CLUSTAL 2.1 multiple sequence alignment ENST00000413835.2 AAACAGAGCCGAAGCTTCGTCTTCGGAATCGAGGAGGAGAGCGCGTCCCCGGGGTTTACC ENST00000484446.1 ----------------------------------AGGA-------TCCTCAAG----ACC **** *** * * *** ENST00000413835.2 TTCTTCGGCTGTTTCCGGAATTCACCCGTAGTCTGTGGCCGGGAGGAGAAGGCGCGCCCC ENST00000484446.1 ATC---------------------------------GGCCAGG--------GCACG---- ** **** ** ** ** ENST00000413835.2 ACCTCCCGTTTCTAGCCGCTTCGGATGTTTCCGGCTGCTGCCGGCGAAAAGAGCCGAGGG ENST00000484446.1 -------------------TTCGG------------------------------TGAGGG ***** ***** ENST00000413835.2 CCGGCGGTGGTGGCGGCCATGTTGGGAGCAGCAGGTCCGGCGGCGGCTGCCTGTGTGCCG ENST00000484446.1 C-----------------ACACT----------GGTCCAGCA-----------TATGCTG * * * ***** ** * *** * ENST00000413835.2 GGCGCGGAGCAGTGCCGCTGAGGGCAGGGGAGGAGCGAGGCAGGCGGCCGGCTGCGGCGG ENST00000484446.1 A-----------------------CAGG--------GACCCAGGTAGCCA---------- **** ** **** *** ENST00000413835.2 CAGAGAGTAGGCGGAGCGGCGCGGCCCGGCCGAAAGGCGGCACAGCCCAGCCGGGGGTCG ENST00000484446.1 ---------------------------------------------------TGGAAATC- ** ** ENST00000413835.2 GGGGGGTGCGGTCCGGAGCCGCTCGGAGCCGGCGCGGCCTAGCCCGAGCGGCGCATCCCC ENST00000484446.1 ----------------------------------------ATCCCGAA------------ * ***** ENST00000413835.2 GGGCTGGCGTGAGCGGCTGCCCGGCCTCCCCGCACCCCCGGCCGGGGCCCATGCGGCGGG ENST00000484446.1 ----------GAA-GGCTG----GCTCCCCCGCA-------------------------- ** ***** ** ******* ENST00000413835.2 TGCTCCTGCTGTGAGAAGCCCCGCCCGGCCGGGCTCCGCGCCTTCCCTTCCCTCCCTTCC ENST00000484446.1 ------------------------------------------------------------ ENST00000413835.2 TCCAAGCTTCTCGGTTCCCTCCCCCGAGATACCGGCGCCATGTCCAGCGCTCGGACCCCC ENST00000484446.1 ---------------TCACTCTCCAGAGAGGTCAGTATCA-------------------- ** *** ** **** * * ** ENST00000413835.2 CTACCCACGCTGAACGAGAGGGACACGGAGCAGCCCACCTTGGGACACCTTGACTCCAAG ENST00000484446.1 -------------------------CGGAG------ACCCT---------------CAAG ***** *** * **** ENST00000413835.2 CCCAGCAGTAAGTCC-AACATGATTCGGGGCCGCAACTCAGCCACCTCTGCTGATGAGCA ENST00000484446.1 C----------GTCTGAACAT----------------TCAGCTCCATCAGGTGA------ * *** ***** ***** * ** * *** ENST00000413835.2 GCCCCACATTGGAAACTACCGGCTCCTCAAGACCATTGGCAAGGGTAATTTTGCCAAGGT ENST00000484446.1 --CTGACACCATAGAC-ACCGACT-----------------------ATTTGG---AGAT * *** * ** **** ** **** * ** * ENST00000413835.2 GAAGTTGGCCCGACACATCCTGACTGGGAAAGAGGTAGCTGTGAAGATCATTGACAAGAC ENST00000484446.1 GGAGTGCGTCGGAC----------------------------GAGGA------------- * *** * * *** ** ** ENST00000413835.2 