CLUSTAL 2.1 multiple sequence alignment ENST00000419292.1 AGAGGCGGAAGTAAAAGCGAACTACAGTGGATGGGTGCAGTTCAGGCATTTCAAAAGGTT ENST00000467363.1 -----------------------ACA----------------CAG-CATTCCGAAAGGTT *** *** **** * ******* ENST00000419292.1 TGAACTACCTAACCATTATGGCACCAGGAAACCTCTGGCATATGAGAAATAACTTTCTCT ENST00000467363.1 TGGGCTACCTGACTATTATGGCACCAAGAAATCTCTGGTATATGAGAA----CTTTCACT ** ****** ** ************ **** ****** ********* ***** ** ENST00000419292.1 TTGGTTCAAGATGTTGGATGACTCGATTTTCAGCAGAAAACATCTTCAAATCAGTTTCAT ENST00000467363.1 TTAATTCAAAATGTTGGATGACCTGATTTTCAGCAGAAATGCTCTTCAAATCAGTTTCAC ** ***** ************ *************** ***************** ENST00000419292.1 TTAGGCTTTTTGGTGTGAAGTGTCATAATACAGACAGTGAGCCTTTGAAAAATGAGGACC ENST00000467363.1 TTAGGCTTTTTGGTGTGAAGTGAAACGATGCAGACAATGAGC-TTTGGAGAATGAGGAAC ********************** * ** ****** ***** **** * ******** * ENST00000419292.1 TACTGAAAAACTTACTTACTATGGGAGTAGATATTGACATGGCAAGGAAACGACAGCCTG ENST00000467363.1 CACTGAATAACTT----ACTATGGAAGTGGATACTGACATGGCAAAGAAACGACAGCCTG ****** ***** ******* *** **** *********** ************** ENST00000419292.1 GAGTTTTTCATAGGATGATTACCAATGAGCAGGACCTGAAGATGTTCCTTCTTTCCAAAG ENST00000467363.1 GAGTTTTTAACAGAATG-TTCCCAATGAGCAGGACCTGAAGATGTTTCTTCGTTCCAAAG ******** * ** *** ** ************************* **** ******** ENST00000419292.1 GAGCTAGCAAAGAAGTGATCGCTAGCATCATATCAAGATATCCACGAGCAATAACACGTA ENST00000467363.1 GAGCTAGCAAAGAAGTGATTGTTAGCATCATATCAAAATAACTAAAAGCTATAACACACA ******************* * ************** *** * * *** ******* * ENST00000419292.1 CTCCCGAGAATCTTTCAAAACGGTGGGATCTGTGGAGAAAGATTGTGACATCAGACCTTG ENST00000467363.1 CTCTTGAACGTCTTTCAAAACAATGGGATCTATGAAG---GATTATGATATCAGATCTTG *** ** *********** ******** ** ** **** *** ****** **** ENST00000419292.1 AAATTGTAAATATTTTGGAACGTTCTCCTGAATCCTTTTTTCGGTCCAATAACAACCTAA ENST00000467363.1 ATACTGTAAATATTTTGGGCCATTCTCCTGAATGCTTTCTTTTGTCCCATGAAAACCTAA * * ************** * *********** **** ** **** ** * ******* ENST00000419292.1 ACTTAGAGAATAATATAAAGTTCCTCTACTCAGTTGGATTGACCCGTAAATGCCTTTGTC ENST00000467363.1 ACTTAGGGATTC-TATGA-GTTCCTCTACTCAGCTGGATTTACCTGTAAATGCCTTTGTT ****** ** * *** * ************** ****** *** ************** ENST00000419292.1 GATTGTTGACCAATGCCCCTCGTACCTTCTCCAATAGTCTTGATCTGAATAAACAGATGG ENST00000467363.1 