CLUSTAL 2.1 multiple sequence alignment ENST00000409514.1 GAAGTCACTCCCTGAGGCAGTGGCGACAGCGGCGGCGAGAGGATGAACAACAAGTTCGAC ENST00000492033.1 ------------------------------------------ATGAACAACAAATTTGAT *********** ** ** ENST00000409514.1 GCTTTGAAAGATGATGACAGTGGGGACCATGATCAGAATGAAGAAAACAGCACACAGAAA ENST00000492033.1 GCTTTGAAAGATGACAACAATAGGGACCATGATCAGAATGAAGAAAGCAGCACACAGAAA ************** *** * ************************ ************* ENST00000409514.1 GATGGTGAGAAGGAAAAAACGGAACGAGACAAGAATCAGAGCAGTAGCAAGAGAAAGGCT ENST00000492033.1 GATACTGAGAAAGAAAAAACACAATGGGACAAGAATAAGAGCAGTAACAAGAGGAAGGCT *** ****** ******** ** * ********* ********* ****** ****** ENST00000409514.1 GTTGTCCCTGGACCGGCAGAGCATCCCCTGCAGTACAACTACACTTTTTGGTACTCCAGG ENST00000492033.1 GTTGTCCCTGGACAGGCAGAGCATCCCCTGCAGTACAACTACACTTTCTGGTACTCCAGG ************* ********************************* ************ ENST00000409514.1 AGAACCCCCGGCCGTCCCACGAGCTCACAGAGCTATGAACAGAATATCAAACAGATTGGC ENST00000492033.1 AGAACCCCTGTCTGTCCCACCAGCTCACAGAGTTATGAACAGAATATCAAACAGATTGGC ******** * * ******* *********** *************************** ENST00000409514.1 ACCTTTGCCTCTGTGGAGCAGTTCTGGAGGTTTTATAGCCACATGGTACGTCCTGGGGAC ENST00000492033.1 ACCTTTGCCTCTGTGGAGCAGTTCTGGAGGTTTTATAGCCACATGGTATGTCCAAAGGAT ************************************************ **** *** ENST00000409514.1 CTGACAGGCCACAGTGACTTCCATCTCTTCAAAGAAGGAATTAAACCCATGTGGGAGGAT ENST00000492033.1 CTGACAGGCCACAGTGACTTCGATCTCTTCAAA-AAGGAATTAAACCCATGTGGGAGGAT ********************* *********** ************************** ENST00000409514.1 GATGCAAATAAAAATGGTGGCAAGTGGATTATTCGGCTGCGGAAGGGCTTGGCCTCCCGT ENST00000492033.1 AATGCAAATAAAAATGGTGACAAGAGGATTATTTGGCTGCGGAAGGGCTTGATCTCCCAT ****************** **** ******** ***************** ***** * ENST00000409514.1 TGCTGGGAGAATCTCATTTTGGCCATGCTGGGGGAACAGTTCATGGTTGGGGAGGAGATC ENST00000492033.1 TGCTGGGAGAATCTCATTTTGGCCATGTTGGGGGAAAAGTTCATGGTTGGGGAGGAGATC *************************** ******** *********************** ENST00000409514.1 TGTGGGGCTGTGGTGTCTGTCCGCTTTCAGGAAGACATTATTTCAATATGGAATAAGACT ENST00000492033.1 TGTGGGGCTGTGGTCTCTCTTCACTGTCAAGAGGACATTATTTCAATATGGAA-AAGACT ************** *** * * ** *** ** ******************** ****** ENST00000409514.1 GCCAGTGACCAAGCAACCACAGCCCGAATCCGGGACACACTTCGGCGAGTGCTTAACCTA ENST00000492033.1 GCCAGTGACCAAGCAACCACAACGTGAATCTGGGATACACTTTGGCGAGTGCTTAACCTA ********************* * ***** **** ****** ***************** ENST00000409514.1 