TCAACTGAACTCCTCCAGCCTCCAGAAACTATTCCGCGAAGTAAGAATAATGAAGGTTTT ENST00000484446.1 -CAGCTGCAC---------CACCAGA---------------------------------- ** *** ** * ***** ENST00000413835.2 GAATCATCCCAACATAGTTAAATTATTTGAAGTGATTGAGACTGAGAAAACGCTCTACCT ENST00000484446.1 ----TATGCCACCACAGCCACAT------------------------------------- ** *** ** ** * ** ENST00000413835.2 TGTCATGGAGTACGCTAGTGGCGGAGAGGTATTTGATTACCTAGTGGCTCATGGCAGGAT ENST00000484446.1 ---------------------CGAGGAGG------------------------------- ** **** ENST00000413835.2 GAAAGAAAAAGAGGCTCGAGCCAAATTCCGCCAGATAGTGTCTGCTGTGCAGTACTGTCA ENST00000484446.1 -----AGGAGGAGGCCCACACCCGGTTCAGGCAGATTCCGTCAACACTGCAGGACTGCCA * * ***** * ** *** * ***** *** * ***** **** ** ENST00000413835.2 CCAGAAGTTTATTGTCCATAGAGACTTAAAGGCAGAAAACCTGCTCTTGGATGCTGATAT ENST00000484446.1 CTTAAAGAACATCTCACATGGAGACCTAAAGCCACAAAACATCCTACTGGATGAGGATGG * *** ** *** ***** ***** ** ***** * ** ****** *** ENST00000413835.2 GAACATCAAGATTGCAGACTTTGGCTTCAGCAATGAATTCACCTTTGGGAACAAGCTGGA ENST00000484446.1 CAACATCAAATACCTGGACTTTGGCTTCAGCACCACACTTAC-----GAAGTGTGCCAG- ******** **************** * * ** * * ** * ENST00000413835.2 CACCTTCTGTGGCA-GTCCCCCTTATGCTGCCCCAGAACTCTTCCAGGGCAAAAAATATG ENST00000484446.1 --CCTTTTGTGGCACGTACCCCCTACGTGGCCCCAGAACTCTTCCTGGGCCAGGGGTGTC **** ******* ** **** ** * **************** **** * * * ENST00000413835.2 ATGGACCCGAGGTGGATGTGTGGAGCCTAGGAGTTATCCTCTAT-ACACTGGTCAGCGGA ENST00000484446.1 A-GTGCCCGCCGTGGAGGTATG----CTTAGAGTAATGCTACACCACA-TGGTAGCCGGG * * **** ***** ** ** ** **** ** ** * *** **** *** ENST00000413835.2 TCCCTGCCTTTTGATGGACAGAACCTCAAGGAGCTGCGGGAACGGGTACTGAGGGGAAAA ENST00000484446.1 GCTCTGCCCTTCTA----------CTCTATGCACATCAAGAACAAA-ATAAACAGGAAAG * ***** ** * *** * * * * **** * * ***** ENST00000413835.2 TACCGTATTCCATTCTACATGTCCACGGACTGTGAA-AACCTGCTTAAGAAATTTCTCAT ENST00000484446.1 TAC-ACATTGC-CTCCATTTTTCTTTTCATTTCAAATAGATTTATTAAAAAGTTACTAAC *** *** * ** * * ** * * ** * * **** ** ** ** * ENST00000413835.2 TCTTAATCCCAGCAAGAGAGGCACTTTAGAGCAAATCATGAAAGATCGATGGATGAATGT ENST00000484446.1 ACTAGACCCCAGGGTGTGACCCCCACTGGAACAACCAATGAGGGACCCGTGGGTGGACAG ** * ***** * ** * * * ** *** **** ** * *** ** * ENST00000413835.2 GGGTCACGAAGATGATGAACTAAAGCCTTACGTGGAGCCACTCCCTGACTACAAGGACCC ENST00000484446.1 TGGCCA-GAAGATGCT--ACTGACTTCATACCAAGAATGACTCCTGAACTACCCGAACCC ** ** ******* * *** * * *** ** ***** ***** * **** ENST00000413835.2 CCGGCGGACAGAGCTGATGGTGTCCATGGGTTATACACGGGAAGAG-ATCCAGGACTCGC