GATTGTTGACCAATGTCCCTTGTACCTTTTCCAATAGTCTCGATCTGAATAAACAGATGG *************** **** ******* *********** ******************* ENST00000419292.1 TTGAATTTTTGCAGGCAGCCGGTTTGTCATTGGGTCACAATGATCCCGCAGATTTTGTCA ENST00000467363.1 TTAAAGTTTTGCAGGAAGTATATTTTTCATTGGGTCACAATGATCCCACAGATTTTGTAA ** ** ********* ** *** ********************* ********** * ENST00000419292.1 GAAAGATAATTTTTAAAAACCCTTTTATCTTAATTCAGAGCACCAAGCGGGTGAAAGCTA ENST00000467363.1 GAAAGATGATTTTTTAAAACCCTTTCATCTTAATTCAGGGTACCAAGCAGGTAAAAACTA ******* ****** ********** ************ * ******* *** *** *** ENST00000419292.1 ACATTGAATTCTTACGGTCAACTTTCAATTTGAACAGTGAGGAACTGCTGGTTCTGATAT ENST00000467363.1 ACATTGAATTTTTACAGGCAAGTTTCAATTTGAACAGTAGGGAATTGCTA-TTTTAATAT ********** **** * *** **************** **** **** ** * **** ENST00000419292.1 GTGGTCCAGGAGCTGAAATCCTAGACCTTTCCAATGACTATGCCAGAAGAAGCTACGCAA ENST00000467363.1 GTGGTCCAGGAACCAAAATCCTAGACCTTTCCAATGACTATGCCAAAACAAACTACACAA *********** * ****************************** ** ** **** *** ENST00000419292.1 ACATCAAAGAGAAGCTGTTTTCTCTTGGATGTACTGAAGAAGAGGTACAGAAGTTTGTCT ENST00000467363.1 ATATCAAACAGAAGCTGTTTTCTCTCTGAGGTACTGAAGAAGAGGTACAAAAGCTTGCCT * ****** **************** ** ******************* *** *** ** ENST00000419292.1 TAAGCTATCCAGATGTG-------------ATCT----------TCTTGGCAGAGAAAAA ENST00000467363.1 TAAGTTATCCAGATGTGGGGAAAAAAAGTTATCCAGATGTGATCTTTTGGCAGAGAAAAA **** ************ *** * ************** ENST00000419292.1 GTTTAATGATAA------------------------------------------------ ENST00000467363.1 GTTTAGTGAGAAGAATATTTTAGCTTGGTGCAAAAGTAACTATGGTTTTTGGGCAAAAAC ***** *** ** ENST00000419292.1 -----------------------AATAGACTGCCTCATGGAAGAAAACATTAGCATTTCA ENST00000467363.1 CATAGTTACTTTTGCACCAATCTAATGGATTGTCTCATAGAATAATAAATTAGCCTTCTG *** ** ** ***** *** ** * ****** ** ENST00000419292.1 CAAA------------TAATCGAAAA-TCCTCGGGTTCTGGATTCAAGCATAAGTACTTT ENST00000467363.1 TGAAAGTAATTTGTGATAACTGAAAAATCCTTGGGTTCTGGATTCAAGCATAAGTACTTT ** *** ***** **** **************************** ENST00000419292.1 AAAAAGTCGAATCAAAGAATTGGTAAATGCTGGCTGTAACTTGAGTACTTTAAACATCAC ENST00000467363.1 ATAAAGTCAAATCAAAGAATTAGTAAATGCTGGCTGTAACTTGAGGACATCAAGCATCAC * ****** ************ *********************** ** * ** ****** ENST00000419292.1 TCTTCTATCTTGGAGT----AAAAAAAGATATGAAGCTAAATTGAAAAAGTTAAGCAGAT