CLUSTAL 2.1 multiple sequence alignment ENST00000405805.1 TTTCTGCGGAGGGATTACGCTGACGAAAGAGACCTGCTTGCGCGTCGCTGTTCCGTGGTC ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 CGCGCGAGCGTGGTCGGGAGCCGCTGGTTCCTGGGGTGACCCGCGGAGGTGGGAGAGGGA ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 AGGGCTTCCGAAGCCGGCGGGGGTGCCATGGACCCTCTCCGCCGGCGCGGCCTTCACAGC ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 TGGGCCGCGCCGGGCATCCGTAGTCCGCTCTCCCAAAGCCTCGGTGGAGCTGAAGCTGCC ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 ACAGAGTGCATGTTCACAAAGGGTCATCACACACGGAGCTGCCCCTCCCTGTCTCCCTAG ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 AGCCCATCTTCGAGGCCAGGGGCTTTTCTACCAGGATTCTGGGGTGTTTCTCCTCCTTTC ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 CTCCCTCCCAGATCTTCTCACGGTAAGGGGAGCAGCGAAAGCGCAGGGACTTTGCATTCC ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 ACGACCCGTTCTGACTAGTCAACAGCCGATCTGTCCCTGCTGCTCTAATTCCAGCTGCCC ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 TGCCTTGTTTTAACTTCAGAGAAAGGGGGAGTTCTCATTTGATAAGTTTAAGCCTTTGCT ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 TTCGTAGGAAGGTCATGTGGCTTAAGGGACATCGTGACCGCGTATGCTATTTCTGCCTGT ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 GCATTCTAAATCTTGGGGGCAGCATATTCCAGAAGTCCTTTTGGTCGATTGGTTCTGTGT ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 CCTAGGATAACAATTTGTAGTTTCTGACCATTTCTTTACAGAAAAACCACAATTGGTATT ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 TTGGACTGCGGGGTTTTTTAGTGGTCTCAAACTAAATGATTATATTCTGGAATAATGCTG ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 ACAATTTGGATAGGGTGGTGTGGAGGAAACAAGTCTCGTGTAGAAGAAATTATTTAGTAA ENST00000452520.1 ------------------------------------------------------------ ENST00000405805.1 AAAGGATTTTAGTTTTTGGTACTTCTGAATGCAAATGGCCAAGGAATCCAGCAGTTTGTT ENST00000452520.1 -----------------GGTA--------------------------------------- **** ENST00000405805.1 GGGGTTTCTCCAGACAAAAATAGGCTGAAAAATAACTAAACATGGGCAAAGGAGATCCTA ENST00000452520.1 -----------------------------------------------AAGGGAGATCCTA ** ********** ENST00000405805.1 AGAAGCCGAGAGGCAAAA-TGTCATCATATGCATTTTTTGTGCAAACTTGTCGGGAGGAG ENST00000452520.1 AGAAGCCGAGAGGCAAAAATTTCATCATCTGCATTCTTTGTGCAAGCTTGTCAGGAGGAG ****************** * ******* ****** ********* ****** ******* ENST00000405805.1 CATAAGAAGAAGCACCCAGATGCTTCAGTCAACTTCTCAGAGTTTTCTAAGAAGTGCTCA ENST00000452520.1 CATAGGAAGAAGTACCCAGCTGCTCCAGTCAACTCCTCAGAGTTTGCTCAGAAGTGCTCA **** ******* ****** **** ********* ********** ** *********** ENST00000405805.1 GAGAGGTGGAAGACCATGTCTGCTAAAGAGAAAGGAAAATTTGAAGATATGGCAAAAGCG ENST00000452520.1 GAGAGGTGGAAGACCATATATGCTAACGAGAAAGGAAAATTTGAAGACATGGCAAAGGCA ***************** * ****** ******************** ******** ** ENST00000405805.1 GACAAGGCCCGTTATGAAAGAGAAATGAAAACCTATATCCCTCCCAAAGGGGAGACAAAA ENST00000452520.1 GACAAGACCTGTTATGAAAGAGAAATGAAAAGCCATATAACTTCCAAAGGGGAGAGAAAA ****** ** ********************* * **** ** ************ **** ENST00000405805.1 AAGAAGTTCAAGGATCCCAATGCACCCAAGAGGCCTCCTTCGGCCTTCTTCCTCTTCTGC ENST00000452520.1 AAGAAGTTCAAGAATCCCAATGCACCAAAGAGGCCTCCATGAGCCTTTTTCTTGTTCTGT ************ ************* *********** * ***** *** * ***** ENST00000405805.1 TCTGAGTATCGCCCAAAAATCAAAGGAGAACATCCTGGCCTGTCCATTGGTGATGTTGCG ENST00000452520.1 TCTGAGTATCACCCCAAAATCACAGGAGAACATCCTGGCCTGTCCATTGGTGATGTTGCA ********** *** ******* ************************************ ENST00000405805.1 AAGAAACTGGGAGAGATGTGGAATAACACTGCTGCAGATGACAAGCAGCCTTATGAAAAG ENST00000452520.1 AAGAAACTGGGAGAGATGTGGAATAACACTGCTGCAGATGACAAGCAGCCTTATGAAAAG ************************************************************ ENST00000405805.1 AAGGCTGCGAAGCTGAAGGAAAAATATGAAAAGGATATTGCTGCATATCGAGCTAAAGGA ENST00000452520.1 AAGGCTGCAAAGCTAAAGGAAGAATACAGAAAGGATATTGCTGCATATTGAGCTAAAGGA ******** ***** ****** **** ******************* *********** ENST00000405805.1 AAGCCTGATGCAGCAAAAAAGGGAGTTGTCAAGGCTGAAAAAAGCAAGAAAAAGAAGGAA ENST00000452520.1 AAGCCTGATGCAGCAAAAAAGGGAGTCGTCAAG-CTGAAAAA-GTGAGAAAAAGAAGGAA ************************** ****** ******** * ************** ENST00000405805.1 GAGGAGGAAGATGAGGAAGATGAAGAGGATGAGGAGGAGGAGGAAGATGAAGAAGATGAA ENST00000452520.1 GA------------------TGAAAAGGACAAGGAGGAA---GAAGTTGAAG----TGAA ** **** **** ******* **** ***** **** ENST00000405805.1 GATGAAGAAGAAGATGATGATGATGAATAAGTTGGTTCTAGCGCAGTTTTTTTTTTCTTG ENST00000452520.1 TATGAAGAAGA---TGACGATGGTGAATAAGTTGGTTCTAGCACAGTTTTCTTTTTCTTG ********** *** **** ******************* ******* ********* ENST00000405805.1 TCTATAAAGCATTTAACCCCCCTGTACACAACTCACTCCTTTTAAAGAAAAAAATTGAAA ENST00000452520.1 TCTTTAAAGCATTTAACCCCCCTGTACACAACTCACTCCTTTTAAAGCAAGACATTGAAA *** ******************************************* ** * ******* ENST00000405805.1 TGTAAGGCTGTGTAAGATTTGTTTTTAAACTGTACAGTGTCTTTTTTTGTATAGTTAACA ENST00000452520.1 TGGGAGGCTGTGTAAGATTTATTCTTAA-CTGTACAGTGTTTTTTTTTGTATAGTTAACA ** **************** ** **** *********** ******************* ENST00000405805.1 CACTACCGAATGTGTCTTTAGATAGCCCTGTCCTGGTGGTATTTTCAATAGCCACTAACC ENST00000452520.1 CATTACTGAATGTGTCTTTAGATAGCCCTGTCTTGGTGATATGTTCAATAGCCACTAACT ** *** ************************* ***** *** **************** ENST00000405805.1 TTGCCTGGTACAGTATGGGGGTTGTAAATTGGCATGGAAATTTAAAGCAGGTTCTTGTTG ENST00000452520.1 TTGCCTGATACAGTATGGGG-TTGTAAATTGGCATGGATATTTCAAGCAGGTTGTTGTTG ******* ************ ***************** **** ********* ****** ENST00000405805.1 GTGCACAGCACAAATTAGTTATATATGGGGATGGTAGTTTTTTCATCTTCAGTTGTCTCT ENST00000452520.1 GTGCACAGCACAAATTAGGAACGTATGGGGATGGTAGTTTTTTCATCTTCGGTTGTTTCT ****************** * *************************** ***** *** ENST00000405805.1 GATGCAGCTTATACGAAATAATTGTTGTTCTGTTAACTGAATACCACTCTGTAATTGCAA ENST00000452520.1 GATGCAGCTTATATGAAATAATTGTTGTTCTGTTAA-TGAATACCACTCTGTAGCCGCAA ************* ********************** **************** **** ENST00000405805.1 AAAAAAAAAAAAAGTTGCAGCT-GTTTTGTTGACATTCTGAATGCTTCTAAGTAAATACA ENST00000452520.1 AACAAAAAAAAA-GTTGCAGTTTGTTTTGTTGACATTCTAAATGCTTCTAAGTAAATACA ** ********* ******* * **************** ******************** ENST00000405805.1 ATTTTTTTTATTAGTATTGTTGTCCTTTTCATAGGTCTGAAATTTTTCTTCTTGAGGGGA ENST00000452520.1 ATTTTCTTTGTTAATA-----------------------AAAT----------------A ***** *** *** ** **** * ENST00000405805.1 AGCTAGTCTTTTGCTTTTGCCCATTTTGAATCACATGAATTATTACAGTGTTTATCC-TT ENST00000452520.1 AGAT----------------TCATTT-----------AGCTGT----GTATTCATTCATT ** * ***** * * * ** ** ** * ** ENST00000405805.1 TCAT-ATAGTTAGCTAATAAAAAGCTTTTGTCTACACACCCTGCATATCATAATGGGGGT ENST00000452520.1 TCATCATTGTTGG-TAATAGTAAA-------------------------ACAAAAGAAG- **** ** *** * ***** ** * ** * * ENST00000405805.1 AAAGTTAAGTTGAGATAGTTTTCATCCATAACTGAACATCCAAAATCTTGATCAGTTAAG ENST00000452520.1 AAAGACAAGAAAAGACAA---------------GAAA----AGAATCTAGA------AGG **** *** *** * *** * ***** ** * * ENST00000405805.1 AAATTTCACATAGCCCACTTACATTTACAAACTGAAGAGTAATCAATCTACTCAAAGCAT ENST00000452520.1 A-----------GTCCA--------TACATACGGAA-------CCACTTACTTATA---- * * *** **** ** *** * * **** * * ENST00000405805.1 GGGATTATTAGAATCAAACATTTTGAAAGTCTGTCCTTGAAGGACTAATAGAAAAGTATG ENST00000452520.1 ---ATTATTATAAGTAAAC-TTCTAA-------------------TAATAAAA------- ******* ** **** ** * * ***** ** ENST00000405805.1 TTCTAACCTTTACATGAGGACTCTATTCTTTAACTCCCATTACCATGTAATGGCAGTTAT ENST00000452520.1 ----------TACA----------------------------------AAT--CAGTCAT **** *** **** ** ENST00000405805.1 ATTTTGCAGTTCCCACATTAAAGAAGACCTGAGAATGTATCCCCAAAAGCGTGAGCTTAA ENST00000452520.1 A------AATC----------AGAAAATC-------GTATTATCAAAATCAATGCCTTGA * * * **** * * **** ***** * *** * ENST00000405805.1 AATACAAGACTGCCATATTA-AATTTTTTGTTGACATTAGTCTCAGTGAAGACTATGAAA ENST00000452520.1 TTTT---GATCATCATAATGTAATTATGTAA-GATATTAATGTTTATGGAATTTGGGAAA * ** **** * **** * * ** **** * * ** * * **** ENST00000405805.1 ATGCTGGCTATAGATGTCTTTTCCCATTTATCTAAATATGGACTGCTCAGGAAACGAGAC ENST00000452520.1 AGGTA---TATGGTAATTTTCTCTAATTTTTTTGTAAGTGA---------GAAATTAG-- * * *** * * ** ** **** * * * ** **** ** ENST00000405805.1 