CLUSTAL 2.1 multiple sequence alignment ENST00000393909.2 GTAGTCTTGACGTGAGCTAGCTGGCATGGCGGCCTGCATTGCAGCGGGGCACTGGGCTGC ENST00000504640.1 ------------------------------------------------------------ ENST00000393909.2 AATGGGCCTAGGCCGGAGTTTCCAAGCCGCCAGGACTCTGCTCCCCCCGCCGGCCTCTAT ENST00000504640.1 ------------------------------------------------------------ ENST00000393909.2 CGCCTGCAGGGTCCACGCGGGGCCTGTCCGGCAGCAGAGCACTGGGCCTTCCGAGCCCGG ENST00000504640.1 ------------------------------------------------------------ ENST00000393909.2 TGCGTTCCAACCGCCGCCGAAACCGGTCATCGTGGACAAGCACCGCCCCGTGGAACCGGA ENST00000504640.1 ------------------------------------------------------------ ENST00000393909.2 ACGCAGGTTCTTGAGTCCTGAATTCATTCCTCGAAGGGGAAGAACAGATCCTCTGAAATT ENST00000504640.1 ---CAG-TTCTTGAGTCCCTAATTCATTCCTCCAAGGGGAAGAATAAATCCTCTGAAGTT *** *********** ************ *********** * ********** ** ENST00000393909.2 TCAAATAGAAAGAAAAGATATGTTAGAAAGGAGAAAAGTACTCCACATTCCAGAGTTCTA ENST00000504640.1 TCAAATAGGAAGAAAAGTTATGTTAGAGAGGAGAAAAGTACTCCACATTCCAGAGTTCTA ******** ******** ********* ******************************** ENST00000393909.2 TGTTGGAAGTATTCTTCGTGTTACTACAGCTGACCCATATGCCAGTGGAAAAATCAGCCA ENST00000504640.1 TGTTGGAAGTATTCTTTGTGTTACTACAGCTGACTCATATGCCAGTGAAAAAATCAGCCA **************** ***************** ************ ************ ENST00000393909.2 GTTTCTGGGGATTTGCATTCAGAGATCAGGAAGAGGACTTGGAGCTACTTTCATCCTTAG ENST00000504640.1 GTTTCTGGGGATTTGCATCTAGAGATCAGGAAAAGGACTTGGGGCTACTTTTATCCTTAG ****************** ************ ********* ******** ******** ENST00000393909.2 GAATGTTATCGAAGGACAAGGTGTCGAGATTTGCTTTGAACTTTATAATCCTCGGGTCCA ENST00000504640.1 GAATGTTATTGAAGGACAAGGTGTTAAAATTTGCTTTGAACTTTATAATCCTCGAATCCG ********* ************** * ************************** *** ENST00000393909.2 GGAGATTCAGGTGGTCAAATTAGAGAAACGGCTGGATGATAGCTTGCTATACTTACGAGA ENST00000504640.1 GGAGACTCAAGTGGTCAAATTAGAGAAATGGGTGGATGATAGCTTGCTGTGGTTACGAGA ***** *** ****************** ** **************** * ******** ENST00000393909.2 TGCCCTTCCTGAATATAGCACTTTTGATGTGAATATGAAGCCAGTAGTACAAGAGCCTAA ENST00000504640.1 TGCTTTTCCTGAATATAGCACTGTTGATGTGAATATGAAGCCAGTAGCACAAGAGCCTAG *** ***************** ************************ *********** ENST00000393909.2 CCAAAAAGTTCCTGTTAATGAGCTGAAAGTAAAAATGAAGCCTAAGCCCTGGTCTAAACG ENST00000504640.1 CCAAGAAGTTCCTGTTAATAAGCTGAAAATGAAAATGAAGCCTCAGCCCTGGTCCAAATG **** ************** ******** * ************ ********** *** * ENST00000393909.2 CTGGGAACGTCCAAATTTTAATATTAAAGGAATCAGATTTGATCTTTGTTTAACTGAACA ENST00000504640.1 CTGGGACTGTCCAAATTTTAATATTTAAGGAATAATATTTGATCCTTGTTTCACTGAAGA ****** ***************** ******* * ******** ****** ****** * ENST00000393909.2 GCAAATGAAAGAAGCTCAGAAGTGGAATCAGCCATGGCTTGAATTTGATATGATGAGGGA ENST00000504640.1 ACAAATGAAAGCAGCTTAGAAGTAGAGACAGCTGTGGCTTGAATTTGATACGATGAGGGA ********** **** ****** ** **** **************** ********* ENST00000393909.2 ATATGATACTTCAAAAATTGAAGCTGCAATATGGAAGGAAATTGAAGCGTCGAAAAGGTC ENST00000504640.1 ATATGATGCTTTAAAAATTGAAGCTGCAATATGGGATGAAAATGAAGCATCCAGAAAGTC ******* *** ********************** * **** ****** ** * ** *** ENST00000393909.2 TTGATTCTGAGAATGAATTTGGTTAGTTGCAGAAGATACATTGGCTCTAAGAGGATATAT ENST00000504640.1 CTGATTCTGAGAATGAATTTGGTTACTTGCAGAAGATATATTGGCTCTAAGAGGATATAT ************************ ************ ********************* ENST00000393909.2 TTTGAGACCAATTTAATTTCATTTATAAGAACATAGTAATTAAGTGAACTAAGCATTCAT ENST00000504640.1 TGAGAGACCAATTTAATTTCATTTATAAGAACACAGTCATTAAATGAACTAAGCATTCAT * ****************************** *** ***** **************** ENST00000393909.2 TGTTTTATTAATACTTTTTTTCTAAAATAAAACTTGTACACCAGTTTATTACTCTAAAAA ENST00000504640.1 TGTTTCATCAGTACTTTTTT-CTAAAATAAAACTTGCACACCAGTTTATTACTCTAAAAA ***** ** * ********* *************** *********************** ENST00000393909.2 GA----GAATTACACATGCCAAATGGACCAATGTCCATTTGCTTATTGGAGGCAAAGCTA ENST00000504640.1 AAAAAAGAATTATATATGCCAAATGGTCCAATATCCATTCCCTTACTGGAGGCACAGTTA * ****** * *********** ***** ****** **** ******** ** ** ENST00000393909.2 CAATAGAAGTCAGAGCATCACCAGAATGGTCTTTAATGAGCATGGAACCTGAGCAAAGGG ENST00000504640.1 CAATAGGAGTCAGAGCATCACCAGAATGCTCTTTAATGAGCATGGAATCTGAGCAA-GGG ****** ********************* ****************** ******** *** ENST00000393909.2 AATAGGTGGGATGAATTTTTTTTTTAATTGTGAAACAATTCATAAGCACAA-----TATG ENST00000504640.1 CATTGGTGG--TGA--TCTTTCTTAAATTGTGAAATAAATCATAAGCACAACAATGTATG ** ***** *** * *** ** ********** ** ************ **** ENST00000393909.2 ATTTACAGAATAATAAA-----CATTCATGTACCCACTATCAGGTTAAGAAATAGAACAT ENST00000504640.1 ATTTACAGAATAATAAAATGGACATTTACATAACCATCATCAGGTTAAGAAACAGAACAT ***************** **** * ** *** ************** ******* ENST00000393909.2 TTATTAATATGTAGGAATGTTAAGAAATAAAACATTTAATAAGATCTCAGAAGACTCCAG ENST00000504640.1 TTAG------GCAGGG-TGTGGTGGCTT---ACGCTTG-TA--ATCCCAGTA--CTTTGG *** * *** *** * * ** ** ** *** *** * ** * ENST00000393909.2 TAAATCT--GCAATTGTATCTCTCTCCTTTTTAAATGTAAATATCATCTTGACTTGT-TA ENST00000504640.1 GAGGCCAAGGCGGGCAGATCACTTGAGGTCAGGAGTTCGAG-ACCAACCTGGCCAACATG * * ** *** ** * * * * * ** * ** * * ENST00000393909.2 ATTATTCCCTTGCATTTCTTTTAGTTTACTGCCAACACATATATTCTTCAACAATATATT ENST00000504640.1 GGGAAACCCT---GTCTCT--------ACTAAAAATACAAAAATTTGCCGG------ATG * **** * *** *** ** *** * *** * ** ENST00000393909.2 TAATTTTGAAAAACCTGAAAAAAAAAACCTGTTAGCAAGTATAAAGGGGCAGTATTACTA ENST00000504640.1 TGGTCATGCATG-CCTGTAATCCCAG--CTACTTGGGAGGCTGAGGCAGGAGAATCACT- * * ** * **** ** * ** * * ** * * * * ** ** *** ENST00000393909.2 TTATTGCATGAAGGCTTCAAGGGAAACGTTACAGTCTTTGGGTCATAGTCTGGCTTCAGC ENST00000504640.1 TGA--ACCCGAGAGCT-----GGAG--GTTGCAG----TGAGCCAAAATT--GCACCACC * * * ** *** *** *** *** ** * ** * * ** ** * ENST00000393909.2 TTCCTCTGAGAGTTTACAGAGGCCAATTTTGAGCAAATTCATGGCTAAGGTTATGAGTGA ENST00000504640.1 GCACTC----------CAG--------CCTGGGTGA---------CAGAGTGA-GACTCA *** *** ** * * * ** * ** * * ENST00000393909.2 GTTCTGCTAAACAGAAGGCTCACCACAAGGTATCTGGCAGGATTATACTGGGTAGCTGGA ENST00000504640.1 GTCTCAAAAAAAAAAAG----------AAATATCTGAGAAGGTTAAG--AAATAAC---- ** *** * *** * ****** * * *** ** * ENST00000393909.2 TGTTGCAGAA-ATGTGGTTAGAGGAAGTAAACTGTT-----TTTTGATGCTCA--CAGCA ENST00000504640.1 -ATTGAATAAGATCTAAAACAAAAAAGGAAACTATTCCACATTTTGTTTTTCAACTAGC- *** * ** ** * * *** ***** ** ***** * *** *** ENST00000393909.2 TGATGAATCA---AACTCTGTATCTTAGGATTAGGTTAAAACAATACCTTTGGTATGATA ENST00000504640.1 TGTTAAATCAGATAATTTTATTTTCT----TTA---TATAGCAA-------------ATG ** * ***** ** * * * * * *** ** * *** ** ENST00000393909.2 TGAGTGTTGTTGCTGATCCATGCAGCATGGATTGGAAAGCTGGGGTATAAGCACACATGC ENST00000504640.1 TCAGT-TAG--GCTGGTCC----------GATAGTAA----GGGATATCAGAACTTAT-- * *** * * **** *** *** * ** *** *** ** ** ** ENST00000393909.2 TAAAG--AAAAACATGTAATTTGGTCCATACTCACCTGGATATACTGTTCCTCAGGTTAA ENST00000504640.1 TAACATTAGTGTCACTAAAGTTGGT--GTACAGCCCTGCCCCTGCCACCCCCCCCACC-- *** * ** ** ***** *** **** * * ** * ENST00000393909.2 AAAATACAGTACTATCCTAAATCTTGAAGGCAACTCTCAGCCTATCCATTGAGTTACCTT ENST00000504640.1 ------CCGTGCCAGC-TAAATTT-------GACT---GGCTTAAAAAAAAAAACACCAA * ** * * * ***** * *** ** ** * * *** ENST00000393909.2 CAGATCTGCCCTCTGGTTCCTAGCTGTCTTGGGACTAACTTCTTTCCTGCGCTCAGCTGT ENST00000504640.1 