ENST00000484446.1 C-AACA-ACGCAGCTCATGGTGGCCATGGGAT-TCCAGGCCAAGAGCATCTC---CATGT * * ** **** ****** ******* * * ** * ***** *** * * ENST00000413835.2 TGGTGGGCCAGAGATACAACGAGGTGATGGCCACCTATCTGCTCCTGGGCT--ACAAGAG ENST00000484446.1 CAAAGAAA-AAACATTCAACTATCGCATGGCCACCTGCCTCATTTTAGAGTGCACAAAAA * * * ** **** * ********** ** * * * * **** * ENST00000413835.2 CTCCGAGCTGGAAG-GCGACACCATCACCCTGAAACCCCGGCCTTCAGCTGATCTGACCA ENST00000484446.1 AACAGAAGAGGAAGCGCTCCACCATCA----GAGCACCCTCCCTTCCTCTGGGGTTCCCA * ** ***** ** ******** ** *** ***** *** * *** ENST00000413835.2 ATAGCAGCGCCCCATCCCCATCCCACAAGGTACAGCGCAGCGTGTCGGCCAATCCCAAGC ENST00000484446.1 ------CCTTTTCTTCCCCAGCCCCCAAAGTTT---CCACCTTCTGGGAGAAACTGAAG- * * ****** *** *** ** ** * * * ** ** * *** ENST00000413835.2 AGCGGCGCTTCAGCGACCAGGCAGCTGGTCCTGCCATTCCCACCTCTAATTCTTACTCTA ENST00000484446.1 AG-GGC---TCAG-AGCGAGCCAGCT----------------TTTGAGACTTTTA----- ** *** **** * ** ***** * * * *** ENST00000413835.2 AGAAGACTCAGAGTAACAACGCAGAAAATAAGCGGCCTGAGGAGGACCGGGAGTCAGGGC ENST00000484446.1 ------------------------AAATTCAGCTGCCCGAGGAGGGCCAGAAGTCAGGAC *** * *** *** ******* ** * ******* * ENST00000413835.2 GGAAAGCCAGCAGCACAGCCAAGGTGCCTGCCAGCCC-CCTGCCCGGTCTGGAGAGGAAG ENST00000484446.1 AGAAGACCACCA------------TTCCTGCCAGTGCACCTGCC-GGCCTGCAGAGGAAG *** *** ** * ******** * ****** ** *** ******** ENST00000413835.2 AAGACCACCCCAACCCCCTCCACGAACAGCGTCCTCTCCACCAGCACAAATCGAAGCAGG ENST00000484446.1 ---------CCAGCC--------------------------------------------- *** ** ENST00000413835.2 AATTCCCCACTTTTGGAGCGGGCCAGCCTCGGCCAGGCCTCCATCCAGAATGGCAAAGAC ENST00000484446.1 -ATTTCC----------------------------------------------------- *** ** ENST00000413835.2 AGCACAGCCCCCCAGCGTGTCCCTGTTGCCTCCCCATCCGCCCACAACATCAGCAGCAGT ENST00000484446.1 AGTGAAGTCCCCCAGCATGACTCCATGGCCTCTCCCTCCAGCCAGAGCACCAGCAGCAGT ** ** ******** ** * * * ***** ** *** *** * ** ********** ENST00000413835.2 GGTGGAGCCCCAGACCGAACTA-ACTTCCCCCGGGGTGTGTCCAGCCGAAGCACCTTCCA ENST00000484446.1 GG----GTCCCTGGCTCAGTGACAATCATCACAGGA-------AGCC--AGCGTCCTCCA ** * *** * * * * * * * * ** **** *** * **** ENST00000413835.2 TGCTGGGCAGCTCCGACAGGTGCGGGACCAGCAGAATTTGCCCTACGGTGTGACCCCAGC ENST00000484446.1 AGCTGGGCAGC-CCAA-------------AGC----------------TGTGATGTC-GC ********** ** * *** ***** * ** ENST00000413835.2 CTCTCCCTCTGGCCACAGCCAGGGCCGGCGGGGGGCCTCTGGGAG-CATCTTCAGCAAGT ENST00000484446.1 CTCGCTGTCAAGA---AGCTGGGGCTGCCGCAGGGCCGCCAGGAGATGCCTTT--CAA-- *** * ** * *** **** * ** ***** * **** *** *** ENST00000413835.2 