * ** **** **** * ** **** ENST00000393552.2 TAAAAGCATTTCATATTGT-----GAGCAGCA--------------------TGTGGA-- ENST00000478377.1 TAAAAACATTCTCTGCTACATCCAGGGAGGCAGTCCTCTGAGTCTAACCCTGTCTGGAGT ***** **** * * * * *** * **** ENST00000393552.2 CTACAAAAGACCATCTTGGACCAAGGAAGAAATATCCTCAATGAAACCAA---------A ENST00000478377.1 CTGCGTGGGACCACCTGCAGTAAAAGAGGTAGTGAATTTCATGTG-CCAGGTGCGCTCCA ** * ***** ** ** ** * * * * *** *** * ENST00000393552.2 AGAATTCACCATCTCTCCTGACTGTGGCACCAT-TCGCCC---CCAGGGATTTGC-TGCT ENST00000478377.1 AGCACACGCAGACCATCCTG-CTGTCAAACCGCACCAACCAGACCTGGAATCTGCACCCC ** * * * * ***** **** *** * ** ** ** ** *** * ENST00000393552.2 ATC----AGGGTGA-CATTATGC----------TCCAACACTGTG---------CAGAAA ENST00000478377.1 ATCTTTGAGGGCGAGCACTGGGAGGGGCCTGAGTTCATCACCCTGGAGGCCCACCAGCAA *** **** ** ** * * * ** *** ** *** ** ENST00000393552.2 TACGAGC----TGG---CACTCGTGG-----------TGGACGTGGAGGGCATCGGAGAA ENST00000478377.1 AACAAGCCCTATGAGATCACCTACAGGCCCCGCACCATGAACTTGGAGAACCGCAAGCAC ** *** ** *** * ** ** ***** * * * ENST00000393552.2 GAGG---------TGCTGGCGCTCTTAATTACAGCAAGGTGTGTTGTACCTGCCCTCCAC ENST00000478377.1 CAGGGCACCCTCTTCTTCCCCCTCCCAGATGGGACCGGCTG-GCTGTA--TGCTCTGCA- *** * * * *** * * * * ** * **** *** ** ** ENST00000393552.2 CTGGTCAATACAGAGGT-----GGACTTTGGGCACTGCTT--CCTGAAGTACCCGTATGA ENST00000478377.1 -TGGG-ACTTCTGAGCTCCCCAAAGCTGTAGCCAATATCTATCGTGAAGTGCC-ATGTAA *** * * * *** * ** * * ** * * * ****** ** * * * ENST00000393552.2 GAAA----ACACTCCAGCTT--GCCAATCA--AGATGACC-------TCCCAG-GATTCT ENST00000478377.1 GACCCCCTACACTG-AGCTTCTGCCAATCACCAACTGGCTGAACAAGCCCCAGAGATTCC ** ***** ***** ******** * ** * ***** ***** ENST00000393552.2 A-----------------TGAGGTC--------CAGCCTCAGGTGT----GTGAGGAGG- ENST00000478377.1 GGGTCATCGTGGAAATACTGAAACCAGAGAAGCCGGACCTAAGCATCACTATGAAGGGCC *** * * * * * * * *** * * ENST00000393552.2 -TGCCTACTGTGCTGT--TTTCCAGCCCCA-------CCCCCAGCGGGG--TCATCTCCC ENST00000478377.1 TTGATTACATTGATGTACTGTCTGGCTCTAAGAAAGACTACAAGCTGAACTTCTTTTCCC ** *** ** *** * ** ** * * * * *** * ** * **** ENST00000393552.2 -CAAGCAGC-ACCATCCAC-ATACCACTGGTCCTGGAGACCCAGGTCACTGGAGAACACA ENST00000478377.1 ACAAGGAGGGAACGTACGCTGCAAAGGTGATCTTCCGAAACGAGGTGAC------AAATG **** ** * * * * * * ** ** * * * **** ** * * ENST00000393552.2 GATCCACGGTTTACATCTCAATCTTTGGGAGCCAGGACCCCCCTTTGGTATGTCACTTAA ENST00000478377.1 AGTTC-----TTGTACTACAATGT--GAGTTTCAGGGTCATCCCTTCAGGCATCATCAAA * * ** * **** * * * **** * ** ** *** ** ENST00000393552.2 AGAGCGCTGGAGAAGG----CCCAGTT-----ATCTACGTCCATCCCAATCAAGTGGACT