CCTCCCAACACCATTATGGAATACAAAACTCACACCGACAGCATCAAG--GCCTGGGAG- ENST00000492033.1 TCTCCCAACACCATTATGAAATACAAAACTCACACCGACAGCATCAAAACGCCAGGCAGC ***************** **************************** *** ** ** ENST00000409514.1 --GAGTTTC--ATGGCCTGGTGAACA---------GCAGCGGCCGCTGATCGGACGCT-- ENST00000492033.1 CTGGGCTCCCAAAGGCTCCTTTATCAAAACCTCTGGAAGCTGCGGTTGAATGTGCCATGA * * * * * *** * * ** * *** ** * *** * * * ENST00000409514.1 CCCCCTCTGTCTCTCACACTCAGGGGACAATTC---AAGCTTTCGAAATACAAAAATCAC ENST00000492033.1 CCCTCTCCATCTCTGG-----ATGGCACTATCCTTGAAGCTGGTGTCATTAGAGTCTCTT *** *** ***** * ** ** ** * ***** * ** * ** ENST00000409514.1 ATTGTGAGAGTACACAAGCTGGCAATAATCCTTTTCTGTATGTGTGTGTTTGTCCGAAAT ENST00000492033.1 GTTCTGTTGGTATGCTACCTGGAAG--ATCCTTCTAT-----------CCTGGACAAGAT ** ** *** * * **** * ****** * * ** * * ** ENST00000409514.1 GGATGGGAGGCCTCCAGCCAGTCCTTCCATTGCTCACTGAAGGGACGTCCCTGAGCCGTG ENST00000492033.1 AATTAAAAG------AG-----CATTTTATGTTTTAAGAACAGGCTGACACACAGCAG-- * ** ** * ** ** * * * ** * * * *** * ENST00000409514.1 CGCTCTCCTTTTGCACTCATTCCTGGAGGACGGATTCCGCTAGACACCCTCCAGCATCGC ENST00000492033.1 ----------CTACAGCAACAGCTG------AGATT--GCTCAATA------AATGGTGC * ** * *** **** *** * * * ** ENST00000409514.1 TGACTTTATAAAGCGGAAAAACGGAAAACGTGACTTTGTAATAGACAAACATTGTTTTTT ENST00000492033.1 TAAATTTAAAAAAAAAAAAGAGAGAAGA-----------AATGCAGAGTCACT-----TT * * **** *** *** * *** * *** * * ** * ** ENST00000409514.1 AATGGGGTTCCATGGGGGGGCGTTCAGCCTTTCTGTTTGCTGTGTGCTGTCCAGATGCCT ENST00000492033.1 GGTTGAAATGAATATAGAGGCTTCTGAC---TAAGCTTTCT-TGGACT--CCAGA---GT * * * ** * *** * * * * ** ** ** ** ***** * ENST00000409514.1 CTTGGGCGTCCTGTTGTTCTCTTCCCGTGTTGTACGAAGGGTACCGTGGCCACGTGTACA ENST00000492033.1 TTTGGGGATC----TGTATAAATCACATTT-------AGGAAACCA---CTAGATG-AT- ***** ** *** ** * * * *** *** * * ** * ENST00000409514.1 TGCCAGAGCTGTTGATGAGAGTTACCAGTATTATGAATGTCTGTGCATCCAGGAAAAGTG ENST00000492033.1 TTCTACAACTACTGATTGGCCTTACTGAT----TAAAC-TTGGTGCCTC-------AACT * * * * ** **** * **** * * ** * **** ** * ENST00000409514.1 TTCTGTTGGAGAGTCCCAAAATAGCTGTAAATGCTCTCTTCTAGCTCTGCCATTAAATTA ENST00000492033.1 TTCCTTT---------------AGTTGT----------TCCCA-------CACCAAAACA *** ** ** *** * * * ** *** * ENST00000409514.1 TTGGG-ACATTTTGTTTCTTTCTCTCCCCTCCTCCAAGCCCACCACTTTCTGAAGCTGTG ENST00000492033.1 TTGTCCACA---TATTTCTACCCACTCCCTACTCCCTGCCGCCCACAT--GGATGCTCTG *** *** * ***** * **** **** *** **** * ** *** ** ENST00000409514.1 