CLUSTAL 2.1 multiple sequence alignment ENST00000394053.2 CGGGGCCTGCCACGAGGCCGCAGTATAACCGCGTGGCCCGCGCGCGCGCTTCCCTCCCGG ENST00000489784.1 ------------------------------------------------------------ ENST00000394053.2 CGCAGTCACCGGCGCGGTCTATGGCTGCGACTTCTCTAATGTCTGCTTTGGCTGCCCGGC ENST00000489784.1 --------------------ATGGCTGTGGCTTCCCTCATGTCTGCGTTGGCTGCCCAAC ******* * **** ** ******** ********** * ENST00000394053.2 TGCTGCAGCCCGCGCACAGCTGCTCCCTTCGCCTTCGCCCTTTCCACCTCGCGGCAGTTC ENST00000489784.1 TGCTCTGTCCCCCGCAGAGCTGCCGCCCGCGCTCTCGCACCTTCCACAGCACGGCATTTT **** *** **** ****** ** *** **** * ****** * ***** ** ENST00000394053.2 GAAATGAAGCTGTTGTCATTTCTGGAAGGAAACTGGCCCAGCAGATCAAGCAGGAAGTGC ENST00000489784.1 G----------------------------------------------------------- * ENST00000394053.2 GGCAGGAGGTAGAAGAGTGGGTGGCCTCAGGCAACAAACGGCCACACCTGAGTGTGATCC ENST00000489784.1 ------------------------------------------------------------ ENST00000394053.2 TGGTTGGCGAGAATCCTGCAAGTCACTCCTATGTCCTCAACAAAACCAGGGCAGCTGCAG ENST00000489784.1 ------------------------------------------------------------ ENST00000394053.2 TTGTGGGAATCAACAGTGAGACAATTATGAAACCAGCTTCAATTTCAGAGGAAGAATTGT ENST00000489784.1 ------GAATCACCAGTGAGACAATTGTGAAACCAGCTTCAATTTCTGAGGAAGAATTGT ****** ************* ******************* ************* ENST00000394053.2 TGAATTTAATCAATAAACTGAATAATGATGATAATG-------TAGATGGCCTCCTTGTT ENST00000489784.1 TGAAGTTAATAAATAAACTGAGTAATGTTGATAATTAGATAATTAGATGGCCACCTTGTT **** ***** ********** ***** ******* ********* ******* ENST00000394053.2 CAGTTGCCTCTTCCAGAGCATATTGATGAGAGAAGGATCTGCAATGCTGTTTCTCCAGAC ENST00000489784.1 CAGCTGCCTCTTCCAGAGCACACTGATGAGAGAAAGATCTGCAATGCTTTTTCTCCAGAC *** **************** * *********** ************* *********** ENST00000394053.2 AAGGATGTTGATGGCTTTCATGTAATTAATGTAGGACGAATGTGTTTGGATCAGTATTCC ENST00000489784.1 AAGGATGTTGATGGCTTTCCTGTAATGAATGTAGGACGAAAGTGTTTGGACCAATATTCC ******************* ****** ************* ********* ** ****** ENST00000394053.2 ATGTTACCGGCTACTCCATGGGGTGTGTGGGAAATAATCAAGCGAACTGGCATTCCAACC ENST00000489784.1 ATGTTACCGGCTACCCCATGGGGTGTGTGGGAAATAATTAAGCGAACTGACATTCCAACC ************** *********************** ********** ********** ENST00000394053.2 CTAGGGAAGAATGTGGTTGTGGCTGGAAGGTCAAAAAACGTTGGAATGCCCATTGCAATG ENST00000489784.1 CTAGGGAAGAATGTGGTTGTGACTGGAAGGTCAAAAATTGTTGGAATGCCCATTGTAATG ********************* *************** **************** **** ENST00000394053.2 TTACTGCACACAGATGGGGCGCATGAACGTCCCGGAGGTGATGCCACTGTTACAATATCT