CLUSTAL 2.1 multiple sequence alignment ENST00000394836.2 CGAGCCCAGGCGTCTGAGACCTACTGACCGGCCGCGGGCAGGGCTGACAGGCGGTGGGGC ENST00000423599.1 ------------------------------------------------------------ ENST00000394836.2 GGCTCGGCCCCTGGCGGAGTCGGCGGCGGGCGGGGACGCGGCGCTGGGAGGACGCGGCGG ENST00000423599.1 ------------------------------------------------------------ ENST00000394836.2 CGCTGGGAACGGACGCCTGGGCGCCCCGAGGCGCCGGGATGTGGAGCGGCCCACCCCAGC ENST00000423599.1 ------------------------------------------------------------ ENST00000394836.2 CAGACCAGGGCCTCCCGCCGCCCCTTGCAGCTGTCCCGGTCCCCTGGAAGAGCACGGACC ENST00000423599.1 ------------------------------------------------------------ ENST00000394836.2 CCTGCCAAGGCCACAGGGAGTCCCCAGGAGCCCTGGTGGAGACCTCTGCAGGGGAGGAGG ENST00000423599.1 ------------------------------------------------------------ ENST00000394836.2 CCCAAGGCCAGGAGGGCCCCGCAGCCGCCCAGCTGGACGTGTTGCGCCTGCGCAGCTCTT ENST00000423599.1 ------------------------------------------------------------ ENST00000394836.2 CCATGGAGATCCGAGAGAAGGGCTCCGAGTTCCTGAAGGAGGAGCTGCACAGAGCGCAGA ENST00000423599.1 --------------AAGAAGGGCTCTGAGCTCCTGAAGGAGAAGCTGCACAAAGCTCACA ********** *** *********** ********* *** ** * ENST00000394836.2 AGGAGCTGAAGCTAAAGGACGAGGAATGTGAGCGGCTGTCCAAGGTGCGGGAGCAGCTAG ENST00000423599.1 AGGAGCTGCAGCTGAAGGGCGAAGACTGTGAGCAGCTGTTCCTAGTGCAGGAGCAGCT-G ******** **** **** *** ** ******* ***** * **** ********* * ENST00000394836.2 AACAGGAGCTGGAAGAGCTGACGGCCAGCCTGTTTGAGGAAGCTCACAAGATGGTTCGAG ENST00000423599.1 CACGGGAGCTGGAGGAGCTGATGACTAGCCTGTTTGAGGAAGCCCACAAGATGGTGTGGG ** ********* ******* * * ***************** *********** * * ENST00000394836.2 AAGCCAACATGAAGCAGGCGGCATCAGAAAAGCAGCTGAA---GGAGGCTCGGGGCAAGA ENST00000423599.1 AAGCCAGCATACAGCAGGCAGTGTCAGAAAAGCAGCTGAATGCGGAGGCATGGGGAAAGA ****** *** ******* * ***************** ****** **** **** ENST00000394836.2 TCGACATGCTGCAGGCAGAGGTGACAGCCTTGAAGACGCTGGTCATCACGTCCACACCAG ENST00000423599.1 TAGACATGCTGCAGGCAGAGGTGACAGC-TTGAAGACACTGGTCATCATGTCCACACCAG * ************************** ******** ********** *********** ENST00000394836.2 CCTCTCCCAACCGCGAGCTTCACCCCCAGCTGCTGAGCCCCACCAAGGCCGGGCCCCGAA ENST00000423599.1 CCTCTCCCAACTACAAGCTCCACCTGCACCTGCTGAGCCCCACTAAGGGTGGGCCCTGCA *********** * **** **** ** ************** **** ****** * * ENST00000394836.2 AGGGCCACTCTCGCCACAAGAGCACCAGCAGCACCCTCTGCCCCGCCGTGTGTCCCGCTG ENST00000423599.1 AGGCCCACTGCCAACCTAAGAGCACCAGCAGTGCCCTCTCCTTGGCCTTGTGCCCCACTG *** ***** * * ************** ****** * *** **** *** *** ENST00000394836.2 CGGGACACACCCTCACCCCAGACAGAGAGGGCAAGGAGGTGGACACAATCCTGTTTGCAG ENST00000423599.1 TGAGACATGCCCTCACCTTGGACA---------AGGAGGTGGATGTGACACTATTGGCAG * **** ******** **** ********** * ** ** **** ENST00000394836.2 AGTTCCAGGCCTGGAGGGAATCCCCCACCCTGGACAAGACCTGCCCCTTCCTGGAAAGGG ENST00000423599.1 AGTTCCAAGCCTGGAAGGAATTACCTACCTTGGACAAGACCTGTTCCTTGCTGCAAAGGG ******* ******* ***** ** *** ************* **** *** ****** ENST00000394836.2 TGTACCGAGAGGACGTGGGCCCCTGCCTGGACTTCACAATGCAGGAGCTCTCGGTGCTGG ENST00000423599.1 TGTAGTGGGAGGATATGGACCCCTGCCTGGACTTCACAGTGCAGAATCTCTTGCCACAGG **** * ***** *** ******************* ***** * **** * * ** ENST00000394836.2 TACGGGCCGCCGTGGAGGACAACACGCTCACCATTGAGCCGGTGGCTTCGCAGACGCTGC ENST00000423599.1 TGTAGGCCTCTATGGGGGACACCACACTCACTATCAAGCCTGTGGCTCTGCAGAAGCTGC * **** * *** ***** *** ***** ** **** ****** ***** ***** ENST00000394836.2 CCACAGTGAAGGTGGCCGAGGTTGACTGTAGCAGCACCAACACATGTGCCCTGAGCGGGC ENST00000423599.1 CTATAGTGAGGGTAACTGTGGTCAATTGTGGCAGTGCCAATATATGTGTCTTGAGCAATT * * ***** *** * * *** * *** **** **** * ***** * ***** ENST00000394836.2 TGACCCGCACCTGCCGCCACCGA---ATCCGGCTCGGGGACTCCAAAAGCCATTACTACA ENST00000423599.1 TGGCCCATACCTGCCACCACCACCACATCTGGCTTTGTGACTTTGCGAGCCACTACCACA ** *** ******* ***** *** **** * **** ***** *** *** ENST00000394836.2 TCTCGCCATCTTCCCGGGCCAGGATCACCGCAGTGTGCAACTTCTTCACCTACATCCGCT ENST00000423599.1 TCTCACTGTCTTCTCAGGCCAGGATCACTGCAGTGTGCAACTTTTTCATCTATATCTGCT **** * ***** * ************ ************** **** *** *** *** ENST00000394836.2 ACATCCAGCAAGGCCTGGTGCGGCAGGACGCAGAGCCCATGTTCTGGGAGATCATGAGGT ENST00000423599.1 ACATCCA-CAAGGCCTGGTGCGACAGGATTTGAAGCCAGTGTTCTGGGAGATCACAAAGC ******* ************** ***** **** *************** * * ENST00000394836.2 TGCGGAAGGAGATGTCACTGGCCAAGCTCGGCTTCTTCCCCCAGGAGGCTTAGGGCGCGG ENST00000423599.1 TGTGAAAAGAGATACAGCTGGCCAAACTCAGCT----CCCCCTAGAAGCCTAGGGTGTTA ** * ** ***** ******** *** *** ***** ** ** ***** * ENST00000394836.2 CCCAGGCCTGAAGGGGAGCT--CTGAGACAGAGCAAACACCCACCCCAGAACAAG----C ENST00000423599.1 CCTGGGCCTAGATGTGGGCTGCCTAGGATGGA-CAGACACACATA--AAAATAAGGATCC ** ***** * * * *** ** ** ** ** **** ** * ** *** * ENST00000394836.2 CGACACACAGG---GAGACGGGG----GCCT---GGAGCCAGCCCTGAGCCA----GAG- ENST00000423599.1 TGGTACA-AGATCTGAGACAGGTCTGTACCTCATGAAATGATCTTTCTTTCACACCGAGT * *** ** ***** ** *** * * * * * ** *** ENST00000394836.2 ---GCAGA--ATGGATGGAC-----AGACAG-GCCATGGA---GGCAGCACTGAGCCAGC ENST00000423599.1 TCTGCAACTCACAGGTGGACTTTCAAGAAAATACCAAAGACCAGGGGGTTCAGAGCCTGA *** * * ***** *** * *** ** ** * * ***** * ENST00000394836.2 ACCACACGTCCA-----------TCCTGGGACAG--ACGGGCCTGGAC------------ ENST00000423599.1 AAAACACTTTTAATGGCAGTTTTTCCTGAGGCAGCCATGAGCATCTATCATTGTTAATAT * **** * * ***** * *** * * ** * * ENST00000394836.2 --TTCACGGCAAG------ACCCCCCTCTCTTCCCCA-CTG------GGTTCTGCCACCA ENST00000423599.1 