TTACTGATGTGATGACTGTCCAGGATTTTGTATCATCCCCTGCCTTATGCCCTCCGGTCT ENST00000492033.1 CTT----TATCAAGA--AACCAAGA--------CATCCCTT-----------TCAGA--- * * * * ** *** ** ****** * ** * ENST00000409514.1 CCTCTCCTGTGGGACTCTCTCCTTCTTAGGCACAGCTGCACTTAGAATTGTAATCCAGTG ENST00000492033.1 -----------AGACTTTTTCATCCTTA----------CA-----AATTTTAA------- **** * ** * **** ** **** *** ENST00000409514.1 GCTCTCACTG-GTTTCACTGAGGCAGCTTAGAGGGAATGCCTTAGTAAACTGAACTGGAG ENST00000492033.1 ATTCCCACAGTATTTGACTGTAGAACTTTC-------TGGCTC--TAAATTCCA-TAGAG ** *** * *** **** * * ** ** ** **** * * * *** ENST00000409514.1 CAGAATCTAGTTTGATTAGGAGCTAGATTATAATCTAGGTTCCAAGT-ACAGAATTTGGA ENST00000492033.1 TAA---CT----------GAAGTTACTTGAAAATATACTTCCTATTTGACAAAACCTGCA * ** * ** ** * * *** ** * * * * *** ** ** * ENST00000409514.1 GCTAAGGACTGTGACTGAAATCATTTTCCCATATGAGCAGACCCTGTGTGTCAGGCCTGT ENST00000492033.1 ACTAAGGGGCCT---TAGAGTAATCTTGAAAAAAAATTACAA---ATATGTCAG-CTAGG ****** * * * * ** ** * * * * * * ****** * * ENST00000409514.1 TTCCCATATGAGCAGAGCCTGTGTGCAAGTCTGTTTCTGGCATGTCCCTCATTGAGGAAG ENST00000492033.1 TTTTTGTATGA-TA----CTGTC------TTTATCTTTAATGTGTTC------------- ** ***** * **** * * * * * *** * ENST00000409514.1 GGAAGCAAAAGCTGGTTATTGCCAGGCCTATTAACACTTAATATGCAAATTCTATCATCC ENST00000492033.1 ------------TGTTTATT----------TT----CTTAATTTTGAAA----ACCA--- ** ***** ** ****** * *** * ** ENST00000409514.1 TGAAACTGGGGCATCTGAGGAAAAGGTGACCTTGCTGGATGGCTTTATTTGCATGGCTCT ENST00000492033.1 --AGGCCG---TATTTTTAGA-----TG-CCT--CTGGGCACATGTACCAAAATATCTCT * * * ** * ** ** *** **** * ** ** **** ENST00000409514.1 GCCTGT-CTGCAGTGGTTGAGTCCTCATCACCTGGTATGTGTATGAGCAAATGTGTGCTG ENST00000492033.1 GTAAATTCTGCACTCAT---GT-----TTCCCTGTTTTTTTTTT----AAATGTCTGTTT * * ***** * * ** * **** * * * * * ****** ** * ENST00000409514.1 ATTGTGATGCCCAGGCAGAAACCTCTTGAAGACTGCTGCAGGCATGCTTTAAAAATGACC ENST00000492033.1 CTTGTGA-----------AAGCCTGT-AAAGACTG--------------TGAAGA--ACT ****** ** *** * ******* * ** * ** ENST00000409514.1 AGTCACTCATCAGAGAAGCTGGGTGATCTGACTCCAGAAGGACTGAAGTCAGAGAAGTCA ENST00000492033.1 --TCCTTCAC-----AAACAGGGTG--CTGTTTCC----------------------TCA ** *** ** * ***** *** *** *** ENST00000409514.1 CAAGAGCACCTAGGATTCAAATAAATAGCGTCAGAGTCCTATAGCAACCTCCAAGTAGCA ENST00000492033.1 C-----TACCCA---TTC-------TGGCCT-AAAATCT---------CCCCATGCG--- * *** * *** * ** * * * ** * *** * ENST00000409514.1 