ENST00000489784.1 TCACTGCACATACGTGGGGTGCATGAACGTCCCAGAGATGATGCCACCGTTAGAATATCT * ******** * ***** ************* *** ********* **** ******* ENST00000394053.2 CATCGATATACTCCCAAAGAGCAGTTGAAGAAACATACAATTCTTGCAGATATTGTAATA ENST00000489784.1 CATGGATATACTCCCAAAGAGCAGTTGAAGAAACAA--AATATTTGCAGATATTGTAACA *** ******************************* *** *************** * ENST00000394053.2 TCTGCTGCAGGTATTCCAAATCTGATCACAGCAGATATGATCAAGGAAGGAGCAGCAGTC ENST00000489784.1 TCCGCTGCACGAATTCTAAACCTGTTCACAATAGATATAATCAAGGAAAGAACAGCAGTT ** ****** * **** *** *** ***** ****** ********* ** ******* ENST00000394053.2 ATTGATGTGGGAATAAATAGAGTTCACGATCCTGTAACTGCCAAACCCAAGTTGGTTGGA ENST00000489784.1 GTTGATGTGGGAATAACTAGAGTTCAAGATCCCGTAACTGCTCAACCCAAATTGGTTGGA *************** ********* ***** ******** ******* ********* ENST00000394053.2 GATGTGGATTTTGAAGGAGTCAGACAAAAAGCTGGGTATATCACTCCAGTTCCTGGAGGT ENST00000489784.1 GACGTGGGTTTTGAAGGAGTCAGATAAAAAGCCGGTTACATCATGCCACTTCCTGGAGGT ** **** **************** ******* ** ** **** *** *********** ENST00000394053.2 GTTGGCCCCATGACAGTGGCAATGCTAATGAAGAATACCATTATTGCTGCAAAAAAGGTG ENST00000489784.1 GTTGGCCTCATGACGGTGGCGATGCTAATGAAGAATACCATTACTGTTGCAAAAAAG-TT ******* ****** ***** ********************** ** ********** * ENST00000394053.2 CTGAGGCTTGAAGAGCGAGAAGTGCTGAAGTCTAAAGAGCTTGGGGTAGCCACTAATTAA ENST00000489784.1 CTGAGGCTTGAAGAACAGTAAGTGCTGACGTCTAAAGAGCTTGGAGTAGCCACTAATGAA ************** * ********* *************** ************ ** ENST00000394053.2 CTACTGTGTCTTCTGTGTCACAAACAGCACTCCAGGCCAGCTCAAGAAGCAAAGCAGGCC ENST00000489784.1 CTATTGTGTCTTCTATGTCACAAACAGCACTCCAAGCCAGCTCAAGAAGCAAAGCAGGCC *** ********** ******************* ************************* ENST00000394053.2 AATAGAAATGCAATATTTTTAATTTATTCTACTGAAATGGTTTAAAATGATGCCTTGTAT ENST00000489784.1 AATAGAAAGACAATATTTTTTATTTATTCTACTGAAGTGGTTTAAAATGATGCTTTGTAT ******** ********** *************** **************** ****** ENST00000394053.2 TTATTGAAAGCTTAAATGGGTGGGTGTTTCTGCACA-TACCTCTGCAGTACCTCACCAGG ENST00000489784.1 TTATTGAAAGCTTAAATTGGAGGGTGTTTGTGCACAATAGCTCTGCAGTACCTCACCAGG ***************** ** ******** ****** ** ******************** ENST00000394053.2 GAGCATTCCAGTATCATGCAGGGTCCTGTGATCTAGCCAGGAGCAGCCATTAACCTAGTG ENST00000489784.1 GAGCATTCCACTAT---GCAGGGGCGTGT-ATCTAGCTAACAGCAGCCATTAACCCAGTG ********** *** ****** * *** ******* * ************** **** ENST00000394053.2 ATTAATATGGGAGACATT-ACCATATGGAGGATGGATGCTTCACTTTGTCAAGC-ACCTC ENST00000489784.1 ATGAACCTGGGAGACATTTGTCATATTGAG-ATGGATATTTAACTCTGTCAAACCACCTC ** ** *********** ***** *** ****** ** *** ****** * ***** ENST00000394053.2 AGTTACACATTCGCCTTTTCTAGGATTGCATTTCCCAAGTGCTATTGCAATAACAGTTGA ENST00000489784.1 GGTTGAATATTTGCCTTCATTAGGACTGCGTTTCCCAAATGCTATTTCAATAAGAGTTGA *** * *** ***** ***** *** ******** ******* ****** ****** ENST00000394053.2 TACTCATTTTAGGTACCAAACCTTTTGAGTTCAACTGATCAAACCAAAGGAAAAGTGTTG ENST00000489784.1 TACTCATTTTAGGCACCAAAACTTTTGGATTCAACTGATCAAACCAAAGGAAAAGTGTTG ************* ****** ****** ******************************* ENST00000394053.2 CTAGAGAAAATTAGGGAAAAGGTGAAAAAGAAAAA-ATGGTAGTAATTGAGCAGAAAAAA ENST00000489784.1 CTAGACAAAATTAGGGAAAAGGTGAAAGAGGAAAATATGGTAGTAATCGAGTAGAAAAAA ***** ********************* ** **** *********** *** ******** ENST00000394053.2 ATT-----AATTTATATATGTATTGATTGGCAACCAGATTTATCTAAGTAGAACTGAATT ENST00000489784.1 ATTCCTCTAATTTATATATGCATTGATTAGTAACCAGATTTATCTAAGTAGGACTGAATT *** ************ ******* * ******************** ******** ENST00000394053.2 GGCTAGGA-AAAAAGAAAAACTGCATGTTAATCATTTTCCTAAGCTGTCCTTTTGAGGCT ENST00000489784.1 GGCTAGGATAAAAAGAAAAAATACGTATTAATCCTTTTCCTAAGCTGTCTTTTTGAGGCT ******** *********** * * * ****** *************** ********** ENST00000394053.2 TAGTCAGTTTATTGGGAAAATGTTTAGGATTATTCCTTGCTATTAGTACTCATTTTATGT ENST00000489784.1 TAGTCAGTC-ATTGGGAAAATGTTTAAGATTGTTCCTTGATATTTGTCCTCATTTTATGT ******** **************** **** ******* **** ** ************ ENST00000394053.2 ATGTTACCCTTCAGTAAGTTCTCCCCATTTTAGTTTTCTAGGACTGAAAGGATTCTTTTC ENST00000489784.1 ATGCTACCCTTCAGTACGTTCTCCCCATTTTAGATTTCTAGGATTGAAAGGCTTACTTTA *** ************ **************** ********* ******* ** *** ENST00000394053.2 TACATTATACATGTGTGTTGTCATATTTGGCTTTTGCTATATACTTTAACTTCATTGTTA ENST00000489784.1 TAAATTAGTCATGTGTATTGTCATATTTGGCTTT-GCTATATACTTTAATTTCATTGTTA ** **** ******* ***************** ************** ********** ENST00000394053.2 AATTTTTGTATTGT--------------ATAGTTTCTTTGGTGTATCTTAAAACCTATTT ENST00000489784.1 AAATTTTGTACTGTTAGGGAATATCTGTATAGTTTATTTAATTTATGTTAAAACCTATTT ** ******* *** ******* *** * *** ************* ENST00000394053.2 TTGAAAAACAAACTTGGCTTGATAATCATTTGGGCAGCTTGGGTAAGTACGCAACTTACT ENST00000489784.1 TTGAAAAACAAACTTGCCTTGATAATCATTTGGGCAGCTTGGATAAGTATGCAACTTACT **************** ************************* ****** ********** ENST00000394053.2 TTTCCACCAAAGAACTGTCAGCAGCTGCCTGCTTTTCTGTGATGTATGTATCCTGTTGAC ENST00000489784.1 TT-CCACCAAAGAATTGCCAGC----------TTTTCTGAGATGTA----TCCTGTTGAT ** *********** ** **** ******* ****** ********* ENST00000394053.2 TTTTCCAGAAATTTTTTAAGAGTTTGAGTTACTATTGAATTTAATCAGACTTTCTGATTA