ENST00000478377.1 A---CCATCGAGATGGTGACCCCAGTCCGGCAAGTTGCGTCAGCCTCCATCAAGTTG--- * * * **** ** ****** * * **** * * ******* * ENST00000393552.2 TCGGGAATATCTACGTCCTA---AAAGACTCT-TCCA---------GGATTCTCAAC--- ENST00000478377.1 --GAGAAC-CCTCTGCCCTACTCGGTGACCTTCTCCACAGAATGCCAGATGCCCGACATC * *** ** * **** *** * **** *** * * ** ENST00000393552.2 ---CTATGCAACCAGTCCTTCATTCCCGCATTTTTCCAGGCACA----CATGGCACACAA ENST00000478377.1 GCCCTGCCCTCCCAGTTTGTGGTGCCTGCCAACTCCGAGGTACGTCCCCTTGGCTGTCGG ** * ***** * * ** ** * * *** ** * **** * ENST00000393552.2 AAAATCCCTTTGGAC-----GATTGA-----ACCCAATGAAGGCA-TGGTTCC------- ENST00000478377.1 GGGCTCCCTGAGAGCTGTGAGAGTGGCTTCCACCCA-TGAGATCTCTGGATCCACACTCT ***** * * ** ** ***** *** * *** *** ENST00000393552.2 -----TCCAGAAACTGATGTTCAAC--TGGCACTGACCGCCAACCTGAATGAC---ACAC ENST00000478377.1 GCATCCCCAGAGGGTG--GGCCAGCCCTGACAGTGGTCAGGAAGGCAGAGGACGGGACAA ***** ** * ** * ** ** ** * ** * *** *** ENST00000393552.2 TGACATTCAAGGAC--TGTGTTATT-TTGGA-----CATTGAAAAT--AGCAGTACCTAT ENST00000478377.1 TCACCCTCATGTTCCTTTTCTTGTTGCTAAAGTCCTCATAGGAGCTTGGGCACATCGTTT * ** *** * * * * ** ** * * *** * * * *** * * * ENST00000393552.2 CGGATTCCTGTTCAGG-------CTTCCGGAACTGGTTCCACTA--TTGTTTCAGATAAG ENST00000478377.1 GGAATTCTCTCTTATGAACCTTGTCTCTGTGATTTGTTTGTTTTCTTTGTTCCAGCTAAA * **** * * * ** * * * *** * ***** *** *** ENST00000393552.2 CCCTTTGCTCCAGAA----CTCAATT-TGGGGGCA-CAT----TTTAGCC----TGG--- ENST00000478377.1 ACTATTTTTCTTGTTTTTTCTTAATTATAAAAGTAGTATAGAGTCCAGGCGCAGTGGCTC * ** ** * ** **** * * * ** * ** * *** ENST00000393552.2 ATACCCACTATT--ACCACTTTAAGTTGATCAACAAGGGACGTCGGATC---------CA ENST00000478377.1 ACACCTATAATCCCACCACTTTGGGAGG-----CCAGGGACGGCAGATCACTTGAGGTCA * *** * ** ******** * * * ******* * **** ** ENST00000393552.2 ACAGTT-------GTTCTGGATGA-ATGAT--AGCTTCCGACCCCAGGCCAAGCTGAGTA ENST00000478377.1 GGAGTTTGAGACTAGCCTGGCTAACATGGTGAAACCCCCATCTCTA--CTAAAAATACAA **** **** * * *** * * * ** * * * * ** * * ENST00000393552.2 AGAAGGGCCGGGTTAAGAAGGGACATGCTCATGTCCAACCCCAGCCCAGTGGCTCTCAGG ENST00000478377.1 AAATTAGCCCAGC-ATGGTGGTGGGTGCCTGT----AATCCCAGCTACTTGGGAGGCTGA * * *** * * * ** *** * ** ****** *** * * ENST00000393552.2 AGCCCAGGGATCCACAGAGCCCCGT--GTTTCATCTCCACCCCGCCAGCATGGAGC---T ENST00000478377.1 GGCAGAAGAATTGCTTGAACCCAGGAGGTGGAGGCTGCAGTGAGCCGAGATTGTGCCACT ** * * ** ** *** * ** ** ** *** ** * ** * ENST00000393552.2 GTACC-CAGGCCAGGCAATTGATGTGATACTCGAAGGCTATTCTGCTACTCCCAGGAAAC ENST00000478377.1 