ENST00000467363.1 TCTTCTACTCTGGAGTTAAAAAAAAAAGATACAAAG-TAAATTTAAAAAGTTAAGCAGAA ******* ****** *********** *** ****** *************** ENST00000419292.1 TTGCCTAAGGATGCCAATGTTTTTAATTCTCAGGAACTGTGAATATGTTATGCCACATTG ENST00000467363.1 C--ACTGGGGA--------------ATTTTTGAAAGCCA-------GTCAT---ATAATG ** *** *** * * * ** ** * * ** ENST00000419292.1 CAAAAGAATTTTGCAGAAGTGATTAATTTAAAATGTTATTAAGGGCCTTGAGATGGGGAG ENST00000467363.1 TAGTGGTATCTT----------TTCATTTTGAATTT------GGGCCTT----------- * * ** ** ** **** *** * ******* ENST00000419292.1 ATTATCCTGAATTACTTTGGAGGGCCTAATATAATTGTAGGGATCTTTAAAAGTTGAAGA ENST00000467363.1 ----TCAAAAA-------GGAGGG----GTATGATT-------TCTT------------- ** ** ****** *** *** **** ENST00000419292.1 GGGAGGCAAAAGAGGAGGTCAGAGTGATCCTGTATAAGAAAGACAACTACTTTTGAAGGA ENST00000467363.1 ---AACCA-----------CAGA-------TATATATATGTAATAATT-CTTT------- * ** **** * **** * ** * **** ENST00000419292.1 AGTTAAAAGGTGGCTTTGAAGGAGGAAGACACCTTGAGCCAAGGAATGAAGGGGGCCTGT ENST00000467363.1 --------GGCTATTTTG-------------TTTT------------------------- ** **** ** ENST00000419292.1 AAAAAAAGATTGAAAAGGCAAGGAAACAGATTCTCCATTAGAGTCCCCAGAAAGGAATGC ENST00000467363.1 ----ACAGGTT-------TATGGAAAC----TCATGGTTGATATGCTCAGG------TGC * ** ** * ****** ** ** * * *** *** ENST00000419292.1 AGCCTTGCTGGC-ACCTTTTTAGCCCAGTGAGATCAATGTCAAACTTCTGACCCACAGAA ENST00000467363.1 AGTCCTCCTAGCTACCTATTT--TCCAGT----------TTGAATTACT--CCAACATA- ** * * ** ** **** *** ***** * ** * ** ** *** * ENST00000419292.1 CCATAAGATGGTA-AATTTGTGTTGTTTTAAA--CCACTGAGTCAGTGATAATTTGCTGA ENST00000467363.1 CCATTATTTGATACAGGCTGTGCTGCTGTAGAGATGGTAGTGCCA-TGGTGATTTGCT-- **** * ** ** * **** ** * ** * * * ** ** * ******* ENST00000419292.1 AGAAGCAAATAGATTAACATAGCAACTAAGTAGATGATTAGTTGCATTATAGGTGAAGTC ENST00000467363.1 ------ACACAGATCATCCCATCACCTAGGTA---------------------TTAAGCC * * **** * * * ** *** *** * *** * ENST00000419292.1 AAAAATACAGTCCTTTAGTAAAGTCTCTATTTCTTCCTTTTATAAGAGTAATTATATTTA ENST00000467363.1 CAGCAT-----CCATTAGTTA---------CTCTTCCTTATGC--------TCTCCCTCC * ** ** ***** * ******** * * * ENST00000419292.1 AAAAATCTACCTACCCTTCTGGAATTGCTAATGT-TAGTGTTTATA--AAGTCTTAA-AT ENST00000467363.1 CAGCAGC-ACC---CCTCCAACAGGCCCCAGTGTGTGTTGTTCCCTCCATGTGTTGACGT * * * *** *** * * * * *** * **** * ** ** * * ENST00000419292.1 