TTTCCATTACAAGTATTTTTAATTAATTGGGCCAGCTTTTCAAACAAAGATGCCACATTC ENST00000452520.1 CTTAAATGAAAAG--TTTTAAAATA-------CAGAA----AAAATAAGAAACCA---TC ** ** * *** **** ** ** *** *** **** *** ** ENST00000405805.1 AAAATAGGGTATATTTTCCTATATTACGGTTTGCCCCTTTATAAATCCAAGTAGATAGGA ENST00000452520.1 ATAATAAGATAGAAACT----TACCAAAGTTCCTGTTTTTATACCCCAAGGGACATAAGA * **** * ** * * ** * *** ****** * * * * *** ** ENST00000405805.1 AGAAAGAAGACAAACTTT----GCATCTCAGTATGAATTATTCAATTTATTTGAATGATT ENST00000452520.1 C-ACAGGAGACAAAGACCAGGGGCTGCCTAGGGTGGGA-----AATGTACT---AAGAGA * ** ******* ** * ** ** *** ** * * ** ENST00000405805.1 TTTCTTTACAAAACAAACTCATTCATTAGTCATGTTTATCTGCTTAGGAGTTTAGGGAAC ENST00000452520.1 TACCTTCGGGAGCTAAGCT-----ATGAGG-ATGC--AAAGGCCTAAGAAT----GATGC * *** * ** ** ** ** *** * ** ** ** * * * ENST00000405805.1 AATTTGGCAATTTTGTGGTTTTCGAGATTATCGTTTTCTTAAAGTGCCAGTATTTTAAAA ENST00000452520.1 AA--TGG--ACCATGGAGCCTCAGGGAAGGGTGG-----GAGGGAGTAAGGGATAGGAAA ** *** * ** * * * ** * * * * ** * *** ENST00000405805.1 TAGCGTTCTTG-TA-ATTTTACAC-GCTTTTGTGATGGAGTGCTGTTTTGTTATATAATT ENST00000452520.1 CTGCACGTTGGGTACAGTTTACACTGCTCAGGTAATGGG---------TGCACCAAAAT- ** * * ** * ******* *** ** **** ** * *** ENST00000405805.1 TAGACTTGGATTCTTTCCATTT--GCATTTGTTTATGTAATTTCAGGAGGAATACTGAAC ENST00000452520.1 ----CTTAGAAACTG-CCATTAAAGAACTTATTCATGTTACCTAAATAAATAAATAAAAG *** ** ** ***** * * ** ** **** * * * * * * ** ENST00000405805.1 ATCTGA-GTCCTGGATGATACTAATAAACTAATAATTGCAGAGGTTTTAAATACTAGTTA ENST00000452520.1 GCTTACTGTTCAGAAAGA----AAGAAAGGAAAGAAGGGAAGGG-----AAGGGAAGGGA * ** * * * ** ** *** ** * * * ** ** ** * ENST00000405805.1 AATGGCTTTCACTTAAGAACTTAAGATTTTGTTACATATTTTTAAATCTTGTTTCTAATA ENST00000452520.1 A--GGCTATGGCT----------GGGCGCTGTGGC-----------TCACGCCTGTAAT- * **** * ** * *** * ** * * **** ENST00000405805.1 ATACCTCTTAGCAGTACCTTTTAAATAAGTATAAGGGATGGCAAAGTTTTTCCCTTTAAA ENST00000452520.1 ------CCCAGCA----CTTT-------------GGGAGGCCGAGG------CGGGTGGA * **** **** **** * * * * * * * ENST00000405805.1 AATACTCACTTTATGCTTATAAATAGGTTAATGGGCTGATAAAAGGTTTTGTCAAACATT ENST00000452520.1 -----TCACCT------------GAGGTCAGGAGTTTGAGACCAGGC--TGACCAACATG **** * **** * * *** * *** ** * ***** ENST00000405805.1 GCAAGTATTCGGTGCTATATATAAAGGAGGAAAAACTAGTTTTACTTTCAGAATGATTTA ENST00000452520.1 GTGAA-ACCCCGT-CTCTAC-TAAAAATACAAAAATTAGCC-------CGGTATGGT--- * * * * ** ** ** **** ***** *** * * *** * ENST00000405805.1 AACAAGATTTTTAAAAACAAGATACATGCAAGCGAACAGCAGGGTTAGTGATAGGCTGCA ENST00000452520.1 --------------------GGCATGTGCCGGTAATC-------CCATCTAC---TTGGG * * *** * * * * * ** ENST00000405805.1 ATTGTGTCGAACATCAGATTTTTTGTTAAGAGGAGCAAATGACTCAATCTGATTTAGATG