CLUSTAL 2.1 multiple sequence alignment ENST00000422163.1 ACACGTTGCCCAGCCGTGTGGCTGGGATGGTCGGTACCCATGGCCGTGCG--GTCGAG-- ENST00000541815.1 AAAAGCTGTTTGACAGCAT--CTGCAACAAGTGGTTCACAAACACGTCCATCATCTACTT * * * ** * * * *** * *** * ** *** * ** * ENST00000422163.1 CCTTGA-----------TGCTCCAGGACAG--TCCTGGAAGGCTTCCTGGCAGA-----T ENST00000541815.1 CCTCAACAAGAAGGAGCTGTTGGAGGAGAAGATCACACACAGCC-CCTGACCATCTGCTT *** * ** * **** * ** * ** **** * * ENST00000422163.1 CCGTGGGAAGAAAG---CCGACAGAAGGGCGG-GAGGCGGGAGGGGAAAGGTCCCCCGGG ENST00000541815.1 CCCTGAGTACACAGGGTCCAACA--AGTATGATGAGGCAGCCAGCTACAA-----CCAGA ** ** * * * ** ** *** ** * ***** * * * * ** * ENST00000422163.1 ATGGGT---AGGGCCTCAACGCTGGGCATCGGCGCAGGTGTGTACTGCAGGGAGCCAGCC ENST00000541815.1 GTAAGTCTGAGGACCTGAA---TAAGCA----CAAAGAC----ACCAAGGAGATCTACAC * ** *** *** ** * *** * ** ** * ** * * * ENST00000422163.1 AGACCCCCCACGGACTGCCTG-ACCTTGGGGGAAGCCCGGAGTAGAGGAAGAGGCCGGAC ENST00000541815.1 ACACTTCACATGCGCCACCGATACCAAGAACGTAGTTCGTGTTTGA------TGCC--AT * ** * ** * * ** *** * * ** ** * ** *** * ENST00000422163.1 CCCCAGACCCGCCATTGACTATGTCCGCCATTGACTATG---TGTTCTGAGAGAAATTTT ENST00000541815.1 CACCGACGTCATCATCAAGAACAACC-TGAAGGACTGGGGCCTCTTCTGAGGGGCAGTGG * ** * *** * * ** * **** * * ******* * * * ENST00000422163.1 TTTTTTTTTTTTTGAG-----ACTGAGTCT-CACTCTTTCGCCCAGGCCGGAG-TGCAGT ENST00000541815.1 GACCTAGCAGGATGGGCCACCACCAACTCTGTACCCCCCAACCCCTGAGGAAGATGGGGC * ** * ** * *** ** * *** * * ** ** * ENST00000422163.1 GGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGG-----TTCACGCCATTCTCCTG ENST00000541815.1 AAGAAGACCATGG-TCCCCAC-----CTGTTCCCTGGACACTTTTCTCTTCTTTCCTTTG ** * ** ** * * * * ** ** *** * * *** ** ENST00000422163.1 C-CTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCTACCGCGCCCGGC-TAATTTT ENST00000541815.1 TTCTTAGCTCCCCCATCCCCTCAG-CTTCAGACATAGGGGA--GGGGTTGCCACAGGCCT ** *** *** * ** * ** *** * * * * * * * * * ENST00000422163.1 TTGTATTTTTAATAGAGACGGGGTTTCACCGTGTTAGCCAG-GATGGTCTCGAT-CTCCT ENST00000541815.1 CCCTGTTT-----GAAGCCTGCCCTTGTCTGAGGT-GCCAGTAATGGCCATGGTACCCCC * *** ** * * ** * * * * ***** **** * * * * ** ENST00000422163.1 GACCTCGTGATCCGCCCGCCTTGGCCTCCCAGAGTGCTGGGATGACAGGCGTGAGCCTCT ENST00000541815.1 