GCACTGCAGCCTGGGCAACAGA-GTAAGACTCTA-------TCTCAAAATAATATAAAAT * ** *** * ***** ** ** * **** * *** * * * *** ENST00000393552.2 CTAACAGTATCCTGAAACCTGATT-ACCAGCCCTTGGCCATAAAGAACATTTCCACCCTG ENST00000478377.1 AAAATAATAAAATAAAATAGTATAGAATAGGTGT-GGTGAAAAGGAAAA----------- ** * ** * *** ** * ** * ** * ** *** * ENST00000393552.2 CCCGTGAACTTGTTGCTGTCAACATCTGGACCCTTCTTTATATGTGAGACTGATAAATCC ENST00000478377.1 -CAAGGTATGTAATAGTGTGCGCACACACATACTACTTCAGGAAGGAGCACAAGAAAACT * * * * * *** ** * ** *** * *** * *** * ENST00000393552.2 CTGCTGCCGGC----AACTC----CTGAGCCTATTAAACTGGAAATTGATGAAGAAAAAA ENST00000478377.1 TTGACAGTGGTTAGGAGTGCATGGCTGGAATTATAGAATTGTGAACTGGCAGGGAGAGGA ** ** * * *** *** ** ** ** ** ** * * ENST00000393552.2 ACCTGCTGATCAAGTTTGACCCTTCCTACAGAAACGATCTGAACAACTGGGTGGCAGAAG ENST00000478377.1 ACTTTCT-------TTGGAGTCTTTTTAT-----------------CTGGTTATCACTCC ** * ** ** ** *** ** **** * ** ENST00000393552.2 AAATTCTAGCAATTAAG--TATGTGGAACACCCTCAGATAGACAGCCTGGA-CCTGCGCG ENST00000478377.1 AAACTCTCACTGTCCAGATTCTATCAAATCTCTTCTGTTTTTCCACCTTCAGCCCACCTG *** *** * * ** * * * ** * ** * * * *** * ** * * ENST00000393552.2 GAGAAGTGCATT-ACCCCAACCTCAGCT----------TTGAGACAAAGGAGCTG----G ENST00000478377.1 ACGAGTTCCCCTCACTCCAGCTCCAGCTGACTTCCTTCTTCAGGCTGGTCATTTGTGTTG ** * * * ** *** * ***** ** ** * * ** * ENST00000393552.2 ATTT---TGGCTG--CATCCTGAACGAT------ACTGAGCTC----------------- ENST00000478377.1 GTTTCAATGTCTAGTTATCCTGAAAAATGTGGCCATGGATCTCCTGGTACATGTATCCTC *** ** ** ******** ** * ** *** ENST00000393552.2 ---ATTCGC-------TACGTTA--CCATCACCAACTGC-----AGT----CCGTTGGTT ENST00000478377.1 CCAATGCGCATAGGCATACGTTGTTCCA-CAGCATATGCCTAGGAGTAGAACCACAGGTC ** *** ****** *** ** ** *** *** ** *** ENST00000393552.2 GTGAAGTTTCGCTGGTTCTT--CTTGGTGAATGATGAGGAAAATCAG--ATAAG-GTTTG ENST00000478377.1 ATAGAGTGTGCATAGCTTTCACTTTAGTAGGTAAT--TGCCAATTAGTGATGAGAGTTCC * *** * * * * * ** ** * ** * *** ** ** ** *** ENST00000393552.2 TGACATTGCCGAAGAAGCCCTACAGTGCCCCAGTGTCCCAGATGGAGTCCATCCCAGCAA ENST00000478377.1 TAATGTT--CAACG--TCTTCACCAACCCTTGGTATTGTCGGTTTTTTTAAGGTTACTAA * * ** * * * * ** ** ** * * * * * * ** ENST00000393552.2 CCTCAGAGGCTGCCAGCCCACCAG-----CAAT---CCTAGTTACAG-TAGAGTCCCCCG ENST00000478377.1 TCTGATAAACTGCTAACTCCTCGTGGACTTAATTTCCCTTTTTACAAACAGATTGATTTC ** * * **** * * * * *** *** ***** *** * ENST00000393552.2 AGATGGAT----TTAAAT------GATTT-------TGTTAAGAAATAA----AAATTAG ENST00000478377.1 AGTTGGGTAATATTATATATAGGAGATCTGCATCTGTGTTCATGAGTGAGCTTAGACCAC ** *** * *** ** *** * **** * * * * * * * ENST00000393552.2 