CLUSTAL 2.1 multiple sequence alignment ENST00000395248.1 ATGCCGCGAACGGCTTCTGGGCGGGGCCGGTCCCTCGGACGATTGGACCTAGCTTGGCGC ENST00000491506.2 ATGCC-CTACCAATATC----CATTGCTGA-CCCCGGAGCAGAAGGAGCT-GTCTGACAT ***** * * * ** * ** * *** * * *** ** * ** * ENST00000395248.1 GGAATCCGTGAATTGC-CCGCGGCCCGAGGGTGCAGCTCCCGGACTG--ACTGGCTCTGC ENST00000491506.2 G-ACTC-----ATCGCATCGTAGCTCTGGGCAAGGGCATCCCGGCTGCAGATGAGTCCAC * * ** ** ** ** ** * ** ** ** * *** ** ** * ENST00000395248.1 C-------CTTCCCCATGGACGCC-TCCTCTAGCCCGTGGAATCC-------AACCCCGG ENST00000491506.2 TGGGAGCACTGCCAAGTGGCTGCAGTCCATTGGCACCGAGAATACCGAGGAGAACCGGTG ** ** *** ** *** * ** * **** * **** * ENST00000395248.1 CTCCTGTCAGCAGCCCTCCCCTGCTGCT-----CCCCAT----CCCTGC--------CAT ENST00000491506.2 CTTCTACCGCCAGCTGTGGCTGACAGCTGACAACCGCGTGAACCCCTGCATCAAGGGTGT ** ** * **** * * * *** ** * * ****** * ENST00000395248.1 CGTCTTCATCGCTGTGG----GCATCTATTTGTTGCTGCTGGG--TCTAGTCCTGCTGAC ENST00000491506.2 CATCCTCTTCCATGAGACGCTGTACCAAAAGGCGGATGATGGGCGTCCCTTCCCCCAAGT * ** ** ** ** * * * * * * * ** **** ** *** * ENST00000395248.1 TAGGAACTGC----------CTGCTGGC-CCAGGGCTGCTGCGCGGACGGTAGCTCCCCC ENST00000491506.2 TATCAAATCCAAGGGCAATGTTGTGAGCATCAAGGTAGACAAGGGGGTGGTA----CCCC ** ** * * ** ** ** ** * * ** **** **** ENST00000395248.1 TGCAGGAAGCAA--GGTT---CCTCCGGGCCCCCAGACTG------CTG-CTGGAC-CTG ENST00000491506.2 TGGAAAGGGCAAATGGTGAGACCACCA--CCCAAGGGCTGGATGGGCTGTCTGAGCGCTG ** * **** *** ** ** *** * *** *** *** * *** ENST00000395248.1 TGC--------AGAAGCCTGCAACTTTCCTCTGCCTAGCCCGGC-CCACTTCCTGGATGC ENST00000491506.2 TGCCCCATACAAGAAGGATGGAGCCCAC-TTTGCCAAG--TGGCATCATGTGCTGAAGAT *** ***** ** * * * * **** ** *** ** * *** * ENST00000395248.1 TTGCTG-------CCCCCAGCCC--ACCA-----GAG-------------CTGGCTT-CC ENST00000491506.2 TGGGAAACACACCCCCTCAGCCCTCACCATCATTGAAAATGCCAAATGTCCTGGCCCACT * * *** ****** **** ** ***** * ENST00000395248.1 ATTCTGGTGATGGAGAG-AGAGAAATAACCAGGCCATTACAA---CAGAGG--------- ENST00000491506.2 ATGCCAGCATCTGCCAGCAGAATGGCATTGTGCTCATCGTGGAGCCTGAGGATCCTCCCC ** * * * ** *** * * *** * **** ENST00000395248.1 -GTGAGAA--ATGACGTGC-----------TATG-----GAGCAG---CGGTTGCTC--- ENST00000491506.2 AGTGGGGACCATGACTTGTAGTACTGCCAGTATGTAACCGAGAAGGTGTGGCTGCTCTAC *** * * ***** ** **** *** ** ** ***** ENST00000395248.1 --AGCCCTGCATG-CGATCAGA---AGCAGGACTGGGCACCTCGCTGCC-CCCGCTGCTG ENST00000491506.2 AAGGCTCTGAGTGACCATGACATCTACCTGGA--AGGCACCTTGCTGAAGTCCAATA-TG ** *** ** * ** * * * * *** ******* **** ** * ** ENST00000395248.1 CCCACTCTGCGACTGTGCCTGTACGTGCCAGCTCCCC--------GACTGCCAGAGC--- ENST00000491506.2 GTCACCCCA-GGCCATGCCTGCATCCAGAAGTTTTCTCATGAGGAGATTGCCATGGCAAC *** * * * ****** * ** * * ** ***** ** ENST00000395248.1 --------------------CTCAACTGTCTCTG-------CTTC-------GAGATCA- ENST00000491506.2 TGTCACAAGCGCACAGTGTCCCCCACTGTCCCTGGGATCACCTTCCTGTCTGGAGGCCAG * * ****** *** **** *** ** ENST00000395248.1 ------------------AGCTCCGATG--AGGACCCAGGGCCCCTGCC-----CTCTGG ENST00000491506.2 AGCAAGGAAGTGTCCATCAACCTCAATGCCATTAACAAGTGCCCCCTCCTGAAGCCCTGG * * * *** * * * ** ***** ** * **** ENST00000395248.1 GGAGCGGCCAGCCCCCAGGGC----CCATGT-GCCCTCCTCCCTGAAGAGCCTTT----- ENST00000491506.2 GGCCTGACCTTCTCATATAGCTGAGCCCTGCAGGCCTCTGCCCTGAAG-GCCTGGGGCAG ** * ** * * * ** ** ** * **** ******** **** ENST00000395248.1 ------------CCCCACGCCACTG--GAACCA------CAGATGG--CCTGCCGAGCAC ENST00000491506.2 GAAGAAGGAGAACCTGAAGGCTGTGCAGAAGGAGTATGTCAAGTGAGCCCTGGCAGATAG ** * * * ** *** * ** ** **** * * ENST00000395248.1 CCAGGCCTG----GGAA------CTGGAAGTGGCAGCGCAGGGCCTG--GC-------TC ENST00000491506.2 CCACGCCTGTCAAGGAAAGTATACTCCAAGCGGTCAGGCTGGGGCTGCTGCCAGTGAGTC *** ***** **** ** *** ** ** *** *** ** ** ENST00000395248.1 CCT----------------GC--AG--GGCAGGACTCTTGGCCGGCTG------------ ENST00000491506.2 CCTCTTCATCTTTAACCATGCCTAGTAAGCGGAGGTGTTCCCAGGCTGCCCCCCAACACC *** ** ** ** * * ** * ***** ENST00000395248.1 ---GACGGCAGCTCCTCTGGAGGGCCAGAAAAGAGAGGGGCTAGTGCTCGGG--TCC--- ENST00000491506.2 CCAGGCCCCATCCCCTCCCACGCTCTCTTGAAGAGGGGGACTCCTCTTCGGGGCTCCAGG * * ** * **** * * ***** *** ** * ***** *** ENST00000395248.1 CTGGC-----CAAAGATTTATTTCTCT--TGACAACCAAGGGCCTCCGTCTG-GATTTCC ENST00000491506.2 CTGGCTTGCCCGCGCGCTTGCCTCCCTCGTGACAGCGGTGTGTGTT-GTCTGTGAATGCT ***** * ** ** ** ***** * * * * ***** ** * * ENST00000395248.1 AAGGA-AGAATTTCCTCTGAAGCACCGGCAA-----GGTGACCCCATGGC---AAGGCGC ENST00000491506.2 AACTCCATCACCCTTTCTAGCACATTGCTAATAAACAGCTATTTAAGGGAGAAAAAATAA ** * * *** ** * ** * * * ** ** ENST00000395248.1 AAGCCAGAA---------------GGGTCCAGCTTCAACATGACCCACCTGTCCATGG-C ENST00000491506.2 AAATAAAAATAAAAATAGTTCCTGGGGCCCAGAATAAAAAGGGGGAAT---TCTAGGGGC ** * ** *** **** * ** * * * ** * ** * ENST00000395248.1 TA----TGGCCTTTTCCTTTC-CCCCAGTTGCCAG-TGGGCA------ACTCCACCCTCA ENST00000491506.2 TGGGGTTGACATTTTCCTTTTGCCTTGACCATTGGGTGGGTACTATGTGCAGCAGCCCCG * ** * ********* ** * **** * * ** ** * ENST00000395248.1 GCTGG-----------GCAACACCCAGCAC----CAGACAGAGTT--AGGAAAGGAACTT ENST00000491506.2 GACGGTGATAGTGATGGTAATGATGACCATGATGCAGACTGGGTGGGAGGGAAAAAAGTC * ** * ** * ** ***** * ** *** ** ** * ENST00000395248.1 GCTACTACCAGCACC---ATG---CCCTACCAATATCCAGCACTGAC--CCCGGAGCAGA ENST00000491506.2 CCCAGCGTCATCCCTGGGATGGGGCCTGACCTTGCCTCAACTCCAGCTGCCCAGGGCC-- * * ** * * *** ** *** ** * * * *** * ** ENST00000395248.1 AGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATCCTGGCTG ENST00000491506.2 AGAGCGAGTGATAAGATGA-GTTTAT---ACTGTAGC-TCTGAGAAGGAAGGGAGGGAGG *** *** * ** * * * * ** ** *** **** ** * ENST00000395248.1 CAGATGAGTCCACTGGGAGCATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCG ENST00000491506.2 GAGAAGGAGGGAAGGAGGGAAAAGGGAGGGAGGGGTAA------GGGAGAGAGAAAAAGG *** * * * * * * * * * * * * ** * ***** * * ENST00000395248.1 AGGAGAACCGGCGCTTCTACCGCC--AGCTGCTGCTGACAGCTGACGACCGCGTGAACCC ENST00000491506.2 GAGAGAAAGGGAAAAGAAGATGGGGAAGGAGGGAAGGACAAGGGAGGA--GTGAGAGGCG ***** ** * ** * **** ** ** * * ** * ENST00000395248.1 CTGCATTGG--GGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGATGGG ENST00000491506.2 AAGAAGGAGAAGGAAAAGAAGAAAAAGAAAGAAGAAGAGGAGGAGGGGGCGGAGGGGAGA * * * ** * * ** * * ** ****** * * ENST00000395248.1 CGTCCCTTCCCCCAAGTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGGT------- ENST00000491506.2 AGAAGAGGCCCCGAAGG-ATCACAACTG-GAGCAGAATAGTGCCCACCCAGACTCATCAC * **** *** **** * * * ** * * *** ** * ** ENST00000395248.1 --AGACAAG-GGCGTGGTCCCCCTGGCAGGGACAAATGGCGAGACTACCACCCAAGGGTT ENST00000491506.2 TGAGGCAGATGGGGTCATTCTCATTTCACAGACACA----AAAACTAAGATTTAAGGCAT ** ** ** ** * * * * ** **** * * **** * **** * ENST00000395248.1 G-GATGGGCTGTCTGAGCGCTGTGC-CCAGTACAAGAAGGACGGAGCTGA--CTTCGC-- ENST00000491506.2 GAGGCAATTTGCTCAAGATCTCAGAGTTAGGACTAGAACT-CATGGCTTATGCCTTGCTC * * ** ** ** * ** ** **** * *** * * * ** ENST00000395248.1 --CAAGTGGCGTTGTGTGCTGAA--GATTGGGGAACACACCCC-------CTCAGCCCT- ENST00000491506.2 TTCAA--GGTCTCAAACCTTGAACCACTCAAGAAACATATTCCAAGATACCTCACCCTTA *** ** * **** * * **** * ** **** ** * ENST00000395248.1 CGCCATCA-----------TGG--AAAATGCCAATGTTCTGGCCCGTTATGCCAG-TATC ENST00000491506.2 CCTCATCAGAAAGGGGAGCTGGTTAAAATGCAGAT-TTCTGGGTCAAAATCAAAGGTGTG * ***** *** ******* ** ****** * ** ** * * ENST00000395248.1 TGCCAGCAGAATG-GCATTGTGCCC---ATCGTGGAGCCTGAGATCCT-----CCCTGA- ENST00000491506.2 TGGCACAGGAATCTGCATTTTGACCGGTACCCTGGGG---GTGGTTCTTTGGGCCCTGAC ** ** **** ***** ** ** * * *** * * * * ** ****** ENST00000395248.1 --TGGGGA---CCATGACT----TGAAGCGCTGCCAGTATGTGACCGAGA----AGGTGC ENST00000491506.2 ACTGGGAAACCCCGTGGCTCATTTAGGGCCTTTCTGGTCTGACCTCTTGGCGTCAGGTCC **** * ** ** ** * ** * * ** ** * * **** * ENST00000395248.1 TGGC--TGCTGTC--TACAAGGCT--CTGAG-TGAC-CACCACATCTACCTGGAAGGCAC ENST00000491506.2 TGACCATACTCCCGTTGCCCAGCTATTTGGGCTGACTCACGCTGACCCCCCAACCGCCAC ** * * ** * * * *** ** * **** *** * ** * *** ENST00000395248.1 CTTGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTC--TCAT ENST00000491506.2 CCCCACAGGGCTGAGCCTTTTCCATCCAAG----GCTT-CACCCACAGTCTCCCAGTCGC * ** * * * ** *** * **** *** ** * * * ** ENST00000395248.1 