TTTCTGGGCATCTTTCTGGT---ACCCCCCAGAA-GCTGTGAAGAT-----------TCT ** * *** * * ** ****** **** ** ** *** ENST00000422163.1 GAGAGCAAATTTTACCCAGTTCCTCTC--TATCCTCCCGATGACTCTGAAATCAAACTCA ENST00000541815.1 --------ATTCTACTCAGTAGCTCTCATTATGTAAAGAGGAACCCTGAAATAAA--TCA *** *** **** ***** *** ** ******* ** *** ENST00000422163.1 GCAAGTCATCCGAGCCCCCACGGCGCAGCGGCCCTAGGCTGGCATGGGCGATGCGGAGCT ENST00000541815.1 GTTGTTCCTGAAAGTTCACAAGAGTAAGAAAAC--AGACTGA-AT---CGTAAAAGAACT * ** * ** * ** * ** * ** *** ** ** ** ** ENST00000422163.1 ACTCCGCCCTCAGGAAGCAGGCG--AGGT----GCCCAG--CGGGAGAATCACCCACATC ENST00000541815.1 AACTGGTATAAAAGAAGAAGCCAGAAAGTAGTGGACTGGGACCAGAGAAATA---ATATT * * * **** ** * * ** * * * * ***** * * ** ENST00000422163.1 ACCGTCTAATC--TCTGCTGTG-AAGTGGAAGCGCGAGAAGGAGGGAGCGTCTCATGACG ENST00000541815.1 TGAATTTAATTAATCTGTTCAACAAATATTTGCTCCTT-----GCTAACATTT--TGCC- * **** **** * ** * ** * * * * * * ** * ENST00000422163.1 GAGGGTGTGAAGACGCTAGGCTGGACGAAGCAGAAAGGCGGGTGTCACTGGGGACGTTCT ENST00000541815.1 -AGGTCCTATGCTTGTTATACAGTTTTGATCAGACAGACACG-GCCCAAGGGTAC-TTAG *** * * ** * * * **** ** * * * * *** ** ** ENST00000422163.1 GAGGGTGCTGGGGAGTCAGGGAAGAGCACCATCGT-CAAGCAGATGAAGAT---CATCCA ENST00000541815.1 AAAGCTAGTTGCGGGTGAAGGGGGAGAGCCAATGTACAAGAAAACAAATATATATAATTG * * * * * * ** * ** *** *** ** **** * * ** ** * ENST00000422163.1 CGAG----GATGG--CTACTCCGAGGAGGAA-----TGCCG-GCAGTACCGGGCGGTTGT ENST00000541815.1 TAAGTTACAGTGGTGCTACAACAGAAAAAAAGAGGTTGCCATGTAAGATGATAAGAAGGT ** *** **** * * ** **** * * * * ** ENST00000422163.1 CTACAGCAACACCATCCAGTCCATCATGGCCATTGTCAAAGCCA-TGGGCAACCTGCAGA ENST00000541815.1 ATA-AGGAATTTACTTTGGACCA----AGCATTCAGGAAGGCCTCTGAGGAAG--GCAAA ** ** ** * * *** ** * ** *** ** * ** *** * ENST00000422163.1 TCGACTTTGCCGACCCCTCCAGAGCGGACGACGCCAGGCAGCTATTTGCACTGTCCTGCA ENST00000541815.1 ---GCTTGACCAG-------AGGGTAGGAGGAACTCAGAGG------ACAGTG----AAA *** ** ** * * * * * * ** ** * ENST00000422163.1 CCGCCGAGGAGCAAGGCGTGCTCCCTGATGACCTGTCCGGCGTCATCCGGAGGCTCTGGG ENST00000541815.1 GGAGAGAGGAATAAGGGGTG------GGGGGGGAGGGTGGAG--ATTTCAAGG---TGGA ***** **** *** * * * ** * ** *** *** ENST00000422163.1 CTGACCATGGTGTGCAGG-CCTGCTTTG---GCCGCTCAAGGGAATA-----CCAGCTCA ENST00000541815.1 