C-------TCTACTGAAATAG--------AAAGAATATACTCAAGCCA---GAGCCAGGT ENST00000478377.1 CGTTTTCCTCTCTCGTACTGTCTCTGTCCAGTTTGCATATCAAAGTTTTGCAAGCCATAT * *** * * * * *** *** ***** * ENST00000393552.2 GGAGGATCAGGAATCCCTACA-------GAC-CTGTGA----ACAGAA---TGAGAT--- ENST00000478377.1 AGAG--TCAGGCATTTTCTCACTTTCTGGATTCTGTGAGTTTACAAAAGATTGAAATTAC *** ***** ** ** ** ****** *** ** *** ** ENST00000393552.2 GCTTTCCATTGGG---ATAGAAGAAGT-------GTTTGATA---TTTTGCCCCTGTTTG ENST00000478377.1 GTCTTTC-TTGAACTCACAGATGAAGCCACCTAGGCCTGGTGGGTTTTTGTA--TGTGTG * ** * *** * *** **** * ** * ***** *** ** ENST00000393552.2 GAGTGTTGCAGCCACACAGTAGCCACCAAATATCGTTCACCTTCTATGGA--CACGCTAA ENST00000478377.1 GAG-GTGGGAG----AGATTGTCTGCTACTTATTTGTCTACTACTATTCAATTCCTTTAA *** ** * ** * * * * * * *** ** ** **** * * *** ENST00000393552.2 CA--TCATTGCACAAGCTAAAGCT-CTGTGT------GAAGTGGAAGAAGGACC------ ENST00000478377.1 TGGGTTATTGGACTACTTAGATTTTCTGTTTCTTCTTGCATCAGTAATAAGACCATGTTC * **** ** * ** * * **** * * * * * * **** ENST00000393552.2 ----CACCTACGAAATAACAC-TGAAGGGAGAGGCGTCCCTGGTCA-ACTATTCCTTTGA ENST00000478377.1 ATTGCATCCATATATTAAAATGTTGGTATAAAGTTGTTAATG-TCATATTACCTTTGTAA ** * * * *** * * * ** ** ** *** * ** * * * ENST00000393552.2 CACCAAGG---------ATATTCACTACGGATTACAG--CTGTTTGACCATGTCACAG-- ENST00000478377.1 TGTGACGTCGCTTTTTCATTTCTAATATTGGTTATTGTGCCTTCTCTCTGTTTCTTAGTC * * ** * * ** * *** * * * * * * ** ** ENST00000393552.2 -----AGAGG---------GAAAT-CA-CGCTGACGAACATGGGGAAA--GTTGGCT--T ENST00000478377.1 TTACCAGAGGTTTCTTTCCAAAATGCATCTTTTGTCTCCATTGTGACTCTATTGTATGCT ***** **** ** * * *** * ** *** * * ENST00000393552.2 TGAGTTCAAGGTTCTGACTGACCACCAGTCTTCTCCAGACAACCTTCTCCCTGGAGTGCC ENST00000478377.1 TGCTTTCTGGTTACT---TGATTTCTGCTCTTGTCTTTATTATTTCCTTCCTTCTGCTTC ** *** * * ** *** * **** ** * * * ** *** * * ENST00000393552.2 ACT---AATCCTGCCTGTGTCTGTAAGT----AAATGGTGGG--AGGGGCCCGAATTCAA ENST00000478377.1 CTTTGGGATACTGGGGGCTTATTTAATTTCTAAGATGAAGGCTTAGTGCTTTGACTTCTA * ** *** * * * *** * * *** ** ** * ** *** * ENST00000393552.2 ACCTAC----------GAGCCCCACTCCGAAGCAGGTGAGTATTCACG---------ACC ENST00000478377.1 GTCTTCTTGATTTTCCAAGCTAGACATTTAAAATTATAAATATCTAAGTACTGCTTTAGC ** * *** ** ** * * *** * * * * ENST00000393552.2 AGGATTACAAGT-GTGATTTT--TTCTTTTTGTTAAAACTAAAGA-------ACTCTCGG ENST00000478377.1 AGTTATACAAATTGTGATTGTAGTGTTTTTTATTCAGTTCAAAAAGGTTCTAATTTTTGT ** ***** * ****** * * ***** ** * *** * * * * * ENST00000393552.2 AAGCA--------------- ENST00000478377.1 GATTAATACTTCTTTTTTAA * *