TCACCTCCAAGTTTGTACGCAGAAATCTGTCTTTCAGGTTTGCCAGAAGGAACCTGAATG ENST00000484446.1 -TGCTTTTAAA---------AGTATTATGTGTGT---GTCCACCGAAGAAAAC------- * * ** ** * * *** * * ** ** * *** ENST00000413835.2 AACCTGAAAGCAAAGACCGAGTGGAGACGCTCAGACCTCACGTGGTGGGCAGTGGCGGCA ENST00000484446.1 -------AAGCAAAA--TGATTGC-----------CCCGACATAGTTGG--ATGGCTGAA ******* ** ** ** ** * ** ** **** * * ENST00000413835.2 ACGACAAAGAAAAGGAAGAATTTCGGGAGGCCAAGCCCCGCTCCCTCCGCTTCACGTGGA ENST00000484446.1 --GACAAAAATCGAGTAGG---TGGGGCAGTCAAGCCGCACTTCCTGCATTTTACT---- ****** * * ** * *** * ****** * ** *** * ** ** ENST00000413835.2 GTATGAAGACCACGAGCTCCATGGAGCCCAACGAGATGATGCGGGAGATCCGCAAGGTGC ENST00000484446.1 GCATTAAGGCCCTGAGGTTCAAAAA---TATTAAAAACCTGTGACATGTTGGCCATGTGT * ** *** ** *** * ** * * * * ** * * * ** * *** ENST00000413835.2 TGGACGCGAACAGCTGCCAGAGCGAGCTGCATGAGAAGTACATGCTGCTGTGCATGCACG ENST00000484446.1 AGACTGC-AACAGCTGTGGGTGGGAGGCAGGCAAGAGGCCAATGCTTCCATG--TGCCCA * ** ******** * * *** *** * ***** * ** *** * ENST00000413835.2 GCACGCCGGGCCACGAGGACTTCGTGCAGTGGGAGATGGAGGTGTGCAAACTGCCGCGGC ENST00000484446.1 GCACACCCAGCCCAGTGG----CATTCAGCAGAGGATGGAGGTGTCCAAGTTGCTGCCGG **** ** *** * ** * * *** * *********** *** *** ** * ENST00000413835.2 TCTCTCTCAACGGGGTTCGATTTAAGCGGATATCGGGCACCTCCATGGCCTTCAAAAACA ENST00000484446.1 GGTCAGTGAACATGATTCTAGTCAAGACGGCATCTGGCAACCCTGCGGCCTTCAAAGGCC ** * *** * *** * * *** * *** **** * * ********** * ENST00000413835.2 TTGCCTCCAAAATAGCCAACGAGCTGAAGCTTTAACAGGCTGCCAGGAGCGGGGGCGGCG ENST00000484446.1 TCCTATCCAAAGCTACGGATGAGCTGAAG----GACAGCATGACA--------------- * ****** * * ********* **** ** ** ENST00000413835.2 GGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCGCCGCCCCACCTGGGCGAGACTGCA ENST00000484446.1 --------CCTCCTGGA-GACCAGAGGGCCCCT---CTGCCCCACCTGGTCCAGG--GCA ** ***** * * * **** ** * *********** * ** *** ENST00000413835.2 GCGATGGATTGGTGTGTCTCCCCTGCTGGCACTTCTCC--CCTCCCTGGCCCTTCTCAGT ENST00000484446.1 CCA-------------TCTCTTCCTCCGGTCTGTCCCCTGCTTCCTCTGCCCTGCCC--C * **** * * ** ** ** * *** ***** * * ENST00000413835.2 TTTCTCTTACATGTTTGTGGGGGGTGGGAGATTGTTCTCCAGCACCCCACATTCACCCCT ENST00000484446.1 CTTCCCCTTCCTCCCTGC--------------------CCAGC---------TCAC---T *** * * * * ** ***** **** * ENST00000413835.2 GCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAGGCAAAGGAAGGGGAGGGTGGATG ENST00000484446.1 GCC-----ATCCTCTCTCCACCTTTCC-----------------------AAGGTAGA-- *** ** * * ** * *** *** * *** ** ENST00000413835.2 