AAAA---------CAGTCCATGAAAGCTTTGAAA---ACTACTTACTT----TCAACTGC * * ** * * * *** * *** *** * * *** *** ENST00000393909.2 TTTCTGGATTCCATGTTTTCCATTTTATTGAGTACTAACTTGTTTTGCTGCAGCACATCC ENST00000504640.1 ------AAAAGCACATTTTC--------TGA-----AATTTCTTTCAC-ATAACACA--- * ** ***** *** ** ** *** * * **** ENST00000393909.2 TTTGGTAGCTTCTAGAGGAAGTTTGTGTGGAGGTAAAATTTTTGAGACCTTGCATGTCTC ENST00000504640.1 --TGGTAACATTTGCA--ACGACTGT------------CTTTGAATAACTT-----TCTC ***** * * * * * * *** *** * * *** **** ENST00000393909.2 ATGTTTGATTGATACTTTATACGTTTAGGTAGGAGGTAATTTTCCTTCAGGAC----TTT ENST00000504640.1 TTGCCTAATAAACAATTTG-------AGATAGAAT-TAA--------CAAGACCTTTTTT ** * ** * * *** ** *** * *** ** *** *** ENST00000393909.2 AAAAATATTGTTGCTCCATTTTCTTTGTTTCTATTGTTGTATTGAGAAATCCAATGCCAT ENST00000504640.1 AAAAAAATAAATG-----------TTG--------GCTGGGT-GCGGTGGCTCACGCC-- ***** ** ** *** * ** * * * * * *** ENST00000393909.2 TTTGATTTCCCCATCATAAATTTCATGATGATGTGTCTTGGTGTGGGTCTATATTTATCC ENST00000504640.1 TGTAAT---CCCAGCAC----TTTGGGAGGCCGAG-------GCGGGTGGAT---TGTCT * * ** **** ** ** ** * * * * **** ** * ** ENST00000393909.2 ATTGTATTGGGTTTTAGGTGAACCCTTCCAG-ATAGT---AACTCATTTCTGTCAGTTCT ENST00000504640.1 GAGGTCAGGGGTTCAAGACCAGTCTGGCCAACATGGGGAAAACCTGTCCCTACAAAAAAT ** ***** ** * * *** ** * *** * ** * * ENST00000393909.2 GGGAAACACTTAGCATTGGT-TGATGATTTATTCTCTGCTGCTTTGTTCTCCCAACTATT ENST00000504640.1 ACAAAAAAATTAGC-CAGGTGTGGTGGC---------GTGAGCCTGTAATCCTAGCTAC- *** * ***** *** ** ** * *** *** * *** ENST00000393909.2 ATTTGGATGTTGGATATCCAGCACTGGGTATCTATTTTCTTACCTCCCTCCCTTGACCCC ENST00000504640.1 -TCGGGAGGCTGA------GGCA--AGGAAATTG-----------------CTTGAACCA * *** * ** *** ** * * ***** ** ENST00000393909.2 AGTCTCTGTT--TTTTAGCTCTTTAGCTCAATCTTCCAACTCTTTGCTATTGTATTT-TA ENST00000504640.1 GGGAGGTGGAAGTTGCAG----TGAGC-CGAGATCGCACCACTGCACTCTAGCCTGGGCA * ** ** ** * *** * * * ** * ** ** * * * * ENST00000393909.2 AAATCTTAAGACCCCTTCTTGATTTGTAGAAGTTCCTTTTCTTACAACCAAAAAGCCTTT ENST00000504640.1 ACAGAGTGAGAC----TATTGTCTCCAAAAAAAA---------AAAAAAAAAAAAGTTCT * * * **** * *** * * ** * ** ***** * * ENST00000393909.2 ATCTATGGATTTGTTCACAGATAAGGGGTATTCAA-TATAGTG----TATTTTTTTTTCA ENST00000504640.1 GTTAATGGATG-GTTTGTTG----GGGTTTTTCAAATGTCTTGACAATGTCTCAATCCCA * ****** *** * *** * ***** * * ** * * * * ** ENST00000393909.2 TTTAAAATTGTTTGCGCATCTATTTCCTCCAAATTTCTTTCTGTATTTATTTTTTGTTGT ENST00000504640.1 