ENST00000489784.1 TTTTTCAGAA-------------------------------------------------- **** ***** ENST00000394053.2 AAGGGTTTTCTTTCTTTTTTAATAAAACACATCTGTCTGGTATGGTATGAATTTCTGAAA ENST00000489784.1 ------------------------------------------------------------ ENST00000394053.2 TTCTGTCTTCCTATGACTCCTAGTTGTGACCTAACCAGTTTTTTTCTCATTTAATCAATG ENST00000489784.1 ------------------------------------------------------------ ENST00000394053.2 TAGCTATTCCTATATTCAGTAACACTTACTTCTATAGCCTTAAATAGATAATTTTTTTTC ENST00000489784.1 ------------------------------------------------------------ ENST00000394053.2 TTCTATTTTTTTTTTTTTTTTTGTAGAGATGGGGTCTTGCTATGTTGCCTGGGCTGGTAT ENST00000489784.1 ------TTTTTTTTTCTTTTTTG------------------------------------- ********* ******* ENST00000394053.2 TGAACTCCTGGCCTCAAGCAATCAATCCTCTTGCCTCAGCTTCCCAGAGGGCTGGGATTA ENST00000489784.1 ---------------------------------------------AGAAGG--------- *** ** ENST00000394053.2 CAGGCCTGGGCCACCCACACCCAAACAGAGGTTTAAAGAGCTTTGGAGAAACCAGCCTCG ENST00000489784.1 ------------------------------------------------------------ ENST00000394053.2 TCCTCCAGTCTCTTTGTTTGTTTGTTTTGAGACTGAGTCTTGCTCTGTTGCCCAGGCTGG ENST00000489784.1 -----------------------------------AGTCTTGCTCTGTTGCC-AGGTTGG ***************** *** *** ENST00000394053.2 AGTGCAGTGGCATGATCTCGGGTCACTGCAACCTCTGCCTCTCGGGTTCAAACAATTCTT ENST00000489784.1 AGTGCAGTGGCGTGATCTTGGCCCACTGCAACCTCCGCCTCCTTGGTTCAAGCAAATCTC *********** ****** ** ************ ***** ******* *** *** ENST00000394053.2 GTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCATGCCACCATGCCTGGCTAATTT ENST00000489784.1 CTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGAGTACACCACCATGCCCAGCTAATTT ************* ************ ****** * * ********** ******** ENST00000394053.2 TTGTGTTTTTAGTAGAGATGGGGTTTCATCACATTGGCCAGGCTGGTCTCAAACTCCTGA ENST00000489784.1 TTGTATTCTTAGTAGAGATGGGTTTTCACCATGCTGGCCAGGATAGTCTCGATCTCTTGA **** ** ************** ***** ** ******** * ***** * *** *** ENST00000394053.2 CCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAATGCTAGGATTACAGGC--------GT ENST00000489784.1 CCTCA--TGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCTTACAGGCGT ***** ***** ******* *********** **** *********** ** ENST00000394053.2 GAGCCACTGCACCTGGCCTGTCCTACAGTCTTATATCACAACAGGTTGTGCCAA-GCTAG ENST00000489784.1 GAGCCACTGCACCCAGCCCGG---AAGATTTT------TAACAGTCTGAGTTAATATTA- ************* *** * * * ** ***** ** * ** ** ENST00000394053.2 GAGCTTAATCTGTAAAATACTTGAGGCAGGGATAGGTTTGTCTGTTTTGGCTTTTGGCTT