CCGTCTTACTTGGCTCTTGTGAGCAAAGACTGCAGTACCTTAAATTAAGGCCTCTCTTTA ENST00000492033.1 --GTCCTGCTGTGTACTT------------TGCAGTACTCTGGCTTCAGTCCT------- *** * ** * *** ******** * ** ** *** ENST00000409514.1 AAACATATGTGGAAGAC-TAGGGGATCCTTGGCCACCTGGTCTCAGAGAAATCATATGAG ENST00000492033.1 AGTCCTATACAGGAAATGTGTGAAATCCTT---------GCCTCAGTGGCA--ATATGAG * * *** * * * * * ****** * ***** * * ******* ENST00000409514.1 AGTAACAGGCATTTCCTTATTGTATTTGTACTACACTCTTCCTACT--TTTCCATTCCTG ENST00000492033.1 TTCA--------TTTCTTA--GAAGCTAAGC----CCCGTGCCAGTAATTCCCATTTATG * ** **** * * * * * * * * * * ** ***** ** ENST00000409514.1 AACACCCTCTAAT-TACCACTGTTTTGGGGATGCTTTTTTTCTGAAAGAACGGGGAGTAC ENST00000492033.1 A------TCCAGTGTCTTATTGTCCCA-------TCTCCTT-----AGAGTGGGA--TTC * ** * * * * *** * * ** *** *** * * ENST00000409514.1 AGGGGCCAAAAGGGAGGTGCTTCT--ATTACAGGGCAAGTTAGATCAGATAAGAAGATCT ENST00000492033.1 AGATTCTTAAAG-----TATTTCCTGATTCTTA--CTACTT-GTTCTTGCCACTGGACCC ** * **** * *** *** * * ** * ** * ** * ENST00000409514.1 AGCAGTGATTTAAACTCCAGGAATATGAAGAGTGCATTCTGGTGTCCAGACAGTTGTGAA ENST00000492033.1 TCCACTGTCTTGAACT------ATATCAACTGTCCAG-CTGATCTCC---------TAAA ** ** ** **** **** ** ** ** *** * *** * ** ENST00000409514.1 GGGCTCGGCAAATATAAGAGCACCATTGGCTACATGGAGAGCAAAGGCTGTCTTTGAAGA ENST00000492033.1 ---CTTGAT-------------CCTTTCCCTGCCTGAA---CCCAGGATG-CTTTCACAA ** * ** ** ** * ** * * *** ** **** * * ENST00000409514.1 CCCCAGGGAGGTCTTCACTT---TTGCCTAAATTCAGATTTGCCGTGAAAATTCCAAAGA ENST00000492033.1 TT--------GCTTTTTCTTACCTTATCTAAGAACATCTCTATTTT-----TTCTACTGC * ** *** ** **** ** * * * *** * * ENST00000409514.1 GAGCAGATATTTGGATTTGCCCTCCTTTGGGCATCTACCTGACTGTTGTGTGTGTGGGAA ENST00000492033.1 AGTC--TCATTTTGATGAGTCTTTCCT---GT-TCTACCCTATCCTT-TTCCTGCCCCAA * **** *** * * * * * * ****** * ** * ** ** ENST00000409514.1 AGTCAGTGTGTATGTGTAGAGTGTGCTTAGGAGTGAGTGAGTGGTCAGGCCTCCTGGCTA ENST00000492033.1 ACCTAATTTG---ACCTCCTTTCCACACAGGGTTT--TAAGAGATCAAGATACT------ * * * ** * * * *** * * ** * *** * * ENST00000409514.1 GGTGTGTTGTCCATAGTTTTGTTGTTGTTGTTGTTGTTGTTCAGAGTTTTGAATCTTACG ENST00000492033.1 GATGCA--------AATTTCAACATTAGC-TTGCAAAATCTCAAAGGTT---GCTTTTCT * ** * *** ** *** *** ** ** ** * ENST00000409514.1 TTTTCTAGAGCTGCTCATGTTTTCCCTTCCTTTTTGTCGTTGTAGTATTTGACAGTTGTC ENST00000492033.1 TATCCTGAAACTACC---ATCCTCCTTTCCCTGTT----CCAAAGTCCTTCACAGTGATA * * ** * ** * * *** **** * ** *** ** ***** * ENST00000409514.1 T------TTTCCATCAAAAAC--ATACTGGCCCTAGGCTGGTTAGAGCAAGGGGTTATGC