GTGA--AAAATGCAAAGATCCTAAAATAAAAGCATCTCTAAGAATCAGAGGGCCAGTTTG *** * ** ** *** * ** *** * * * * **** * ENST00000422163.1 -ACGACTCAGCTGCCTAC--TACCTGAACGACCTGGAGCGTATTGCACAGAGTGACTACA ENST00000541815.1 GATGGCTTGACC-TCTACCCTTCTTGAATCCCCTTTG--ATACTGAACATTTTGG--AAA * * ** * **** * * **** *** ** ** *** ** * * ENST00000422163.1 TCCCCACACAGCAAGATGTGCTACGGACCCGCGTAAAGACCACGGGGATCGTGGAGACAC ENST00000541815.1 ATCCCGTGTAGCA---TATACTGTGTGCCTTC-------CCACAATAACTGATGA----C *** **** * * ** * ** * **** * * ** * ENST00000422163.1 ACTTCACCTTCAAGGACCTACACTTCAAGATGTTTGATGTGGGTGGTCAGCGGTCTGAGC ENST00000541815.1 TCTTAAATCTCACAAAAACAAA-TTCAA-----CTGATG-----AATTCACGTCCTT--- *** * *** * * * ***** ***** * ** ** ENST00000422163.1 GGAAGAAGTGGATCCACTGCTTTGAGGGC-GTCACAGCC---ATCATCTTCTGCGTAGCC ENST00000541815.1 --------TTAACATAC-ATTTTGAAGATTATCTTAGCCCAAACCGGCACCCACATCCTT * * ** ***** * ** **** * * * * * * ENST00000422163.1 TTGAGCGCCTATGACTTGGTGCTAGCTGAGGACGAGGAGATGAACCGCATGCATGAGAGC ENST00000541815.1 CTGAGCGTAC-TGACTC---ACTAGACAAAGCCAACCCCTCCCCTCCTGTGTACAAAAAT ****** ***** **** * * * * * ** * * * ENST00000422163.1 ATGAAGCTATTCGATAGCATCTGCAACAACAAGTGGTTCACAGACACGTCCATCATCCTC ENST00000541815.1 A----GCTTTTCCATA---TCTACTGTTGTAATTGTTTTTTTTCCAGGGCT-TTATGCTC * *** *** *** *** * ** ** ** ** * * * ** *** ENST00000422163.1 TTC-----CTCAACA---AGAAGGAC---------CTG--TTTGAG----GAGAAGATCA ENST00000541815.1 TACTGAAACTAAACACTTAAATGAGCAATTTCACTCTGGTTTTAAGCCCAGGGGAAATGA * * ** **** * * * * *** *** ** * * * ** * ENST00000422163.1 CACACAGTCCCCTGACCATCTGCTTCCCTGAGTACACAGGGGCCAAC---AAATATGATG ENST00000541815.1 CA-ACGGTTT--TGTC--TCTGTTT---TGAG-ACTTAGGGGCAAATTTTAAAT-CGTTA ** ** ** ** * **** ** **** ** ****** ** **** * * ENST00000422163.1 AGGCAGCCAGCTACATCCAGAGTAAGTTTG-AGGACCTGAATAAGCGCAAAGACACCAAG ENST00000541815.1 ATATA--TAATTA-ATCCTATGTAACATCATAGAAACAAAACATCTGATTCTTCTTTCAG * * * ** **** **** * ** * * ** * * * ** ENST00000422163.1 GAGATCTACACGCACTTCACGTGCGCCACCGACACCAAGAACGTGCAGTTCGTGTTTGAC ENST00000541815.1 TATATT---GCACACGTAAAATGCACA--TGAAACCAGGTTTGGAGAGTG-ATTCTTAGT * ** * *** * * *** * ** **** * * *** * ** ENST00000422163.1 GCCGTCACCGATGTCATCATCAAGAACAACCTGAAGGACTGCGGCCTCTTCTGAGGGGCA