TTTTGGAACA----CACAGC-ATGTTGACAAAG-----------GCTTGCTTTTTTTTTT *** * * ** * ** * * ** ** ***** ** * ENST00000393909.2 CTATATTTCAGACTTTTCCAGGATATCTGATAATCTTTGGCTGTCTTCTTATGGTTGAAA ENST00000504640.1 TTTTTTTACAAACT------AAGTATTT---AATTTTTGG-----TTCTTGT-------- * * ** ** *** *** * *** ***** ***** * ENST00000393909.2 GAGGGACTAAAAAGCTTGGAAAGCCTTTGGGTTGTGGGAAGGGGCTGTCTTTAGGATT-A ENST00000504640.1 --------------CTTGA-------------TGGAGCAAGG---TATATTAAAGATTTA **** ** * **** * * ** * **** * ENST00000393909.2 TCTGAATGGGCTTTTTTGGGAGTCCCCTCCTCCACATGAATATTTTGGTTTTGTCAGATT ENST00000504640.1 TCAAAAT--------TTA------CACTC------ATGAAC----------TAT--GACC ** *** ** * *** ***** * * ** ENST00000393909.2 CCCTAGAATAGAGGCTTCCAATCTCCTTCCTGGAGGGGTCTGTCCAGGAAGGAGATTGTC ENST00000504640.1 TGTGAAGACAGATG-TTACA----------TGGA-----CTA--CAGCACAGAG------ * * *** * ** ** **** ** *** * *** ENST00000393909.2 TAGGGGTCTGTCAGACAGCAGCTTTCAGCTACTTCCTTGATCTTTTTCA--CTAATGATT ENST00000504640.1 CATGAGTTAGGAAGACA----CTTAAGGAAACCTGTGTAGTTCTCTACAGCCCCATGG-- * * ** * ***** *** * ** * * * * * ** * *** ENST00000393909.2 ATATAGTCATCTAACTACTGTCAACAAGTAATAGATATCCTATCCTT-CACTTGTTTAGA ENST00000504640.1 GAGTAGT--TCTATGT-CTGTTAG--AATAAGA------CTATAGTTGCACCAG--TAGA **** **** * **** * * *** * **** ** *** * **** ENST00000393909.2 TTATTTGCTGAGATAACCTCTCAAAAGAACCTCTCAAAATAAAAGGTTAACAAGAGCCTA ENST00000504640.1 TTCTTT-----------------AAGGAA-----------GAGAGG------AGAG---- ** *** ** *** * *** **** ENST00000393909.2 TATCTTATATTTTTCTTCTCTTTATCTTGTTAGAAGATAGCTATTAAAACCTGTTCTTTT ENST00000504640.1 -----------------------------TAGGAAGAGGG-------AACCTGATTTTCT * ***** * ****** * ** * ENST00000393909.2 TCTGTCTTGATAAACACACTTCAATCTTGGTAGAATGGTAGATGGGACAGTATATTTTAG ENST00000504640.1 GAGCACTTAATATGTG---TCAGACCTTG------TGCTAG-CAGGACTGCATA----AG *** *** * * **** ** *** **** * *** ** ENST00000393909.2 GACCTAAAGCTCTGCAAATGTATGATCAGCTTGTAAGTACAGGTGCTCAAAAACATGTAA ENST00000504640.1 GATTT------TTGCT----TGTTCTTCGTTT-TATGTCTAG------------------ ** * *** * * * * ** ** ** ** ENST00000393909.2 ACAATCATGCTTTTTACTCTGTAGGAATATCTTTAAAATTCTTGTGAATTTTTCCCCAGA ENST00000504640.1 -------TGACCCTTATTCT---------TCCTTCAGATCTC---AAGTGTTTCTTAGTA ** *** *** ** ** * ** * * **** * ENST00000393909.2 AGTAAAGCAAATCTTCCCCCAGAAATAAAATTAAATGTGCATAATCTAAA ENST00000504640.1 TGTGGAGC------TTTCCCAGACTTG--ACCAAATTTGCCTATCACAAA ** *** * ****** * * **** *** ** ***