ENST00000492033.1 TGGGGTATTTTAATAAAAAAACAATATTT-TCTTAAGC-------AGCA----------- * *** ** ***** *** * * ** ** **** ENST00000409514.1 CTGTTAGGCAGCATCTTACGCCCAGTGTTCTCCCAGATATTCTGCCTAACAGGTTTAAGT ENST00000492033.1 ---TTAAATGAAATCCCACTTTCAGTA--CTACTGGTTCTTCTGTTTGCAAAGTTC---- *** *** ** **** ** * * * ***** * * *** ENST00000409514.1 AGGAGATTAAATAGTCAGTTTATCTAAACCCTCTATTTTTCCAAACTAGCTTGAGAGGTC ENST00000492033.1 --------------TCTGTT---CTGG----TTTCCTTTCCTAAACC--CTT------TC ** *** ** * * *** * **** *** ** ENST00000409514.1 TTTTCATCTATTTTTACTCCATGGGCCTCTGATATGCTGAGATGTGGCACGGTTATGATT ENST00000492033.1 TTTTGAC-------TACTGCAAAAGT-----ATAGACCAAA--GAGGCA--------ACC **** * **** ** * *** * * * **** * ENST00000409514.1 ATGGTATCACCGTTACAGAGGCAAAGGGATAAAGGTCTACCAGGGCCAACGTAACCAGAA ENST00000492033.1 -TAATAAAACAGCTA---AGACAAGA----------CTACTAG---CTATTTTGCTA-AA * ** ** * ** ** *** **** ** * * * * * ** ENST00000409514.1 TGTGAGGAGAGTGAAGAGTCGGTCTCCGCTTTGCACAGTACCAGAATGTGAGGTTGCCAC ENST00000492033.1 TGTTT------TCAAAATCTGATTT--ATTCTGCACAATATC--------------CCTC *** * ** * * * * * ****** ** * ** * ENST00000409514.1 TGGAGAGTGGAGAGTCGGTCTCCACTTTGCACAGTTGGAGCTGTTCTCCTCTAACTCCTT ENST00000492033.1 TGAAAGAGATACTATTATTATCCACATTTTATAGGTGAGGA-----------AACTC--- ** * * * * ***** ** * ** ** * ***** ENST00000409514.1 TGCTGGGTTTTCTGTTTGAAATTGGCCCCTACTCCTCTCCAGCCCTTTACTGGGTTTTCT ENST00000492033.1 ---TGAAT----------AAGTTG---CCAAGGTCAC-CCAGCTAAT-ACT--------- ** * ** *** ** * * * ***** * *** ENST00000409514.1 GTTTGAAATTGGCCCCTACTCCTCTCCAGTGTCTGCTTTTTGAATCCTTCTGTTCGTGTG ENST00000492033.1 -TTTGAAACCAGGACTCA---------AAT---------TTGAACCTTTC---------- ******* * * * * * ***** * *** ENST00000409514.1 TGTGTGTGTGTGTGTGTGTGTTCCCTATGATACTGGCAGTGGCAATAATTTTCCACCCAG ENST00000492033.1 TGAATCCAAACCTCACTAAGCTCTATATCATCTC-----TGACATCAATCTACTACC-AA ** * * * * ** *** ** ** ** *** * * *** * ENST00000409514.1 AGAGAAGCTTGTGGTCCACAAT-GCTCGAAGAATGAATTTCCAAGTATTTGCCAGTGGAA ENST00000492033.1 ATAGA---TGGTGACCTTGACTTACTTGCATTTTGAAAACACTTATATTCATTAGTGGTA * *** * *** * * * ** * * **** * **** ***** * ENST00000409514.1 ACGGAGCAGAGGCTAT-GACAAGAGTGATTTAGTGTTGCACTTTCAGAGCAATTATCTAC ENST00000492033.1 --GAAATA---TTTATAGACAA--ATCACTAA-----------CCAGAAGGAA-ATCTG- * * * *** ***** * * * * **** * **** ENST00000409514.1 TGCAGTAATAAATTGAAAATATCAGCAAG ENST00000492033.1 ---AGAAAAAGA---GAAGCATCAGAAAA ** ** * * ** ***** **