ENST00000541815.1 AACGTAGCC--TTGCATT-TGTGCTTCGACATAAA--ATTGAGACATTCTC-AAGAGGCC *** ** * *** * * ** * ** * ** * * * ** ** *** ENST00000422163.1 GCGGGGCCTGGCGGGATGGGCCACCGCCGACTTTGTACCCCCCAACCCCTGAGGAAGATG ENST00000541815.1 TTGGGACATGGTGACATG-----TTGCGCAGTTTGG-----CCAGCA---GAGGGAGACC *** * *** * *** ** * **** *** * **** *** ENST00000422163.1 GGGG---CAAGAAGATCACGCTCCCCGCCTGTTCCCCCGCC--GCTTTTCTCCTCTTTCC ENST00000541815.1 AGAGAGTCGTGAAG--CACGCAACGAAGCCACACCCAGATTAGGGTTATTATCTGTCTCT * * * **** ***** * * *** * ** * ** * ** ENST00000422163.1 TCTCTTTGTTCTCAGCTCCCCCTGTCCCCTCAGCTCCAGACGTAGGGGAGGGGTTGCCA- ENST00000541815.1 TCTCTGAATTTTCAAAA--------------AACACAAAAAGAAAATGAGAAATTCTTAA ***** ** *** * * * * * * * *** ** * ENST00000422163.1 --CAGGCCTCCCTGTTT---GAAGC--------------------CT-GCCCTTGTCTGA ENST00000541815.1 AACAAAGCCCCTTTTTTATTGAAGCAAAATCCACATAACATAAAACTAGCCCTTCTAAAG ** * ** * *** ***** ** ****** * ENST00000422163.1 GATGCTGGTAATGGCCATGGTACCCCCTTCTGGGCATCTGTTCTGGTTTT-TAACCATTG ENST00000541815.1 TGTGCAATTAAGTGGCATC-TACCTCATTCACAG----TGTTATGGAACCGTCACCTCTA *** *** * *** **** * *** * **** *** * *** * ENST00000422163.1 TCTTGTTCTGTGATGAGGGGAGGGGGGCACATGCTGAGTCTCCCA-AGGCTGCGTCTGGA ENST00000541815.1 TCTAGTTCCAAAACATAAGAA-------ATGT-TTAAATTTTCTATAAAGGGAACTTGCA *** **** * * * * * * * * * * * * * ** * ENST00000422163.1 GGGGCCCCTGCTTCTCCAGCCTGGACCCCCAGCTTTGCC-CAACACCAGCCCCTGCCCCA ENST00000541815.1 AAAACCCAGGCGTGTCCTATC----CTCCTTATTTCGTCACATTCCCAGTTT-TGTGTCC *** ** * *** * * ** ** * * ** **** ** * ENST00000422163.1 GCCCAAGTCCAAATGTTTACAGGGA-GCCTCCTGCCCAGTCCCCCAACCCCAGCCGCTCG ENST00000541815.1 ACCGGTATTC---TGT---CAGGAATGGTCCCCACGTGTTCCCCCAAC---AGCC-TTCG ** * * *** **** * * ** * ********* **** *** ENST00000422163.1 GAGGCCCCAAAGGAAAAAGCACAAGAAGCG---TGAGACGCCACCATTCCTGG-----AA ENST00000541815.1 ------TCACTGTACAATTCATA-GAATCGGATTCAGG-GTTACAATTACAGGTTCGAAA ** * * ** ** * *** ** * ** * ** *** * ** ** ENST00000422163.1 ACCA---------CAGTCCACCTGCTCATTCTCGTAGCTTTTTA-------AAAAAATGA ENST00000541815.1 ACCAAAAACATCCCAGTTCTTTAGTTCTTCCTCTAGGAATTGCACAGTTGCAATAGACAA **** **** * * ** * *** * ** * ** * * * ENST00000422163.1 A--AGTAAAGG ENST00000541815.1 GCCAGTATA-- **** *