ENST00000452520.1 ATTGC-----ACTTCAG---CCTGGGCAACAAGAGCGAA--ACTCCATCTCAAAAAAAAA **** ** **** * * ** * **** ** **** **** * * * ENST00000405805.1 GAAGTTTCTACTGTATAGAAATCACCATTAATCACCAACATTAATAATTCTGATCCATTT ENST00000452520.1 AAA-----------AAAGAAA---------------GAAAGAAATGA------------- ** * ***** * * *** * ENST00000405805.1 AAAATGAATTCTGGCTCAAGGAGAATTTGTAACTTTAGTAGGTACGTCATGACAACTACC ENST00000452520.1 GAGAGAGAT---GGCTTAAA-AGCACTTGT-------GCAAG---GTAATGG-AAGGATC * * ** **** ** ** * **** * * * ** *** ** * * ENST00000405805.1 ATTTTTTTAAGATGTTGAGAATG--GGAACAGTTTTTTTAGGGTTTATTCTTGACCACAG ENST00000452520.1 --TTAATGGGGAAACTGAGTATGCAGGAAC----TCTCTG-----TACTCTT---CGCAA ** * ** **** *** ***** * * * ** **** * ** ENST00000405805.1 ATCTTAAGAAAATGGACAAAACCCCTCTTCAATCTGAAGATTAGTATGGTTTGGTGTTCT ENST00000452520.1 CTTTTCTGTAAACC--TCAAACTACTCTCAAAT--GACTATTATTATTACT--GTTATTA * ** * *** **** **** *** ** **** *** * ** * ENST00000405805.1 AACAGTATCCCCTAGAAGTTGGATGTCTAAAACTCAAGTAAATGGAAGTGGGAGGCAATT ENST00000452520.1 AACAGCA------AAAAA----------AAAA---AAAAAAAAGAAAGAGAGAG------ ***** * * ** **** ** *** * *** * *** ENST00000405805.1 TAGATAAGTGTAAAGCCTTGTAACTGAAGATGATTTTTTTTAGAAAGTGTATAGAAACTA ENST00000452520.1 -AGAGAGATACCA----TCATAATGCTAG--GATCCC-----AAAGGGGTATAC------ *** * * * * *** ** *** ** * ***** ENST00000405805.1 TTTTAATGCCAAGATAGTTACAGTGCTGTGGGGTTTAAAGACTTTGTTGACATCAAGAAA ENST00000452520.1 TCTCAGTGCAAGAGCAAAT-CAG-------AAGT---AAGCC--TGCCCTCACCCAGAGT * * * *** * * * *** ** *** * ** ** * *** ENST00000405805.1 AGACTAAATCTATAATTAATTGGGCCAACTTTTAAAATGAAGATGCTTTTTAAAACTAAT ENST00000452520.1 AGACTA----TGAAGAAAATTG--CTGTCTCATAAATTG-----GCATTATATGGATGGG ****** * * ***** * ** **** ** ** ** ** * ENST00000405805.1 GAACTAAGATGTATAAATCT-TAGTTTTTTTGTATTTTAAAGATAGGCATATGGCATATT ENST00000452520.1 AGAAAAAAACTCAGGGATTCATAACCTCATGGTAGTTCTCAGATAGTTTTGTAGCCCA-- * ** * * ** ** * * *** ** ****** * * ** * ENST00000405805.1 GATTAACGAGTCAAATTTCCTAACTTTGCTG-TGCAAAGGTTGAGAGCTATTGCTGATTA ENST00000452520.1 --------AATCCA---TACTATTTTTATGGCTAGAAAAACTTCAAACTGAGTCTTTTTA * ** * * *** *** * * *** * * ** ** *** ENST00000405805.1 GTTACCACAGTTCTGA--TGATCGT-CCCATCACAGT--GTTGTTAATGTTTGC---TGT ENST00000452520.1 AAAACCA-GGTTCTGAGTTAATAGTGCCCATCTAGGCCAGGCACAGAGGCTCACGCCTGT **** ******* * ** ** ****** * * * * * * *** ENST00000405805.1 ATTTATTAATTTTCTTAAAGTGAAATCTGAAAAATGAAATTTGTGTGTCCTGTGTACCCG ENST00000452520.1 AATC-CCAGCACTTT---GGTGGGCCAAGGCAGGTGGATTGCCTGAGGTCAG-GAGTTCG * * * * * *** * * ** * * ** * * * * ** ENST00000405805.1 AGGGGTAA--TGATTAA-ATGATAAAG----AT- ENST00000452520.1 AGAC-CAGCCTGGCCAACATGGTGAAACCCCATC ** * ** ** *** * ** **