ENST00000489784.1 -AATTTAATC---ACACTCTCTGA-------ATG---TTATCTATTT---CTTTT----T * ****** * * * *** ** ** *** *** ***** * ENST00000394053.2 TCATGCGAGCAGAAGTAGCTCCTGCTCTAGGCAGCTTGAGGCAGAAAGAGAAGAAACAAT ENST00000489784.1 TAAT-CAAACAAAGA-----------------------------AAAAAAAACAAAC--T * ** * * ** * *** * ** **** * ENST00000394053.2 TGAGTTGACCTACCTCCGTCCTCGTTCTTCTGCCAGCTGGCGTT-ATTCTTTTGATAGTT ENST00000489784.1 TAAATT---------------TCATTTTAA----AACTGAAACTCATTTTGTTCATG--- * * ** ** ** * * *** * *** * ** ** ENST00000394053.2 CTCTGGAGTTTAAAGAAGTTTAGATAGTTTGCTGGAGATGTTTTTGTAAGTGACGTATAG ENST00000489784.1 ---TGGA---TACAAATACTAAAGCA---------AAATTTTTTTCT------------- **** ** * * * * * * ** ***** * ENST00000394053.2 CTTATGTCTCTAATCCATGCCTGCTTACCTAGATTATTAAATGTGGAGCAAGATGACCAG ENST00000489784.1 -TCATAT---TGATTCAT---------------TTATTGGA------------------- * ** * * ** *** ***** * ENST00000394053.2 ACAGGATTAAATTTTATTGAATTACAGTTACAAGTGGAAAAAATGACTGACTTACTGCAT ENST00000489784.1 --------AAACTTT--TGAGT-ATATTTGCAA--------------CAACTCG-TGTAT *** *** *** * * * ** *** *** ** ** ENST00000394053.2 GGAGAAGTATTATGTCAACCTGTTAAAAGCTATGGAAATTAAAATGTTCATGTATATACA ENST00000489784.1 GTGAAATTACTTTTTCAA-------------ACGTAAATT----------------CATA * ** ** * * **** * * ***** * * ENST00000394053.2 AAATATAAATGACATGTAAGGTAAAATTACAGTGATCAATTTACAACAAAGAAATTAACA ENST00000489784.1 AAATCTAAAT-ACACATAAAATGC--TTCCGATGAA-AATTT--AGTATCTGAATTAAAA **** ***** *** *** * ** * *** ***** * * ****** * ENST00000394053.2 GTAGTTTTCCAGCTTGTTTGATTAATCAAGCAGGTTTACTCTTGAATCCATAGCATTTCT ENST00000489784.1 TAAGCTGTACA---TATAAAAT--ATAAAGTAGATTT--CAAAGAAT---TAGTATTT-T ** * * ** * * ** ** *** ** *** **** *** **** * ENST00000394053.2 ACAATTTAATTTGGACAAAGTTCTATTCCAGATCAGCCAGGTTTTAAAACTGAAATGTGT ENST00000489784.1 AGAAATCATCTTG-------TTTTAT---------GTCTTGATTTAAAAATATAACATAT * ** * * *** ** *** * * * ******* * ** * * ENST00000394053.2 TAAGGGTGGATTGTTAGCTTCCCCAGGATTGGTGTGGATGATAAATACTTTTTTTAAAAA ENST00000489784.1 TAGGC------------------------------------TAAACAC--------AAAA ** * **** ** **** ENST00000394053.2 TTAATTATTATTGTTTATAAGACATGGATTCCAGCTGTCTCCCTGGCTGGAGTGCAGTGG ENST00000489784.1 T--AGTATTA---------------------------------------AAGT------- * * ***** *** ENST00000394053.2 CATGATTATAGCTCACTGCAGCCTTGAACTCCTGGACTTAAACGATCCTCCTGCATCAGC ENST00000489784.1 --TGATT------------------------------TTAAA-AAT-----TACAT---- ***** ***** ** * *** ENST00000394053.2 CTCTGAAATGGCTGGGACTACAGGTGTGTGCCAGCATGCCTAGCTAATTTTTAAACATTT