GTGTGCATAAAA-AACTAAATGTGAATATAAAATCTAAATAAAGGAATATGTT-TGCCTA ENST00000467363.1 GTGCTCATTATTCAGCTCCCTGT----------TGTAAGTGA--GAACATGTGGTGCTTG *** *** * * ** *** * *** * * *** **** *** * ENST00000419292.1 ATATAGTTTAAGGAAATGATAATCATTTCTGTGCATTTTGTTGGCATTTCAGCTAATATT ENST00000467363.1 GT----TTT-------------CCGTTCCTGCG----TTA-----ATTT--GCTGAGGGC * *** * ** *** * ** **** *** * ENST00000419292.1 AAAGAGTAATT--TTCAGAGGCATTGACTTAAAAAATGGCAAATCAGATAATGTCGGTAT ENST00000467363.1 AAAACCTGATTACTTTGAAAACA---AGTTCTACTGTGGCAGGCAGAATCATGGCCACAC *** * *** ** * ** * ** * ***** ** *** * * ENST00000419292.1 TTTCAAGATACAATCTAGCTCTGACATAAACTGAAAGACGTGAGACAAATTATATGACCT ENST00000467363.1 CTA-AAGATGTCAAC--GTTTTAATTTGAA---GAAGCTGCGA-ATATGTTATGCAA--- * ***** * * * * * * * ** *** * ** * * **** * ENST00000419292.1 TAATTTTAATTGTTTTCCAGAGGCATTTGTTTTCTAGATGTGGTTTTTGAATTAAATAAC ENST00000467363.1 -------AAAGATTTTGCAAATGTGATTAAGTTG-AAATTTGAT---TAAGTTAAGGGCC ** **** ** * * ** ** * ** ** * * * **** * ENST00000419292.1 ATAATGGTGCTCAACCTTTTAAACCTCATTTGCTATCAGTGATACTTCAAAAAACCTTA- ENST00000467363.1 TTGA-GATG----ACCTT--GAA--TCATCTG-----AGTGG-ACCTAATATAATGCTAA * * * ** ***** ** **** ** **** ** * * * ** ** ENST00000419292.1 ---TTCCTACTATTGATAAAAACAATATGTCTGCTTTTCTAAGGCCATTTATATATTCAA ENST00000467363.1 GGGTCCTTAAAAGTGG-AAGAAGGAGGCAAAAG--------AGGTCAG----------AA * * ** * ** ** ** * * *** ** ** ENST00000419292.1 CGATACTCCTATTATAATTTGG--TTAACTA-TTTGATGGCAA-GCATGGCATAGTTT-- ENST00000467363.1 TGATGCT----GTATAAGACAGACTTGACCACTTTGAAGGAGGTGAAAAGGAGGCTTTGA *** ** ***** * ** ** * ***** ** * * * * *** ENST00000419292.1 AGAAAGCAAGAGCTTTAGAGTGATGTAT-CTGGGCACCATTCCTGAGTAACTTGTGTTAA ENST00000467363.1 AGAAGGAAGGGACCATAAGCCAAAGAATGCAGGGGGCCA---CAAAGAAAACTGA----- **** * * * * ** * * ** * *** *** * ** ** ** ENST00000419292.1 TGTTTTAAATTTACTAAACCTGTTTTTCTCATCTGTAACACCAGAAATTGACCTTCCAGA ENST00000467363.1 ------AAAGCCAATGAAACAGAATCTCCC----------CTAAA----GGCC--CCAAA *** * * ** * * * ** * * * * * ** *** * ENST00000419292.1 GTTGGTAGGAATCAAATGAAAA-AGCACCTCTAAGGTTTCTTGCACATAGTA--ATGATG ENST00000467363.1 A-----AGGAATGCAGTACGGCTGGTACCTTTTCAGCCCAGTGGGCCCAGTATCATACTT ****** * * * **** * * ** * **** ** * ENST00000419292.1 CAATCAGTGATAGCTATA--ATAAAAAGATAGTATTTTAAAAAGCAGCTTTATAC-ATAA ENST00000467363.1 