GAGGAGATT-GCCATGGCGACCGTCACAGCGCTGCGCCGCACAGTGCCCCCCGCTGTCAC ENST00000491506.2 ATGTAGATCCACCCTTCCAACCAGCACC-CGCTTCTCTTCTGGAAGCCTTCCTC-GTGGT * **** ** * * *** *** **** * * * *** ** * ** ENST00000395248.1 TGGGATCACCTTCCTGTCTGGAGGCCAGAGTGAGGAGGAGGCGTC-CATCAACCTCAAT- ENST00000491506.2 TGGGATC---CTCCTCTTTCAGCGCCTGTTGGAGTAATAGCCTCCTCCTCTTCCTCCATC ******* **** * * *** * *** * ** * * * ** **** ** ENST00000395248.1 ----GCCATTAACAA------GTGCCCCCTGC----TGAA---GCCCTGGGCCCTGACCT ENST00000491506.2 TGGAGTTGCTTACAACACTCTATTTCACTTTCCATGTGAGTCGGCCTTGTTTCCCAATCT * * **** * * * * * *** *** ** ** * ** ENST00000395248.1 TCTCCTACGGCCGAGCCCTGCAGGCCTCTGCCCTGAAGGCCTGGGGCGGG--------AA ENST00000491506.2 TTCTCTATATTAAA------CAGGAAACT-CCCAGAGGGCTAGGGACTGGCTGGTTTAAA * *** * **** ** *** ** *** *** * ** ** ENST00000395248.1 GAAGGAGAACCTGAA------GGCTGCGCAGGAGGAGTATGTCAA--GCGAGCC-CTGGC ENST00000491506.2 CAATAAGCCTCTGAAATACAGGACTTCACCTGACCCTCCTGCCAGCCACAAGTGGCAGGG ** ** ***** * ** * * ** ** ** * ** * ** ENST00000395248.1 CA--ACAGCCTTGCCTGTCAAGGAAAGTACACTCCGA-------GCGGTCAGGCTGGGGC ENST00000491506.2 CGGGAGAGCTTTACAAATCA-GGAAACCAAGCCTTGAAGAGGTTGTGGCCTGCCCAAGTC * * *** ** * *** ***** * * ** * ** * * * * * ENST00000395248.1 TGCTGCCA-GCGAGTCCCT---CTTCGTCTCTAACC-ACGCCTA---------------- ENST00000491506.2 TATGGCCAAGTAAGATTCAGAGCTGGGTTTGAAACCCATGCCCAACTCCACTATCCAGTT * **** * ** * ** ** * **** * *** * ENST00000395248.1 --TTAAGCGGAGGTGTT--CCCAGGCTGCCCCCAACA-----CT-------CCAGGCCC- ENST00000491506.2 CTTTCTGCTTTGGCTTTGGCTCTGATCACCCCCAAAAAAACCCTATGAGGGCCAGGCGCA ** ** ** ** * * * ******* * ** ****** * ENST00000395248.1 -TGCCCCC---------TCCCAC--TCTTGAAGAG--GAGGCCGCCTCCTCGGGGC---- ENST00000491506.2 GTGGCTCAAGCCTATAATCCCAGAACTTTGGGAAGCTGAGGGTGATCACTTGAGGTCAGG ** * * ***** *** ** **** * ** * ** ENST00000395248.1 ---TCCAGGCTGGCTTGCCCGC---------GCTCTTTCTTCCCTCGTGACA-------- ENST00000491506.2 AGTTCAAGACCAGCCTGGCCATCATGGTGAAACCCCATCTCTACTAAAAATACAAAAATT ** ** * ** ** ** * * *** ** * * ENST00000395248.1 --------GTGGTG-TGTGGTGTCGTCTGT---GAATGCTAAGTCC-----ATCAC---- ENST00000491506.2 AGCTGGGCGTGGTGGTGTAATCCCAGCTGCTCAGGAGGCTGAGGCAGAAGAATCGCTTGA ****** *** * * *** * * *** ** * *** * ENST00000395248.1 -CCT-----------------------------------------TTCCGGC-------- ENST00000491506.2 ACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCGGCCTGGGCAA *** ****** ENST00000395248.1 ---------ACACTGCC--AAATAAACA-------------------------------- ENST00000491506.2 CAGAGGGAGACTCTGTCTCAAACAAACAAACAAAATAACAACAACAACAAAAACAACCTG ** *** * *** ***** ENST00000395248.1 -------GCTATTTAAGGGG----GAGTCGGC--- ENST00000491506.2 TGAGGCAGGCATTTCAGGGATTATGATCCTATTGC * **** **** ** *