AGTTCTTATCATGTATTGTGCCCTTTGCATCTCTCTAGCTGTTGTCTAATTCTTCTGTTA *** ** * *** * ** * * *** **** * * ENST00000394836.2 CCAGG-AGGATTTC---------AAGAAAGCACCAAAGAC-----CAGGGAGCTC---GG ENST00000423599.1 TGTGATAGGCCTTCCTATACTTGAAAATGGTAGTGTATCTTCTTGCGGGGAGGTCCTGGC * *** *** ** * * * * * ***** ** * ENST00000394836.2 ATCCATACT-CGGGG--GGCCTCA-------GCCCT----------TGGGAGGGGA---- ENST00000423599.1 ACCCCTGTGGCAAGGTCAGCCCTAATGATTGGTCCTGAATCAGTGATGGCAGAAGAGTGA * ** * * ** *** * * *** *** ** ** ENST00000394836.2 CACCTGAGGCAGC---CAGC-------------GCCCCCTCCCCA-GTCCCC--AGAACT ENST00000423599.1 TGGCAGAAGCAGTATTCAGTCTTCTGCTATCAGGCTCTCTTTCCAAGTCTCCTGGGAGCT * ** **** *** ** * ** *** *** ** ** ** ENST00000394836.2 GCCTGCAGGTG-------------CCTTGTTGCTGGCTT----------GTCTT-CA--- ENST00000423599.1 CCTTGAGGGCAGAAGCTCTTCTTCCCTTATTCCTGATTTTATCCCCAGTGTCTTGCACTG * ** ** **** ** *** ** ***** ** ENST00000394836.2 ----------------GAAAGGGACTG-------TTCTGGGTG-----GCTGGATCTCCA ENST00000423599.1 AGTTACGTAAATGAATGAAAGTAAATAAATACAATCTAGAGTTAATATGTTGGATCTCAA ***** * * * * ** * ******** * ENST00000394836.2 G---------------------------------------GGTACCCT-CCACC------ ENST00000423599.1 GCTTAGTGTGGATAAGACTAGATTTAAAAGGTTCTTATACGGTACTTTATCATCATTATT * ***** * ** * ENST00000394836.2 ---CCAGCTGCCA----AGCCCTGGGCCAGCA-----GCACCCCCTTGTGGCCATC---- ENST00000423599.1 CTCCCATCTACCTCTCTACCCCTGCCCCGCCACAACTGTACTATCTCTAAAACATTAAAA *** ** ** * ***** ** ** * ** ** *** ENST00000394836.2 ---CTGTGCC--TTGTTCCC--------------GGTGGCCTC----------------- ENST00000423599.1 CTTCAGTGTCATTTATTTACAAAAGTAAATATTTGGTGGCATTTATTTTAAAAAGTATTA * *** * ** ** * ****** * ENST00000394836.2 -------------------CCTATT--------------GGACT---------------- ENST00000423599.1 TCTTTGATTAAGGAAAACACCTAATCAGCATTATGGGCAGAACTCAGCATCCAGAATAAG **** * * *** ENST00000394836.2 ACT-------AGGAGGGGCTGGCAGGGCCTCCA------TAGCACAGAATT---GCCCCA ENST00000423599.1 ACTGGGGTGAAGGGAGGGGTGGTGAAGCTTCAAGGAGAATGGGGTATGACTTCAGCAGCA *** *** *** *** ** ** * * * * * * ** ** ENST00000394836.2 AAGCCT----TGTTAAGATGAGTCAAGACC--CCTCCCCCGCTTCCTCCCTTCCTTTCC- ENST00000423599.1 AAGACCAGTGTGTTTGCATGGATTGTGACAGGCATACCCAGTATATTTTATTCTTTATCA *** * **** *** * *** * * *** * * * *** ** * ENST00000394836.2 ---------------------------------------------CCCT----------- ENST00000423599.1 TTGTGAAAGGGAATGACTAGGGATGAGAGGAGATATACTATTGAATTCTGGATGGAGATG ** ENST00000394836.2 -----------TCCT-----CCCTCCC-------------CCTTCATAAAGGCCTCCCTT ENST00000423599.1 ACAAATTGAAGTCCTAATAACCAATCCGAAGAAGTAATTGCATTTATAAAATTTACCACA **** ** ** * ** ***** ** ENST00000394836.2 GTCACCTT-----------------------------------CCCTCCCACCCCG---- ENST00000423599.1 GTTACCATGGGGAACATAAAGAAATATTTTATATGTCCATGTATCATGCTACTCTAGCTA ** *** * * * * ** * ENST00000394836.2 --TCTCAG----------------------------CCCTGTGCTCC------------- ENST00000423599.1 GATCTTAGATTCCCTAAGCAAGAAGACTGAGTTCATCTTTGTACTCCCAGTGTGTCTCTT *** ** * *** **** ENST00000394836.2 ------------------------------------------------TGGAGGCCCTGC ENST00000423599.1 TATGACATCTGCATAATAGATGGTCAATAAGTGTTGAATTAAATGGAATAGAGGACTTAG * **** * * ENST00000394836.2 TCCCAAAACCGCTGGAAG------------GAC----TGGGGCACTT----TCTGC---- ENST00000423599.1 TCCTAGATCTCAAAAAAGTGTATAATTCCTGACCCAGTGTGGCAGCTCATGTCTGTAGTC *** * * * *** *** ** **** * **** ENST00000394836.2 ----CAC-----------------AGTAGAACACAGA--CAGG-GCTTCAGATCA----- ENST00000423599.1 CCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGGTCAGGAGTTTGAGACCAGCCTG *** ** ** *** **** * ** *** ** ENST00000394836.2 ----------------CCCAC----------------------GCCTGT----------- ENST00000423599.1 ACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTGGCTGTGTGTCATTGCA **** * **** ENST00000394836.2 -----------TTTCAGCTGT--GGGTGGC-----CATG--------------CAGACAC ENST00000423599.1 GGTACCTATAATCCCAGTTGTTTGGGAGGCTGAGGCATGAGAATCACTTGGACCAGGGAG * *** *** *** *** **** *** * ENST00000394836.2 GC------------GCCCTGG---CATGTGG---------GGCCTGGGTGGGCAGGCAGG ENST00000423599.1 GCTGAGGTTACAGTGAACTGAGATCATGCCACTGCACTCCAGCCTGGGTGACAGAGTGAG ** * *** **** ********* * * ENST00000394836.2 ACCTGGGCCC---------------------------TCCC------------------- ENST00000423599.1 ACCCTGTCTCAAAAAAAAAAAAAAAAAAGTGTATAAATTCCTTTAAAGGGAGCAAATGTA *** * * * * ** ENST00000394836.2 ---ACCC----------ATCAGA------------------------GCCCA-------- ENST00000423599.1 ATAATCTTGGAAGTTATATAAGAATGCATGGTTTTACGTAGTTAAGTGCCTAGTGAACTG * * ** *** *** * ENST00000394836.2 -------------------------CTCAGGAC----CAGCGTTCGGAG----------C ENST00000423599.1 TAGACATAGTAAGTCTCTATATAAATTCAGGAAGACACAATGTTATGAGGCAGTTAAGAT ****** ** *** *** ENST00000394836.2 TCCCACCTGG-------ACGCAT---CCCTCACCA--CGTCCGG-------ATTTCCTTC ENST00000423599.1 TAATATCTAGTGTTCCAGTGCCTGCTCTCTTACTAACTGGCTAGTAACACTATTTCTCTC * * ** * ** * * ** ** * * * * ***** ** ENST00000394836.2 ---------------TTTGGATG-------GAATGTAACGCGAT---------------- ENST00000423599.1 ATAGGGCTGTTAGGGTTTAAATGAGAAAGTGAATGTAAAGTGCTTAAAATGTGGCTGGTG *** *** ******** * * * ENST00000394836.2 ---------CTCT----------------------ATTTAA-----------TAAAGGCA ENST00000423599.1 CAGATTGAGCTCCCATGGATATCAGAGAAATCAAGATTTGAGTAGATGAGATTAAAGCCA *** **** * ***** ** ENST00000394836.2 GGCTTTGTTG-----GTA------------------------------------------ ENST00000423599.1 GGTCCTGATGAAGAAGTACGATTTAGGCAGAAGGATATGAACTATTAATTCTAGCACTGG ** ** ** *** ENST00000394836.2 ----------------- ENST00000423599.1 CATTTAATTGCTTTTGA