CTGTCCTACAGAACCACAGGATGATAAATTTGTGTTGTTTGAAGCCACTGAGTCTGATAA * ** * * * * * ** * ** * ** ** * **** ** * **** ENST00000419292.1 TTCACATATTCAATTTACCTATTTAAAGTCTAACACAGTTCAATTTA-TATATAGAGTTG ENST00000467363.1 TTTG----------TTACAGCAGCAAAGATTAACATAG--CAACTAAGTAGAT-GATTTG ** **** **** ***** ** *** * * ** ** ** *** ENST00000419292.1 T-GCAACTTTATCTTCCATTGCTTATAATACATTTATAATTTATTGGAAAATTTATAAGG ENST00000467363.1 TTGCA---TTATA----GGTGGTCACAAAA----TACAATCCTTTAG------TATCA-- * *** **** ** * * ** * ** *** ** * *** * ENST00000419292.1 AAAATGAATTTCTTACAGTTATGGAAGCTGAGAAATCCTAGGTTGAGGGGCCACAT-CTG ENST00000467363.1 ----TGTATTTTTTCCTCTTACAAGAGT-----AATTACATTTAAAAAAGCTATCTACTG ** **** ** * *** ** *** * * * ** * * *** ENST00000419292.1 GTG-AGAGCC-TTCTTGCTGGTGGGGACTCTGAAGAGTCCT---GAGGCG-GCACAGTGT ENST00000467363.1 TTCTAGAATCACTGTCGTTGTTTACAAT-----AAAGTCCTTTAAATGTGCGCATAAAAA * *** * * * * ** * * * ****** * * * *** * ENST00000419292.1 ATCACATGGCGATTGCTAATGTACTTA--GGTCTCTTTTCCTCTTATAAAGCCACCAGTC ENST00000467363.1 ACTAAATGTGAATAA--AATGTAAATAAAGGAATATTTTTGCCTAATAAA--TACAAAGA * * *** ** ****** ** ** * **** ** ***** ** * ENST00000419292.1 CACTCCCATGATAG-CCTATTAATTCATTAATCCATGAATAGATTAATCAATTTCTGATG ENST00000467363.1 AA-----ATGAAAATCCCAGCAACCTATTT-TTTGTGGATA--TTAACAAA---CTGATT * **** * ** * ** *** * ** *** **** ** ***** ENST00000419292.1 ACATAGCCCTTATGATCCAGTCACCTCTTAAAGGCCCCACCTCTCAATACTGCCACATTG ENST00000467363.1 CTAAAGTGTACATGG--------------AAAAGC----------AAAA------GATTC * ** *** *** ** ** * *** ENST00000419292.1 GGGATTAAATTTCAACATGAGTTTTGGAGGGGATGGATAGTCAAACCATAGCAGCAACCA ENST00000467363.1 AGAATA----TGCAAGAC-AATATTAAATGAGAAGAA----CAAA--GTAGGAGCA-CTG * ** * *** * * * ** * * ** * * **** *** **** * ENST00000419292.1 TCACCA--CAATCT--AGTTTTAGAATATGTTTGCAGTCCTAACAGAAACCTTGTACCTG ENST00000467363.1 ACACTATCCGACTTCAAGAGTTAGAACAAAGCTATAG---TAATTGAAACAGTGTGG-TA *** * * * * ** ****** * * ** *** ***** *** * ENST00000419292.1 TTAGTGAATCCCCATTATTTCCCTCCATTTGTTCCCCCAAGCCTAAGCAAAAATGAATCT ENST00000467363.1 TTGGCAAAAGCC-ACCAAATACATCAGT---------GAAACAGAAGAGAAAGCCCACAT ** * ** ** * * * * ** * ** * *** *** * * ENST00000419292.1 GTTTTCTGTGTCTATAAATTTGTTTATTCTGAGCATTTCATATAAATGGAATCATACAGT ENST00000467363.1 AGTCTTT---TCCACAAAT-------------GGATCTAGAACAAATGGATACCCACA-- * * * ** * **** * ** * * ******* * *** ENST00000419292.1 