GGGGGGCAGGGCTCCCCCTCGGTACTGCGGTTGCACAGAGTATTTCGCCTAAACCAAGAA ENST00000484446.1 ------CATAGCT---------TGCTGC----------------TCTCCTGAG------- ** *** * **** ** *** * ENST00000413835.2 ATTTTTTATTACCAAAAAGAAAAAAGAAAAAAAAAATCCCAGCGGCCACCTTTCCTCCCT ENST00000484446.1 ------------------------------------------------------------ ENST00000413835.2 GCCCCATTGGGACAGTCGAGACTGGATCTGTGGGGTTTCCCGGGAGGGTGGCTCAGGGCT ENST00000484446.1 GCCCCACTAAGGCTGT---GACT----CT----GGTCCCC----------GCT------- ****** * * * ** **** ** *** ** *** ENST00000413835.2 GGAACACTCTCAGGCAAGAGTGGTGGAGCTCCCGTCAGGCCCTCCGCCAGGCCCACTGTG ENST00000484446.1 ---ATCCTCTTGGACTTTATT-------TCCCTGGCA--CCCTCCAC-------AC---- * **** * * * * ** * ** ****** * ** ENST00000413835.2 GGCTTCTCCCCTCTCCTCCCTCCTTCCCCTCCAAGCAAACCACCAGAGGTGGCCTTCCCC ENST00000484446.1 --CTCCTTTTTGTTTGTCCCAGCCCCGCCCCCAA---------------------CTCCC ** ** * **** * * ** **** *** ENST00000413835.2 TGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGGGCAGGGGGCGGGGGTGCTGCGC ENST00000484446.1 TGTCCCCCAGCTCCT----------CCT--------------------------CTCC-C ** ** * ** *** *** ** * * ENST00000413835.2 AGCCCTGCAGTGGGTGGGGCTGGGGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCA ENST00000484446.1 ATTCCT--AAT---------------CCCCTC---------------------------- * *** * * * *** ENST00000413835.2 CAAGGCTCCGCCTCCCTCCACACTGTACCCTCTGCCCCTCCTCCCCAGAGCTGGG-CAT- ENST00000484446.1 ----ATCCTGATTCCTTTT---------CTCCTACATCTTCTCT----AGCTAAATCATC * * *** * * ** * ** *** **** *** ENST00000413835.2 TTCCTTCCACAAGCTGCTG-TGGGGACGTGTGTTCCCTCAAAGTCTGTGCCATCTTCTCC ENST00000484446.1 TTTCCTTTACATGCTAATAATCTGCCCTTCTGTCCCCTAGATGTCTGC-----CTTGTGC ** * * *** *** * * * * * *** **** * ***** *** * * ENST00000413835.2 CACCCCTCCCGGGTAGAAGGAGGGGCTGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGA ENST00000484446.1 AAC---------ATGGAATGA-----TGA----AAATCTAGAA-----------ACTGGA ** * *** ** *** * ** * * ****** ENST00000413835.2 GGGCAGACTGGCTTCTCGGTCCCCAGGGGGCCGCTTGGGCTGTTGGTCTCCAGAGCAGGG ENST00000484446.1 AT-----CTAACTCCT------------GGCC----------CTAGTC--------AGGA ** ** ** **** * *** *** ENST00000413835.2 CCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAGCACAGCCCCCTCGCCCTTCC ENST00000484446.1 CT--CAGGTTTTGTGAAAGGGAGAAA---------AAAAAAAAAG-------------CA * ** * ** * ** * * *** * ** * ENST00000413835.2 TCTCCCCATGGCTTCCCCTTCATTGGCATTAATCTGGGCACCAGCTCTCTCCATAGCAGT ENST00000484446.1 ACTCCCCATCAAAACCAATAC-CTAGTCTAGAGCCTGATATAAGCGCCACTCAAAACA-T ******** ** * * * * * * * * * *** * ** * ** * ENST00000413835.2 GACTTCCCTCACCACTCTCATCTCTCAGCCTTGCCTTTTCTTCCTGACACTGTCGCCCCC ENST00000484446.1 GTTTCCTTCCATTATTCT--TCTAT-AGCCAGGTAACTA-TTCCTAAAATAGAAGCCCCT * * * ** * *** *** * **** * * ***** * * * ***** ENST00000413835.2 TCCTCTCAGGAGACACTGCCGAGGGCCACCTGGCAGAAGGCTGAGTTAGGCAGCAGGGCC ENST00000484446.1 ---------GAGAC------------CAC------------TGAG--------------- ***** *** **** ENST00000413835.2 GGGAGCGTCTGCCCTCCACAGGGTGGGGGACAGATAGGCTAAGCGACTCCCAGCTTGCTA ENST00000484446.1 --AAGCATT--------GCAGTGTGG---------------------------------- *** * *** **** ENST00000413835.2 CCCTCAGTGGCCAGTGTGGGCGTGGGCGGTTTGGGGCGCTTGGCTGGTGGTGGCCACTGC ENST00000484446.1 -----AGTGACAAG-------------GGTCTGAGA------GCCGGTC----TTACTG- **** * ** *** ** * ** *** **** ENST00000413835.2 ATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAATTGGGGGTGGGAGTCCTAC ENST00000484446.1 -TCCCTTG-------TCCCC-CAATCACAGTT-------AACATGAAGCCGAACTCCAGA ****** ** * * * * *** ** * * * * *** ENST00000413835.2 ACAGAGGCTGCCCCTACCCTCACCTGAGTTGTACATTTTTTTGTGATGGGTTTTATTTTT ENST00000484446.1 GAAGAGCCAGGCCC-------------ATAGGGCATTT---------AGATTTTACTC-- **** * * *** * * ***** * ***** * ENST00000413835.2 TATTATTTTATTTTATTTTTTTTTTTTTTGATTTATGATGACTCCACCCCTCTTCATCAC ENST00000484446.1 -------CAAGTCTAATTCCCAGTCCAGTGCTCC----TGCCTCCAGCA-TCTGCATTTC * * ** ** * ** * ** ***** * *** *** * ENST00000413835.2 CCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTTGCGTCCTAGGAAGGGGCCT ENST00000484446.1 CTCTGTCC----GCCTGGC----CGAGGAAG--GGG----TGCGT----GGCAGAG---- * * * * *** *** *** *** * * ***** ** ** * ENST00000413835.2 TGCCAACCTCAGCCCTCCTGCCCCACACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCT ENST00000484446.1 TGCAGAGC------------------------ATGGGGAAAGAAAGCGAGG--------- *** * * * * * * * * *** ENST00000413835.2 CCCTCCCTTCCCCCCTCCTGCCCTATGGAACAGCCCGGGTGCTCTGAGGGGGCTGGGAGG ENST00000484446.1 ---------------------CCCACGGG-TAGCCCCAG------GAGGGCGGTGCGATG ** * ** ***** * ***** * ** ** * ENST00000413835.2 GCAT--GGCT-TGGCTCCCAAAGGGGGTAGGGGCCCGGGGCACCCAGGCAAGGTGGCCCC ENST00000484446.1 -CATTCAGCTCTCGCCCCCTGCCTGGGTGCAGGCCT-------CCAAGTGGG------TC *** *** * ** *** **** **** *** * * * ENST00000413835.2 TCCCCGTCTAGCCCCCTCCTCCCCAACCCTGCACTTAGTTTCTCCTCTGGATCAAACACG ENST00000484446.1 TTCCTGTTT--CTCCATCTTCTGAGGCCCAA-----AGCTTCCTC--------------- * ** ** * * ** ** ** *** ** *** * ENST00000413835.2 TAATAAAGAGAATGTTTGGAATCTG-- ENST00000484446.1 ------AGAGCCTCCGTGGGTCCCACC **** * *** *