ENST00000489784.1 -----ATATGGCTCAGGTTACA-------------------------CTTCTA------- * ****** * **** ** ** ENST00000394053.2 GTTTAGAGATGGGTCTCACTATGTTGCCCAGGCTGGTCTTGACCTCCTGACCTCTGCTGA ENST00000489784.1 --TTGGAAA-----------ATGCT-------------------------------CTGA ** ** * *** * **** ENST00000394053.2 TTCCCCCCACCTCTGCCTCCCAAGTAGCGGGATTACAGGTGTGAGCCACTGTGTCTGACA ENST00000489784.1 T-------------------CAAG---CATGATTATCAGGGTGAG--------------- * **** * ***** * ***** ENST00000394053.2 AGAATTTATACTTAAGCATAGGAGATGGTTCTGGAAATTCTAAGAAATTCTGCTCTCAGT ENST00000489784.1 ---ATCAATGCCTA--CATAAA-----GT-------ATTCCAATGATTT----TCTTAG- ** ** * ** **** ** **** ** * ** *** ** ENST00000394053.2 AAGAGTAGAGGTTTGGAGCTTTACCTCTTGGCAGTATCCCTTGGAAGGGAGCTCTGAGAT ENST00000489784.1 ----------------------ACTTTTTGAC---------------------------T ** * *** * * ENST00000394053.2 TAAATGTAATCAAACACTTATTGAGAGCTTTCTATGGACCAGGCACTACACTAGACGCTG ENST00000489784.1 TGAACATGAT--------------------TC------CCAGG-----------GCTCTA * ** * ** ** ***** * ** ENST00000394053.2 GGAATTACAGAGGCAATTACCTGTCCTATACTCAAGGTGTTAATGATCTAGTGTCATTTT ENST00000489784.1 GGAATC-CAGAAA-------------TATGCT------------------GTGACA---- ***** **** *** ** *** ** ENST00000394053.2 TCTTTAAAAAAGAAAGCACCTGCATTTGTCATCTTGAGCAAATATAGTAACTCTAACCTC ENST00000489784.1 -----------------------------------------------------------C * ENST00000394053.2 AAGGTTCAAGTGATTTACTCAAGGTTTAAATCATAGTTGTTTTGGAGAAAGTAAGTGTCA ENST00000489784.1 AGGGTT----TGGTTT---------TTATTTTATAATTGGTT------------------ * **** ** *** *** * *** *** ** ENST00000394053.2 GATGCACTGTGGCTGTCAGGGTCATAGTAGGCATTAAATCAACATGGTTGGTGTTCATTA ENST00000489784.1 ----------GGCT-------TCATAAT---CAT----------------GTGT------ **** ***** * *** **** ENST00000394053.2 AATGTGGATTGAAGATAAAATGACTGATCTTAAGTTTCATGAGGAATAGGTTTGCTTCAT ENST00000489784.1 -ATGTGAA-------------GACT-------------ATATAGAAT------------T ***** * **** ** **** * ENST00000394053.2 TGAAACTGGTTTTTATCTTCCCAAATAGTTTTCAATCATTCCTTTAAAGTACTAGGTTGA ENST00000489784.1 TAAA----------------CCAAA-AG------------CCTCTAAAA----------A * ** ***** ** *** **** * ENST00000394053.2 TTAATATTGCAAAGTTGTAATGTAAAATGTGACCTTACCTCTGTCTAACCTGTATTGTTC ENST00000489784.1 TCTATATG----------AATATAAAAGATGAAATT------------------------ * **** *** ***** *** ** ENST00000394053.2 ACATGAATGGGAGTTTGACTTTGGGAATAAACATTGAAAATTTGCAGGGAGGACCCA ENST00000489784.1 ------------GTTTAGCTT----AGTCAAAA--GAAAG---GCA----------- **** *** * * ** * **** ***