ATGGTCTTTTGTGACTGGCTTCTTTCACTTAGCATATTTTCAAGGTTCATCCATGTAGCA ENST00000467363.1 ---------TGCAA-----------AAAAAAAAAAAAAAAAAAAAAAAAAGAATCTAG-A ** * * * * * ** * ** *** * ENST00000419292.1 CATATTAGTATTTCATTTTTTTTGGCAAGTAATATTCCATTGTATGGGT-ACAGTAGTAT ENST00000467363.1 CA----AAGACCTCACACTATTCA-CAAAAATTGACTCA--AAATGAATCACAG------ ** * * *** * ** *** * * ** *** * **** ENST00000419292.1 TGGGAATACATTTTACTGTTATGGCTTAAAGTATTGATTTCTTAAGTCTTCTGAATTGTA ENST00000467363.1 ---------ACCTAAATGTAAAATGTAAAACCATAGAACTCCTAGA------AAATAATG * * * *** * * *** ** ** ** ** *** * ENST00000419292.1 CGCGAGTGTTTTCTGAGGTATTGTTTTGGAATCTAACAAGCTCATAAGGGACTTGAAGGA ENST00000467363.1 TACAAG--------AAAGTTCAGCT----GATCT--TGAGCATGAAAGTGACTTTTTATA * ** * ** * * **** *** *** ***** * ENST00000419292.1 GGTGGGTAGAAGAGATAATAGTTTATTGACATCAGCAGATCATAGGATTGTAGCTGGGCT ENST00000467363.1 TATAA-TACCAAAGGTG-CAATCCATGAA----AG-AAATCATTG-ATA--AGCTAGACT * ** * ** * * * ** * ** * ***** * ** **** * ** ENST00000419292.1 G-ATGAGAAATGGTATAGCAACGATAGTTGCAAGTGGCCAGAGAGAATGTGGGTTGCACT ENST00000467363.1 TCATTAAAATTGAAA-----ACGTCTCCT-----TGATATAAGACACTGTCAACTGA--- ** * ** ** * *** * ** *** * *** ** ENST00000419292.1 GAAGTACAGTACAGCACTTGATCATTGGGCAGTAGGGGATGGGGGAAGGAAAACTTTGGA ENST00000467363.1 GAAAGACA----AGC-----------------CAAAGGCTAGGAGAA--AATATTTGCAA *** *** *** * ** * ** *** ** * ** * ENST00000419292.1 GAAACAAACA-GATAATGC-CTGTCAGGCAAAATTAACATGTCATACTTTAAGGT-TTGA ENST00000467363.1 GAAACATGTATGATAAAGAACTGTTATCCAAAAT----ATTTT---TTTTAAAGTCTTAA ****** * ***** * **** * ****** ** * ***** ** ** * ENST00000419292.1 GTCTGATCAAGGGAGAGTCAATTCTTTTTTTTTAAAGATAGAATTATAGAAATATTGGCC ENST00000467363.1 AACTCATTAAGAAAAA--TAATT---------TAAAAATGGG----CAAAAGACTTGAAC ** ** *** * * **** **** ** * * ** *** * ENST00000419292.1 AGCCATGTAATCCCAGCTCACGCCTGTAATCCCAGCAATTTGGGAGGCCGAGGTGGGAGG ENST00000467363.1 AGACAC----------CTCAC-----------CAAAAAAT----ACATACAGATGGAA-- ** ** ***** ** ** * * ** *** * ENST00000419292.1 ATTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGTAATACTAGCAAGATATCATTGCTA ENST00000467363.1 --TAC--AGGCATATGAA---AAGA--AGCT-------------CAACATAT-ATTATTA * * ** * ** **** *** *** **** *** ** ENST00000419292.1 GTAGGGAAAAAAAAAAAAAAAAA ENST00000467363.1 GGA-------------------- * *